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Total Results: 1,523 records

Showing results for "randomized controlled trial".

1101. #05 DEPRESSION (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/05_depression_potential_high_impact_june_2012.pdf
      January 01, 2012 - trial design and outcomes seen thus far. … In the double- blind, sham-controlled phase (n=14), the mean (SD) Y-BOCS score difference between active … Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled … add-on trial. … Controlled substance schedules. [internet].

1102. AHRQ Evidence-based Practice Center Program Research Gaps Summary: Telehealth (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/ehc-research-gaps-telehealth.pdf
      April 01, 2023 - However, recognizing potential ethical and logistical challenges, consider different trial designs … Study Design • Nonrandomized controlled study (NRS) designs, ideally using a propensity score matching … Study Design • Randomized controlled trials, with clearly defined comparison groups and health outcomes

1103. PULMONARY with "Discussions" in Exec Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1312.pdf
      December 01, 2013 - This program’s high-impact potential will be reevaluated after results of the IHI-funded trial are … Results of a randomized controlled trial (RCT) on prophylactic azithromycin for COPD exacerbations … III trial.5,6 In a randomized, double-blind, placebo-controlled, phase III trial, cosponsored by the … : In a randomized controlled trial (RTC), patients with COPD who were at increased risk of exacerbations … One trial investigated the OCS Lung’s feasibility for lung preservation during lung transplantation

1104. Pressure-Ulcer-Prevention Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-prevention_executive.pdf
      May 01, 2013 - July 2012, CINAHL (EBSCOhost®) from 1988 through July 2012, and the Cochrane Central Register of Controlled … For Key Questions 1 and 4, we included controlled clinical trials and cohort studies. … For Key Question 3, we included controlled clinical trials. … KQ 4c. 0 trials KQ 1 KQ 2 KQ 3 KQ 4 aCochrane databases include the Cochrane Central Register of Controlled … randomized to repositioning at 2-, 3-, or 4-hour intervals, should provide more rigorous evidence

1105. Disposition of Comments Report for Treatment of Depression During Pregnancy and the Postpartum Period (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_disposition-comments.pdf
      July 08, 2014 - Randomized controlled trials of course would help to remove this bias. … Assessment First sentence of this section is awkward ; also, in the last sentence, add study to randomized … controlled trial’ TEP Member #11 Results I have some question about the strength of the rationale … Changed to: “While there is still hesitancy to conduct randomized controlled trials in pregnant women … report influences is the need for better research, registries, and how difficult it is to complete controlled

1106. Research White Paper Managing Missing Data in Patient Registries Addendum Registries for Evaluating Patient Outcomes Third Edition (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
      February 01, 2018 - accounted for in analyses to the extent possible (known as informative censoring in the context of randomized … Additionally, while randomized clinical trials (RCTs) often limit their samples to a narrow and often

1107. Comparative Effectiveness and Safety of New Therapies (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-glucose-control_research.pdf
      July 01, 2010 - We have published an observational study regarding the effectiveness of exenatide;16 however, controlled … Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized … trial. … twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled

1108. Methods Guide for Medical Test Reviews Chapter 10 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-decision-models_methods.pdf
      July 01, 2012 - Such evidence could be obtained from well designed, conducted and analyzed randomized trials, or even … Randomized trials may exist suggesting that the treatment effects are similar in patients identified … of the diagnostic performance of PET to identify AD, but does not include longitudinal studies or randomized … Using the principles of randomized controlled trial design to guide test evaluation. … Optimization of CT colonography technique: prospective trial in 180 patients.

1109. Engaging Patients in Information Sharing and Data Collection: The Role of Patient-Powered Registries and Research Networks (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/stakeholders-engagement-others_white-paper.pdf
      September 01, 2013 - More importantly, the nature of the clinical trial may or may not yield information that patients and … world” practice and the effectiveness of treatments and procedures, and are to be distinguished from randomized … controlled trials or scientific experiments that cannot measure real-life experience, in some cases … In the view of some, only registries that are created, maintained, and controlled by patients or patient … Terms such as “patient-generated,” “patient-run,” “patient-powered,” and “participant-controlled” can

1110. Methods Guide for Medical Test Reviews - Editorial (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guide-editorial_methods.pdf
      July 01, 2012 - detailed handbook for authors of systematic reviews.5 This methods guide focuses primarily on reviews of randomized … controlled trials of interventions. … Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement

1111. Research Protocol: Breast Reconstruction After Mastectomy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-reconstruction-mastectomy-protocol.pdf
      April 09, 2020 - chemotherapy Timing • Any Setting • Any, including single- and multicenter Design • Randomized … trial. … trial. … difference NRCS nonrandomized comparative study OR odds ratio PAP profundal artery perforator RCT randomized … controlled trial ROBINS-I Risk of Bias in Nonrandomized Studies of Interventions SIEA superficial

1112. Modeling to evaluate benefits and harms of new diagnostic tests compared to established diagnostic tests – uses and limitations (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/benefits-harms-modeling_research.pdf
      November 19, 2009 - most robust empirical demonstration of the utility of a medical test is through a properly designed randomized … These had not been compared head-to-head in a clinical trial.19 3 Conversely, management strategies … measuring sensitivity and specificity sufficient to evaluate a diagnostic test, and when do we need randomized … comparative evidence of test accuracy and other intermediate outcomes be used as an alternative to randomized … controlled trials?

1113. Amendment_HIE-Protocol_3-14-2015 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/health-information-exchange_research-protocol.pdf
      April 20, 2015 - Randomized controlled clinical trials (RCTs) and systematic reviews of such trials will be included … 2015 9 Literature Databases: Ovid MEDLINE, PsycINFO, CINHAL, EMBASE, Cochrane Central Register of Controlled … hereafter, Methods Guide).26 Included studies will be classified according to type of design (e.g., randomized … trial, nonrandomized trial, observational study, etc.)

1114. Disposition of Comments Report for Oral Contraceptive Use for the Primary Prevention of Ovarian Cancer (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_disposition-comments.pdf
      June 07, 2013 - trial. … This population would be more willing to participate as well, and more motivated to adhere to the trial … If all epidemiological evidence is to be regarded as at best moderate without a randomized trial then … controlled trials. … controlled trials

1115. Undescended-Testicle Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/undescended-testicle_executive.pdf
      December 01, 2012 - For randomized controlled trials (RCTs), we used the Cochrane Risk of Bias tool;6 for cohort studies … Short-term testicular descent in two-arm, randomized, placebo-controlled studies Study N Length of … controlled trial 11 body of epidemiologic data and data from noncomparative studies to which we … In order for this comparison to be valid, the trial would also need to control for location within … Such a trial would be ethical, as primary orchiopexy would not be the focus of the study and would

1116. Interventions for Breathlessness in Patients With Advanced Cancer: Evidence Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
      November 01, 2020 - We found 29 randomized controlled trials (RCTs) (2,423 patients). … the evidence supported the effectiveness of opioids for breathlessness, all but one of the placebo-controlled

1117. Evidence Summary_Comparative Effectiveness Review No. 248: Prehabilitation and Rehabilitation for Major Joint Replacement (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/joint-replacement-evidence%20-summary.pdf
      November 01, 2021 - Our searches targeted randomized controlled trials (RCTs) and adequately adjusted nonrandomized comparative

1118. Disposition of Comments Report for CER 134 Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_disposition-comments.pdf
      May 13, 2014 - For disulfiram, we have added the following to the abstract: “Evidence from well-controlled trials does … We did not make any recommendations about trial design. … The part of our report that this comment is referring to was specifically about placebo-controlled trials … Twenty one years later with over 40 randomized trials conducted in four continents by dozens of researchers … Only in one trial did I see the effect disappear and that was in the multi-site Vivitrol trial.

1119. Amended Protocol: Management of Infantile Epilepsy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-epilepsy-amended-protocol.pdf
      March 07, 2021 - We will not require that patients be randomized to groups, nor will we require that studies plan their … For Key Question 3 (harms), we will include single-arm studies as well as controlled studies. 6. … We will search the following databases using controlled vocabulary and text words: EMBASE, MEDLINE, … We will assess randomized trials for Key Question 1 and 2 using the Cochrane Risk of Bias 2 (ROB2) … A cohort study of summary reports of controlled trials. JAMA. 1990 Mar 9;263(10):1401-5.

1120. App-E-Surv-Report-3-Acute-Pain (xls file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-3-acute-pain.xlsx
      May 29, 2025 - Intervention Types Compared Intervention Names and Doses Intervention Dose in Daily Morphine Equivalent N Randomized … Condition Intervention Types Compared Intervention Names and Doses Dose in Daily Morphine Equivalent N Randomized … B Medication controlled pain: 78% (59/76) vs. 69% (51/74), RR 1.13 (95% CI 0.93 to 1.37) NR NR A vs. … 2021 Postoperative to outpatient Norway Total knee arthroplasty Opioid vs. mixed agent A: Oxycodone controlled … acetaminophen 325 mg, single dose B: Ketorolac 10 mg, single dose C: Acetaminophen 500 mg, single dose (Trial