Results

Total Results: 1,523 records

Showing results for "randomized controlled trial".

1261. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-2-risk-of-reinfection-from-SARSCoV2_0.pdf
      December 31, 2022 - Planned Updates For this update, we modified our search strategies to focus on identifying longitudinal controlled … Comparative Trial Netherlands Patients with PCR confirmed COVID- 19 disease, age >18 years. … interventional trial France Group 1: SARS-CoV-2 naive participants (participants without antecedent … interventional trial Mali Group 1: Hospitalized patients in one of the four centers in Bamako … A general parametric approach to the meta‐analysis of randomized clinical trials.

1262. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/vaccine-safety_research-protocol.pdf
      September 18, 2012 - rule out overt toxicity and identify potential toxic effects that might occur during the clinical trial … Investigational New Drug application must be submitted so that the FDA can monitor the safety of clinical trial

1263. Research White Paper - Assessing the Predictive Validity of Strength of Evidence Grades: A Meta-Epidemiological Study (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper.pdf
      September 01, 2015 - Library from 2010 onward to find Cochrane reports that: (1) include an outcome with more than eight randomized … controlled trials (RCTs) on therapeutic interventions that had been graded as high SOE; (2) present

1264. PEPTIC ULCER #11 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1506.pdf
      June 01, 2015 - FDA has recommended classifying eluxadoline as a controlled substance, thus prompting final scheduling … rates up to 24% reported in some vedolizumab trials and the unknown risk of PML outside of well-controlled … clinical trial populations as limiting the drug’s potential to fulfill an unmet need for more efficacious

1265. Cer-240-Acute-Pain-Appendix-F (xls file)
      effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-appendix-f.xlsx
      May 29, 2025 - Risk of bias assessment for randomized controlled trials Author, Year (Full citations are listed in

1266. Disposition of Comments_Comparative Effectiveness Review No. 265_Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-disposition-comments.pdf
      August 29, 2023 - Again, removing this trial would not change the conclusions. … Did trial inclusion criteria or baseline characteristics parse out the timing of interventions like

1267. Executive Summary_Comparative Effectiveness Review No. 261_Postpartum Care up to 1 Year After Pregnancy: A Systematic Review and Meta-Analysis (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-261-postpartum-care-executive-summary.pdf
      June 01, 2023 - • Healthcare Delivery Strategies – Where Care Is Provided o For general postpartum care (5 randomized … controlled trials [RCTs] and 1 nonrandomized comparative study [NRCS]), whether the visit is conducted

1268. Diabetes Mellitus (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_june_2012.pdf
      January 01, 2012 - A phase III trial comparing use of Oral-lyn as a prandial insulin to injected human insulin was expected … o Extended-release exenatide is a controlled-release, once-weekly formulation delivered by subcutaneous … In September 2011, the company announced plans for its phase III trial after releasing final 48-week … results from its phase II trial. … Another research expert noted that another clinical trial compared this intervention to behavioral

1269. genetic-testing-developmental-disabilities-protocol-140930 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/genetic-testing-developmental-disabilities_research-protocol.pdf
      September 30, 2014 - The ideal type of evidence for establishing the clinical utility is from high quality randomized controlled … search other grey literature sources, such as government and specialty society Web sites, clinical trial … For clinical utility studies, randomized controlled For clinical trials, non- utility studies, … health randomized clinical trials, outcomes, observational impact on clinical or family studies … maternal:ti) 24 Limit by publication and study type #23 AND ('clinical article'/de OR 'clinical trial

1270. Disposition of Comments CER 185 Tympanostomy Tubes in Children With Otitis Media (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-disposition.pdf
      May 05, 2017 - Added "Randomized Comparative Studies" header Peer Reviewer #1 Executive Summary P 20 Figure … P23 Line 45 Why is “Quality of life and patient-centered outcomes” in a tinier font than “Non-Randomized … "The two randomized comparative trials were not combined in a meta- analysis on the basis of clinical … It must, because only one trial is nonrandomized. … If children (ww vs TT) are properly randomized there should NOT be a major difference in COME/hearing

1271. Disposition of Comments CER 185 Tympanostomy Tubes in Children With Otitis Media (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/tympanostomy-tubes-disposition.pdf
      May 05, 2017 - Added "Randomized Comparative Studies" header Peer Reviewer #1 Executive Summary P 20 Figure … P23 Line 45 Why is “Quality of life and patient-centered outcomes” in a tinier font than “Non-Randomized … "The two randomized comparative trials were not combined in a meta- analysis on the basis of clinical … It must, because only one trial is nonrandomized. … If children (ww vs TT) are properly randomized there should NOT be a major difference in COME/hearing

1272. breast-cancer-imaging-protocol-131217 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-cancer-imaging_research-protocol.pdf
      December 17, 2013 - None Timing All timing None Setting All care settings None Study design Systematic reviews Randomized … control trials Non-randomized control trials Cohort studies (prospective and retrospective) Case-control

1273. Management of Primary Headache During Pregnancy: Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
      March 23, 2019 - o Cluster headache o Other TACs Timing: • Any 7 Setting: • Any Design: • Randomized … controlled trials • Nonrandomized comparative studies, including pre-post studies • Single group studies … o Cluster headache o Other TACs Timing: • Any Setting: • Any 11 Design: • Randomized … controlled trials • Nonrandomized comparative studies, including pre-post studies • Single group studies … For randomized controlled trials, we will adapt the Cochrane Risk of Bias tool,25 focusing on issues

1274. AHRQ's Evidence-based Practice Center Division Annual Report 2020: Solving the Puzzle for Evidence-Based Decision Making (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2020.pdf
      January 01, 2020 - PreventiveServices-P2P-FPM-Report_FINAL_508.pdf https://pubmed.ncbi.nlm.nih.gov/31931527/ 2020 Clinical Trial … Intellectual equipoise and challenges: accruing patients with advanced cancer to a trial randomizing … Surface perturbation training to prevent falls in older adults: a highly pragmatic, randomized controlled … trial.

1275. Outcomes in COPD patients treated with theophylline (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/decide16final-mortality-risk-in-copd-pts-using-theophylline.pdf
      December 01, 2009 - effects are uncommon and fewer drug interaction issues arise.16 Most theophylline studies have been controlled … was to evaluate outcomes associated with theophylline use in patients with COPD outside the clinical trial … A 4-year trial of tiotropium in chronic obstructive pulmonary disease. … A randomized, controlled trial of theophylline in patients with severe chronic obstructive pulmonary … Propensity score methods for bias reduction in the comparison of a treatment to a non- randomized control

1276. Outcomes in COPD patients treated with theophylline (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-management_research.pdf
      December 01, 2009 - effects are uncommon and fewer drug interaction issues arise.16 Most theophylline studies have been controlled … was to evaluate outcomes associated with theophylline use in patients with COPD outside the clinical trial … A 4-year trial of tiotropium in chronic obstructive pulmonary disease. … A randomized, controlled trial of theophylline in patients with severe chronic obstructive pulmonary … Propensity score methods for bias reduction in the comparison of a treatment to a non- randomized control

1277. Health Information Exchange (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/health-information-exchange_executive.pdf
      December 01, 2015 - ED = emergency department; HIE = health information exchange; RCT = randomized controlled trial We reviewed … Only two randomized trials (in 3 publications) were identified. … Impact of an electronic link between the emergency department and family physicians: a randomized controlled … trial. … Organizational challenges in developing one of the Nationwide Health Information Network trial implementation

1278. Title (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/obesity-child_research-protocol.pdf
      March 31, 2010 - limited by many other shortcomings such as inappropriate management of study heterogeneity, lack of randomized … , controlled interventions; lack of objective outcome measures, poor methodology in the primary studies … quality will be assessed using the Downs & Black quality assessment tool. 30 For the RCTs and non-randomized … sex, ethnicity, socioeconomic status), settings (physical and social environments), study design (randomized

1279. Comparative Effectiveness Review No. 234 Evidence Summary: Management of Primary Headaches in Pregnancy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-234-headaches-pregnancy-summary.pdf
      November 01, 2020 - Results We found 16 primary studies (14,185 patients), representing direct evidence (3 randomized … controlled trials, 8 nonrandomized comparative studies [i.e., observational studies that compared 2

1280. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting_research-protocol.pdf
      August 19, 2011 - therapeutic decisionmaking outcomes, the following study designs will be considered eligible: 7 o Randomized … We will conduct the search in MEDLINE® and in the Cochrane Central Register of Controlled Trials. … A prime example of the failure of randomized clinical trials.