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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_surveillance.pdf
    October 29, 2012 - included 251 unique studies identified by using searches through August, 2011 and addressed six key questions … The key questions of the original CER were as follows: 1. … Qualitative signals See also Table 1 (Summary Table), Appendix B, and Evidence Table (Appendix C) Key questions … Quantitative signals See also Table 1 (Summary Table), Appendix B, and Evidence Table (Appendix C) Key questions … Safety surveillance alerts None of the received safety surveillance alerts was relevant to the key questions
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_surveillance.pdf
    August 01, 2012 - unique studies identified by using searches through the September 28, 2009 and addressed four key questions … The key questions of the original CER were as follows: 1. … Cycle 1 (November 2011) 17 as no comparative studies addressed these key questions 1 cohort … The strength of evidence is insufficient as no comparative studies addressed these key questions … The strength of evidence is insufficient as no comparative studies addressed these key questions
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/phenylketonuria_surveillance.pdf
    January 15, 2013 - Findings and Conclusions For this assessment we constructed a summary table that included the key questions … manufacturer.4 3.3 Identifying qualitative and quantitative signals Table 1 shows the original key questions … portion of the original report does not need updating Are there new data that could inform the key questions … BH4 sensitive patients did not increase their HRQoL (although responses to a set of supplementary questions … New Evidence: Are there new data that could inform the key questions that might not be addressed
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_executive.pdf
    February 01, 2013 - Methods Input From Stakeholders This project began with a topic refinement in which Key Questions … Key Questions Our review focused on five Key Questions: Key Question 1: In patients with CAD, what … Coronary angiography alone was the comparison of interest for Key Questions 1, 2, 3, and 5. … For Key Questions 4 and 5, head-to-head comparisons of two or more intravascular diagnostic techniques … There was insufficient evidence to answer two of the five review’s Key Questions.
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/deliberative-methods_presentation-2011.pdf
    January 01, 2011 - you should be able to: ─ Identify situations appropriate for deliberative methods ─ Develop the questions … Examples of deliberative questions Community Forum Community Forum Community Forum 25 When … Carman kcarman@air.org (202) 403-5090 Jessica Waddell jwaddell@air.org (202) 403-5947 Questions … criteria Coverage elements to consider in determining ‘essential benefits’ Examples of deliberative questions … IOM: using public deliberation to inform coverage decisions Questions, comments?
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/deliberative-methods-demonstration-executive-131125.pdf
    November 01, 2013 - , and asked questions of their own. … Following discussion, the groups had the opportunity to generate questions to be addressed offline by … The research questions for the thematic analysis focused on three main topics related to the overarching … Below, we summarize findings for five research questions addressing the effectiveness of deliberation … The unit of analysis for research questions 1–4 is the individual participant and for research question
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_disposition-comments.pdf
    September 01, 2011 - The key questions are appropriate and explicitly stated. Thank you. … Peer Reviewer #4 General Questions are clearly stated, and they seem (at least to me) the right questions … Peer Reviewer #7 General The key questions are appropriate and explicitly stated. Thank you. … Additional questions that might be included in the document include the following:  Given evidence … The questions are appropriate and well-defined.
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-future_research.pdf
    April 01, 2013 - Most of the research gaps did not suggest new research questions to be addressed; rather they primarily … Nonetheless, we suggested specific research questions that could address each of these needs. … The numbers in the figure refer to the numbers of the Key Questions. Figure 1. … , though the nature of the research needs could yield a number of research questions. … RCTs as well as cohort studies that address any of the Key Questions evaluated in the CER would help
  9. S29 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s29.pdf
    October 01, 2007 - Follow-up questions were asked as needed to clarify responses. … Some questions that were raised would not be answerable before instituting a study. … What questions would you have? What barriers would you foresee? … Subjects would have many questions about any pro- posed CRTs, ranging from general questions about the … need for the study to specific questions about implementation.
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-diff-infections_research-protocol.pdf
    May 24, 2010 - The Key Questions Question 1: How do different methods for detection of toxigenic C. difficile to … These will be organized according to key questions. D. … Review of Key Questions For Comparative Effectiveness reviews (CERs) the key questions were posted for … Therefore study questions, design and/or methodological approaches do not necessarily represent the … Review of Key Questions IX. Technical Expert Panel (TEP) X. Peer Review (Standard Language)
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mass-casualty-events-scarce-resources_executive.pdf
    June 01, 2012 - This report addresses the following Key Questions: Key Question 1. … Analytic Framework Given the heterogeneity in key aspects of study design across the four Key Questions … Investigators at the Southern California Evidence-based Practice Center then refined the questions … For all four Key Questions, we included articles found in the peer-reviewed literature and grey literature … Because of the volume of studies describing tested strategies that were relevant to Key Questions 1
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/labor-nitrous-oxide_disposition-comments.pdf
    August 23, 2012 - Reviewer #11 Introduction Key Questions, p. 24: Here there are 5 key questions. … These are good questions for future research, which is sorely needed. … Key questions are explicit and appropriate to the topic. … For specific questions and suggestions, please see attachment. Thank you. … There are 5 questions, but there was no literature to address Key Question 5.
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting-future_research.pdf
    January 01, 2014 - Evidence gaps affecting conclusions for the Key Questions ..................................... … Figure A depicts the analytic framework used to guide the Key Questions for the CER. … ES-5 Developing Research Questions We transformed the final list of FRN topics into research questions … Coronary angiography was the comparison of interest for Key Questions 1, 2, 3, and 5. … Angiography alone is the comparator for Key Questions 1–3.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-risk-bias.ppt
    June 01, 2012 - Two overarching questions for quality as “value for judgment making”: Are the results for the population … Background (2 of 3) In considering quality as “value for judgment making,” two overarching questions … It contains elements beyond those of systematic bias, such as questions related to reporting. … QUADAS-2 Questions for Assessing Risk of Bias in Diagnostic Accuracy Studies* * Questions related to … For each of the initial questions, the investigator would answer “yes,” “no,” or “unclear.”
  15. effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-risk-bias.ppt
    June 01, 2012 - Two overarching questions for quality as “value for judgment making”: Are the results for the population … Background (2 of 3) In considering quality as “value for judgment making,” two overarching questions … It contains elements beyond those of systematic bias, such as questions related to reporting. … QUADAS-2 Questions for Assessing Risk of Bias in Diagnostic Accuracy Studies* * Questions related to … For each of the initial questions, the investigator would answer “yes,” “no,” or “unclear.”
  16. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/improved-cancer-outcomes-protocol_0.pdf
    December 01, 2021 - Study inclusion criteria for key questions Category Criteria for Inclusion Study Enrollment KQ1 … Review of Key Questions The Agency for Healthcare Research and Quality (AHRQ) posted the Key Questions … This input is intended to ensure that the Key Questions are specific and relevant. VIII. … The EPC solicits input from Key Informants when developing questions for the systematic review or when … Therefore, study questions, design, and methodological approaches do not necessarily represent the views
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
    September 01, 2016 - Objectives Study Purpose: To address questions about how to access and integrate information fromClini … We will conduct a pilot study and prepare a report that addresses the following questions: 1. … The DPN review seeks to address two key questions with sub-questions.
  18. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_executive.pdf
    May 01, 2010 - Key Questions This Comparative Effectiveness Review addresses four key questions to compare alternative … the quality of evidence was moderate in a few instances and was insufficient for the majority of key questions … The strength of evidence is insufficient as no comparative studies addressed these key questions. … The strength of evidence is insufficient as no comparative studies addressed these key questions. … The strength of evidence is insufficient, as no comparative studies addressed these key questions.
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-194-disposition-comments-inhaled-corticosteroids.pdf
    March 19, 2018 - Peer reviewer #2 Clearly laid out with questions well identified. Thank you. … I felt that the questions asked throughout the review were clearly stated in the introduction. … Addressing these 2 questions would be very helpful. … I have a few specific questions and comments below but have one general procedural/methods questions … that covers all the Key Questions.
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-complaints-tests-children_disposition-comments.pdf
    March 07, 2012 - Peer Reviewer #1 General Comments The Key Questions appear to be appropriate. … The wording of the questions cannot be changed. … The Key questions are well thought out and clearly stated. Thank you. … seem appropriate, although there is considerable overlap in answering the questions (i.e. … The key questions are appropriate and explicitly stated.

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