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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer-update_executive.pdf
    December 01, 2014 - Key Question 2. … Key Question 3. … Key Question 4. … In this update, we did not identify any new evidence that specifically addressed Key Question 3. … In this update, we did not identify any new evidence that specifically addressed Key Question 4.
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/palliative-care-tools_research-protocol.pdf
    April 14, 2016 - We will catalog included tools and compile information on their characteristics (Guiding Question 1) … , catalog the context in which they are used (Guiding Question 2), and describe the current state of … research for tools in each area (Guiding Question 3). … We will provide a summation of relevant issues and gaps to answer Guiding Question 4. … evaluate a patient’s symptoms, such as pain; the quality of care, such as asking a patient a follow-up question
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy_surveillance.pdf
    July 01, 2012 - 2011 Surveillance Report 2nd Assessment: July, 2012 Key Findings, 1st Assessment: • For Key Question … • For Key Question 2, there may now be enough studies to conduct a meta-regression on the effect … • For Key Question 3, experts felt the conclusion on number of surgical procedures required after … SCEPC Conclusions of validity of CER conclusion(s) Prior Assessment Cumulative Assessment Key Question … Do Not Know Key Question 1: In women with a palpable or nonpalpable breast abnormality, what is the
  4. effectivehealthcare.ahrq.gov/sites/default/files/ch_4-user-guide-to-ocer_130129.pdf
    January 01, 2010 - These examples show that methods for measuring exposure, even for addressing the same clinical question … strengths and limitations of different options that are available given the nature of the research question … Conceptual Considerations for Exposure Measurement Linking Exposure Measurement to Study Question … investigators have selected different exposure time windows even when examining the same clinical question … this choice should be related back to the conceptual framework and biological plausibility of the question
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0583-131115.pdf
    March 13, 2013 - Sensitivity of monitoring for low dose tacrolimus [not a comparative effectiveness question; should … monitoring time points. § In addition, tacrolimus dose minimization strategies have raised the question
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_disposition-comments.pdf
    March 10, 2010 - Unclear question, which “case” is the reviewer asking about? … It is too simplistic and not considering the research question, clinical and methodological diversity … As stated above, synthesis of evidence is a dictate of the question posed for a systematic review. … -- therefore this is a very broad question with much explected heterogeneity and it is reasonable to … assume the effect measure to have a distribution, if the research question itself is meaningful.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/presentations-future_research.pdf
    April 01, 2012 - However, many reviews find only low or moderate strength of evidence to address a given Key Question … The question of the ―desirable‖ level of detail in laying out future research needs is related to larger … The advantages and disadvantages of a study design might change depending on the study question or … The final key question of each NIH Consensus Development Conference relates to research needs, based … in a separate table for each question.
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-postpartum-screening_research-protocol.pdf
    May 01, 2013 - A third question should be considered if the woman answers “yes” to either of the initial questions: … Addressing the question of which treatments are most effective would require a different design. … The revised KQs are as follows: Question 1 This question has two parts: a. … Question 2 This question has two parts: a. … Question 4 What are the comparative benefits of screening for postpartum depression when compared
  9. effectivehealthcare.ahrq.gov/sites/default/files/calcineurin-inhibitor_disposition-comments.pdf
    March 15, 2016 - C0 vs C2 for Key Question 2). … The key outcomes to each question are well developed, clear and concise. … 2", they instead found an abbreviation for the question and put that in the title. … C2, Key Question 2) was limited in both quantity and quality. … The focus of our analysis for Key Question 3 was on the use of CNIs.
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening-2010_research-protocol.pdf
    January 01, 2010 - Question 1 Among ambulatory or hospitalized patients, what is the comparative effectiveness of … Question 2 Among ambulatory or hospitalized patients, what is the comparative effectiveness of … Question 3 Among ambulatory or hospitalized patients, what is the comparative effectiveness of … Question 4 Among ambulatory or hospitalized patients, what is the comparative effectiveness of … Question 6 Source: www.effectivehealthcare.ahrq.gov Published Online: October 24, 2011
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharm-treatment-chronic-pain-protocol.pdf
    December 11, 2018 - 1: Nonradicular chronic low back pain o Key Question 2: Chronic neck pain without radiculopathy or … myelopathy o Key Question 3: Pain related to primary or secondary osteoarthritis o Key Question 4 … : Fibromyalgia o Key Question 5: Primary chronic tension headache (defined as 15 or more headache … days per month for at least 3 months) o Key Question 6: Patients with any of the five chronic pain … Analytic framework for noninvasive nonpharmacologic treatment for chronic pain KQ=Key Question
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_disposition-comments.pdf
    March 01, 2012 - utilization, which is a part of Key Question 1. … This is a rhetorical question. … Peer Reviewer #4 Results Therefore, Question 1 is unanswerable. … See response to Question 3. … Key Question #3 is answered in the abstract.
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ankyloglossia_research-protocol.pdf
    June 30, 2014 - Key Question 1 is focused on breastfeeding outcomes in infants treated for ankyloglossia. … Key Question 3 addresses social concerns, and Key Question 4 addresses ankyloglossia with concomitant … Key Question 1 (KQ1) What are the benefits and harms of various treatments in breastfeeding newborns … Key Question 2a + b (KQ2) KQ 2a What are the benefits and harms of various treatments* in newborns, … We will prepare summary tables to address each Key Question.
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia-2011_research-protocol.pdf
    January 01, 2011 - Four KQs will be addressed in our systematic review: Question 1 (Overarching Question) What … If direct evidence is not sufficient to address this question, the overarching question can be indirectly … Question 3 In stages 3–5 nondialysis and dialysis CKD patients with iron-deficiency anemia, what … Question 4 What factors affect the test performance and clinical utility of newer markers of iron … Grading the Evidence for Each Key Question We will follow the AHRQ Methods Guide 32 to evaluate
  15. Title (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-illness-adults-prisons_research-protocol.pdf
    September 13, 2012 - Question 2 was further modified to more clearly indicate the types of community-oriented interventions … Key Question 1 What is the comparative effectiveness of interventions applied within a jail, prison, … Any articles possibly meeting the inclusion criteria for at least one key question will be obtained … 1 and a “yes” on question 2 below and have at least 50 percent of the other items on the checklist … Assessing the Applicability of the Evidence for Each Key Question Applicability will be assessed by
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/public-reporting-quality-improvement_research-protocol.pdf
    August 17, 2011 - Key Questions for Objective 1 Question 1 Does public reporting result in improvements in the … Question 2 What harms result from public reporting? B. … Key Questions for Objective 2 Question 3 Does public reporting lead to change in health care … Question 4 Does public reporting lead to change in the behavior of patients, their representatives … Question 6 What contextual factors (population characteristics, decision type, and environmental)
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_disposition-comments.pdf
    September 29, 2014 - criteria, we broadened criteria to discuss evidence on uncontrolled studies for this Key Question … At best the results demonstrate the inadequacy of the evidence to answer the key question. … Suggest dividing into one table for each key question. … Same question for opioids and fractures (I assume mediated through falls)? … Suggestion question B is addressed by the Key Questions in the report.
  18. Tinnitus Executive (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/tinnitus_executive.pdf
    August 01, 2013 - Summary of findings for Key Question 2: Pharmacological or food supplement interventions Outcome # … Summary of findings for Key Question 2: Pharmacological or food supplement interventions (continued … Summary of findings for Key Question 2: Medical interventions Outcome # of Articles Overall Strength … Key Question 2 Population • Include a broader spectrum of adult patients with respect to age, sex … Key Question 3 • Develop studies to evaluate the natural history and prognostic factors in persons
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay-future_research.pdf
    September 01, 2012 - ES-2 • Key Question 1: Does adding the SFLC assay and the kappa/lambda ratio to traditional testing … • Key Question 3: In patients with an existing diagnosis of PCD (MM, nonsecretory MM, or AL amyloidosis … • Key Question 5: In patients with an existing diagnosis of PCD (MM, nonsecretory MM, or AL amyloidosis … Key Question 4 of the CER was, “In patients with an existing diagnosis of PCD (MM, nonsecretory MM, … We therefore rated the strength of evidence as insufficient for this question.
  20. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/ems-911-workforce-protocol.pdf
    January 01, 2015 - For Guiding Question 1, we will define occupationally-acquired exposures to infectious diseases as contact … prevention and control in EMS/911 workforce (IPC = infection prevention and control; KQ = key question … information about the epidemiologic characteristics of the infectious disease exposures (Guiding Question … manufacturers, researchers, payers, or other perspectives, depending on the technology/intervention in question

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