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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/patient-navigation-model-lung-cancer-rapid.pdf
    December 01, 2018 - Systematic reviews relevant to Question 1 ........................................................... … Completed primary studies relevant to Question 2 .................................................... … For diagnosis, patients were referred to navigators after an abnormal screening test.14-16 Question … Completed primary studies relevant to Question 2 Study Information Author, year • Study Type • … Systematic Reviews Primary Studies Completed Studies Protocols and Clinical Trials Question 3.
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation_executive.pdf
    June 01, 2012 - Key Question 3 What evidence exists to establish a minimum clinically important difference (MCID) … Key Question 2. … Key Question 3. … Key Question 5. … One question involves timing to treatment effect.
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout-management-disposition-160721.pdf
    March 15, 2016 - Additional detail regarding PICOT question development would be helpful. … context referent to question development would be highly informative. … acute gout, so we do not understand the question and cannot respond to it. … We excluded this study for not addressing the Key Question. … We excluded this study for not addressing the Key Question.
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mrsa-screening-2010_executive.pdf
    January 01, 2010 - Key Questions Key Question 1 Among ambulatory or hospitalized patients, what are the effects of a … Key Question 3B Among ambulatory or hospitalized patients, what are the effects of screening surgical … Key Question 2, 14 studies reported outcomes that addressed Key Question 3A, 18 studies reported outcomes … that addressed Key Question 3B, 8 studies reported outcomes that addressed Key Question 3C, and 10 … studies reported outcomes that addressed Key Question 4.
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs-future_research.pdf
    February 01, 2013 - Analytic framework 1 Abbreviations: KQ = Key Question; RLS = restless legs syndrome. … Analytic framework Abbreviations: KQ = Key Question; RLS = restless legs syndrome. … question received three points; number two ranking—two points; number three ranking—one point. … For the topical questions, if a stakeholder assigned a question the number one ranking, that question … For the topical questions, if a stakeholder assigned a question the number one ranking, that question
  6. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_executive.pdf
    October 01, 2006 - Conclusions Key Question 1: Clinical outcomes–Angioplasty with stent vs. aggressive medical therapy … Key Question 2: Baseline predictors of outcomes (Table B) Among the studies reviewed, the value of diagnostic … Key Question 3: Treatment variables as predictors of outcomes after angioplasty (Table B) Two prospective … Key Question 2: Baseline predictors of outcomes Angioplasty with or Weak • In one RCT, patients with … Key Question 3: Effect of periprocedural interventions on outcomes Angioplasty with or Weak • 2 studies
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-disorders-imaging_research-protocol.pdf
    August 05, 2010 - Guiding question 2: What is the current availability and cost of positional MRI testing and what are … Guiding question 3: What published studies have reported on the diagnostic performance, efficacy/ … Guiding question 4: What is the projected uptake of the positional MRI technology in the near future … Data to be abstracted for answering Key Question 3 are described in section III.2.A. … Data Presentation We will generate tables summarizing items relevant to Key Question 3.
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/labor-nitrous-oxide_research-protocol.pdf
    August 24, 2011 - This question was deemed superfluous and subsequently removed after conferring with the internal team … section of the review will note that head-to-head comparisons will be incorporated into each key question … These issues are not specifically addressed in any key question but fall under KQ1, and reviewers will … dimensions (i.e., areas of special focus, or the columns) of each evidence table may vary by key question … Grading the Evidence for Each Key Question Assess the Strength of Evidence.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
    January 01, 2014 - We further request that the EPC add GPIs to the options they consider for Key Question 2. … The comparison of GPI with UFH versus UFH alone was included in the Key Question 2 section. … This question is being addressed by another EPC group (Tufts). … /sub-question. … Peer Reviewer 6 General Related to this, is a question on the treatment algorithm diagram (p.5).
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-bone-fracture_research-protocol.pdf
    May 14, 2010 - A question of considerable interest is whether response to treatment is affected by or predicted by … This question has become a topic of considerable controversy and may influence the prescription and … • Interventions: - The interventions are listed above as part of the question - The trade names … Inclusion criteria for adherence question: for the titles identified from the search for adherence and … In addition, for each question, we will apply the criteria of the GRADE Working Group to assess the
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_disposition-comments.pdf
    March 01, 2012 - The risk factor question was a second order question, not directly answering the key question but providing … Since risk factors were being treated as a second order question for Key Question 2, we felt a brief … It was a second order question. … Key question are appropriate and explicit. … I don’t believe you have asked a key question about diagnosis.
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-adolescents_executive.pdf
    August 01, 2012 - Key Question 5: Among adolescents and young adults with ASD, what harms are associated with available … Key Question 6: What are the effects of interventions on family outcomes? … living skills (n=10) (Key Question 3). … Only studies of medical interventions addressed harms (Key Question 5). … assessed effects of an intervention on family outcomes (Key Question 6).
  13. effectivehealthcare.ahrq.gov/sites/default/files/celiac-disease_disposition-comments.pdf
    January 28, 2016 - Unfortunately, the question of how to best find celiac disease in the general population was beyond … One particular question that perhaps is not answered directly is Key Question #3: Symptomatic Patients … This review includes a section on diagnosis in IgA deficient individuals under Key Question 3. … We have added results on accuracy of IgG DGP tests in IgA sufficient patients to Key Question 1. … The question of challenge and the duration of challenge.
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-grading_methods.pdf
    July 01, 2012 - test literature focuses on test performance (e.g., sensitivity and specificity), at least one key question … The strength of the body of evidence regarding the overarching question of whether a test will improve … directly correlate to effective management and treatment of disease, especially when the test under question … important test characteristics and their precision in the clinical context represented by the key question … The focus should be on providing an overall grade for the relevant key question link in the analytic
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_executive.pdf
    June 01, 2013 - Key Question 1. … Key Question 1a. … Key Question 1c. … Key Question 1d. … Key Question 2.
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-disposition-120516.pdf
    October 01, 2011 - The sentence in question in the Executive Summary is referring to the finding in meta-analysis that … Comparative benefits of NSAIDs were included as a Key Question. … The comparative benefit aspect of this question yielded little important information. … This is not a fault of the review, but the current research to explore each question. … The end results of question four reinforced the need for each patient to be treated based on their
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-loss-surgery_research-protocol.pdf
    December 14, 2010 - Comparators: This key question will conduct within group comparison – comparators will be http: … Comparators: This key question will conduct cross group comparison – comparators will be conventional … Results of this comparison will answer the first key question; 2) cross group comparison: compare surgical … Results of this comparison will answer the second key question. … This will answer key question four. IV. Methods A.
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/nppv-respiratory-failure_research-protocol.pdf
    April 21, 2011 - The KQs are: Question 1 Is noninvasive positive-pressure ventilation (NPPV) associated with … Question 2 Is NPPV with bilevel positive airway pressure (BiPAP™), compared to NPPV with continuous … Question 3 Is early extubation to NPPV, compared to usual care, associated with less morbidity, … Outcomes measures for each question: o Intermediate outcomes: – Physiological measures such … Grading the Evidence for Each Key Question We will grade the strength of evidence for each outcome
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-194-disposition-comments-inhaled-corticosteroids.pdf
    March 19, 2018 - Having the tables throughout the review was helpful to understand and be able to summarize each question … or better yet each section of a question that was evaluated. … Eisenberg Center In key question 1c, conventional best practice (CBP) is used as a comparator, but … As I look at the results on use of the key question 1b I found it confusing when it is supposed to … the question.
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-prevention_executive.pdf
    May 01, 2013 - Key Question 1a. … Key Question 1b. … Key Question 2. … Key Question 2a. … Key Question 3.

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