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effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1412.pdf
December 01, 2014 - Replication of ketamine's antidepressant efficacy
in bipolar depression: a randomized controlled … controlled trial. … Effects of ketamine on explicit and implicit
suicidal cognition: a randomized controlled trial
in … A
pragmatic randomized controlled trial of
computerized CBT (SPARX) for symptoms of
depression … A pilot
double blind randomized placebo controlled trial
of a prototype computer-based cognitive
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-executive-summary.pdf
August 01, 2024 - Our searches covered publications in MEDLINE®,
Embase®, Cochrane Register of Controlled Trials, and … We included randomized controlled trials (RCTs)
and nonrandomized studies of interventions (NRSIs) comparing … Observational studies
should apply advanced methods such as target trial emulation for making causal … mitomycin C; RT- radiation
therapy; derm-dermatologic; GI-gastrointestinal; GU-genitourinary; RCT- randomized … controlled trial; yrs- years; vs.- versus;
RR- relative risk.
5
Strengths and Limitations
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening_research.pdf
June 01, 2013 - Study Design
Considerations Randomized Controlled Trial Quasi-Experimental: Before-After study
(Variations … MRSA = methicillin-resistant Staphylococcus aureus; RCT = randomized controlled trial
28
Discussion … controlled trial
U.S. … controlled trial[pt] OR controlled clinical trial[pt] OR randomized controlled trials[mh] OR
random … AND controlled AND trial OR controlled AND clinical AND trial* OR randomized AND
controlled AND trials
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
March 01, 2013 - Although the use of a
composite outcome as the primary outcome in a clinical trial can reduce sample … For example, Hansen et al.33 combined functional outcomes measured on different
scales in placebo-controlled … Composite outcomes in randomized trials:
greater precision but with greater
uncertainty? … Testing for heterogeneity among the
components of a binary composite outcome
in a clinical trial. … Problems with use of
composite end points in cardiovascular
trials: systematic review of randomised
controlled
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-appendix-3.xlsx
June 24, 2022 - NAM 2018 Lack of alignment between randomized controlled trial (RCT) endpoints and RWE endpoints, noting … NAM2019 Replicating randomized clinical trial results with observational databases can help establish … NAM2019 The cost of the trial?
NAM2019 The risk/benefit ratio of trial participation? … CMS Design_bias For observational, and in some cases randomized controlled trials, the method in that … CMS Design_bias For observational, and in some cases randomized controlled trials, the method in that
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-executive-summary-2023-update.pdf
January 01, 2023 - randomized controlled
trials (RCTs), one of oral THC, CBD, and combination THC/CBD1 and one of two … We included randomized controlled trials and
comparative observational studies with a minimum of 4 weeks … Characteristics of included randomized controlled trials of cannabinoids
Characteristic THC/CBD THC … controlled trial; THC = tetrahydrocannabinol. … d One trial is included in both the synthetic THC and CBD columns, as it compared THC to CBD, CBD/THC
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_disposition-comments.pdf
October 01, 2010 - In November, results from a randomized trial of a similar patient
population were presented at the AHA … To this end, even though it is statistically flawed, it may
be reasonable to compare published controlled … The randomized trial recently reported to
the FDA measured the same QoL endpoints, and produced similar … quality of life after circumferential pulmonary vein ablation for atrial
fibrillation: outcomes from a controlled … Discussion In November, results from a randomized trial on the use of the
NAVISTAR THERMOCOOL Catheter
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/wheelchair-users-amended-protocol.pdf
June 21, 2019 - • Non-U.S. applicable
studies (See Appendix
B, Table B-1)
Study
designs
• Randomized controlled … trial versus
observational study, study location). … controlled trial
29. 27 and (random* or control* or trial or cohort or group* or arm*).ti,ab.
30 … controlled trial
39. 37 and (random* or control* or trial or cohort or group* or arm*).ti,ab.
40 … controlled trial
29. 27 and (random* or control* or trial or cohort or group* or arm*).ti,ab.
30
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-treatment_research-protocol.pdf
February 10, 2010 - controlled trials
Controlled clinical trials
Comparative observational studies
(prospective … controlled trials
Controlled clinical trials
Comparative observational studies
(prospective … controlled trials
Controlled clinical trials
KQ 1, KQ 2, and KQ 3:
Editorials, letters, nonsystematic … Administration Medical and
Statistical Reviews and Authorized Medicines for the European Union), clinical trial … Such criteria include: adequate
randomization methods (for randomized controlled trials [RCTs]), consideration
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_executive.pdf
July 01, 2012 - controlled trial
aSome studies/articles were included for more than one KQ, so that numbers given in … controlled trial; RD = risk difference;
SOE = strength of evidence
aData are for larger studies with … controlled trial
21
Glossary
ACPE acute cardiogenic pulmonary edema
AHRQ Agency for Healthcare … controlled trial
SAPS Simplified Acute Physiology Score
TEP Technical Expert Panel
TOO Task Order … Noninvasive ventilation
in acute cardiogenic pulmonary edema: a meta-analysis of
randomized controlled
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-210-breastfeeding-evidence-summary.pdf
January 01, 2020 - controlled trial; OR = odds ratio; RCT = randomized controlled trial. … Monitoring System; RCT = randomized controlled trial; ROB= risk of bias; WIC = Special
Supplemental … trial; ROB = risk of bias; RCT = randomized controlled trial. … controlled trial; ROB = risk of bias. … Telephone peer counseling
of breastfeeding among WIC participants: a randomized
controlled trial.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
April 01, 2015 - ICU = intensive care unit; KQ = Key Question; PPH = postpartum hemorrhage; RCT = randomized controlled … One randomized
controlled trial (RCT) of tranexamic acid versus no
tranexamic acid reported significantly … All sites,
including those participating in the active sites of a null
cluster randomized trial, were … KQ = Key Question; PPH = postpartum hemorrhage; RCT = randomized controlled trial. … controlled trial;
SOE = strength of evidence.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/crohns-disease_disposition-comments.pdf
February 25, 2014 - This review only contains randomized, controlled trials (RCT) for issues of induction
and maintenance … For efficacy endpoints, we only
included randomized controlled
studies. … Clinically meaningful improvement
in health-related quality of life in a randomized controlled trial … Colombel et al conducted a multicenter, randomized, double-blind, controlled trial comparing
INFLIXIMAB … trial where they were randomized to naltrexone or placebo for 12 weeks.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-evidence-summary-2022-update_0.pdf
January 01, 2022 - Since the original systematic review published in October
2021, one new placebo-controlled randomized … controlled trial (RCT) of oral CBD1
and one new observational study of plant-based comparable THC to … Characteristics of included randomized controlled trials of cannabinoids
Characteristic THC/CBD THC … controlled trial; THC = tetrahydrocannabinol; US = United States. … trial.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/measuring-blood-pressure_research-protocol.pdf
April 11, 2011 - controlled trials, quasi-randomized controlled
trials, and nonrandomized prospective studies) … Thus, randomized controlled trials will be graded as good, fair,
or poor and observational studies will … controlled trial.pt. … C
om
parative studies (K
ey Q
uestion 1-4)
10 controlled clinical trial.pt.
11 randomized controlled … $.tw.
23 (randomized control trial or clinical control trial).sd.
24 (latin adj square).tw.
25
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
December 01, 2011 - Randomized controlled trials (RCTs) of at least 6
weeks’ duration and in adult study populations were … Insomnia
Six head-to-head trials (all fair quality) and one
placebo-controlled trial provide limited … Results from one good placebo-controlled trial showed no
difference between fluoxetine and placebo. … Key Question
IR Immediate release
MDD Major depressive disorder
NNT Number needed to treat
RCT Randomized … controlled trial
SRC Scientific Resource Center
SR Sustained release
SSNRI Selective serotonin norepinephrine
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1406.pdf
June 01, 2014 - Replication of ketamine's antidepressant efficacy
in bipolar depression: a randomized controlled … controlled trial. … Effects of ketamine on explicit and implicit
suicidal cognition: a randomized controlled trial
in … A
pragmatic randomized controlled trial of
computerized CBT (SPARX) for symptoms of
depression … A pilot
double blind randomized placebo controlled trial
of a prototype computer-based cognitive
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-protocol_amended110619.pdf
November 02, 2019 - trial. … controlled trial
RD= risk difference
RP= radical prostatectomy
RR= risk ratios
RT= radiation therapy … , all or clinical trial, phase i or clinical trial, phase ii or clinical trial, phase
iii or clinical … analysis or multicenter study or observational study or pragmatic clinical trial or randomized
controlled … controlled trial/ or random allocation/ or double-blind method/ or single-blind
method/ or placebos
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/grading.ppt
January 01, 2010 - Drug comparisons in randomized controlled trials (RCTs), with either placebo or an active comparator … controlled trial
Number of Studies (Subjects) Domains Pertaining to Strength of Evidence Magnitude … controlled trial
Number of Studies (Subjects) Domains Pertaining to Strength of Evidence Magnitude … For example, for mortality, randomized controlled trials are separate from retrospective cohort studies … This table shows that one fair-quality randomized controlled trial (RCT) with 80 subjects reported mortality
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
January 01, 2007 - Based on direct
data from randomized controlled trials, most oral
diabetes medications (thiazolidinediones … Only two randomized
controlled trials reported information on peripheral
vascular disease, making it … controlled trial should compare
thiazolidinediones, metformin, sulfonylurea, and
metformin plus a sulfonylurea … This randomized trial
of subjects with uncontrolled type 2 diabetes compared
addition of rosiglitazone … controlled
trial; TG = triglycerides.
16
AHRQ Pub.