Results

Total Results: 1,524 records

Showing results for "randomized controlled trial".

1101. Methods-Guide-Chapter-Prioritization-And-Selection-Of-Harms-For-Inclusion-In-Systematic-Reviews (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/prioritization-selection-of-harms.pdf
      February 01, 2018 - consider a broad range of data sources to evaluate harms, including observational studies as well as randomized … Suggested data sources included randomized controlled trials, observational studies (including pharmacoepidemiological … events (e.g., the FDA’s MedWatch program).15 The KIs noted that reviewers should not rely solely on randomized … External validity of randomised controlled trials: “to whom do the results of this trial apply?”. … In macroVascular Events): a randomised controlled trial.

1102. Interventions for Breathlessness in Patients With Advanced Cancer: Evidence Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
      November 01, 2020 - We found 29 randomized controlled trials (RCTs) (2,423 patients). … the evidence supported the effectiveness of opioids for breathlessness, all but one of the placebo-controlled

1103. Cer-243-Prehospital-Airway-Management-Appendix-E-1 0 (xls file)
      effectivehealthcare.ahrq.gov/sites/default/files/cer-243-prehospital-airway-management-appendix-e-1_0.xlsx
      January 01, 2020 - Airway scope: 74.4 (13.6) Laryngoscope: 74.1 (13.0) NR NR Moderate Bartlett, 1992 1992 0 0 1 NR Controlled … Clinical Trial (grouped with prospective observational) U.S. … Clinical Trial (grouped with prospective observational) U.S. … Clinical Trial (grouped with RCT) U.S. … pharyngeo-tracheal lumen PtL pharyngeotracheal lumen airway Q1 quartile 1 Q3 quartile 3 RCT randomized

1104. Methods Guide for Medical Test Reviews - Editorial (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guide-editorial_methods.pdf
      July 01, 2012 - detailed handbook for authors of systematic reviews.5 This methods guide focuses primarily on reviews of randomized … controlled trials of interventions. … Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement

1105. Pressure-Ulcer-Prevention Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-prevention_executive.pdf
      May 01, 2013 - July 2012, CINAHL (EBSCOhost®) from 1988 through July 2012, and the Cochrane Central Register of Controlled … For Key Questions 1 and 4, we included controlled clinical trials and cohort studies. … For Key Question 3, we included controlled clinical trials. … KQ 4c. 0 trials KQ 1 KQ 2 KQ 3 KQ 4 aCochrane databases include the Cochrane Central Register of Controlled … randomized to repositioning at 2-, 3-, or 4-hour intervals, should provide more rigorous evidence

1106. Understanding Health-Systems’ Use of and Need for Evidence To Inform Decisionmaking (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/health-systems-research.pdf
      October 01, 2017 - KIs felt that randomized controlled trials are specifically desired by clinical experts on health- system … However, KIs felt that for those who are not experts int the field, randomized controlled trials are … A whole lot of the trial evidence is not useful for the questions that I’m asking. … recommendations and systematic reviews that included recommendations for practice and not just clinical trial … Guidelines, systematic reviews, and randomized controlled trials were all highly sought after sources

1107. Disposition of Comments Report for CER 134 Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_disposition-comments.pdf
      May 13, 2014 - For disulfiram, we have added the following to the abstract: “Evidence from well-controlled trials does … We did not make any recommendations about trial design. … The part of our report that this comment is referring to was specifically about placebo-controlled trials … Twenty one years later with over 40 randomized trials conducted in four continents by dozens of researchers … Only in one trial did I see the effect disappear and that was in the multi-site Vivitrol trial.

1108. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1406.pdf
      February 01, 2015 - Results The table below lists the one topic for which (1) preliminary late-phase clinical trial data … The largest clinical trial to date is scheduled to conclude in 2015. … regardless of ApoE-ε4 status.17 In 2013, the Alzheimer’s Disease Cooperative Study registered the largest randomized … , controlled trial (n=240) to date for this intervention to investigate intranasal insulin’s efficacy … The latter group is lead sponsor on the largest ongoing trial, a phase II/III trial investigating intranasal

1109. Methods Guide for Medical Test Reviews Chapter 10 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-decision-models_methods.pdf
      July 01, 2012 - Such evidence could be obtained from well designed, conducted and analyzed randomized trials, or even … Randomized trials may exist suggesting that the treatment effects are similar in patients identified … of the diagnostic performance of PET to identify AD, but does not include longitudinal studies or randomized … Using the principles of randomized controlled trial design to guide test evaluation. … Optimization of CT colonography technique: prospective trial in 180 patients.

1110. Modeling to evaluate benefits and harms of new diagnostic tests compared to established diagnostic tests – uses and limitations (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/benefits-harms-modeling_research.pdf
      November 19, 2009 - most robust empirical demonstration of the utility of a medical test is through a properly designed randomized … These had not been compared head-to-head in a clinical trial.19 3 Conversely, management strategies … measuring sensitivity and specificity sufficient to evaluate a diagnostic test, and when do we need randomized … comparative evidence of test accuracy and other intermediate outcomes be used as an alternative to randomized … controlled trials?

1111. Braddock (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/braddock.pdf
      January 01, 2011 - Fewer people remaining  undecided o Fewer patients choosing  major surgery, PSA tests Slide 9: A randomized … trial of telephone care-­‐management strategy • RCT of usual care versus telephone coaches for >170,000

1112. Ced-Topic-Refinement (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-topic-refinement.pdf
      November 01, 2022 - 9 This specific Decision Summary specifies that the product may be covered in a randomized controlled … analysis of real- world data.”13 We did not extract recommendations for the conduct of traditional randomized … controlled trials, such as those that are conducted for regulatory marketing approval, as we expect … contemporaneous comparator groups, prospective cohort studies with contemporaneous comparison groups, self- controlled … implementing CED programs, such as when access is limited to centers with the resources to conduct randomized

1113. Research Protocol: Breast Reconstruction After Mastectomy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-reconstruction-mastectomy-protocol.pdf
      April 09, 2020 - chemotherapy Timing • Any Setting • Any, including single- and multicenter Design • Randomized … trial. … trial. … difference NRCS nonrandomized comparative study OR odds ratio PAP profundal artery perforator RCT randomized … controlled trial ROBINS-I Risk of Bias in Nonrandomized Studies of Interventions SIEA superficial

1114. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1412.pdf
      February 01, 2015 - The largest clinical trial to date is scheduled to conclude in 2015. … In 2013, the Alzheimer’s Disease Cooperative Study registered the largest randomized, controlled trial … and neuroanatomy, is scheduled to conclude in February 2015.12 A large German clinical trial (n=90 … The latter cooperative sponsors the largest ongoing trial, a phase II/III trial investigating intranasal … Available: https://www.clinicaltrialsregister.eu/ctr- search/trial/2008-008555-41/DE/. 22.

1115. Disposition of Comments Report for Treatment of Depression During Pregnancy and the Postpartum Period (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_disposition-comments.pdf
      July 08, 2014 - Randomized controlled trials of course would help to remove this bias. … Assessment First sentence of this section is awkward ; also, in the last sentence, add study to randomized … controlled trial’ TEP Member #11 Results I have some question about the strength of the rationale … Changed to: “While there is still hesitancy to conduct randomized controlled trials in pregnant women … report influences is the need for better research, registries, and how difficult it is to complete controlled

1116. Executive summary_Evaluation of Dietary Protein and Amino Acid Requirements: A Systematic Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-protein-intake-executive-summary.pdf
      November 01, 2024 - We included randomized and nonrandomized controlled trials, prospective cohort, and nested case-control

1117. Amended Protocol: Management of Infantile Epilepsy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-epilepsy-amended-protocol.pdf
      March 07, 2021 - We will not require that patients be randomized to groups, nor will we require that studies plan their … For Key Question 3 (harms), we will include single-arm studies as well as controlled studies. 6. … We will search the following databases using controlled vocabulary and text words: EMBASE, MEDLINE, … We will assess randomized trials for Key Question 1 and 2 using the Cochrane Risk of Bias 2 (ROB2) … A cohort study of summary reports of controlled trials. JAMA. 1990 Mar 9;263(10):1401-5.

1118. Community Forum Deliberative Methods Demonstration: Evaluating Effectiveness and Eliciting Public Views on Use of Evidence--Executive Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/deliberative-methods-demonstration-executive-131125.pdf
      November 01, 2013 - This report describes the results of the Deliberative Methods Demonstration, a randomized controlled … trial comparing deliberative methods with one another and with a control intervention. … controlled trial to examine the effectiveness of public deliberation and to compare alternative approaches … Effectiveness of Public Deliberation The randomized design of the Deliberative Methods Demonstration … (This result controlled for differences in other demographics, including income and education.)

1119. Amendment_HIE-Protocol_3-14-2015 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/health-information-exchange_research-protocol.pdf
      April 20, 2015 - Randomized controlled clinical trials (RCTs) and systematic reviews of such trials will be included … 2015 9 Literature Databases: Ovid MEDLINE, PsycINFO, CINHAL, EMBASE, Cochrane Central Register of Controlled … hereafter, Methods Guide).26 Included studies will be classified according to type of design (e.g., randomized … trial, nonrandomized trial, observational study, etc.)

1120. Microsoft Word - 3-DKE274__ACEI-ARB-DRI__Comments_Disposition_Table-21_Jan_2011 cyk _2_.docx (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_disposition-comments.pdf
      October 07, 2011 - The question is whether by excluding whatever trial had the original clue, we missed the clue; and … Source: www.effectivehealthcare.ahrq.gov Published Online: October 7, 2011 10 this trial may be … NEJM. 2008. 358;15:1547-1559. [2] The VALUE Trial Group. … and Mortality in the Losartan Intervention For Endpoint Reduction in Hypertension Study (LIFE): A Randomized … Trial Against Atenelol.