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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy-disposition-170415.pdf
    January 17, 2017 - The report addresses each Key Question. … We note that each Key Question section in the main report includes a section of Key Points. … all the studies addressing a given question. … The are set out well so that each key question is discussed in turn. … KQ=Key Question Structure Bookmarks
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin_research-protocol.pdf
    September 08, 2011 - Key Question 1: In selected populations of patients with suspected local or systemic infection, what … Grading the Evidence for Each Key Question-Applicability of findings in this review will be assessed … Key Questions, Question 1 Intermediate outcomes, such as diagnostic accuracy for occurrence of … Key Questions, Question 1 Adverse events of testing, such as pain, local bleeding, or infection … Key Questions, Question 2 Adverse events of testing, such as persistent or recurrent infection
  3. M (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-de-novo-processes_methods.pdf
    September 01, 2009 - • EPCs can choose to replace a de novo process to answer a key question by selecting the best review … no time savings associated with using the existing SR vs. using de novo methods to answer the key question … In essence, use an existing SR to answer a key question but then conduct additional analyses using data … For example, use an SR to answer a key question in a CER about whether or not to use coenzyme Q10 in … 3 • Used search and synthesis instead of de novo processes (n=3) o Key Question 4 (meta-review)
  4. M (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/systematicreviewsreplacedenovo.pdf
    September 01, 2009 - • EPCs can choose to replace a de novo process to answer a key question by selecting the best review … no time savings associated with using the existing SR vs. using de novo methods to answer the key question … In essence, use an existing SR to answer a key question but then conduct additional analyses using data … For example, use an SR to answer a key question in a CER about whether or not to use coenzyme Q10 in … 3 • Used search and synthesis instead of de novo processes (n=3) o Key Question 4 (meta-review)
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/meditation_research-protocol.pdf
    October 17, 2012 - On TEP input we have removed the question on surrogate outcomes and focused on clinical outcomes of … Based on TEP input we have removed the question about the time-course and pattern of changes because … Data Synthesis For each Key Question, we will create a set of detailed evidence tables containing … Grading the Evidence for Each Key Question F. … Data Synthesis For each Key Question, we will create a set of detailed evidence tables containing
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
    November 01, 2012 - The Key Questionsa addressed in this review include: Key Question 1. … Key Question 2. … Key Question 3. … Specifically for Key Question 3, data that described the association between the prespecified subgroups … Key Question 2 The literature base for the comparative safety of systemic biologic agents and systemic
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_disposition-comments.pdf
    November 27, 2012 - Key question 2a - see references in comment above. Key question 3 - the reference Stewart, et al. … This concern also relates to key question 6C. … Public Reviewer #1 Results Question 4a: This question is based on previous recommendations from … This should also be factored into this question. … Key Question 6b.
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/smoking-pregnancy-infants_disposition-comments.pdf
    February 25, 2014 - The categories used to classify interventions for Key Question 1 and Key Question 4 are the same; however … , Key Question 1 is organized by primary intervention while Key Question 4 examines the primary and … 1 and contribute to the meta- analysis, with results reported in Key Question 4. … The data from the 2000 publication contributes to Key Question 5. … The study data did contribute to Key Question 5.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-meta-analysis.ppt
    June 01, 2012 - True False Practice Question 1 (1 of 2) Practice Question 1 (1 of 2) Explanation for Question 1 … Practice Question 1 (2 of 2) Practice Question 1 (2 of 2) Why does this module recommend directly … Practice Question 2 (1 of 2) Practice Question 2 (1 of 2) Explanation for Question 2: The correct … 3 (1 of 2) Practice Question 3 (1 of 2) Explanation for Question 3: The correct answer is a. … Practice Question 4 (1 of 2) Practice Question 4 (1 of 2) Explanation for Question 4: The correct
  10. effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-meta-analysis.ppt
    June 01, 2012 - True False Practice Question 1 (1 of 2) Practice Question 1 (1 of 2) Explanation for Question 1 … Practice Question 1 (2 of 2) Practice Question 1 (2 of 2) Why does this module recommend directly … Practice Question 2 (1 of 2) Practice Question 2 (1 of 2) Explanation for Question 2: The correct … 3 (1 of 2) Practice Question 3 (1 of 2) Explanation for Question 3: The correct answer is a. … Practice Question 4 (1 of 2) Practice Question 4 (1 of 2) Explanation for Question 4: The correct
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/bundled-payments-quality-effects_executive.pdf
    August 01, 2012 - The impact of these design features is addressed by Key Question 2. … The impact of these contextual factors is addressed by Key Question 3. … Key Question 1 addresses how different potential responses affect study outcomes, including health … 3), and none included analyses of differential effects by key design features (Key Question 2). … Key Question 3: Differential Effects by Key Contextual Factors The effects of most key contextual
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research.pdf
    June 01, 2017 - Both studies address Key Question 5: Treatments for in-tube otorrhea. … Thus, we were unable to compare these results with the analysis for this key question in the original … Question 3: What adverse events, surgical complications, and sequelae are associated with inserting … Six of 54 RCTs in the report were found in the registries: four for key question 1, one RCT for key … question 2, and one for Key Question 5.
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-staging_research-protocol.pdf
    May 20, 2013 - 6 (blinding of readers), and question 10 (avoided verification bias), and at least six of the other … Each question can be answered “Yes,” “No,” or “Not Reported,” and each question is phrased such that … 8 (methods of analysis); and question 10 (conflicts of interest). … Was this strategy appropriate to address the relevant Key Question of the CER? 3. … Are the inclusion/exclusion criteria appropriate to address the relevant Key Question of the CER?
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/allergy-seasonal_executive.pdf
    July 01, 2013 - Key Question 2. … Key Question 3. … Key Question 4. … Key Question 3. … Key Question 4.
  15. CERs Report cover (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-feature-treatment-future_research.pdf
    September 23, 2010 - Stakeholders then ranked hip fracture research question and theme area priorities. … Following refinement, the key questions addressed were: Key Question 1. … Key Question 2. … Key Question 3. … Key Question 4.
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/sodium-potassium_research-protocol.pdf
    April 18, 2017 - to question. … Key Question 1. … Key Question 2. … Key Question 3. … Key Question 4.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-brain-injury_research-protocol.pdf
    December 09, 2009 - for a subsequent CER During interactions with content experts and the AHRQ Task Order Officer, one question … Methods We will systematically search, review, and analyze the scientific evidence for each key question … dimensions (i.e., areas of special focus, or the columns) of each evidence table will vary by key question … Grading the Evidence for Each Key Question We will develop explicit criteria for rating the overall … strength of the collective evidence on each key question into qualitative categories (e.g., good,
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_disposition-comments.pdf
    August 23, 2012 - It is likely that studies using diagnostic samples will yield inflated estimates and Key Question 1 … Undiagnosed patients were selected as the relevant population for Key Question 1 by the Technical Expert … Hence these papers were reviewed under the framework of Key Question but were ultimately not eligible … We agree that with regard to Key Question 5, "other interventions" could include the need for 24-hour … However, as we explain in the review, we found that the papers that addressed this question did so in
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-pharmacologic-treatment_research-protocol.pdf
    December 27, 2016 - The Key Questions Key Question 1a: What is the comparative effectiveness of intermittent ICS compared … Key Question 1b: What is the comparative effectiveness of intermittent ICS compared to ICS controller … Key Question 1c: What is the comparative effectiveness of ICS with LABA used as both controller and … Key Question 2c: What is the comparative effectiveness of LAMA as add on to ICS plus LABA compared to … Intervention and Comparator per Key Question Interventions Comparator(s) No treatment, pharmacologic
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/disparities-quality-improvement_research-protocol.pdf
    February 23, 2012 - Key Question 1: What evidence is available about the effectiveness of quality improvement strategies … Key Question 2: What evidence is available about the harms related to quality improvement strategies … The following PICOTS framework elements apply to both Key Question 1 and Key Question 2:  Population …  Outcomes measures for each question: The outcome measures of interest include: health outcome … Harms of the intervention are represented within an oval with an attached box for key question 2: “

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