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effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-prevention_disposition-comments.pdf
May 08, 2013 - Baseline differences in a randomized trial can occur due to
chance or because of manipulation of treatment … Randomised, controlled trial of
alternating pressure mattresses compared with alternating
pressure … Second, prospective, randomized clinically controlled
trials of nutritional supplementation are often … Finally, to prospectively analyze the incidence of pressure ulcer
development in a randomized and controlled … All
five studies were randomized controlled trials, which limits their
risk of bias.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f-surv-report-3-acute-pain.xlsx
October 08, 2025 - Risk of bias assessment for randomized controlled trials
Author, Year
(Full Citations Are Listed in … No Yes; 11% Yes Poor
Ilyas, 2021 No (by birth year) No Yes Yes No No Yes No/No No Yes; excluded 44 randomized
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f-surv-report-2-acute-pain.xlsx
October 08, 2025 - Risk of bias assessment for randomized controlled trials
Author, Year
(Full Citations Are Listed in … No Yes; 11% Yes Poor
Ilyas, 2021 No (by birth year) No Yes Yes No No Yes No/No No Yes; excluded 44 randomized
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-adults_executive.pdf
August 01, 2012 - We included studies if they: were randomized (RCTs) or
nonrandomized controlled trials (nRCTs), or prospective … controlled trial; SANS = Scale for the Assessment of Negative Symptoms; SAPS = Scale for the
Assessment … KQ = Key Question; RCT = randomized controlled trial
KQ3: Medication-Associated AEs and Safety
The findings … KQ = Key Question; RCT = randomized controlled trial; SoE = strength of evidence
10
We were unable … controlled trial
aResponse rates were defined by authors of the primary studies and may have varied
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/engaging-caregivers-appendix-c.xlsx
October 08, 2025 - Risk of bias for randomized controlled trials
Author, Year Randomization Adequate?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_surveillance.pdf
January 01, 2013 - One pragmatic trial in 19,934 women
randomized to vitamin E plus aspirin
versus aspirin alone for 10 … controlled trial; SCEPC: Southern California Evidence-based Practice Center; TG triglyceride; VLDL … ,
randomized trial. … Bays 201210
12-week multi-center
randomized
controlled double
blinded trial of
Icosapent
ethyl( … One pragmatic trial in 19,934 women randomized to vitamin
E plus aspirin versus aspirin alone for 10
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-executive-summary.pdf
May 01, 2025 - We found no
controlled studies that reported the effectiveness of screening with MCSTs, though some … This
includes the NHS-Galleri trial, a randomized trial among 140,000 persons in the United
Kingdom … larger trial of screening with
MCSTs. … trial. … Cancer
stage compared with mortality as end points
in randomized clinical trials of cancer
screening
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-treatment_research-protocol.pdf
September 30, 2010 - We will focus on published randomized controlled clinical trials. … We will review unpublished randomized controlled clinical trials that were included in the FDA
medical … controlled trials;
Published non randomized trials;
Unpublished supplemental trials data from the … For randomized controlled trials (RCTs), we will abstract the number randomized to each
treatment group … Systematic review: randomized, controlled trials
of nonsurgical treatments for urinary incontinence
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-193-naloxone-executive-summary.pdf
November 01, 2017 - controlled trials (RCTs) conducted in field settings … Randomized controlled trials in U.S. field settings that
compare the FDA-approved IN formulations of … Randomized controlled
trials could pose ethical and logistical challenges in field
settings, such as … Randomized controlled
trial comparing the effectiveness and safety of intranasal and
intramuscular … a
randomized clinical trial.
-
effectivehealthcare.ahrq.gov/sites/default/files/vte-protocol-8-4-10.pdf
February 01, 2008 - Additionally, randomized controlled
trials will be assessed for randomization technique and allocation … Randomized controlled trials (RCTs) will be pooled
separately from observational studies with a control … For study design,
whether the study was a randomized controlled trial or an observational study will … controlled trial
RR Relative risk
THR Total hip replacement
TKR Total knee replacement
V/Q Ventilation … controlled trial
RCT
Relative risk
RR
Total hip replacement
THR
Total knee replacement
TKR
Ventilation
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/blood-clots-hip-knee-surgery_research-protocol.pdf
February 01, 2008 - Additionally, randomized controlled
trials will be assessed for randomization technique and allocation … Randomized controlled trials (RCTs) will be pooled
separately from observational studies with a control … For study design,
whether the study was a randomized controlled trial or an observational study will … controlled trial
RR Relative risk
THR Total hip replacement
TKR Total knee replacement
V/Q Ventilation … controlled trial
RCT
Relative risk
RR
Total hip replacement
THR
Total knee replacement
TKR
Ventilation
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-evidence-summary.pdf
December 01, 2020 - due to adverse events, nausea, dizziness, and somnolence,
but serious adverse events are uncommon in randomized … Methods
Electronic databases (Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane
Central Register of Controlled … Randomized controlled trials (RCTs) of opioid therapy versus nonopioid
pharmacologic or nonpharmacologic … Neck pain (5 trials): No trial evaluated pharmacologic therapy for acute neck pain.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-202-thermoplasty-comments.pdf
December 14, 2017 - to be
weak, and agree that a blinded and
randomized trial was appropriate for
assessing impact on … treatment effect and safety can be made based on
five-year follow-up from all three randomized controlled … Six trials, including three randomized
controlled trials (RCTs) (n=432)18-20
and their 5-year, single-arm … Both the comparisons with standard of care and the sham
controlled trial were done well and all have … As noted above, only one sham-controlled trial of BT
has been conducted thus far.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
March 01, 2022 - • Large high-quality randomized controlled trials to
evaluate new treatment options of whole-body … • Large high-quality randomized controlled trials to
evaluate new treatment options of whole-body … • Multisite trial-based studies, where patients are
randomized to standard management, telehealth … • Randomized controlled trials with adequate power
to compare risk of clinical fracture endpoints … • Randomized controlled trials with adequate power
to compare risk of clinical fracture endpoints
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharma-treatment-pain_research-protocol-amended.pdf
September 20, 2017 - controlled
trials (RCTs) for specific interventions and conditions. … standards for a randomized controlled trial. … controlled trials or high
quality systematic reviews of
randomized controlled trials published
in … controlled trial or systematic reviews)
29 27 and (random* or systematic or meta*).ti,ab.
30 28 or … controlled trial or systematic reviews)
35 33 and (random* or systematic or meta*).ti,ab.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharm-treatment-chronic-pain-protocol.pdf
December 11, 2018 - controlled trials or high
quality systematic reviews of randomized
controlled trials published in … The feasibility of a quantitative synthesis will
depend on trial size, the number and completeness of … As a
qualitative assessment, clinical trial registries will be searched for
unpublished studies and … controlled trial or systematic reviews)
29 27 and (random* or systematic or meta*).ti,ab.
30 … controlled trial or systematic reviews)
23
35 33 and (random
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_executive.pdf
July 01, 2009 - Data from three fair
quality RCTs with fewer than 100 patients in each trial
did not show significant … trial has examined the effect
of catheter ablation on the risk of stroke or death. … Only one small RCT suggested that first-line RFA
(prior to a trial of AADs) may be of benefit for patients … Only randomized controlled trials could receive a
“good” grade. … controlled trial;
RFA=radiofrequency catheter ablation; WACA=wide area circumferential ablation.
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
June 02, 2011 - controlled trials a high grade. … Scales to assess the quality of randomized controlled
trials: a systematic review. … and non-
randomized studies). … controlled trial, or an observational
study with a clear pre-defined inception cohort
0: study … Scales to assess the quality of randomized
controlled trials: a systematic review.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/preterm-birth-terbutaline-pump_research-protocol.pdf
October 18, 2010 - A scoping literature search suggests that no randomized
controlled trials have been published since … trials (randomized and
non-randomized)
• Observational studies
o Prospective and retrospective … Table 2: Criteria to assess risk of bias within included studies
Criteria Randomized
Controlled
trials … controlled trials
• Nonrandomized controlled/comparative trials
• Prospective cohort studies
• … Terbutaline pump maintenance therapy for prevention of preterm delivery: a double-blind trial.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-surgery-preparation_research-protocol.pdf
March 26, 2013 - tool for randomized controlled trials.23 For nonrandomized comparative studies and
single-group studies … Thus, randomized controlled trials will be
graded as having a high, medium, or low risk of bias, and … Single-blinded randomized trial of mechanical
bowel preparation for colon surgery with primary intraperitoneal … trial. … A generalized linear modeling framework for pairwise
and network meta-analysis of randomized controlled