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Showing results for "randomized controlled trial".

1061. Disposition of Comments_Blood-Based Tests for Multiple Cancer Screening: A Systematic Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-disposition-comments.pdf
      May 14, 2025 - The fact that KQ4 required a randomized study (top of page 23) makes sense, but may need to be re-emphasized … We have revised the text to further emphasize that controlled studies were required for eligibility … It makes a great deal of sense to collect and monitor these data in randomized studies so that if … This would include controlled cohort studies. … The Consortium noted that “randomized controlled trials(RCTs) with mortality endpoints, which are the

1062. Disposition of Comments_Systematic Review: Implementing Recommended Mental Health and Substance Use Screening and Counseling Interventions in Primary Care Settings for in Children and Adolescents (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/behavioral-health-screening-disposition-comments.pdf
      April 09, 2025 - This statement refers to the use of the risk of bias assessment tool for randomized controlled trials … (2017) Cognitive-behavioral family treatment for suicide attempt prevention: a randomized controlled … trial. … Controlled Trial. … (2010) Attachment-based family therapy for adolescents with suicidal ideation: A randomized controlled

1063. Arthritis and Nontraumatic Joint Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1412.pdf
      December 01, 2014 - In the CLEAR1 trial, patients given lesinurad 200 mg or 400 mg, and 54% and 59%, respectively, achieved … 6, compared with 28% of patients treated with allopurinol and placebo (p<0.0001).5 In the CLEAR 2 trial … number of gout flares or number of patients with complete tophus resolution.8 In the phase III, randomized … , double-blind CRYSTAL trial (n=324), patients with gout, sUA levels of 6.0 mg/dL or more, and at least … and febuxostat did not achieve a statistical improvement at month 6 (p=0.13).6 In the phase III, randomized

1064. Postpartum Care for Women Up to One Year After Pregnancy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/postpartum-care-one-year-protocol-amendment.pdf
      April 25, 2022 - controlled trials (N ≥10 participants per group) ● Nonrandomized comparative studies, longitudinal … U.S. only ● Outpatient care ● Exclude: Institutionalized settings (e.g., prisons) Design ● Randomized … controlled trials (N ≥10 participants per group) ● Nonrandomized comparative studies, longitudinal … We will include specific controlled vocabulary terms (MeSH or Emtree), along with specific free-text … controlled trial ROBINS-I Risk of Bias in Nonrandomized Studies of Interventions SoE strength of evidence

1065. #05 DEPRESSION (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/05_depression_potential_high_impact_2012-12-10.pdf
      January 01, 2012 - trial design and outcomes thus far. … for an FDA IDE trial. 18-20 Investigators concluded from a 2010 Reclaim DBS Therapy trial of 10 … Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled … add-on trial. … Controlled substance schedules. [internet].

1066. Comments to Effective Heath Care Program Draft Documents (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/registries-guide-2nd-edition_disposition-comments.pdf
      March 03, 2010 - By definition, pregnant women would not be 'randomly' exposed postapproval except in a clinical trial … disease and a first product with proven efficacy, it would not be ethical to randomize patients in a trial … pregnant women, or in populations where it may be difficult to accrue sufficient numbers of clinical trial … Page 18: A number of questions around stents have been addressed by a number of meta‐analyses of randomized … product will depend upon the size, duration, representativeness, and thoroughness of the clinical trial

1067. Disposition of Comments for CER 171 Noninvasive Testing for Coronary Artery Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/coronary-artery-disease-testing_disposition-comments.pdf
      March 29, 2016 - Risk difference (RD) provides an absolute measure for randomized controlled trial data. … Trial. … Diagnostic performance and cost of CT angiography versus stress ECG--a randomized prospective study … Relations and Advocacy General Key References CCTA in the Symptomatic Stable Chest Pain – Large Randomized … A randomized, multicenter, multivendor study of myocardial perfusion imaging with regadenoson CT perfusion

1068. Pharma-Nonpharma-Ptsd-2022-Update-App-G1 (xls file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/pharma-nonpharma-ptsd-2022-update-app-g1.xlsx
      January 01, 2022 - RoB judgement 2.1) Were ppts aware of their assigned intervention during the trial? … carers and people delivering the interventions aware of participants' assigned intervention during the trial … masking carers or ppts) were there deviations from the intended intervention that arose because of the trial … substantial impact (on the result) of the failure to analyse participants in the group to which they were randomized … RoB judgement 3.1) Were data for this outcome available for all, or nearly all, participants randomized

1069. Stem-Cell-Children Surveillance (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_surveillance.pdf
      October 29, 2012 - Indexed Citations and Ovid MEDLINE(R) <1946 to September 25, 2012> and the Cochrane Central Register of Controlled … search strategies appearing in the CER’s Appendix A.1 The syntax and vocabulary, which include both controlled … one new trial), practice guideline (from major specialty organization or published in peer-reviewed … is defined as: 1) a trial published in top 5 general medical journals such as: Lancet, JAMA, Annals … No new evidence NA NA NA NA NA CER=comparative effectiveness review; RCT=randomized controlled trial

1070. Organisation (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-radiation_appendixes.pdf
      June 16, 2008 - Final report of a Northern California Oncology Group randomized prospective clinical trial. … A prospective, randomized, dynamically balanced trial. … A randomized controlled trial of varying radiation doses in the treatment of choroidal melanoma. … Advanced prostate cancer: the results of a randomized comparative trial of high dose irradiation boosting … controlled trial [see comment].

1071. Disposition of Comments Report for Strategies To Reduce Cesarean Birth in Low-Risk Women (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cesarean-birth-2010_disposition-comments.pdf
      January 01, 2010 - Team midwifery care in a tertiary level obstetric service: a randomized controlled trial. … trial of 1299 women. … To be a site in a randomized trial, at minimum, the leadership of units involved was invested in the … In the included randomized studies, trial assignment could not possibly be masked at all levels - sites … We agree that unlike in placebo controlled trials, the "comparator" is varied.

1072. Evidence Report on the (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/arthritis-psoriatric_research-protocol.pdf
      December 06, 2010 - biologic agents were introduced; management options tended to be adapted from rheumatoid arthritis (RA) trial … evidence (study design and other criteria) Original research; eligible study designs include: • Randomized … controlled trials (RCTs) with a sample size of equal to or greater than 100 • Nonrandomized controlled

1073. Appendicitis Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_executive.pdf
      December 01, 2015 - Searches were conducted in PubMed®, Embase®, the Cochrane Central Register of Controlled Trials, and … controlled trials (RCTs), one reviewer extracted and a second reviewer verified the data. … Flow chart of included studies CCRCT = Cochrane Central Register of Controlled Trials; KQ = Key Question … Flow chart of included studies CCRCT = Cochrane Central Register of Controlled Trials; KQ = Key Question … If randomized studies are deemed necessary, consideration should be given to paired randomized designs

1074. Obesity-Child Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/obesity-child_executive.pdf
      March 31, 2010 - We included only randomized controlled trials (RCTs), quasi-experimental studies, and natural experiments … characteristics of the enrolled subjects, described the intervention clearly, described the main findings, randomized … One quasi-experimental study included only female adolescents and the other study randomized adolescents

1075. autism-update-protocol-130920 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-update_research-protocol.pdf
      September 20, 2013 - method relies heavily on one-on-one therapy sessions during which a trained therapist uses discrete trial … And for randomized controlled trials, was there an intent-to-treat analysis? … controlled trial, prospective observational study, etc.). … we will present results by study design, with a focus on those designs less subject to bias (i.e., randomized … controlled trials, controlled trials) and those studies rated as of higher quality in our quality-assessment

1076. Disposition of Comments Report for Comparative Effectiveness of Bariatric Surgery and Nonsurgical Therapy in Adults With Metabolic Conditions and a Body Mass Index of 30.0 to 34.9 kg/m2 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_disposition-comments.pdf
      June 05, 2013 - When we examine the emerging scientific literature on the subject, there are a modest number of randomized … However, it is difficult to do randomized trials of surgery and the report concludes it would be nice … Therefore, in selected patients with inadequately controlled diabetes or other metabolic conditions … randomized trials) evaluating the effects of bariatric surgery in diabetic patients with BMI < 35. … None needed OAC General Therefore, in selected patients with inadequately controlled diabetes or

1077. Disposition of Comments Report for Vitamin D and Calcium: A Systematic Review of Health Outcomes (Update) (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/vitamin-d-calcium_disposition-comments.pdf
      September 15, 2014 - clinical trial were combined. … There appears to be no effort to find those trials, for example, the Lappe trial in Nebraska did not … Both the update and older report cover studies with different designs (randomized clinical trials, prospective … Lynette, Vitamin D does not Increase Calcium Absorption in Young Women: A Randomized Clinical Trial … (Reference: Aloia, J.F., et al., A randomized controlled trial of vitamin D3 supplementation in African

1078. #14 SUBSTANCE ABUSE (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/14_substanceabuse_potential_high_impact_june_2012.pdf
      January 01, 2012 - A larger trial is planned. … in the ClinicalTrials.gov database, the developers of the program state that they are conducting a randomized … , controlled trial that will investigate the Text2Quit program combined with the Smokefree.gov program … July 2011 press release, the manufacturer stated that data from a phase III placebo- and active-drug-controlled … Naltrexone (once-monthly controlled-release, Medisorb). [138 p].

1079. PEPTIC ULCER #11 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/11_pepticulcer_potential_high_impact_june_2012.pdf
      January 01, 2012 - In the absence of randomized or long-term trials for POEM, some experts are uncertain of POEM’s degree … In three patients, GERD symptoms were controlled with proton pump inhibitors. 24 In another case … In the absence of randomized or long-term trials for POEM, some experts remain unsure how impactful … controlled trials. … , double-blind, placebo-controlled, phase III trial, investigators reported that 63% of patients (n

1080. Screening and Diagnosing Gestational Diabetes Mellitus Disposition of Comments Report (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/gestational-diabetes-screening-diagnosis_disposition-comments.pdf
      January 01, 2020 - The decision to limit the review to randomized controlled trials and cohort studies is stated but the … For key question 4 the RCTs used are not of equal quality and differ significantly in the population randomized … for GDM.2 We applaud the reviewers for considering the full body of available evidence—including randomized … controlled trials; nonrandomized controlled trials; and prospective and retrospective cohort studies—in … At least two high-quality randomized controlled trials of treatment of lesser degrees of glucose intolerance