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effectivehealthcare.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar_research.pdf
August 01, 2015 - When asked to prioritize the final research question within each
category, glucose monitoring methods … Abbreviations: KQ = Key Question; CSII = continuous subcutaneous insulin infusion; MDI = multiple daily … Research Question Development and Research Design
Considerations
Research questions were developed … When asked to prioritize the final research question within each category, glucose monitoring
methods … Abbreviations: KQ = Key Question; CSII = continuous subcutaneous insulin infusion; MDI = multiple daily
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19.pdf
December 31, 2022 - In the setting of high vaccination rates, the
question of protective immunity has become increasingly … The evidence base for Key Question 1 has several limitations. … Background
Purpose
Methods
Results
Key Question 1- Durability of the Antibody Response
Key Question … 2 - Risk of Reinfection
Key Question 3 - Duration of Protection
Discussion
Appendix A. … Methods
Key Question 1 Methods Notes
Key Question 2 and 3 Methods Notes
Appendix B.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-abnormalities-tests-update_research-protocol.pdf
July 01, 2010 - people commented that breast density and breast implants
need to be considered when addressing Key Question … Question 1
What is the accuracy (expressed as sensitivity, specificity, predictive values, and
likelihood … of the lesion, breast density) that affect the accuracy of the tests
considered in Question 1? … Each question can be
answered “yes,” “no,” or “not reported,” and each is phrased such that an answer … Grading the Evidence for Each Key Question
We will use a formal grading system that conforms with the
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/pelvic-pain_disposition-comments.pdf
January 01, 2012 - One might even
question its prevalence in other nations. … Peer Reviewer #6 General Question 1: Prevalence of comorbidities
The prevalence of comorbidities is … It might be wise to convey which or all of these
issues are the goal of the question. … 3 Evidence for differences in surgical outcomes by
etiology This question does not mirror what is done … This further hampers answering this question.
Thank you for your comments.
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effectivehealthcare.ahrq.gov/sites/default/files/transcript_deliberativemethodswebinar.pdf
April 19, 2012 - 43
The second question here is how will facilitators be
trained? … And there was also a question that came up about,
you know -- What was the question? … I saw that question
earlier, of course, and was very interested in it. … Your voice was
breaking up when you were reading the question. … That’s a great question.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/dietary-supplements_research-protocol.pdf
December 15, 2010 - The remaining seven comments were question-specific; five (one for each key question) shared with
us … Question 4
. . . pharmacokinetic outcomes (e.g., T1/2, area under the concentration curve [AUC]) … Question 5
In the general adult population, what is the clinical evidence (i.e., in vivo studies) … Key outcomes for each review question were determined in consultation with the TEP and are
included … Protocol Amendment
Item Amendment
Section of the
report in
question
Date of
proposed
changes
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-pancreas_disposition-comments.pdf
September 23, 2014 - Peer Reviewer 2 Discussion For question 2a - staging accuracy. … We added mention of this advantage,
see the beginning of the evidence for Key Question
1b. … Specifically, the question is whether surgical therapy
appropriate. … We appreciate your comments on the staging
question. … Only six
studies met the inclusion criteria for Key Question 4.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation_disposition-comments.pdf
June 28, 2013 - Peer Reviewer #3 General Another common clinical question is whether to attempt cardioversion
(DC or … TEP #6 ES (General) I had several concerns with regard to key question 5. … The current
CABANA trial, funded by NIH, is recruiting patients to answer this
question. … Furthermore, various other endpoints are assessed when
addressing Key Question 5. … Out recommendation is that Key Question 5 includes an emphasis on
patient centered outcomes.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/public-reporting-quality-improvement_disposition-comments.pdf
July 26, 2012 - This would be interesting to look at, however
most of the research does not address this
question. … A brief description, explaining this, has been
added to the presentation of the key question
that is … partly meant to address this issue (Key
Question 5). … Other interventions fall under key question 6 and
text stating this has been added. … However we have
added it to the overview of results by key
question.
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effectivehealthcare.ahrq.gov/sites/default/files/cer-244-safety-vaccines-update-evidence-summary.pdf
May 01, 2021 - Key Question 1: Safety of Vaccines in Adults
Table A synthesizes the findings across the prior 2014 … vaccine (either because the risk was not
statistically significantly increased or was reduced)
Key Question … Key Question 3: Safety of Vaccines in Pregnant Women
Table C synthesizes the findings across the prior … 3Awhite_paper&f%5B4%5D=field_product_type%3Am
Main Points
Background and Purpose
Methods
Results
Key Question … 1: Safety of Vaccines in Adults
Key Question 2: Safety of Vaccines in Children
Key Question 3: Safety
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effectivehealthcare.ahrq.gov/sites/default/files/cer-251-integrated-pain-management-evidence-summary.pdf
October 01, 2021 - Summary of outcomes with a least low strength of evidence for IPMPs for noncancer
pain: Key Question … Summary of outcomes with a least low strength of evidence for CPMPs for noncancer
pain: Key Question … 1 fair-quality trial in which patients got antidepressants only.
4
Contextual Question
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_surveillance.pdf
August 01, 2012 - that addressed a number of the outcomes for that question, we also used the
Ottawa Method to assess … Up-to-date Up-to-date
Key Question 2. … Key Question 3: In patients with CF, what is the strength of evidence that intermediate outcomes of … Key Question 4. … Up-to-date Up-to-date
Key Question 5.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/long-term-care-adults-future_research.pdf
July 01, 2013 - Many stakeholders raised the important question of whether research should continue to
compare the … From a policy and payer perspective, this resonated
as a particularly salient research question. … Many stakeholders raised the important question of whether research should continue
to compare the … , regardless of the number ranking that they assigned to the
research question. … If a stakeholder assigned a
question the number one priority, that question received the highest number
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-artery-stenosis_research-2007.pdf
January 01, 2007 - Grading a Body of Evidence for Each Key Question
We assigned an overall grade describing the body … There is no
important scientific disagreement across studies in the results for the key question. … There is little disagreement across studies in the
results for the key question. … These
studies would directly address Key Question 1. No published studies qualify for Tier I. … This study is not included here, but is
discussed below under Key Question 2.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-2.pdf
April 01, 2022 - Question 2a (Opioids Vs. … Key Question 2. Harms and Adverse Events:
a. … Key Question 3. Dosing Strategies:
a. … Effectiveness and Comparative Effectiveness:
Key Question 2. … Harms and Adverse Events:
Key Question 3. Dosing Strategies:
Key Question 4.
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effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_research_executive.pdf
February 01, 2016 - Key Question 1. … Key Question 1. … Key Question 1. … Key Question 2. … Key Question 2.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharma-treatment-pain_research-protocol-amended.pdf
September 20, 2017 - 1: Nonradicular chronic low back pain
o Key Question 2: Chronic neck pain without radiculopathy or … myelopathy
o Key Question 3: Pain related to primary or secondary osteoarthritis
o Key Question 4: … Fibromyalgia
o Key Question 5: Primary chronic tension headache (defined as 15 or more
headache days … per month for at least 3 months)
o Key Question 6: Patients with any of the five chronic pain conditions … • Three general categories of comparator will be employed:
o To evaluate the question whether the
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-research-report-pilot-promote-entry-data-srdr_0.pdf
October 01, 2019 - The most common reasons were that the learning curve was too steep (7
respondents; 78%), the question … )
• The question types in SRDR were not flexible enough. … Click on the dropdown labeled Key Question and type in the key question
addressed by the Section File … Portion of the “+ Create Project” page with “Key Question” dropdown
Figure D-11. … Portion of the “+ Create Project” page with “Key Question” box
c.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_disposition-comments.pdf
September 10, 2014 - We agree that in clinical practice the question
about the relative merits of open versus core
needle … Results Key question 2- ES11-12, 46 The authors need to find a different
word for "dissemination". … It
appears that the question about MRI-guided CNB was premature,
given the amount of evidence that … It seems adverse events (Question 2 could
have included information on this important topic. … We have clarified the number of new studies
identified for each key question..
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_research-protocol.pdf
January 30, 2014 - Key Question 4: In children under 18 years of age treated for disruptive behaviors, are
any combined … psychosocial and pharmacologic interventions listed in Key Question 2
more effective for improving … We added a separate Key Question for harms and
adverse effects associated with interventions. … We added family history to Key Question 6
(formerly Key Question 5) and plan to collect data on this … We will make these judgments as
appropriate for each Key Question.