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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar_research.pdf
    August 01, 2015 - When asked to prioritize the final research question within each category, glucose monitoring methods … Abbreviations: KQ = Key Question; CSII = continuous subcutaneous insulin infusion; MDI = multiple daily … Research Question Development and Research Design Considerations Research questions were developed … When asked to prioritize the final research question within each category, glucose monitoring methods … Abbreviations: KQ = Key Question; CSII = continuous subcutaneous insulin infusion; MDI = multiple daily
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19.pdf
    December 31, 2022 - In the setting of high vaccination rates, the question of protective immunity has become increasingly … The evidence base for Key Question 1 has several limitations. … Background Purpose Methods Results Key Question 1- Durability of the Antibody Response Key Question … 2 - Risk of Reinfection Key Question 3 - Duration of Protection Discussion Appendix A. … Methods Key Question 1 Methods Notes Key Question 2 and 3 Methods Notes Appendix B.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-abnormalities-tests-update_research-protocol.pdf
    July 01, 2010 - people commented that breast density and breast implants need to be considered when addressing Key QuestionQuestion 1 What is the accuracy (expressed as sensitivity, specificity, predictive values, and likelihood … of the lesion, breast density) that affect the accuracy of the tests considered in Question 1? … Each question can be answered “yes,” “no,” or “not reported,” and each is phrased such that an answer … Grading the Evidence for Each Key Question We will use a formal grading system that conforms with the
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pelvic-pain_disposition-comments.pdf
    January 01, 2012 - One might even question its prevalence in other nations. … Peer Reviewer #6 General Question 1: Prevalence of comorbidities The prevalence of comorbidities is … It might be wise to convey which or all of these issues are the goal of the question. … 3 Evidence for differences in surgical outcomes by etiology This question does not mirror what is done … This further hampers answering this question. Thank you for your comments.
  5. effectivehealthcare.ahrq.gov/sites/default/files/transcript_deliberativemethodswebinar.pdf
    April 19, 2012 - 43 The second question here is how will facilitators be trained? … And there was also a question that came up about, you know -- What was the question? … I saw that question earlier, of course, and was very interested in it. … Your voice was breaking up when you were reading the question. … That’s a great question.
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/dietary-supplements_research-protocol.pdf
    December 15, 2010 - The remaining seven comments were question-specific; five (one for each key question) shared with us … Question 4 . . . pharmacokinetic outcomes (e.g., T1/2, area under the concentration curve [AUC]) … Question 5 In the general adult population, what is the clinical evidence (i.e., in vivo studies) … Key outcomes for each review question were determined in consultation with the TEP and are included … Protocol Amendment Item Amendment Section of the report in question Date of proposed changes
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-pancreas_disposition-comments.pdf
    September 23, 2014 - Peer Reviewer 2 Discussion For question 2a - staging accuracy. … We added mention of this advantage, see the beginning of the evidence for Key Question 1b. … Specifically, the question is whether surgical therapy appropriate. … We appreciate your comments on the staging question. … Only six studies met the inclusion criteria for Key Question 4.
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation_disposition-comments.pdf
    June 28, 2013 - Peer Reviewer #3 General Another common clinical question is whether to attempt cardioversion (DC or … TEP #6 ES (General) I had several concerns with regard to key question 5. … The current CABANA trial, funded by NIH, is recruiting patients to answer this question. … Furthermore, various other endpoints are assessed when addressing Key Question 5. … Out recommendation is that Key Question 5 includes an emphasis on patient centered outcomes.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/public-reporting-quality-improvement_disposition-comments.pdf
    July 26, 2012 - This would be interesting to look at, however most of the research does not address this question. … A brief description, explaining this, has been added to the presentation of the key question that is … partly meant to address this issue (Key Question 5). … Other interventions fall under key question 6 and text stating this has been added. … However we have added it to the overview of results by key question.
  10. effectivehealthcare.ahrq.gov/sites/default/files/cer-244-safety-vaccines-update-evidence-summary.pdf
    May 01, 2021 - Key Question 1: Safety of Vaccines in Adults Table A synthesizes the findings across the prior 2014 … vaccine (either because the risk was not statistically significantly increased or was reduced) Key Question … Key Question 3: Safety of Vaccines in Pregnant Women Table C synthesizes the findings across the prior … 3Awhite_paper&f%5B4%5D=field_product_type%3Am Main Points Background and Purpose Methods Results Key Question … 1: Safety of Vaccines in Adults Key Question 2: Safety of Vaccines in Children Key Question 3: Safety
  11. effectivehealthcare.ahrq.gov/sites/default/files/cer-251-integrated-pain-management-evidence-summary.pdf
    October 01, 2021 - Summary of outcomes with a least low strength of evidence for IPMPs for noncancer pain: Key Question … Summary of outcomes with a least low strength of evidence for CPMPs for noncancer pain: Key Question … 1 fair-quality trial in which patients got antidepressants only. 4 Contextual Question
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_surveillance.pdf
    August 01, 2012 - that addressed a number of the outcomes for that question, we also used the Ottawa Method to assess … Up-to-date Up-to-date Key Question 2. … Key Question 3: In patients with CF, what is the strength of evidence that intermediate outcomes of … Key Question 4. … Up-to-date Up-to-date Key Question 5.
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/long-term-care-adults-future_research.pdf
    July 01, 2013 - Many stakeholders raised the important question of whether research should continue to compare the … From a policy and payer perspective, this resonated as a particularly salient research question. … Many stakeholders raised the important question of whether research should continue to compare the … , regardless of the number ranking that they assigned to the research question. … If a stakeholder assigned a question the number one priority, that question received the highest number
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-artery-stenosis_research-2007.pdf
    January 01, 2007 - Grading a Body of Evidence for Each Key Question We assigned an overall grade describing the body … There is no important scientific disagreement across studies in the results for the key question. … There is little disagreement across studies in the results for the key question. … These studies would directly address Key Question 1. No published studies qualify for Tier I. … This study is not included here, but is discussed below under Key Question 2.
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-2.pdf
    April 01, 2022 - Question 2a (Opioids Vs. … Key Question 2. Harms and Adverse Events: a. … Key Question 3. Dosing Strategies: a. … Effectiveness and Comparative Effectiveness: Key Question 2. … Harms and Adverse Events: Key Question 3. Dosing Strategies: Key Question 4.
  16. effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_research_executive.pdf
    February 01, 2016 - Key Question 1. … Key Question 1. … Key Question 1. … Key Question 2. … Key Question 2.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharma-treatment-pain_research-protocol-amended.pdf
    September 20, 2017 - 1: Nonradicular chronic low back pain o Key Question 2: Chronic neck pain without radiculopathy or … myelopathy o Key Question 3: Pain related to primary or secondary osteoarthritis o Key Question 4: … Fibromyalgia o Key Question 5: Primary chronic tension headache (defined as 15 or more headache days … per month for at least 3 months) o Key Question 6: Patients with any of the five chronic pain conditions … • Three general categories of comparator will be employed: o To evaluate the question whether the
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-research-report-pilot-promote-entry-data-srdr_0.pdf
    October 01, 2019 - The most common reasons were that the learning curve was too steep (7 respondents; 78%), the question … ) • The question types in SRDR were not flexible enough. … Click on the dropdown labeled Key Question and type in the key question addressed by the Section File … Portion of the “+ Create Project” page with “Key Question” dropdown Figure D-11. … Portion of the “+ Create Project” page with “Key Question” box c.
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_disposition-comments.pdf
    September 10, 2014 - We agree that in clinical practice the question about the relative merits of open versus core needle … Results Key question 2- ES11-12, 46 The authors need to find a different word for "dissemination". … It appears that the question about MRI-guided CNB was premature, given the amount of evidence that … It seems adverse events (Question 2 could have included information on this important topic. … We have clarified the number of new studies identified for each key question..
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_research-protocol.pdf
    January 30, 2014 - Key Question 4: In children under 18 years of age treated for disruptive behaviors, are any combined … psychosocial and pharmacologic interventions listed in Key Question 2 more effective for improving … We added a separate Key Question for harms and adverse effects associated with interventions. … We added family history to Key Question 6 (formerly Key Question 5) and plan to collect data on this … We will make these judgments as appropriate for each Key Question.

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