-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hro-protocol.pdf
January 01, 2023 - the
primary reviewer will use the Cochrane Collaboration’s tool for assessing the risk of bias of
randomized … controlled trials (RCTs) or the ROBINS-I tool for assessing the Risk Of Bias In
Non-randomized Studies … performance bias, detection bias, attrition bias, reporting bias, and other bias.10 When
assessing non-randomized
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-267-adhd-disposition-comments.pdf
March 25, 2024 - Double-Blind Placebo-Controlled Randomized
Clinical Trial of Neurofeedback for Attention-
Deficit/Hyperactivity … Neurofeedback for ADHD: 25-month
follow-up of double-blind randomized controlled trial
(2023). … EEG
neurofeedback for ADHD: double-blind sham-controlled
randomized pilot feasibility trial. … Double-blind placebo-controlled
randomized clinical trial of neurofeedback for attention-
deficit/hyperactivity … A randomized placebo-
controlled trial of electroencephalographic (EEG)
neurofeedback in children with
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertensive-disorders-pregnancy-disposition-comments.pdf
May 31, 2023 - For example, one randomized controlled trial of a text-message-based
blood pressure surveillance program … Of the 103 women in each arm of the trial, no women in the
treatment arm required hospital readmission … Munnery M, Wallace S, Rowe C,
Cockcroft JR, Wilkinson IB, on Behalf of the Anglo-Cardiff
Collaborative Trial … The Anglo-Cardiff Collaborative
Trial II. Hypertension. 2008;51:1476-1482. … In Section 4.6 Implications for
Research, we have edited to recommend
that trial design and analysis
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-immunotherapy-2010_executive.pdf
January 01, 2010 - Data Sources and Selection
We reviewed titles and then abstracts to identify
randomized controlled … The magnitude
of effect in a trial was considered “weak” if there was
less than a 15 percent difference … Literature search
RCT = randomized controlled trial; SCIT = subcutaneous immunotherapy; SIT = specific … How to design
and evaluate randomized controlled trials in immunotherapy for
allergic rhinitis: an … controlled trial
SIT Allergen-specific immunotherapy
SCIT Subcutaneous immunotherapy
SLIT Sublingual
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/patient-family-engagement-protocol.pdf
December 31, 2019 - standards set by the Institute of Medicine38) published since 2015, including systematic reviews of
randomized … controlled trials (RCTs) and/or observational studies with comparison groups. … trial. … Managing depression as a chronic disease: a randomised trial of
ongoing treatment in primary care. … A randomized trial to improve patient-centered care and
hypertension control in underserved primary
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_research-protocol.pdf
December 06, 2010 - evidence (study
design and other
criteria)
Original research; eligible study designs include:
• Randomized … controlled trials with a sample size
≥100
• Nonrandomized controlled trials
• Observational studies
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_executive.pdf
April 01, 2012 - Data Sources and Selection
We included randomized controlled trials (RCTs), quasi-
randomized controlled … and quasi-randomized
trials. … controlled trials as the highest level of
evidence, followed by comparative observational studies. … controlled trial of glaucoma screening
would be the optimal study design, as an RCT design
would allow … assessment
of stereoscopic optic disc photographs for glaucoma: the European
Optic Disc Assessment Trial
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-244-safety-of-vaccines.pdf
May 25, 2021 - -
controlled designs). … Evidence
[Comment in pdf file on “The most
frequent study designs identified in the
update were randomized … followed by cohort
studies (n=26), pre-post designs
(n=12), case-control designs (n=9),
and one non-randomized … controlled
clinical trial, along with 13 others that
used selfcontrol methods (either self-
controlled … The data for autism comes from the
clinical trial record for NCT01240746;
this trial is the basis of
-
effectivehealthcare.ahrq.gov/sites/default/files/01_-arthritis_potential_high_impact_june_2012.pdf
January 01, 2012 - The evidence base for PRP lacks large,
blinded, prospective, randomized, controlled trials. … One open-label extension trial demonstrated durable
responses to tofacitinib up to 36 months. … However, some of the experts stated that large,
randomized, double-blind trials are needed to better … perspectives stated that PRP injections could gain
larger acceptance if shown to be effective in randomized … In another clinical trial, patients in whom RA was diagnosed (n=1,070) were given tofacitinib 5 or
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-function_research-protocol.pdf
June 13, 2013 - Long-term outcomes
– All-cause mortality
– ≥1 year MACE rates
Type of
study
• We will include randomized … controlled trials and
observational studies with a comparison group … the following databases for primary studies: MEDLINE®, EMBASE®,
and the Cochrane Central Register of Controlled … anticipate the studies to be predominantly observational
in nature, including post-hoc analyses of randomized … controlled trials that studied ACS
interventions.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/long-term-care-adults-future_research.pdf
July 01, 2013 - controlled trials (RCTs) were identified. … controlled trial
References
1. … controlled trials (RCTs) were identified. … For example, factors that affect the feasibility of
conducting randomized controlled trials include … controlled trial
20
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-194-disposition-comments-inhaled-corticosteroids.pdf
March 19, 2018 - Although the duration
of a trial is not specifically
considered as a domain, the
duration could contribute … Reporting bias was
also evaluated when a trial was
matched with a published protocol
on clincitaltrials.gov … race and ethnicity as
well as environmental factors all of which
contribute to control or poorly controlled … methodological similarity criterion is
broadly met through the availability of data from
good quality randomized … controlled studies of the
treatments of interest.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-bias_methods.pdf
July 01, 2012 - Categorizing individual studies into general quality classes*
Category Application to Randomized … Controlled Trials
Application to Medical Test
Performance Studies
Low.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/home-dialysis-ESKD-rapid-research.pdf
April 01, 2025 - Facilities and Clinicians Treating
Patients With End-stage Kidney Disease and Use
of Home Dialysis: A Randomized … Clinical Trial. … clinical trial or randomized controlled trial).pt. or (control or controls or
controlled or random* … or Comparative Study/ or Controlled Before-
After Studies/ or Cross-Sectional Studies/ or exp Evaluation … , Randomized Controlled Trial (19)
S9 TI S3 AND S6 Limiters - Published Date: 20180301-20230731; English
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_executive.pdf
February 01, 2012 - For example,
the literature on the use of HSCT in
hematologic malignancies is robust,
including randomized … controlled trials
that date back 20 years, and its practice is
supported by evidence-based guidelines … Sources and Study Selection
Electronic databases searched were MEDLINE®,
Embase®, and the Cochrane Controlled … Randomized controlled trials were
rare for any of the indications included in this systematic
review … For inherited metabolic diseases, controlled trials with
sufficient followup are needed to evaluate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fetal-surgery_disposition-comments.pdf
July 05, 2011 - In fact, the poorly conducted randomized
clinical trial in the United States (100% prematurity,
100% … text to be more specific: 8 of 32
(25%) with recurrent pulmonary
infections; and 25% with asthma
controlled … has been put
forth by theData Monitoring and Safety Committee of
the BostonChildren‟s study, a well-controlled … We have strengthened information
regarding the lack of randomized trials
making direct comparisons … The Senat (Eurofoetus) trial randomized patients to
either amnioreduction or laser PRIOR to any
intervention
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-child-adolesc-mental-health-grand-rounds.pptx
May 22, 2025 - treatment study of >4 weeks Any study of evaluating a monitoring strategy
Diagnostic accuracy study Controlled … We also identified 69 trial registrations through clinical trial registries. … Of the 65 included studies, 33 studies were randomized clinical trials (RCTs), 13 were comparative
After … FFT
Designed for bipolar youths.
1 trial found no differences for SI. … emerging biological treatments on suicide highlight a gap in the evidence base and a critical need for controlled
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-disposition-comments-analgesics-prehospital-setting.pdf
September 03, 2019 - study for opioids or ketamine in to
the review, assuming the pain had to be at least
moderate for a trial … controlled trial. … In EMS, accountability for
controlled substances has a particular set of
challenges, as does deploying … Example: Prehospital
Analgesia with Intranasal Ketamine (PAIN-K): A
Randomized Double-Blind Trial in … The inclusion of mainly
randomized controlled trials is rigorous.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-interventions-maltreatment-child_disposition-comments.pdf
April 15, 2013 - KQ3 because the
theoretical orientation of the
comparator was not clearly
described in either CPP trial … We
also note that PCIT was not
included in KQ3 because there
was no head-to-head trial
comparing … At least
2,000 randomized subjects would be required to diminish this uncertainty to a change
of less … A., et al. (2004) Effect size in cumulative meta-analyses of mental
health randomized trials evolved … interventions, but ultimately it is not clear whether the strongest findings reflect
effects obtained under controlled
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-236-maternal-fetal-child-outcomes-disposition-comments.pdf
April 15, 2021 - Rather than using the vague term “trials”, it
would be better to specify if this refers to randomized … controlled trials or other types of trials (e.g., non-
randomized, non-controlled trials). … “Rates of loss of consciousness did not
appear to vary by dose and were similar
among women randomized … specific about the reasons that the evidence
on harms of treatment is of low quality (e.g., poorly
controlled … This now reads: “for both
drugs, we found evidence bases with two
or more randomized controlled trials