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Total Results: 1,524 records

Showing results for "randomized controlled trial".

1261. Disposition of Comments_Comparative Effectiveness Review No. 265_Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-disposition-comments.pdf
      August 29, 2023 - Again, removing this trial would not change the conclusions. … Did trial inclusion criteria or baseline characteristics parse out the timing of interventions like

1262. Executive Summary_Comparative Effectiveness Review No. 261_Postpartum Care up to 1 Year After Pregnancy: A Systematic Review and Meta-Analysis (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-261-postpartum-care-executive-summary.pdf
      June 01, 2023 - • Healthcare Delivery Strategies – Where Care Is Provided o For general postpartum care (5 randomized … controlled trials [RCTs] and 1 nonrandomized comparative study [NRCS]), whether the visit is conducted

1263. breast-cancer-imaging-protocol-131217 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-cancer-imaging_research-protocol.pdf
      December 17, 2013 - None Timing All timing None Setting All care settings None Study design Systematic reviews Randomized … control trials Non-randomized control trials Cohort studies (prospective and retrospective) Case-control

1264. Noninvasive Testing for Coronary Artery Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-disease-testing_research-protocol.pdf
      January 15, 2015 - ; PET = positron emission tomography; PTCA = percutaneous transluminal coronary angioplasty; RCT = randomized … controlled trial; SPECT = single photon emission computed tomography; STEMI = ST-segment elevation … Randomized controlled trials (RCTs) as well as observational studies will be considered and those included … guidance from the AHRQ Methods Guide for Effectiveness and Comparative Effectiveness Reviews. 15 Randomized … of diagnostic testing and statistical methods of assessing this may be misleading.18, 21 Clinical trial

1265. Research White Paper - Assessing the Predictive Validity of Strength of Evidence Grades: A Meta-Epidemiological Study (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper.pdf
      September 01, 2015 - Library from 2010 onward to find Cochrane reports that: (1) include an outcome with more than eight randomized … controlled trials (RCTs) on therapeutic interventions that had been graded as high SOE; (2) present

1266. Gestational-Diabetes-Screening-Diagnosis Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/gestational-diabetes-screening-diagnosis_executive.pdf
      October 01, 2012 - ), ClinicalTrials.gov, and Current Controlled Trials. … We included published randomized controlled trials (RCTs), nonrandomized controlled trials (NRCTs), … BMI = body mass index; RCT = randomized controlled trial studies may not have had the power to detect … Gestational diabetes mellitus screening and diagnosis: a prospective randomised controlled trial comparing … A multicenter, randomized trial of treatment for mild gestational diabetes.

1267. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/telehealth_disposition-comments.pdf
      June 30, 2016 - [Cluster- Randomized Trial of a Mobile Phone Personalized Behavioral Intervention for Blood Glucose … [WellDoc™ Mobile Diabetes Management Randomized Controlled Trial: Change in Clinical and Behavioral … Implant-based multiparameter telemonitoring of patients with heart failure (IN-TIME): a randomised controlled … Trial. … trial.

1268. Title (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/obesity-child_research-protocol.pdf
      March 31, 2010 - limited by many other shortcomings such as inappropriate management of study heterogeneity, lack of randomized … , controlled interventions; lack of objective outcome measures, poor methodology in the primary studies … quality will be assessed using the Downs & Black quality assessment tool. 30 For the RCTs and non-randomized … sex, ethnicity, socioeconomic status), settings (physical and social environments), study design (randomized

1269. PULMONARY with "Discussions" in Exec Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/13_pulmonary_potential_high_impact_june_2012.pdf
      January 01, 2012 - Another drug, roflumilast, failed to meet its primary endpoints in a just-completed phase III trial … In a randomized, double-blind, placebo-controlled, phase III, clinical trial, cosponsored by the Cystic … patients with CF who have two copies of the CFTR-F508del mutation, according to recent, phase II trial … and is simpler to administer than the injected drug. 28 Oral treprostinil was investigated in a randomized … phase III clinical trial.

1270. Guidance for the Conduct and Reporting of Modeling and Simulation Studies in the Context of Health Technology Assessment (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/decision-models-guidance_methods.pdf
      October 01, 2016 - Clinical trial simulation in drug development. Therapie. 2004 May;59(3):287-304. … Clinical trial simulation in drug development. Pharm Res. 2000;17(3):252- 56. … controlled trials. … controlled trials. … The use of propensity scores and observational data to estimate randomized controlled trial generalizability

1271. genetic-testing-developmental-disabilities-protocol-140930 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/genetic-testing-developmental-disabilities_research-protocol.pdf
      September 30, 2014 - The ideal type of evidence for establishing the clinical utility is from high quality randomized controlled … search other grey literature sources, such as government and specialty society Web sites, clinical trial … For clinical utility studies, randomized controlled For clinical trials, non- utility studies, … health randomized clinical trials, outcomes, observational impact on clinical or family studies … maternal:ti) 24 Limit by publication and study type #23 AND ('clinical article'/de OR 'clinical trial

1272. Breast-Biopsy-Update Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
      September 01, 2014 - positive or negative predictive value; (4) were prospective or retrospective cohort studies (including randomized … controlled trials); and (5) enrolled 10 or more patients and followed at least 50 percent of them … tool,17 and the checklist proposed by Drummond et al.,18 to assess nonrandomized cohort studies, randomized … controlled trials, and studies of resource utilization and costs, respectively. 5 Data Synthesis … We believe that a randomized comparison of alternative biopsy methods would not be fruitful because

1273. AHRQ's Evidence-based Practice Center Division Annual Report 2020: Solving the Puzzle for Evidence-Based Decision Making (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2020.pdf
      January 01, 2020 - PreventiveServices-P2P-FPM-Report_FINAL_508.pdf https://pubmed.ncbi.nlm.nih.gov/31931527/ 2020 Clinical Trial … Intellectual equipoise and challenges: accruing patients with advanced cancer to a trial randomizing … Surface perturbation training to prevent falls in older adults: a highly pragmatic, randomized controlled … trial.

1274. Disposition of Comments Report for Primary Care Management of Abnormal Uterine Bleeding (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/abnormal-uterine-bleeding_disposition-comments.pdf
      March 21, 2013 - Peer reviewer #5 Executive Summary ES-10 l.19 Placebo controlled studies have failed to find any increase … The search did not identify randomized clinical trials of cyclic progestins of fair or good quality … We have modified the summary to indicate there are no “controlled” longer term follow-up studies. … They were able to reduce the total number of studies to a relatively few randomized clinical trials, … This is why we report the proportion of trial arms that discontinued study drug.

1275. Comparative Effectiveness Review No. 234 Evidence Summary: Management of Primary Headaches in Pregnancy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-234-headaches-pregnancy-summary.pdf
      November 01, 2020 - Results We found 16 primary studies (14,185 patients), representing direct evidence (3 randomized … controlled trials, 8 nonrandomized comparative studies [i.e., observational studies that compared 2

1276. Research Protocol: Characteristics of Existing Asthma Self-Management Education Packages (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-education-protocol.pdf
      January 01, 2018 - recent review of reviews3 synthesized the findings of twenty-seven systematic reviews encompassing 270 randomized … controlled trials (RCTs) of AS-ME packages. … We will search the following databases using controlled vocabulary and text words: MEDLINE, PubMed

1277. Management of Primary Headache During Pregnancy: Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
      March 23, 2019 - o Cluster headache o Other TACs Timing: • Any 7 Setting: • Any Design: • Randomized … controlled trials • Nonrandomized comparative studies, including pre-post studies • Single group studies … o Cluster headache o Other TACs Timing: • Any Setting: • Any 11 Design: • Randomized … controlled trials • Nonrandomized comparative studies, including pre-post studies • Single group studies … For randomized controlled trials, we will adapt the Cochrane Risk of Bias tool,25 focusing on issues

1278. Effectiveness of Early Diagnosis, Prevention, and Treatment of Clostridium difficile Infection (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_disposition-comments.pdf
      March 01, 2012 - Peer Reviewer #6 Executive Summary Page 5, Treatment: I believe there was one clinical trial comparing … This key question was interested in treatments or therapies under investigation, whether through controlled … Additionally, we analyze the data using a strict intention-to- treat analysis, where all randomized … Peer Reviewer #5 Results Pages 91 and 95: Surawicz articles, all patients enrolled in this trial … The FDA is now realizing that in their clinical trial requirements.

1279. Dental Care for People With Sickle Cell Disease: A Rapid Response Literature Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/sickle-cell-dental-rapid-response.pdf
      July 01, 2024 - controlled trials, controlled observational studies, and clinical practice guidelines. … Disease Control and Prevention, National Institutes of Health, World Health Organization); clinical trial … controlled trials and practice guidelines. … A double-blind randomized trial of low-dose oral urea to prevent sickle cell crises J Chronic Dis, 35 … controlled trial SCD Sickle Cell Disease SME Subject Matter Expert SR Systematic review UK United

1280. Outcomes in COPD patients treated with theophylline (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-management_research.pdf
      December 01, 2009 - effects are uncommon and fewer drug interaction issues arise.16 Most theophylline studies have been controlled … was to evaluate outcomes associated with theophylline use in patients with COPD outside the clinical trial … A 4-year trial of tiotropium in chronic obstructive pulmonary disease. … A randomized, controlled trial of theophylline in patients with severe chronic obstructive pulmonary … Propensity score methods for bias reduction in the comparison of a treatment to a non- randomized control