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Total Results: 1,524 records

Showing results for "randomized controlled trial".

1401. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-complaints-tests-children_research-protocol.pdf
      September 29, 2010 - Source: www.effectivehealthcare.ahrq.gov Published Online: September 29, 2010 Central Register of Controlled … SLE, undiagnosed limb pain or index test results Design • Two or more participants • Diagnostic randomized … controlled trial: Studies randomly assigned participants into receiving either the test or the reference

1402. DEcIDE 33: Summary Variables in Observational Resesarch: Propensity Scores and Disease Risk Scores (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
      May 01, 2012 - This large sample size requirement means that answering the question through a randomized controlled … trial would be very expensive and need to include a very large patient population followed for some … confounding, by presenting a comparison of characteristics similar to a “Table 1” from a clinical trial … biostatistics: propensity score methods for bias reduction in the comparison of a treatment to a non- randomized … design versus the analysis of observational studies for causal effects: parallels with the design of randomized

1403. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay_research-protocol.pdf
      May 02, 2011 - This search will be conducted in MEDLINE® and the Cochrane Central Register of Controlled Trials. … Database of Systematic Reviews <2005 to February 2011>, EBM Reviews - Cochrane Central Register of Controlled

1404. Renal-Function Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_executive.pdf
      August 01, 2014 - ACS.13 However, in the Clopidogrel in Unstable Angina to prevent Recurrent Events (CURE) clinical trial … following databases for primary studies: MEDLINE®, Embase®, and the Cochrane Central Register of Controlled … controlled trials (RCTs) or observational studies. … controlled trials and observational studies with a comparison group … trial.

1405. Gout Dx protocol_140715-draft (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_research-protocol-2014.pdf
      January 01, 2014 - Randomized controlled trials as well as prospective cohort and case control studies that compare outcomes

1406. Colorectal-Cancer-Liver-Metastases-Therapies Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_executive.pdf
      December 01, 2012 - controlled trial (RCT) data comparing local hepatic therapies31,32 contribute to uncertainty regarding … The gray literature was also searched, including in databases with regulatory information, clinical trial … controlled clinical trial evidence on the use of local hepatic therapies for the included indications … existing case series can aid in identifying additional factors that should be documented and potentially controlled … Phase III trial comparing protracted intravenous fluorouracil infusion alone or with yttrium-90 resin

1407. White Paper: Narratively Describing Effects of Interventions in Systematic Reviews (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-roadmap-interventions.pdf
      November 01, 2020 - The roadmap will be undergoing trial use, and we will revisit and re-evaluate this document after receiving … Abbreviations: RCT = randomized controlled trial.

1408. Disposition of Comments Technical Brief 41: Evaluation of Mental Health Mobile Applications (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-health-mobile-apps-disposition-of-comments.pdf
      May 20, 2022 - For example, the evidence section asks whether a randomized trial showing efficacy exists but not whether … that randomized trial is of any quality. … For example, if the app being evaluated has a clinical trial, how close is the app being evaluated … to the app that was evaluated during the clinical trial? … Demanding that an app be identical to what was evaluated in a trial that may have taken place years

1409. Disposition of Comments for CER 163 Appropriate Antibiotics (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_disposition-comments.pdf
      January 27, 2016 - it is likely to be relevant but on the other hand we do have evidence from one large international trial … the CCRCT abbreviation with CENTRAL to refer to our search of the Cochrane Central Register of Controlled … Most studies can be randomized. 93. … We suggest including the citation when referencing a particular trial and outcome measure as “best … No, it is correct as stated that most studies can be randomized. 187.

1410. Disposition of Comments Report for Relationship Between Use of Quality Measures and Improved Outcomes in Serious Mental Illness (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-outcomes_disposition-comments.pdf
      January 15, 2015 - both observational (i.e., retrospective electronic medical records, registries) and interventional randomized … I also agree that one needs to be sensible and practical in that randomized controlled trials will … Sunovion (Public Comment) Next Steps AHRQ recommends “the design and implementation of a randomized … controlled trial to test the effectiveness of a QM or set of QM relative to a meaningful and feasible … While a randomized clinical controlled trial design is considered high-rigor with respect to balancing

1411. Breastfeeding and Health Outcomes for Infants and Children (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/breastfeeding-health-outcomes-protocol-amendment.pdf
      February 03, 2025 - cohort and case-controld studies and studies with observational follow-up of health outcomes from randomized … or non-randomized clinical trials of breastfeeding support interventions All other designs, including … domains defined in the AHRQ Methods Guide49, 50 and using an adapted version of the Risk Of Bias In Non-randomized … Risk Of Bias In Non- randomized Studies - of Exposure (ROBINS-E). [2022 June 1].

1412. Chicago-Area DEcIDE Center (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/off-label-use-research-priorities_research.pdf
      May 01, 2009 - The USP-DI assessment, however, is based on expert consensus, rather than clinical trial evidence. … review may subsequently include a range of analyses from retrospective database queries to prospective randomized … III Not Recommended A B C A B C DRUGDEX STRENGTH OF EVIDENCE A Good and/or consistent Randomized … Controlled Trials (RCTs) B Less adequate or inconsistent RCTs C Non-RCT evidence RESULTING … research step will be to conduct a series of meta- analyses to accumulate and assess past clinical trial

1413. Disposition of Comments Report for Whole-Body Vibration Therapy for Osteoporosis (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-vibration-therapy_disposition-comments.pdf
      November 15, 2011 - cited articles, in the draft technical brief, which was a systematic review and meta- analysis of randomized … controlled trials about whole-body vibration, concludes that “before recommendations can be made for … Factors that can be adjusted and tightly controlled for with this new technology include: frequency,

1414. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/rotator-cuff-tear_disposition-comments.pdf
      October 05, 2010 - In lieu on an appendix, we have provided a reference to an example of a well-conducted randomized controlled … trial comparing operative versus nonoperative treatments, as well as references of guidelines for

1415. PowerPoint Presentation (ppt file)
      effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-strength-evidence.ppt
      June 01, 2012 - Trial evidence can directly assess the effect of tests on clinical outcomes (rarely done). … Trial evidence can directly assess the effect of diagnostic tests on clinical outcomes, but this is rarely … In the case where trial evidence is available, the application of grading criteria (such as those of … measuring sensitivity and specificity sufficient to evaluate a diagnostic test, and when do we need randomized … controlled trials or observational studies) Aggregate quality of the studies under consideration from

1416. PowerPoint Presentation (ppt file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-strength-evidence.ppt
      June 01, 2012 - Trial evidence can directly assess the effect of tests on clinical outcomes (rarely done). … Trial evidence can directly assess the effect of diagnostic tests on clinical outcomes, but this is rarely … In the case where trial evidence is available, the application of grading criteria (such as those of … measuring sensitivity and specificity sufficient to evaluate a diagnostic test, and when do we need randomized … controlled trials or observational studies) Aggregate quality of the studies under consideration from

1417. Proposed Governance and Data Management Policy for the Systematic Review Data Repository (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/data-repository-reviews_white-paper.pdf
      September 01, 2012 - creation of the proposed repository, we convened a panel of technical advisors with expertise in trial

1418. Wireless-Motility-Capsule Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/wireless-motility-capsule_executive.pdf
      May 01, 2013 - We asked the manufacturer of WMC about any published or unpublished randomized controlled trials or

1419. Comparative Effectiveness Review Disposition of Comments Report (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/bundled-payments-quality-effects_disposition-comments.pdf
      August 24, 2012 - controlled trials of bundled payments ever published. … There was only one study randomized at the provider level, and we identified no studies of bundled … payment programs randomized at the patient level.” … trial (home health care agencies were randomized) of a prospective payment demonstration that studied … control trial) are naïve and inappropriate.

1420. Disposition of Comments_Systematic Review_Trauma Informed Care: A Systematic Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-informed-care-disposition-comments.pdf
      January 14, 2025 - additional review questions were needed to better address the variable contextual landscape in ways the randomized … whether enough organizational units are available for the randomization required for a gold- standard randomized … trial, and we agree with the recommendation that alternative study designs should be explored.