-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-topic-nomination_methods.pdf
November 01, 2012 - If very few controlled trials are found or for topics that are
not appropriate for controlled trials … Decisions about
Effectiveness; PICO = populations, interventions, comparators, and outcomes; RCT = randomized … controlled trial
The final step in completing the topic brief is assigning a team recommendation for … AHRQ = Agency for Healthcare Research and Quality; MRI = magnetic resonance imaging; RCT = randomized … controlled trial
16
Stakeholder Engagement
Table 5 shows the points of stakeholder engagement
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/registries-guide_executive.pdf
April 01, 2007 - Registries are a valuable complement to randomized
controlled trials in determining real-world outcomes … Defining Quality
A definition of “quality” for registries was adapted
from a definition developed for randomized … controlled trials; the term is used to refer to the
confidence that the design, conduct, and analysis … of
the trial or registry can be shown to protect against
bias (systematic error) and errors in inference—that
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd_research-protocol.pdf
August 10, 2010 - Strategies will use
combinations of controlled vocabulary (medical subject headings, keywords) and text … Data Synthesis
Qualitative synthesis
For each trial, information on population characteristics (including … Additionally, if there are sufficient studies we
will explore trial specific factors such as 1) duration
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-other-plant-based-treatments-surveillance-report-1-updated_0.PDF
December 01, 2021 - Results to Date
Results Overview
The systematic review included evidence from 27 studies (20 randomized … controlled trials
and 7 observational studies), all assessing cannabis interventions (see the full
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-225-substance-abuse-adolescents-evidence-summary%20225%20Substance%20Use%20Adolescents.pdf
May 01, 2020 - Results
We found 118 randomized controlled trials that evaluated treatment of adolescents or
young
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/dementia-nursing-home-characteristics_executive.pdf
October 01, 2012 - We
included 14 published articles: 9 randomized controlled
trials (RCTs), 1 nonrandomized controlled … trial, and 4
prospective cohort studies.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypofractionated-radiation-therapy-draft-appendix-d2.xlsx
January 01, 2024 - Intervention Details
Author, year KQ Trial Arms, number Arm Group Total dose, Gy Total number of fractions … Dose constraints were applied to organs at risk and were amended during the trial… Androgen deprivation … Rectal balloon used for planning only No NR No NR
Kishan, 2023 KQ5 IG1 IG1 40 5 8 UHF NR Patients were randomized … MRI No NR No NR Yes Full bladder, Empty rectum
Kishan, 2023 KQ5 IG2 IG2 40 5 8 UHF NR Patients were randomized … (Computed tomography) No NR No NR No NR No NR No NR
Wang, 2022 KQ1 IG2 IG2 78 39 2 CF NR Patients randomized
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-197-fractional-exhaled-nitric-oxide-disposition-comments.pdf
December 20, 2017 - Typically adherence studies are
not conducive to randomized controlled double blind
studies, therefore … 20Value%20Proposition%20White%20Paper%20-
%20Circassia%202017.pdf
The reviewer’s
comment about
randomized … adherence being not
conducive for
evaluating adherence
is incorrect (in fact,
there are numerous
randomized … (continued)
Pavord 2012: the aim
of this trial is to
evaluate the
effectiveness of
Mepolizumab
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/bundled-payments-quality-effects_research-protocol.pdf
June 23, 2011 - [tiab]
AND
payment[tiab] OR finance*[tiab] OR reimburse*[tiab] OR incentive*[tiab]
AND
trial … The following data will be abstracted from included studies:
Trial name. … Abbreviations: EPC = Evidence-based Practice Center; RCT = randomized controlled trial.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_surveillance.pdf
January 01, 2013 - Evidence From Systematic Reviews
A systematic review of randomized
trials of screening modalities … "scanning laser polarimetry"[tiab]) AND ("Cohort Studies"[Mesh] OR "Case-Control
Studies"[Mesh] OR randomized … controlled trial [pt] OR controlled clinical trial [pt] OR
randomized [tiab] OR placebo [tiab] OR drug … exam for APD was
9.1%, specificity
99.3%
IOP
Measurement
Scuderi 201014
Italy
Non-randomized … Evidence From Systematic Reviews
A systematic review of randomized trials of
screening modalities
-
effectivehealthcare.ahrq.gov/sites/default/files/suppl-1-user-guide-to-ocer_130129.pdf
January 01, 2011 - However, the classic
discussions of these concepts mainly focus on the
extent to which estimates from randomized … Likewise, randomized trial designs
have limited ability to identify average treatment
effects for those … patients not studied (i.e., patients
not meeting trial inclusion criteria or refusing to
participate … whether
surgery rates from AMI patients should increase
(objective 4) in comparison to existing randomized … controlled trial (RCT) evidence.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-200-comments-post-acs.pdf
November 14, 2017 - I think it should first be shown in
randomized trials that screening plus treatment has
indeed a benefit … ; Jolly's BRUM Trial; Kim K-DEPACS,
O'Neil MoodCare; Hunger's KORINNA Trial, Jorstad's
RESPONSE Trial … ; and Roncella's STEP-IN-AMI Trial,
among others). … is not the Cochrane Database of systematic
reviews that was searched, but the Cochrane database of
randomized … For the CODIACS trial, effects on
total costs are reported.
-
effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_june_2012.pdf
January 01, 2012 - A phase III trial
comparing use of Oral-lyn as a prandial insulin to injected human insulin was expected … o Extended-release exenatide is a controlled-release, once-weekly formulation
delivered by subcutaneous … In September 2011, the company announced plans for its phase III
trial after releasing final 48-week … results from its phase II trial. … Another
research expert noted that another clinical trial compared this intervention to behavioral
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/radiotherapy-proton-beam_research.pdf
May 01, 2012 - research applications
since the 1950s and entered clinical practice in the United States
in 1990.1
No randomized … controlled trials and only a few well-conducted
cohort studies have compared proton beam radiation … A requirement (for some indications) that
the patient be treated as part of a clinical
trial.
4. … Dose-response in ra-
diotherapy for localized prostate cancer: results of the Dutch Multicenter
Randomized … Phase III Trial comparing 68 Gy of radiotherapy with 78
Gy.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
May 18, 2011 - Study
Design
KQs 1–2: Systematic review, randomized or nonrandomized controlled
trial, prospective … databases:
MEDLINE
Cochrane Database of Systematic Reviews
Cochrane Central Register of Controlled … For the purposes of this
review, grey literature comprises information that is not controlled by commercial … and
manufacturer Web sites, and information regarding ongoing and future research via
clinical trial
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/child-growth-development-outcomes-draft-report-rob.xlsx
January 01, 2017 - RCT
RefID Author, year
(Trial/Study Name if applicable) Is randomization adequate? … Yes Yes Low Yes- (KQ4) RCT to evaluate the developmental outcomes of children at 6 y.o in the IFOS trial … Quality Rating Non-randomized
Cohort
RefID Author, year
(Trial/study name if applicable) Did the … Quality Rating Non-randomized
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/pediatric-ehr_research-protocol.pdf
January 01, 2014 - Examples of sources of grey literature include government
websites, clinical trial databases, trade … Designs: We will allow randomized controlled trials, cohort, and pre-post study designs because
these … population Pediatric, outpatient
Publication languages English only
Admissible evidence Study design
Randomized … controlled trials, including wait-list control, cohorts with comparison, pre-post
cohort without comparison
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/carbohydrate-intake-appendix-d.xlsx
January 01, 2019 - . 70%
Smoked during first trimester: 0.8% vs. 5.7% Dietary counseling (from Piirainen 2007: further randomized … age, smoking during pregnancy, 2-h OGTT plasma glucose value, energy intake, offspring sex The TOP trial … ) Australia NR Inclusion: Overweight and obese pregnant women with complete data enrolled in SPRING trial … Data System for Research
NR not reported
NS not significant
OGTT oral glucose tolerance test
RCT randomized … controlled trial
SD standard deviation
SE standard error
SPRING Study of Probiotic IN Gestational
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-nerve-blocks-disposition-comments.pdf
August 15, 2025 - We cannot
say with certainty what the relative distribution of poorly
controlled pain, new persistent … To better understand that we extracted any information
offered by the trial authors regarding geographical … We did not require certain diagnosis criteria to be included in
the randomized controlled trials (RCTs … is collected as per the
protocol of the individual RCT, and we extracted demographic
data from the trial
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/field-triage-glascow_executive.pdf
January 01, 2017 - For all
Key Questions, we included cohort studies and randomized
trials that directly compared the … of the mGCS versus the tGCS were published in 1998 and
2003.18,19
The Cochrane Central Register of Controlled … A number of studies
on predictive utility were conducted in ED settings, which
is more controlled and … Research Recommendations
Head-to-head observational or randomized studies that
assess one set of patients … Randomized controlled
trial of a scoring aid to improve Glasgow Coma Scale scoring
by emergency medical