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  1. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/multiple-sclerosis_research-protocol.pdf
    December 17, 2013 - Thus, major questions of interest are whether or not disease-modifying MS drugs alter the natural history … Therefore, questions related to switching between disease modifying treatments are outside the scope … The Key Questions The draft Key Questions developed during AHRQ’s topic Refinement process were posted … Review of Key Questions For all EPC reviews, key questions were reviewed and refined as needed by … Therefore study questions, design and/or methodological approaches do not necessarily represent the
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/rapid-reviews-end-user_white-paper.pdf
    April 01, 2016 - Guiding questions included: a. … KIs felt that the key questions were often the most important part of the review. … If the key questions do not address what the user needs, the review is not very useful. …  KIs stressed the relevance of the key questions, noting that if the questions did not directly … Under what circumstances, for what questions, would end-users trust a rapid review product?
  3. effectivehealthcare-admin.ahrq.gov/sites/default/files/product/pdf/ems-911-workforce-protocol.pdf
    January 01, 2015 - review, the technical brief should help to identify future research needs by identifying research questions … Guiding Questions 1. … The external experts will provide advice on how we answer each of our Guiding Questions. … Sample questions for the Key Informants include: 1) do they suggest any revision in our analytic framework … Studies will be included if they provide original data on the guiding questions. Table 1.
  4. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/pressure-ulcer-treatment_research-protocol.pdf
    November 08, 2011 - The Key Questions (KQs) were developed with input from Key Informants representing clinicians, wound … The Key Questions A preliminary set of KQs was posted on the Effective Health Care Program Web site … Review of Key Questions For all EPC reviews, key questions were reviewed and refined as needed by … In addition, for Comparative Effectiveness reviews, the key questions were posted for public comment … Therefore study questions, design, and/or methodological approaches do not necessarily represent the
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-197-fractional-exhaled-nitric-oxide-disposition-comments.pdf
    December 20, 2017 - The discussion follows the order of Key Questions. … We agree that the questions are important. … The Key Questions are also clearly defined, explicitly stated, and appropriate. … I think the authors can move KQ1e after KQ1a, then move the other questions down. … The key questions are stated explicitly and are appropriate.
  6. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/emt-naloxon_research-protocol.pdf
    November 29, 2016 - The Key Questions The scope and key questions for this topic were developed by AHRQ in conjunction … with naloxone to a healthcare facility vs. non-transport • Outcomes for each question: o All key questions … Due to the expected small numbers of randomized controlled trials to address the Key Questions, we also … Review of Key Questions Not applicable to this project. IX. … Therefore study questions, design, and methodological approaches do not necessarily represent the views
  7. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_disposition-comments.pdf
    November 24, 2014 - Peer Reviewer #1 Methods Some questions on the risk of bias methods used. … Answers for key questions were presented with adequate details and precision. … Also, Key Questions 1-3 were clearly delineated. … The research questions are explicitly stated and the work is definitely meaningful. … In that way, similar key questions might be better answered in the future.
  8. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
    September 01, 2016 - Objectives Study Purpose: To address questions about how to access and integrate information fromClini … We will conduct a pilot study and prepare a report that addresses the following questions: 1. … The DPN review seeks to address two key questions with sub-questions.
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/children-special-needs-transition_disposition-comments.pdf
    June 17, 2014 - Reviewer 5 (TEP) Background- Guiding Questions So I believe your questions were sufficient and … As mentioned the guiding questions take a mostly pediatric perspective. … Overall the guiding questions are appropriate for the topic. … Peer Reviewer 8 Background- Guiding Questions The questions posed by the authors are appropriate … Peer Reviewer 12 Background – Guiding Questions The guiding questions are appropriate to the
  10. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_executive.pdf
    February 01, 2013 - Methods Input From Stakeholders This project began with a topic refinement in which Key Questions … Key Questions Our review focused on five Key Questions: Key Question 1: In patients with CAD, what … Coronary angiography alone was the comparison of interest for Key Questions 1, 2, 3, and 5. … For Key Questions 4 and 5, head-to-head comparisons of two or more intravascular diagnostic techniques … There was insufficient evidence to answer two of the five review’s Key Questions.
  11. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/phenylketonuria_surveillance.pdf
    January 15, 2013 - Findings and Conclusions For this assessment we constructed a summary table that included the key questions … manufacturer.4 3.3 Identifying qualitative and quantitative signals Table 1 shows the original key questions … portion of the original report does not need updating Are there new data that could inform the key questions … BH4 sensitive patients did not increase their HRQoL (although responses to a set of supplementary questions … New Evidence: Are there new data that could inform the key questions that might not be addressed
  12. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/stem-cell-children_surveillance.pdf
    October 29, 2012 - included 251 unique studies identified by using searches through August, 2011 and addressed six key questions … The key questions of the original CER were as follows: 1. … Qualitative signals See also Table 1 (Summary Table), Appendix B, and Evidence Table (Appendix C) Key questions … Quantitative signals See also Table 1 (Summary Table), Appendix B, and Evidence Table (Appendix C) Key questions … Safety surveillance alerts None of the received safety surveillance alerts was relevant to the key questions
  13. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/head-neck-cancer_surveillance.pdf
    August 01, 2012 - unique studies identified by using searches through the September 28, 2009 and addressed four key questions … The key questions of the original CER were as follows: 1. … Cycle 1 (November 2011) 17 as no comparative studies addressed these key questions 1 cohort … The strength of evidence is insufficient as no comparative studies addressed these key questions … The strength of evidence is insufficient as no comparative studies addressed these key questions
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/blumenthal-presentation.pdf
    November 11, 2015 - We did   question   counting and  we saw that these women  had  more questions and  there … “I don't know if the reason  why I was so poorly informed  was because I didn’t ask enough   questions … And  after it’s all over I think to myself why didn’t I ask them more questions?” … somehow make it a social  norm that doctors ask patients about what’s important to them, or what questions … They can  go into these modalities and  ask questions that maybe they didn’t have time to have in
  15. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/deliberative-methods-demonstration-executive-131125.pdf
    November 01, 2013 - , and asked questions of their own. … Following discussion, the groups had the opportunity to generate questions to be addressed offline by … The research questions for the thematic analysis focused on three main topics related to the overarching … Below, we summarize findings for five research questions addressing the effectiveness of deliberation … The unit of analysis for research questions 1–4 is the individual participant and for research question
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_disposition-comments.pdf
    September 01, 2011 - The key questions are appropriate and explicitly stated. Thank you. … Peer Reviewer #4 General Questions are clearly stated, and they seem (at least to me) the right questions … Peer Reviewer #7 General The key questions are appropriate and explicitly stated. Thank you. … Additional questions that might be included in the document include the following:  Given evidence … The questions are appropriate and well-defined.
  17. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0272_03-06-2008.pdf
    January 01, 2008 -  When key questions have been drafted, they will be posted on the AHRQ Web site and open for … Key Questions from Nominators: Nominator 1 (public payer): For each of the treatment options for … obstructive sleep apnea (CPAP, oral appliances, UPPP, and RFA), we ask the following questions: 1
  18. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mass-casualty-events-scarce-resources_executive.pdf
    June 01, 2012 - This report addresses the following Key Questions: Key Question 1. … Analytic Framework Given the heterogeneity in key aspects of study design across the four Key Questions … Investigators at the Southern California Evidence-based Practice Center then refined the questions … For all four Key Questions, we included articles found in the peer-reviewed literature and grey literature … Because of the volume of studies describing tested strategies that were relevant to Key Questions 1
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/c-diff-infections_research-protocol.pdf
    May 24, 2010 - The Key Questions Question 1: How do different methods for detection of toxigenic C. difficile to … These will be organized according to key questions. D. … Review of Key Questions For Comparative Effectiveness reviews (CERs) the key questions were posted for … Therefore study questions, design and/or methodological approaches do not necessarily represent the … Review of Key Questions IX. Technical Expert Panel (TEP) X. Peer Review (Standard Language)
  20. S29 (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/s29.pdf
    October 01, 2007 - Follow-up questions were asked as needed to clarify responses. … Some questions that were raised would not be answerable before instituting a study. … What questions would you have? What barriers would you foresee? … Subjects would have many questions about any pro- posed CRTs, ranging from general questions about the … need for the study to specific questions about implementation.

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