Results

Total Results: 1,519 records

Showing results for "randomized controlled trial".

1261. Cer-240-Acute-Pain-Appendix-F (xls file)
      effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-appendix-f.xlsx
      May 29, 2025 - Risk of bias assessment for randomized controlled trials Author, Year (Full citations are listed in

1262. PEPTIC ULCER #11 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1506.pdf
      June 01, 2015 - FDA has recommended classifying eluxadoline as a controlled substance, thus prompting final scheduling … rates up to 24% reported in some vedolizumab trials and the unknown risk of PML outside of well-controlled … clinical trial populations as limiting the drug’s potential to fulfill an unmet need for more efficacious

1263. breast-cancer-imaging-protocol-131217 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-cancer-imaging_research-protocol.pdf
      December 17, 2013 - None Timing All timing None Setting All care settings None Study design Systematic reviews Randomized … control trials Non-randomized control trials Cohort studies (prospective and retrospective) Case-control

1264. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1312.pdf
      December 01, 2013 - Initial clinical trial results suggest that insulin may improve certain cognitive measures in patients … nasal spray bottles.5,7,11 In 2013, the Alzheimer’s Disease Cooperative Study registered the largest randomized … , controlled trial to date (n=240) for this intervention for treating AD and amnestic MCI.10 Various … Experts stated that the available clinical trial data are not yet robust enough to assume efficacy … Further, only one of two insulin doses used in the trial appeared to be effective, one expert with

1265. Management of Primary Headache During Pregnancy: Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
      March 23, 2019 - o Cluster headache o Other TACs Timing: • Any 7 Setting: • Any Design: • Randomized … controlled trials • Nonrandomized comparative studies, including pre-post studies • Single group studies … o Cluster headache o Other TACs Timing: • Any Setting: • Any 11 Design: • Randomized … controlled trials • Nonrandomized comparative studies, including pre-post studies • Single group studies … For randomized controlled trials, we will adapt the Cochrane Risk of Bias tool,25 focusing on issues

1266. AHRQ's Evidence-based Practice Center Division Annual Report 2020: Solving the Puzzle for Evidence-Based Decision Making (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2020.pdf
      January 01, 2020 - PreventiveServices-P2P-FPM-Report_FINAL_508.pdf https://pubmed.ncbi.nlm.nih.gov/31931527/ 2020 Clinical Trial … Intellectual equipoise and challenges: accruing patients with advanced cancer to a trial randomizing … Surface perturbation training to prevent falls in older adults: a highly pragmatic, randomized controlled … trial.

1267. The Empirical Evidence of Bias in Trials Measuring Treatment Differences | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/treatment-effects-bias/research

1268. PULMONARY with "Discussions" in Exec Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/13_pulmonary_potential_high_impact_june_2012.pdf
      January 01, 2012 - Another drug, roflumilast, failed to meet its primary endpoints in a just-completed phase III trial … In a randomized, double-blind, placebo-controlled, phase III, clinical trial, cosponsored by the Cystic … patients with CF who have two copies of the CFTR-F508del mutation, according to recent, phase II trial … and is simpler to administer than the injected drug. 28 Oral treprostinil was investigated in a randomized … phase III clinical trial.

1269. Disposition of Comments CER 185 Tympanostomy Tubes in Children With Otitis Media (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/tympanostomy-tubes-disposition.pdf
      May 05, 2017 - Added "Randomized Comparative Studies" header Peer Reviewer #1 Executive Summary P 20 Figure … P23 Line 45 Why is “Quality of life and patient-centered outcomes” in a tinier font than “Non-Randomized … "The two randomized comparative trials were not combined in a meta- analysis on the basis of clinical … It must, because only one trial is nonrandomized. … If children (ww vs TT) are properly randomized there should NOT be a major difference in COME/hearing

1270. Disposition of Comments CER 185 Tympanostomy Tubes in Children With Otitis Media (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-disposition.pdf
      May 05, 2017 - Added "Randomized Comparative Studies" header Peer Reviewer #1 Executive Summary P 20 Figure … P23 Line 45 Why is “Quality of life and patient-centered outcomes” in a tinier font than “Non-Randomized … "The two randomized comparative trials were not combined in a meta- analysis on the basis of clinical … It must, because only one trial is nonrandomized. … If children (ww vs TT) are properly randomized there should NOT be a major difference in COME/hearing

1271. Outcomes in COPD patients treated with theophylline (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/decide16final-mortality-risk-in-copd-pts-using-theophylline.pdf
      December 01, 2009 - effects are uncommon and fewer drug interaction issues arise.16 Most theophylline studies have been controlled … was to evaluate outcomes associated with theophylline use in patients with COPD outside the clinical trial … A 4-year trial of tiotropium in chronic obstructive pulmonary disease. … A randomized, controlled trial of theophylline in patients with severe chronic obstructive pulmonary … Propensity score methods for bias reduction in the comparison of a treatment to a non- randomized control

1272. Outcomes in COPD patients treated with theophylline (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-management_research.pdf
      December 01, 2009 - effects are uncommon and fewer drug interaction issues arise.16 Most theophylline studies have been controlled … was to evaluate outcomes associated with theophylline use in patients with COPD outside the clinical trial … A 4-year trial of tiotropium in chronic obstructive pulmonary disease. … A randomized, controlled trial of theophylline in patients with severe chronic obstructive pulmonary … Propensity score methods for bias reduction in the comparison of a treatment to a non- randomized control

1273. Title (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/obesity-child_research-protocol.pdf
      March 31, 2010 - limited by many other shortcomings such as inappropriate management of study heterogeneity, lack of randomized … , controlled interventions; lack of objective outcome measures, poor methodology in the primary studies … quality will be assessed using the Downs & Black quality assessment tool. 30 For the RCTs and non-randomized … sex, ethnicity, socioeconomic status), settings (physical and social environments), study design (randomized

1274. Health Information Exchange (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/health-information-exchange_executive.pdf
      December 01, 2015 - ED = emergency department; HIE = health information exchange; RCT = randomized controlled trial We reviewed … Only two randomized trials (in 3 publications) were identified. … Impact of an electronic link between the emergency department and family physicians: a randomized controlled … trial. … Organizational challenges in developing one of the Nationwide Health Information Network trial implementation

1275. Comparative Effectiveness Review No. 234 Evidence Summary: Management of Primary Headaches in Pregnancy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-234-headaches-pregnancy-summary.pdf
      November 01, 2020 - Results We found 16 primary studies (14,185 patients), representing direct evidence (3 randomized … controlled trials, 8 nonrandomized comparative studies [i.e., observational studies that compared 2

1276. Methods Research Report: Developing Consistent and Useful Quality Improvement Study Data Extraction (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/developing-consistent-useful-quality-improvement.pdf
      September 01, 2020 - this more standardized approach to data extraction versus more traditional observational studies and randomized … We anticipate that when the intervention was randomized, the intervention is mandatory by definition … We classified a 3+ plan as fully complete if over the 12 month trial period the child attended their … MCO = Managed Care Organization; PCI = planned care intervention; PLE = peer leader education; RCT = randomized … controlled trial; US = United States; WK = week; Y = year.

1277. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting_research-protocol.pdf
      August 19, 2011 - therapeutic decisionmaking outcomes, the following study designs will be considered eligible: 7 o Randomized … We will conduct the search in MEDLINE® and in the Cochrane Central Register of Controlled Trials. … A prime example of the failure of randomized clinical trials.

1278. Disposition of Comments for CER 167 Renal Masses (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/renal-cancer_disposition-comments.pdf
      February 24, 2016 - Also the randomized trial showed this, more urine leaks after PN, more patients needing repeat surgery … partial nephrectomy has emerged as the recommended treatment for T1 renal masses, yet the single randomized … Meanwhile, I would've expected a separate analysis for the single randomized controlled trial versus … EORTC is an exception due to its randomized control trial design with the most valid analysis being … This report includes a single randomized controlled trial.

1279. Crosscutting-Horizon-Scan-High-Impact-1406 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1406.pdf
      June 01, 2014 - The Sedasys system was studied in a randomized controlled trial that compared propofol- mediated sedation … second such bolus for 90 seconds.8 Clinical trials: The Sedasys system was studied in an open-label, randomized … controlled trial.9 In this trial, 1,000 adults undergoing sedation during a routine colonoscopy or … Results of this second trial will be used to determine whether to maintain the requirement that an … Computer-assisted personalized sedation for upper endoscopy and colonoscopy: a comparative, multicenter randomized

1280. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
      December 20, 2011 - and other criteria) Original research For KQs 1 through 5, eligible study designs include: • Randomized … controlled trials. … In addition, we will include nonrandomized controlled trials of any sample size, prospective cohort … decided to include large observational studies with the lowest potential risk of bias to supplement the trial