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  1. Gout Executive (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout_executive.pdf
    March 01, 2016 - Key Question 1: Acute Gout Treatment a. … Key Question 2: Dietary and Lifestyle Management of Gout a. … Key Question 3: Pharmacologic Management of Hyperuricemia in Gout Patients a. … Key Question 4: Treatment Monitoring of Patients with Gout a. … Key Question 5.
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_surveillance.pdf
    May 16, 2013 - Key question #3 Reduction in recurrence rates of AF (PVI vs. C-PVI) No new evidence. … Experts (Cycle 2): One expert stated that conclusions in the key question # 1 are still valid. … Experts (Cycle 2): One expert stated that conclusions in the key question # 2 are still valid. … Experts (Cycle 2): One expert stated that conclusions in the key question # 3 are still valid. … Experts (Cycle 2): One expert stated that conclusions in the key question # 4 are still valid.
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
    November 20, 2013 - Rev 7 Intro In question #6, this question could have been further divided whether BNP/NT-proBNP guided … OR is this more a monitoring question? … We have included the QUADAS question on threshold in the assessment of Risk of Bias. … The signaling question asks about “inappropriate” exclusions. … The target population and key elements of each question are explicitly defined.
  4. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd-2005_executive.pdf
    January 01, 2005 - Summary of Comparative Data on Treatments of GERD Key Question 1: Quality of comparisons evidence Summary … Summary of Comparative Data on Treatments of GERD (continued) Key Question 1: Quality of comparisons … Key Question 2: Quality of modifying factors evidence Summary/conclusion/comments Weak Data largely … Summary of Comparative Data on Treatments of GERD (continued) Key Question 3: Quality of adverse events
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/preterm-birth-terbutaline-pump_research-protocol.pdf
    October 18, 2010 - A question raised by an individual concerned whether the review will examine outcomes specific to women … with decreased cervical length and/or women with a positive fetal fibronectin test for Key Question … Key question 5 This question aims to further explore reasons for heterogeneity in outcomes by examining … This, we think, is a question that is unnecessary and not applicable for our primary studies. … Justification: This is essentially the same question as another one we ask while assessing risk of
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-213-lower-limb-protheses-evidence-summary.pdf
    September 01, 2018 - Key Question 2. … Key Question 3. … Key Question 5. Expectations of Ambulation We found no study that addressed this key question. … Key Question 6. Patient Satisfaction With Process Two studies addressed this Key Question. … Note that this Key Question did not address satisfaction with the LLP itself.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-surveillance_research-protocol.pdf
    May 19, 2011 - —EDITOR] Question 1 How have the patient population and the natural history of prostate cancer … Differences in geographical access Question 2 How are active surveillance and other observational … Behavioral indicators Question 3 What factors affect the offer of, acceptance, and adherence … Decisionmaking tools and aids Question 4 What are the comparative short- and long-term outcomes … Costs Question 5 What are the research needs regarding active surveillance (or watchful waiting
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-knee-future_research.pdf
    February 01, 2013 - Analytic framework KQ = Key Question; OA = osteoarthritis; PT = physical therapy … Stakeholders brought up this question as a research gap. … If a stakeholder assigned a question the number one priority, that question received four points; … First topical research need: research design considerations Research Question: Which PT treatments … Stakeholders brought up this question as a research gap.
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/pelvic-pain-therapies-future_research.pdf
    January 01, 2015 - Key Question 2. … Key Question 3. … Key Question 4. … Key Question 5. … interventions (Key Question 5).
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-pci-adjunctive-devices_research-protocol.pdf
    July 01, 2010 - The Key Questions Question 1 In patients with ACS who are undergoing PCI of native vessels, what … Question 2 In patients with ACS who are undergoing PCI of native vessels, how does the rate and type … Question 3 In patients with ACS who are undergoing PCI of native vessels, which patient characteristics … Grading the Evidence for Each Key Question We will use the Grading of Recommendations Assessment, … The evidence pertaining to each key question will be classified into three broad categories: high, moderate
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-framework_research.pdf
    March 01, 2012 - However, many reviews find only low or insufficient SOE to address a given key question. … the problem, studies that replicate the same methodological problems are unlikely to resolve the question … If a question cannot be answered because all existing studies only measured surrogate markers, additional … The advantages and disadvantages of a study design may change depending on the study question or the … The urgency with which an answer to the research question is needed may be an additional ethical
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism_research-protocol.pdf
    December 09, 2009 - In addition, Key Question 5 specifically addresses the question of effectiveness of individual components … abstracted from data presented in the papers • Sample sizes must be appropriate for the study question … dimensions (i.e., areas of special focus, or the columns) of each evidence table will vary by key question … Grading the Evidence for Each Key Question Quality grading. … develop explicit criteria for rating the overall strength of the collective evidence on each key question
  13. effectivehealthcare.ahrq.gov/sites/default/files/therapies-for-autism-spectrum-disorder-2-9-2010.pdf
    January 01, 2010 - In addition, Key Question 5 specifically addresses the question of effectiveness of individual components … abstracted from data presented in the papers • Sample sizes must be appropriate for the study question … dimensions (i.e., areas of special focus, or the columns) of each evidence table will vary by key question … Grading the Evidence for Each Key Question Quality grading. … develop explicit criteria for rating the overall strength of the collective evidence on each key question
  14. effectivehealthcare.ahrq.gov/sites/default/files/palliative-care-tools-disposition.pdf
    May 04, 2017 - When data do not exist specific to a question, it would have helped a comprehensive response to the … and compiled tool characteristics by domain • Guiding Question 2: we described the current state … Question 3 on the questionnaire for this group delineates on line 20, page C-1 ". . .what do doctors … They did not have much feedback regarding this question. … . 28 Peer Reviewer #3 Methods Page C-2 Questions for the Providers--asks in Question 7, line 57,
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/palliative-care-tools-disposition.pdf
    May 04, 2017 - When data do not exist specific to a question, it would have helped a comprehensive response to the … and compiled tool characteristics by domain • Guiding Question 2: we described the current state … Question 3 on the questionnaire for this group delineates on line 20, page C-1 ". . .what do doctors … They did not have much feedback regarding this question. … . 28 Peer Reviewer #3 Methods Page C-2 Questions for the Providers--asks in Question 7, line 57,
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
    January 01, 2015 - exclusion of lipid concentrations as an intermediate outcome.4 The proposed key questions are: Key Question … Key Question 3a: In adults age 18 or older with type 2 diabetes mellitus, what is the comparative safety … Key Question 3b: In adults age 18 or older with type 2 diabetes mellitus, what is the comparative safety … Key Question … Priority Medication Comparisons Included for Each Key Question Main Intervention Comparisons Source
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_research-protocol.pdf
    November 30, 2011 - Question 2 What is the comparative effectiveness of antiviral treatments on intermediate outcomes … Source: www.effectivehealthcare.ahrq.gov Published Online: November 30, 2011 4 Question 3 … Question 4 Have improvements in intermediate outcomes (SVR, histologic changes) been shown to reduce … To identify articles relevant to each Key Question (KQ), the librarian will search the Cochrane Database … Grading the Evidence for Each Key Question We will use the methods outlined in Chapter 10 of the
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/undescended-testicle_research-protocol.pdf
    September 02, 2011 - 3 Source: www.effectivehealthcare.ahrq.gov Published Online: September 2, 2011 Key Question … 4 Source: www.effectivehealthcare.ahrq.gov Published Online: September 2, 2011 Key Question … The development of testicular malignancy The size, location, and function of the testes Key Question … Key Question 5 What is the nature and frequency of harms associated with workup or treatment for … Grading the Evidence for Each Key Question Assess the Strength of Evidence We will also use
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_disposition-comments.pdf
    November 24, 2014 - The question arises how good and reproducible is bias scale? … Peer Reviewer #2 Results The results for key question 3 are unclear. Would Dr. … We agree that the reviewer’s question about how accurate and reproducible these measures are, which … There is no direct mention of PK/PD in the question at all (at least on page 7, lines 24-28). … It is disappointing that there is not more evidence pertaining directly to the PK/PD question.
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-disseminating-findings_0.pdf
    October 01, 2018 - in systematic review methods, experience in drafting key messages and general understanding of the question … In these cases we inserted the question used to assess the item, with the thought that the questions … Other sections of the EtD were not applicable due to the nature of the question addressed in the selected … Thus, for the criterion of “Benefits and harms” we inserted the relevant question (“how substantial … Section Question: Does different contrast media, within and between osmality classes, affect the

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