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Total Results: 1,519 records

Showing results for "randomized controlled trial".

1161. Disposition of Comments for Child Exposure to Trauma: Comparative Effectiveness of Interventions Addressing Maltreatment (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-interventions-maltreatment-child_disposition-comments.pdf
      April 15, 2013 - KQ3 because the theoretical orientation of the comparator was not clearly described in either CPP trial … We also note that PCIT was not included in KQ3 because there was no head-to-head trial comparing … At least 2,000 randomized subjects would be required to diminish this uncertainty to a change of less … A., et al. (2004) Effect size in cumulative meta-analyses of mental health randomized trials evolved … interventions, but ultimately it is not clear whether the strongest findings reflect effects obtained under controlled

1162. Improving Health Care and Palliative Care for Advanced and Serious Illness Disposition of Comments Report (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/quality-gap-palliative-hospice_disposition-comments.pdf
      October 01, 2012 - Published Online: October 2012. 8 Comment# Commentator & Affiliation Section Comment Response randomized … trials, which did not capture many issues of methodologic quality within non-randomized quality improvement … trials, which did not capture many issues of methodologic quality within non-randomized quality improvement … A CQI study could be an RCT, but it would need to be cluster-randomized design. … The Temel study in the NEJM was done at a single site essentially as a randomized Phase II trial.

1163. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-liver-metastases-therapies_research-protocol.pdf
      September 27, 2012 - Source: www.effectivehealthcare.ahrq.gov Published Online: September 27, 2012 equipoise and limited randomized … trial data comparing liver-directed therapies22, 23 leaves uncertainty around which techniques, either … Criteria for Inclusion/Exclusion of Studies in the Review We will include randomized controlled trials … • MEDLINE® • EMBASE® • Cochrane Controlled Trials Register http://www.effectivehealthcare.ahrq.gov … Phase III trial comparing protracted intravenous fluorouracil infusion alone or with yttrium-90 resin

1164. Suppl-2-User-Guide-To-Ocer 130129 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/suppl-2-user-guide-to-ocer_130129.pdf
      January 01, 2011 - In an ideal randomized experiment, treatment assignment is independent of the counterfactual outcomes … trial, the outcome experience had the entire population been treated (Pr[Ya=1=1]) is equal to the … To simplify, consider a randomized trial of antihypertensive treatments (CCB or other) and the outcome … Treatment (A) is randomized. … Subjects randomized to CCBs (A=1) are more likely to drop out due to adverse drug effects.

1165. Evaluating Practices and Developing Tools for Comparative Effectiveness Reviews of Diagnostic Test Accuracy: Methods for the Joint Meta-Analysis of Multiple Tests (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/diagnostic-tests-accuracy_research.pdf
      January 01, 2013 - sufficient to evaluate a diagnostic test, and reliably identifies trisomy 18 and trisomy 13 when do we need randomized … Using the principles of randomized controlled trial 17. Bromley B, Lieberman E, Benacerraf BR. … Modeling between-trial variance structure in mixed treatment comparisons. Biostatistics.

1166. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/lung-cancer-nonsurgical-therapies_research-protocol.pdf
      February 22, 2012 - Study Selection Criteria We will seek to include only comparative studies, preferably randomized … controlled trials (RCTs), but also nonrandomized comparative studies (including case-control and cohort … librarian for citations from January 1995 through December 2011: • MEDLINE® • EMBASE® • Cochrane Controlled

1167. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism_research-protocol.pdf
      December 09, 2009 - review found methodological weaknesses in systematic reviews of psychosocial interventions.7 While controlled … languages English only Admissible evidence (study design and other criteria) Admissible designs • Controlled … country, city, state) and time period, population description, sample size, and study type (e.g., randomized … controlled trial, prospective observational study, etc).

1168. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/therapies-for-autism-spectrum-disorder-2-9-2010.pdf
      January 01, 2010 - review found methodological weaknesses in systematic reviews of psychosocial interventions.7 While controlled … languages English only Admissible evidence (study design and other criteria) Admissible designs • Controlled … country, city, state) and time period, population description, sample size, and study type (e.g., randomized … controlled trial, prospective observational study, etc).

1169. Frameworks for Determining Research Gaps During Systematic Reviews (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-research-steps-framework_research.pdf
      June 01, 2011 - If no recent reviews of a specific topic were found, a search was made for randomized controlled trials … controlled trial, STI=sexually transmitted infection … controlled trial (RCT) for each topic.5 Research gaps/needs were identified as areas of insufficient … Controlled Trial RFA Request For Applications RTI Research Triangle Institute SBU The Swedish Council … controlled trial, RTI=Research Triangle Institute, TEP=technical expert panel, UNC=university of North

1170. Functional-Limitations-Horizon-Scan-High-Impact-1306 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/functional-limitations-horizon-scan-high-impact-1306.pdf
      June 01, 2013 - maintenance dosage of 240 mg twice a day, orally.14 Clinical trials: In two multicenter phase III, randomized … Clinical trials: In two multicenter, double-blind, randomized controlled trials, the effects of icatibant … Placebo- controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. … Placebo- controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. … Results from FAST-3: a phase III randomized, double-blind, placebo-controlled, multicenter study

1171. Disposition of Comments Report for Otitis Media With Effusion (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/ear-infection_disposition-comments.pdf
      May 04, 2013 - The studies that the reviewer mentions are randomized by child and by ear. … There is a single randomized controlled trial (RCT) by Gates in 1987 that showed in a very select group … This was not simply a trial comparing adenoidectomy plus myringotomy vs. adenoidectomy plus tubes. … controlled trials (RCTs), nonrandomized controlled trials and cohort studies.” … It is directly contradicted by the Paradise clinical trial reported in the NJM and elsewhere and it

1172. S89 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/s89.pdf
      October 01, 2007 - In addition, common adverse events have usually already been identified in preli- censure randomized … controlled trials, limiting their appropri- ateness for analysis with maxSPRT. … and induction of immunologic memory by a serogroup C meningococcal conjugate vaccine in infants: a randomized … controlled trial.

1173. Mixed MethodsReview -Integrating Palliative Care with Chronic Disease Management in Ambulatory Care (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/palliative-care-research-amended-protocol.pdf
      November 21, 2019 - controlled trials • Non-randomized studies with concurrent or historical controls • Articles … following databases for primary quantitative studies: PubMed, CINAHL, and the Cochrane Central Register of Controlled … For nonrandomized studies, we will use the Cochrane Risk of Bias Assessment Tool for Non-Randomized … Randomized controlled trials and nonrandomized studies will be analyzed separately. … dichotomous outcomes are presented, we will calculate a pooled effect estimate of relative risk between trial

1174. Disposition of Comments_Systematic Review: Breastfeeding and Health Outcomes for Infants and Children (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/breastfeeding-health-outcomes-disposition-comments.pdf
      March 31, 2025 - of breastfeeding can be, and this was done in the PROBIT trial. … All of the observational analyses from the PROBIT trial are included in our review. … insufficient evidence to draw conclusions about the relationship with food allergies and no well-controlled … We also agree that randomized clinical trials, including cluster randomized trials, can help to understand … Given that randomized controlled trials (RCTs) are not feasible in breastfeeding research, we encourage

1175. Executive Summary_Comparative Effectiveness Review No. 263: Management of Postpartum Hypertensive Disorders of Pregnancy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-263-postpartum-hypertensive-pregnancy-executive-summary.pdf
      May 01, 2023 - Our searches targeted comparative studies (i.e., randomized controlled trials [RCTs] and nonrandomized

1176. Topic-Brief1-Care-Coordination (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-brief1-care-coordination.pdf
      April 01, 2021 - multidisciplinary Enhanced Recovery After Surgery (ERAS) model in post- pancreatectomy patients,3 but identified no randomized … • One other meta-analysis (not in the review of reviews) also identified no randomized trials and … ERAS model with usual care and three low quality uncontrolled ERAS cohort studies, but identified no randomized … Although we identified 26 systematic reviews (17 in a review of reviews and 9 additional), no randomized … It evaluated the ERAS protocol in persons with post-surgical pain but identified no randomized trials

1177. Topic-Brief1-Care-Coordination (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/topic-brief1-care-coordination.pdf
      April 01, 2021 - multidisciplinary Enhanced Recovery After Surgery (ERAS) model in post- pancreatectomy patients,3 but identified no randomized … • One other meta-analysis (not in the review of reviews) also identified no randomized trials and … ERAS model with usual care and three low quality uncontrolled ERAS cohort studies, but identified no randomized … Although we identified 26 systematic reviews (17 in a review of reviews and 9 additional), no randomized … It evaluated the ERAS protocol in persons with post-surgical pain but identified no randomized trials

1178. Disposition of Comments for Local Nonsurgical Therapies for Stage I and Symptomatic Obstructive Non-Small-Cell Lung Cancer (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/lung-cancer-nonsurgical-therapies_disposition-comments.pdf
      June 12, 2013 - performed a thorough, deep search of the published literature, including NLM MEDLINE, EMBASE, Cochrane Controlled … alternatives for inoperable patients with stage 1 NSCLC the lack of comparative data between modalities in a randomized … It is not clear that there is equipoise present with such a trial. … Results of randomized studies looking at SBRT vs wedge or SBRT vs RFA are maturing and studies. … Randomized trials for PBRT vs IMRT are also not currently organized to my knowledge. 3.

1179. CER 215 Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-215-depression-older-adults-comments.pdf
      March 28, 2019 - Consider adding “not-placebo-controlled” in parentheses. This was added. … Thus if the majority of sample came from a low risk of bias trial, the ROB domain in the SOE rating … Consider separate sections for placebo-controlled and no treatment trials. … phases” should be “was conducted in two randomized phases” This change has been made. … Peer reviewer #6 Discussion Could make more explicit that people that tolerate treatment were randomized

1180. Effectiveness of Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypothyroidism-hyperthyroidism-screening-treatment_disposition-comments.pdf
      February 01, 2012 - It is a controlled clinical trial. … This study was described as a controlled trial not a randomized controlled trial.