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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-reporting-bias_methods.pdf
November 01, 2013 - As a third example, given the
fact that only 60 percent of randomized controlled trials (RCTs) described … Comparison of registered and published primary
outcomes in randomized controlled trials. … Transition from meeting abstract to full-length
journal article for randomized controlled trials. … A
systematic review of controlled trials. Controlled
Clinical Trials. 1998;19(2):159-66.
98. … controlled trial
RePORT Federal Research Portfolio Online Reporting Tools
SAE Serious adverse event
-
effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_conductingquantitativesynthesis.pdf
October 01, 2010 - Randomized controlled trials (RCT) of A vs. … In principle, studies from different randomized trial designs,
e.g. parallel, cross-over, factorial … The results of direct and indirect treatment
comparisons in meta-analysis of randomized
controlled … Randomized, controlled trials, observational
studies, and the hierarchy of research
designs. … A comparison of
observational studies and randomized,
controlled trials.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-quantitative-synthesis_methods.pdf
October 01, 2010 - Randomized controlled trials (RCT) of A vs. … In principle, studies from different randomized trial designs,
e.g. parallel, cross-over, factorial … The results of direct and indirect treatment
comparisons in meta-analysis of randomized
controlled … Randomized, controlled trials, observational
studies, and the hierarchy of research
designs. … A comparison of
observational studies and randomized,
controlled trials.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-210-breastfeeding-evidence-summary.pdf
January 01, 2020 - controlled trial; OR = odds ratio; RCT = randomized controlled trial. … Monitoring System; RCT = randomized controlled trial; ROB= risk of bias; WIC = Special
Supplemental … trial; ROB = risk of bias; RCT = randomized controlled trial. … controlled trial; ROB = risk of bias. … Telephone peer counseling
of breastfeeding among WIC participants: a randomized
controlled trial.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-g-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - Quality assessments of included randomized controlled trials
Author, Year Randomization Adequate Allocation … Quality Assessment of Included Randomized, Controlled Trials
image1.jpeg
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_executive.pdf
July 01, 2012 - controlled trial
aSome studies/articles were included for more than one KQ, so that numbers given in … controlled trial; RD = risk difference;
SOE = strength of evidence
aData are for larger studies with … controlled trial
21
Glossary
ACPE acute cardiogenic pulmonary edema
AHRQ Agency for Healthcare … controlled trial
SAPS Simplified Acute Physiology Score
TEP Technical Expert Panel
TOO Task Order … Noninvasive ventilation
in acute cardiogenic pulmonary edema: a meta-analysis of
randomized controlled
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effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1412.pdf
December 01, 2014 - Replication of ketamine's antidepressant efficacy
in bipolar depression: a randomized controlled … controlled trial. … Effects of ketamine on explicit and implicit
suicidal cognition: a randomized controlled trial
in … A
pragmatic randomized controlled trial of
computerized CBT (SPARX) for symptoms of
depression … A pilot
double blind randomized placebo controlled trial
of a prototype computer-based cognitive
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_surveillance.pdf
July 01, 2012 - Eight large
randomized
controlled trials
provide data on
breast cancer risk
reduction in
women … trial. … controlled trials/ or randomized controlled trial.pt. or rct$.mp.
4-limit 3 to (english language and … Controlled Trials/
13-randomized controlled trial.pt.
14-rct$.mp.
15-11 or 12 or 13 or 14
16-8 and … Eight large randomized controlled trials
provide data on breast cancer risk
reduction in women without
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
April 01, 2015 - ICU = intensive care unit; KQ = Key Question; PPH = postpartum hemorrhage; RCT = randomized controlled … One randomized
controlled trial (RCT) of tranexamic acid versus no
tranexamic acid reported significantly … All sites,
including those participating in the active sites of a null
cluster randomized trial, were … KQ = Key Question; PPH = postpartum hemorrhage; RCT = randomized controlled trial. … controlled trial;
SOE = strength of evidence.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-d.xlsx
January 01, 2023 - No masking, but no indication of deviations due to trial context. … sample, unclear analysis plan
SAMIT OS Low Low Low Some concerns High High This is a factorial 2x2 randomized … controlled trial. … SAMIT Grade 3 to 5 AEs Low Low Low Some concerns High High This is a factorial 2x2 randomized controlled … trial.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/crohns-disease_disposition-comments.pdf
February 25, 2014 - This review only contains randomized, controlled trials (RCT) for issues of induction
and maintenance … For efficacy endpoints, we only
included randomized controlled
studies. … Clinically meaningful improvement
in health-related quality of life in a randomized controlled trial … Colombel et al conducted a multicenter, randomized, double-blind, controlled trial comparing
INFLIXIMAB … trial where they were randomized to naltrexone or placebo for 12 weeks.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-executive-summary-2023-update.pdf
January 01, 2023 - randomized controlled
trials (RCTs), one of oral THC, CBD, and combination THC/CBD1 and one of two … We included randomized controlled trials and
comparative observational studies with a minimum of 4 weeks … Characteristics of included randomized controlled trials of cannabinoids
Characteristic THC/CBD THC … controlled trial; THC = tetrahydrocannabinol. … d One trial is included in both the synthetic THC and CBD columns, as it compared THC to CBD, CBD/THC
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-executive-summary.pdf
August 01, 2024 - Our searches covered publications in MEDLINE®,
Embase®, Cochrane Register of Controlled Trials, and … We included randomized controlled trials (RCTs)
and nonrandomized studies of interventions (NRSIs) comparing … Observational studies
should apply advanced methods such as target trial emulation for making causal … mitomycin C; RT- radiation
therapy; derm-dermatologic; GI-gastrointestinal; GU-genitourinary; RCT- randomized … controlled trial; yrs- years; vs.- versus;
RR- relative risk.
5
Strengths and Limitations
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-evidence-summary-2022-update_0.pdf
January 01, 2022 - Since the original systematic review published in October
2021, one new placebo-controlled randomized … controlled trial (RCT) of oral CBD1
and one new observational study of plant-based comparable THC to … Characteristics of included randomized controlled trials of cannabinoids
Characteristic THC/CBD THC … controlled trial; THC = tetrahydrocannabinol; US = United States. … trial.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-5-final-report-update-2024-executive-summ.pdf
January 01, 2024 - Standardized Data Repository
Executive Summary
Main Points
• This update adds 54 randomized … controlled trials (RCTs) on posttraumatic stress
disorder (PTSD) and comorbid PTSD/substance use disorder … One team member assessed RoB using
Cochrane’s RoB 2: A Revised Tool for Assessing Risk of Bias in Randomized … Controlled Trial Data. … Development of the PTSD-Repository: a
publicly available repository of randomized
controlled trials
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/grading.ppt
January 01, 2010 - Drug comparisons in randomized controlled trials (RCTs), with either placebo or an active comparator … controlled trial
Number of Studies (Subjects) Domains Pertaining to Strength of Evidence Magnitude … controlled trial
Number of Studies (Subjects) Domains Pertaining to Strength of Evidence Magnitude … For example, for mortality, randomized controlled trials are separate from retrospective cohort studies … This table shows that one fair-quality randomized controlled trial (RCT) with 80 subjects reported mortality
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1406.pdf
June 01, 2014 - Replication of ketamine's antidepressant efficacy
in bipolar depression: a randomized controlled … controlled trial. … Effects of ketamine on explicit and implicit
suicidal cognition: a randomized controlled trial
in … A
pragmatic randomized controlled trial of
computerized CBT (SPARX) for symptoms of
depression … A pilot
double blind randomized placebo controlled trial
of a prototype computer-based cognitive
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-251-integrated-pain-management-app-F.xlsx
January 01, 2020 - Risk of bias assessments for randomized controlled trials evaluating integrated pain management programs … Risk of bias assessments for randomized controlled trials of integrated pain management programs
Table … Risk of bias assessments for randomized controlled trials evaluating comprehensive pain management programs … Risk of bias assessments for randomized controlled trials of comprehensive pain management programs
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer-therapy_research-protocol.pdf
November 28, 2012 - Midterm outcomes in patients with
intermediate-sized hepatocellular carcinoma: a randomized controlled … controlled trial. … Randomised controlled trial comparing
percutaneous radiofrequency thermal ablation, percutaneous ethanol … A randomized controlled trial of
transcatheter arterial chemoembolization with lipiodol, doxorubicin … A randomized controlled trial of radiofrequency
ablation with ethanolinjection for small hepatocellular
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening_research.pdf
June 01, 2013 - Study Design
Considerations Randomized Controlled Trial Quasi-Experimental: Before-After study
(Variations … MRSA = methicillin-resistant Staphylococcus aureus; RCT = randomized controlled trial
28
Discussion … controlled trial
U.S. … controlled trial[pt] OR controlled clinical trial[pt] OR randomized controlled trials[mh] OR
random … AND controlled AND trial OR controlled AND clinical AND trial* OR randomized AND
controlled AND trials