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Total Results: 1,523 records

Showing results for "randomized controlled trial".

1081. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
      September 01, 2014 - increased cIMT in the ezetimibe group, observed in a post-hoc analysis of a subset of the originally randomized … Fourth, the results of two large placebo-controlled outcomes trials belie any adverse effect on ischemic … In the types of randomized controlled trials identified in this analysis, adherence is optimized to … We added text to the methods to clarify how cross-over trials were considered: “We considered randomized … All studies that have looked at combo vs. mono therapy have been with a controlled LDL goal as the

1082. Disposition of Comments Report for Vitamin D and Calcium: A Systematic Review of Health Outcomes (Update) (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/vitamin-d-calcium_disposition-comments.pdf
      September 15, 2014 - clinical trial were combined. … There appears to be no effort to find those trials, for example, the Lappe trial in Nebraska did not … Both the update and older report cover studies with different designs (randomized clinical trials, prospective … Lynette, Vitamin D does not Increase Calcium Absorption in Young Women: A Randomized Clinical Trial … (Reference: Aloia, J.F., et al., A randomized controlled trial of vitamin D3 supplementation in African

1083. Obesity-Child Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/obesity-child_executive.pdf
      March 31, 2010 - We included only randomized controlled trials (RCTs), quasi-experimental studies, and natural experiments … characteristics of the enrolled subjects, described the intervention clearly, described the main findings, randomized … One quasi-experimental study included only female adolescents and the other study randomized adolescents

1084. Disposition of Comments CER 214 Stroke Prevention in Patients With Atrial Fibrillation (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-214-afib-disposition-comments.pdf
      October 30, 2019 - For example, the ratio between persistent/permanent and paroxysmal AF differed from trial to trial. … trial. … Newly identified events in the RE-LY trial. … An open- label, randomized, controlled, multicenter study exploring two treatment strategies of rivaroxaban … in Atrial Fibrillation Trial).

1085. PULMONARY with "Discussions" in Exec Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1506.pdf
      October 01, 2015 - Clinical trials: In the phase III, randomized, double-blind, placebo-controlled TRAFFIC trial, patients … , double-blind, placebo-controlled TRANSPORT trial, patients (n=559) homozygous for the F508del mutation … In the phase III, randomized, double-blind, controlled ASCEND trial, patients (n=555) with IPF were … In two replicate, phase III, randomized, double-blind, 52-week trials (INPULSIS-1 and INPULSIS-2), … In the phase III, randomized, controlled, INSPIRE trial, patients (n=264) who were registered primary

1086. Screening and Diagnosing Gestational Diabetes Mellitus Disposition of Comments Report (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/gestational-diabetes-screening-diagnosis_disposition-comments.pdf
      January 01, 2020 - The decision to limit the review to randomized controlled trials and cohort studies is stated but the … For key question 4 the RCTs used are not of equal quality and differ significantly in the population randomized … for GDM.2 We applaud the reviewers for considering the full body of available evidence—including randomized … controlled trials; nonrandomized controlled trials; and prospective and retrospective cohort studies—in … At least two high-quality randomized controlled trials of treatment of lesser degrees of glucose intolerance

1087. Layout 1 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypothyroidism-hyperthyroidism-screening-treatment_executive.pdf
      October 01, 2011 - Additional materials were sought by searching for regulatory information, clinical trial registries, … We identified no randomized controlled trials (RCTs) or observational studies comparing the outcomes … We identified no RCTs or controlled observational studies that evaluated harms associated with screening … The largest trial included 120 patients. … Two controlled trials assessed the efficacy of treatment of subclinical hyperthyroidism; both of these

1088. Making Healthcare Safer IV: Programs for Responding to Harms Experienced by Patients during Clinical Care (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/clinical-care-protocol.pdf
      January 01, 2024 - 7 Study Parameter Inclusion criteria Exclusion criteria Type of studies Systematic reviews, randomized … controlled trials, and observational studies with a comparison group, including pre- post studies … the primary reviewer will use the Cochrane Collaboration’s tool for assessing the risk of bias of randomized … controlled trials (RCTs) or the ROBINS-I tool for assessing the Risk Of Bias In Non-randomized Studies … performance bias, detection bias, attrition bias, reporting bias, and other bias.27 When assessing non-randomized

1089. Vitamin D and Calcium: A Systematic Review of Health Outcomes (Update) (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/vitamin-d-calcium_executive.pdf
      September 01, 2014 - primary studies using a three-grade system (A, B, or C), evaluating each type of study design (i.e., randomized … controlled trial or RCT, cohort, and nested case-control). … NICHD) and Thrasher Research Fund Vitamin D3 Supplementation studies—in which pregnant women were randomized … Colorectal Polyps The B-rated WHI trial identified for the original report was the only trial of combined … Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness

1090. EHC Research Protocol: Documentation Burden (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/documentation-burden-protocol.pdf
      July 26, 2023 - In-Process & Other Non-Indexed Citations, MEDLINE® Daily, MEDLINE®, Cochrane Central Registrar of Controlled … language studies • Conference abstracts Abbreviations: EHR = electronic health record; RCT = randomized … Language Processing PICOTS Populations, Interventions, Comparators, Outcomes, Timing, and Settings RCT Randomized … Clinical Trial SEADS Supplemental Evidence and Data for Systematic Reviews U.K.

1091. App-D-Surv-Report-1-Noninvasive-Nonpharma 0 (xls file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-surv-report-1-noninvasive-nonpharma_0.xlsx
      January 01, 2021 - Veteran Affairs Rehabilitation Research and Development (Grant #RX000474) Fair Groessl 2020 [same trial … participation in standard back school training and psychotherapy, 4) participation in another clinical trial … Spanish language; and (3) providing the exclusion criteria: (1)participation in a concurrent treatment trial … for Complementary and Integrative Health of the National Institutes of Health Fair Joyce 2021 [same trial … Roseen 2020 [same trial as Saper 2017; subsequent publication] See above. See above. See above.

1092. App-D-Surv-Report-2-Noninvasive-Nonpharma (xls file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-surv-report-2-noninvasive-nonpharma.xlsx
      January 01, 2021 - Veteran Affairs Rehabilitation Research and Development (Grant #RX000474) Fair Groessl 2020 [same trial … participation in standard back school training and psychotherapy, 4) participation in another clinical trial … Spanish language; and (3) providing the exclusion criteria: (1)participation in a concurrent treatment trial … for Complementary and Integrative Health of the National Institutes of Health Fair Joyce 2021 [same trial … Roseen 2020 [same trial as Saper 2017; subsequent publication] See above. See above. See above.

1093. Evidence Summary for CER 239: Acute Treatments for Episodic Migraine (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/cer-239-acute-migraine-evidence-summary.pdf
      December 01, 2020 - migraine-treatments/protocol 3 Key Question (KQ) 1: Opioid Therapy • Fifteen studies (13 randomized … controlled trials [RCTs] and 2 comparative observational studies) with 2,208 patients were included … Limitations For many interventions, very few or a single trial were available and most were small,

1094. Disposition of Comments for Comparative Effectiveness Review 133 Transitional Care Interventions To Prevent Readmissions for People With Heart Failure (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-transition-care_disposition-comments.pdf
      May 27, 2014 - Correct. 43 Peer Reviewer 14 General The authors identified 47 randomized controlled trials. … controlled trials are included. … Although the non- randomized comparative studies and observational studies were deemed eligible, none … Correct-no non-randomized or observational studies were eligible. 111 TEP Reviewer 4 Methods Comparators … The one trial assessing a higher intensity intervention showed efficacy1 while the one trial assessing

1095. Methods-Guide-Chapter-Prioritization-And-Selection-Of-Harms-For-Inclusion-In-Systematic-Reviews (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/prioritization-selection-of-harms.pdf
      February 01, 2018 - consider a broad range of data sources to evaluate harms, including observational studies as well as randomized … Suggested data sources included randomized controlled trials, observational studies (including pharmacoepidemiological … events (e.g., the FDA’s MedWatch program).15 The KIs noted that reviewers should not rely solely on randomized … External validity of randomised controlled trials: “to whom do the results of this trial apply?”. … In macroVascular Events): a randomised controlled trial.

1096. Appendix K Rapid Evidence Review Treatments for Clostridium difficile Colitis (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/clinical-pathway-methods-report-appendix-k.pdf
      February 01, 2018 - • One small randomized controlled trial for adjunct use of probiotics had some positive results. … The purpose of this rapid review is to identify recent guidelines, systematic reviews, randomized controlled … controlled trial'/de OR 'systematic review'/de) 273 10 7 AND (rct OR random* OR meta* OR systematic … Since this was a small trial (n=33), the authors concluded that probiotic therapy shows promise for … A randomized controlled trial of probiotics for Clostridium difficile infection in adults (PICO).

1097. advanced-care-decision-aids-protocol-131209 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/advanced-care-decision-aids_research-protocol.pdf
      December 09, 2013 - We will include studies published in English of any sample size and any design (randomized controlled … trial, controlled clinical trial, uncontrolled observational trial, and case reports and series).

1098. Disposition of Comments Report for Treatment for Hepatitis C Virus Infection in Adults (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_disposition-comments.pdf
      November 27, 2012 - As stated on Page 8, the CER included randomized trials for all key questions. … We did include the Marcellin trial in a sensitivity analysis. … an early virological response and were actually randomized to different treatments and analyzed. … Results (p.48) The sentence “A trial of extended early virologic responders…randomized to 4 compared … In the ILLUMINATE Trial patients with an early virological response were randomized at week 20 to either

1099. Understanding Health-Systems’ Use of and Need for Evidence To Inform Decisionmaking (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/health-systems-research.pdf
      October 01, 2017 - KIs felt that randomized controlled trials are specifically desired by clinical experts on health- system … However, KIs felt that for those who are not experts int the field, randomized controlled trials are … A whole lot of the trial evidence is not useful for the questions that I’m asking. … recommendations and systematic reviews that included recommendations for practice and not just clinical trial … Guidelines, systematic reviews, and randomized controlled trials were all highly sought after sources

1100. Ced-Topic-Refinement (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-topic-refinement.pdf
      November 01, 2022 - 9 This specific Decision Summary specifies that the product may be covered in a randomized controlled … analysis of real- world data.”13 We did not extract recommendations for the conduct of traditional randomized … controlled trials, such as those that are conducted for regulatory marketing approval, as we expect … contemporaneous comparator groups, prospective cohort studies with contemporaneous comparison groups, self- controlled … implementing CED programs, such as when access is limited to centers with the resources to conduct randomized