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Total Results: 1,519 records

Showing results for "randomized controlled trial".

361. CER 218 Disposition of Comments: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-disposition-comments.pdf
     April 23, 2019 - blinded phase 2 clinical trial. … blinded phase 2 clinical trial. … Vertebral fractures after discontinuation of denosumab: A post hoc analysis of the randomized placebo-controlled … However, it is unrealistic to consider a new long-term placebo- controlled, fracture end point trial … placebo-controlled FREEDOM Trial and its extension.

362. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_research-protocol.pdf
     November 30, 2011 - Controlled Trials, Clinical Trial Results, WHO Trial Registries), grants databases (NIHRePORTER, … telaprevir.mp OR boceprevir.mp Hepatitis C and treatment 1 AND 2 15019 Methods Limit (randomized … controlled trial or controlled clinical trial or meta analysis or review).pt. or clinical trials as … sustained virological response than peginterferon alpha-2b in chronic hepatitis C: systematic review of randomized … Evaluating non-randomized intervention studies. Health Technol Assess. 2003;7(27):iii-x, 1-173.

363. Evidence Summary_Comparative Effectiveness Review No. 247_Interventional Treatments for Acute and Chronic Pain: Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
     September 01, 2021 - Benefits are smaller in sham compared with usual care controlled trials and larger in trials of patients … Methods Electronic databases (Ovid® MEDLINE®, PsycINFO®, the Cochrane Central Register of Controlled … Randomized controlled trials (RCTs) of populations undergoing the designated interventional procedures … Effects of vertebroplasty were reduced in sham versus usual care controlled trials and larger in trials … However, an important limitation of the evidence is the absence of sham-controlled trials of kyphoplasty

364. Asthma-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-treatment_executive.pdf
     May 01, 2011 - controlled trials (RCTs) except one, which was a randomized crossover trial.22 We excluded the remaining … Buteyko breathing techniques in asthma: a blinded randomised controlled trial. … Randomized trial of the effect of an integrative medicine approach to the management of asthma in adults … controlled trial. … Breathing retraining for dysfunctional breathing in asthma: a randomised controlled trial.

365. The series of articles beginning with this issue of the Journal form the most up-to-date version of the Guide for Conducting Comparative Effectiveness Reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-principles_methods.pdf
     August 01, 2009 - Centralization at the SRC of activities where EPC proficiency and skill vary, such as searching clinical trial … controlled trials (RCTs) to case reports. … of bias from confounding by indication and other threats to internal validity.40,42–47 The ideal trial … The evolution of the randomized controlled trial and its role in evidence-based decision making. … Should meta-analyses of interventions include observational studies in addition to randomized controlled

366. Making Healthcare Safer IV_Rapid Review: Use of Structured Handoff Protocols for Intrahospital Within-Unit Transitions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/structured-handoff-rapid-research.pdf
     January 01, 2025 - Two systematic reviews and two new original research studies (one a randomized controlled trial) provided … RCT = randomized controlled trial. SBAR = situation, background, assessment, recommendation. … RCT = randomized controlled trial. SIGNOUT? = sick or DNR? … A randomized controlled pilot study. … Controlled trial to improve resident sign-out in a medical intensive care unit.

367. The Effectiveness and Risks of Long-Term Opioid Treatment of Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_executive.pdf
     September 19, 2014 - We rated the quality of each randomized trial based on the methods used for randomization, allocation … One randomized trial found no difference between more liberal dose escalation versus maintenance of … Abuse, addiction Low No randomized trial evaluated risk of opioid abuse, addiction, and related outcomes … Nonetheless, pragmatic and other non-traditional randomized trial approaches could be used to address … A randomized trial of 2 prescription strategies for opioid treatment of chronic nonmalignant pain.

368. Ch 9-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_9-user-guide-to-ocer_130129.pdf
     September 21, 2012 - This chapter provides an overview of study size and power calculations in randomized controlled trials … controlled trials (RCTs). … In the case of a trial comparing treatments, this is the probability of finding a statistically significant … cholesterol), investigators must make assumptions about the standard deviation of the outcome in each trial … CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials.

369. Effects of Dietary Sodium and Potassium Intake on Chronic Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sodium-potassium_research-protocol.pdf
     April 18, 2017 - Effects of salt substitutes on blood pressure: a meta-analysis of randomized controlled trials. … controlled trial[pt] OR randomized controlled trials OR rct* OR blind* OR double-blind* OR single-blind … controlled trial[pt] OR randomized controlled trials OR rct* OR blind* OR double-blind* OR single-blind … controlled trial[pt] OR randomized controlled trials OR rct* OR blind* OR double-blind* OR single-blind … controlled trial[pt] OR randomized controlled trials OR rct* OR blind* OR double-blind* OR single-blind

370. Kidney-Stone-Prevention Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-stone-prevention_research-protocol.pdf
     June 15, 2011 - Prevention of Recurrent Stone Disease Many randomized controlled trials (RCTs) have studied dietary … Grey literature searching may include searches of regulatory data, trial registries, and abstracts … clinical trial or meta analysis or randomized controlled trial) 12 limit 10 to systematic reviews … 13 11 or 12 14 exp meta-analysis/ 15 exp randomized controlled trials/ or systematic review.mp … . 16 exp controlled clinical trial/ 17 or/14-16 18 10 and 17 19 13 or 18 20 limit 19 to

371. Stroke Prevention in Atr ial Fibr illation Patients: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-afib-update_research-protocol-amended.pdf
     October 27, 2017 - controlled trial; TIA = transient ischemic attack; VKA = Vitamin K antagonists. … controlled trial SRDR Systematic Review Data Repository TIA transient ischemic attack TEE transthoracic … controlled trial[Publication Type] OR controlled clinical trial[Publication Type] OR randomized[tiab … Controlled Trial"[Publication Type] OR "Controlled Clinical Trial"[Publication Type] OR randomized … Controlled Trial"[Publication Type] OR "Controlled Clinical Trial"[Publication Type] OR randomized

372. Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-nomination-apbi-breast-cancer.pdf
     April 01, 2017 - , 1184 patients were enrolled in a phase 3, noninferiority trial and were randomized to WBI plus a tumor … Breast and Bowel Project B39/Radiation Therapy Oncology Group (RTOG) 0413 trial5 and Randomized Trial … The RTOG 9804 randomized clinical trial included women with screen-detected DCIS, low to intermediate … Most important, the Randomized Trial of Accelerated Partial Breast Irradiation trial randomized 2135 … RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy

373. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1406.pdf
     June 01, 2014 - controlled trial, SCALE™ (Satiety and Clinical Adiposity-Liraglutide Evidence in Non- diabetic and … Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial … Multicenter, placebo-controlled trial of lorcaserin for weight management. … A one- year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM … Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus

374. CER 173 Executive Summary: Diabetes Medications for Adults With Type 2 Diabetes: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
     January 01, 2015 - controlled trial. … HARMONY 3: 104-week randomized, double-blind, placebo- and active-controlled trial assessing the efficacy … In macroVascular Events): a randomised controlled trial. … United Kingdom Prospective Diabetes Study 24: a 6-year, randomized, controlled trial comparing sulfonylurea … controlled trial.

375. Disposition of Comments for CER 202 Effectiveness and Safety of Bronchial Thermoplasty in the Management of Asthma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-202-thermoplasty-comments.pdf
     December 14, 2017 - to be weak, and agree that a blinded and randomized trial was appropriate for assessing impact on … treatment effect and safety can be made based on five-year follow-up from all three randomized controlled … Six trials, including three randomized controlled trials (RCTs) (n=432)18-20 and their 5-year, single-arm … Both the comparisons with standard of care and the sham controlled trial were done well and all have … As noted above, only one sham-controlled trial of BT has been conducted thus far.

376. Assessing the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias-individual-studies_methods.pdf
     March 01, 2012 - controlled trials a high grade. … Scales to assess the quality of randomized controlled trials: a systematic review. … Correlation of quality measures with estimates of treatment effect in meta- analyses of randomized controlled … controlled trial, or an observational study with a clear predefined inception cohort (that attempted … Scales to assess the quality of randomized controlled trials: a systematic review.

377. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-radiation_executive.pdf
     November 01, 2009 - No trial reported significant differences in overall or cancer-specific survival or in total serious … Comparators assessed in the randomized controlled trials Cancer type and center Comparison N Survival … This is simply because of the relative lack of comparative studies in general, and randomized trials … Comparative studies (preferably randomized) are likely necessary to provide meaningful answers on the … theorized advantages of particle beam therapy vs. contemporary alternative interventions are proven in controlled

378. Dietary Intake of Polyunsaturated Fatty Acids and Plasma Lipid and Cardiovascular Events (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/polyunsaturated-fatty-protocol.pdf
     January 01, 2024 - Note that the term “effect” does not necessarily imply restriction to randomized controlled trial evidence … Criteria Exclusion Criteria Design Key Question 1 • Studies of adults o Parallel or cross-over randomized … controlled trials (RCTs)  n ≥25/group* • Studies of children o Parallel or cross-over RCTs  … Search strategies will include filters to restrict to randomized controlled trials (RCTs) and systematic … Controlled Trials.

379. Dietary Saturated Fat Replacement and Plasma Lipid and Cardiovascular Events (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/saturated-fat-replacement-protocol.pdf
     January 01, 2024 - Note that the term “effect” does not necessarily imply restriction to randomized controlled trial evidence … Dietary cholesterol intake None Design Key Question 1 • Studies of adults o Parallel or cross-over randomized … controlled trials (RCTs)  n ≥25/group* • Studies of children o Parallel or cross-over RCTs  … Search strategies will include filters to restrict to randomized controlled trials and systematic reviews … Controlled Trials.

380. Cystic-Fibrosis-Hgh Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_surveillance.pdf
     August 01, 2012 - controlled trial; rhGH recombinant human growth hormone 31 References 1. … A multi-center controlled trial of growth hormone treatment in children with cystic fibrosis. … controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR placebo[tiab] OR drug … controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR placebo[tiab] OR drug … clinical trial randomized 68 participants to receive rhGH 12 months, followed by 6 months followup