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Total Results: 1,524 records

Showing results for "randomized controlled trial".

1241. Layout 1 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_executive.pdf
      May 01, 2010 - The FDA drug approval process mandates randomized clinical trials that demonstrate efficacy and safety … components, we made use of different categories of studies classified by study design and quality: • Randomized … controlled trials (RCTs) on the five selected indications of intracranial hemorrhage, massive bleeding … ff ic ie nt f or c om pa ri ng h ar m s an d be ne fi ts . 15 KQ=Key Question; RCT=randomized … controlled trial; OBS=comparative observational study; TE=thromboembolic; RBC=red blood cell; NA=not

1242. hemorrhage-postpartum-protocol-140611 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/hemorrhage-postpartum_research-protocol.pdf
      June 11, 2014 - After PPH has been controlled, followup management varies and may include laboratory testing (e.g., … not having value for PPH management Abbreviations: KQ=key question; ICU=Intensive Care Unit; RCT=randomized … controlled trial Source: www.effectivehealthcare.ahrq.gov Published online: June 11, 2014 … We will use the Cochrane Risk of Bias tool50 for randomized controlled trials and the Newcastle-Ottawa … trial.

1243. Physiologic Predictors of the Need for Trauma Center Care: A Systematic Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/predictors-trauma-care_research-protocol.pdf
      May 31, 2017 - The studies maybe randomized trials or prospective or retrospective observational studies. … key organizations such as the American College of Surgeons, and searches of the ClinicalTrials.gov trial … Abstracted information relevant for assessing applicability will include the number of patients randomized … of Individual Studies Predefined criteria will be used to assess the risk of bias for individual controlled … 5 and 13 15 limit 14 to humans Database: EBM Reviews - Cochrane Central Register of Controlled

1244. Prostate-Cancer-Risk-Assessment-Genes Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-risk-assessment-genes_executive.pdf
      July 01, 2012 - suggested a wide range of other risk factors for prostate cancer, but these have not been confirmed in controlled … the disease in symptomatic men (but not for screening asymptomatic men).14 A meta- analysis of seven randomized … controlled trials of screening using PSA testing alone, or in combination with digital rectal examination … Screening for prostate cancer: Systematic review and meta-analysis of randomised controlled trials. … in the prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial

1245. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1312.pdf
      December 01, 2013 - Initial clinical trial results suggest that insulin may improve certain cognitive measures in patients … nasal spray bottles.5,7,11 In 2013, the Alzheimer’s Disease Cooperative Study registered the largest randomized … , controlled trial to date (n=240) for this intervention for treating AD and amnestic MCI.10 Various … Experts stated that the available clinical trial data are not yet robust enough to assume efficacy … Further, only one of two insulin doses used in the trial appeared to be effective, one expert with

1246. Disposition of Comments Report for Prevention of Healthcare-Associated Infections (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/health-careassociated-infections_disposition-comments.pdf
      November 30, 2012 - the other more useful. 16 Peer Reviewer #2 General Comments I find the discussion of cluster randomized … compliance with key components of the intervention if this is found to be unsatisfactory during the trial … The cluster randomized trials included in this report did use run in periods and could be considered … it is not clear why this method was singled out in the summation (as opposed to adaptive cluster randomized … “A Randomized Double-Blind Controlled Trial of Taurolidine-Citrate Catheter Locks for the Prevention

1247. Dispostion of Comments Report for Screening for Hepatitis C Virus Infection in Adults (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_disposition-comments.pdf
      November 27, 2012 - Finally, we stand by the insufficient grade for KQ 6c, as there are two conflicting randomized trials … controlled trials or observational studies, the types of studies that are considered valid in the systematic … Moreover, your analysis only considered randomized clinical trials. … It is not correct that the review only included randomized trials. … Data from large, randomized controlled trials with clinical endpoints would be an ideal tool to make

1248. Disposition of Comments for Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_disposition-comments.pdf
      April 02, 2013 - As PTSD only became an official diagnosis in 1986, it is not surprising that large well-controlled prevention … inpatient psychotherapeutic treatment versus continued outpatient psychotherapy on psychosocial outcome: a randomized … controlled trial in trauma patients. … harmful, one would at least expect to see an increase in scores, although this may reflect that some trial … Again reference to single CISD finding seems inconsistent with the review conventions: “The single trial

1249. Methods White Paper: Improving the Utility of Evidence Synthesis for Decision Makers in the Face of Insufficient Evidence (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/improving-utility-evidence-synthesis-white-paper.pdf
      April 01, 2021 - Controlled Trial Data”8 and “Treatment for Acute Pain: An Evidence Map”9 both included clinical practice … In anticipation of sufficient evidence, reviewers may decide to restrict to randomized controlled trials … Controlled Trial Data. … Trial Data17 2019 National Center for Posttraumati c Stress Disorder Yes Yes No No No No … Controlled Trial Data.

1250. MEDICAL MANAGEMENT OF CONGESTIVE HEART FAILURE AND THE EFFECTIVENESS OF ISOSORBIDE DINITRATE AND HYDRALAZINE (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/congestive-heart-failure-medicines_research.pdf
      March 01, 2010 - Health Care Research Report Number 19 1 Introduction In 1986, the Vasodilator in Heart Failure Trial … combination of hydralazine and isosorbide dinitrate (H-ISDN) compared to placebo.1 The V-HeFT-II trial … the superiority of an angiotensin converting enzyme inhibitor (ACEI) over H-ISDN,2 and subsequent randomized … Results of the survival and ventricular enlargement trial. The SAVE Investigators. … A clinical trial of the angiotensin- converting-enzyme inhibitor trandolapril in patients with left

1251. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/ear-infection_research-protocol.pdf
      August 07, 2012 - antihistamines and decongestants for the treatment of OME has been extensively studied in primary randomized … controlled trials (RCTs) and summarized in recent systematic reviews19, 20 and clinical practice guidelines … Category Criteria for Inclusion Study design Meta-analyses, systematic reviews, RCTs, and nonrandomized controlled … with persistent bilateral otitis media with effusion in primary care: double blind randomised placebo controlled … trial.

1252. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-2-risk-of-reinfection-from-SARSCoV2_0.pdf
      December 31, 2022 - Planned Updates For this update, we modified our search strategies to focus on identifying longitudinal controlled … Comparative Trial Netherlands Patients with PCR confirmed COVID- 19 disease, age >18 years. … interventional trial France Group 1: SARS-CoV-2 naive participants (participants without antecedent … interventional trial Mali Group 1: Hospitalized patients in one of the four centers in Bamako … A general parametric approach to the meta‐analysis of randomized clinical trials.

1253. Cer-240-Acute-Pain-Appendix-F (xls file)
      effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-appendix-f.xlsx
      October 08, 2025 - Risk of bias assessment for randomized controlled trials Author, Year (Full citations are listed in

1254. Disposition of Comments CER 185 Tympanostomy Tubes in Children With Otitis Media (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-disposition.pdf
      May 05, 2017 - Added "Randomized Comparative Studies" header Peer Reviewer #1 Executive Summary P 20 Figure … P23 Line 45 Why is “Quality of life and patient-centered outcomes” in a tinier font than “Non-Randomized … "The two randomized comparative trials were not combined in a meta- analysis on the basis of clinical … It must, because only one trial is nonrandomized. … If children (ww vs TT) are properly randomized there should NOT be a major difference in COME/hearing

1255. Disposition of Comments CER 185 Tympanostomy Tubes in Children With Otitis Media (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/tympanostomy-tubes-disposition.pdf
      May 05, 2017 - Added "Randomized Comparative Studies" header Peer Reviewer #1 Executive Summary P 20 Figure … P23 Line 45 Why is “Quality of life and patient-centered outcomes” in a tinier font than “Non-Randomized … "The two randomized comparative trials were not combined in a meta- analysis on the basis of clinical … It must, because only one trial is nonrandomized. … If children (ww vs TT) are properly randomized there should NOT be a major difference in COME/hearing

1256. Depression-Postpartum-Screening Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_executive.pdf
      May 01, 2013 - These included searches of trial registry and conference abstract databases for relevant articles from … controlled trial [RCT] vs. observational). … One fair-quality RCT found improvement in EPDS scores at 6 months in women randomized to screening … found low rates of appropriate followup in the majority of studies, with a notable exception in a trial … data could, in turn, be used to estimate the size, costs, and value of information of a comparative trial

1257. Cover Page (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/medicine-safety-call-center_research.pdf
      September 01, 2007 - heart attacks and strokes on prolonged use was not detected by the MedWatch system but rather through controlled … For example, a paper describing randomized control trials conducted to evaluate the effectiveness of … Brewer N, Lykens M, Harris LE, Newell JA, Collins J, Tierney WM (2002) "Issues in conducting randomized … controlled trials of health services research interventions in nonacademic practice settings: the

1258. Cover Page (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/it-architecture-for-post-marketing-surveillance-arizona-cert.pdf
      September 01, 2007 - heart attacks and strokes on prolonged use was not detected by the MedWatch system but rather through controlled … For example, a paper describing randomized control trials conducted to evaluate the effectiveness of … Brewer N, Lykens M, Harris LE, Newell JA, Collins J, Tierney WM (2002) "Issues in conducting randomized … controlled trials of health services research interventions in nonacademic practice settings: the

1259. PEPTIC ULCER #11 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1506.pdf
      June 01, 2015 - FDA has recommended classifying eluxadoline as a controlled substance, thus prompting final scheduling … rates up to 24% reported in some vedolizumab trials and the unknown risk of PML outside of well-controlled … clinical trial populations as limiting the drug’s potential to fulfill an unmet need for more efficacious

1260. An Evidence Review of Active Surveillance in Men with Localized Prostate Cancer (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_disposition-comments.pdf
      December 01, 2011 - Randomized controlled studies (RCT’s) are the method of choice to determine the appropriate care for … Peer Reviewer 5 Results p.100 line 26: PIVOT trial. … We have provided additional information on harms from randomized trials. … controlled trials ("RCTs") comparing conventional radiation to proton therapy. … If a trial to compare AS vs.