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  1. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-executive.pdf
    December 01, 2009 - Conclusions Key Question 1. … Our conclusions for Key Question 1 are summarized in Table A and Figures A through D. … Key Question 3. … Due to the nature of Key Question 3, we did not use formal inclusion criteria, nor did we come to many … The crux of the decision then becomes the question, “Is core-needle biopsy accurate enough?”
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse_disposition-comments.pdf
    July 10, 2012 - For example, Key Question 1 addresses the question of whether the provision of screening and brief … Key Question 4a addresses the question of whether behavioural interventions improve outcomes for people … Peer Reviewer #8 Results Key Question 1. … Peer Reviewer #8 Results Key Question 5. … Peer Reviewer #8 Results Key Question 6.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/allergy-seasonal_research-protocol.pdf
    March 08, 2012 - Question 2 What are the comparative adverse effects of pharmacologic treatments for SAR for adults … Key Question 1: Comparative effectiveness of treatments—study inclusion criteria Category Inclusion … Monotherapy and combination treatment comparisons reviewed for pregnant women: Key Question 3* AH1 … in Adults 12 Years of Age or Older Key Question 3—Comparative Effectiveness and Adverse Effects of … Grading the Evidence for Each Key Question G. Assessing Applicability V. References VI.
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/predictors-trauma-care_research-protocol.pdf
    May 31, 2017 - Key Question 1: For patients with known or suspected trauma who are treated out-of- hospital by EMS … Examples are provided for each Key Question; however, additional measures may be identified by the search … o Include: § Key Question 1: Physiologic measures of circulatory compromise, including but not limited … ., end-tidal CO2, lactate, base deficit), or advanced out-of-hospital airway intervention § Key Question … Date Section Original Protocol Revised Protocol Rationale 5/31/17 Key Question 3 Key Question 3: For
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
    March 23, 2019 - Contextual Question: What is the available evidence concerning levels in maternal serum/blood, fetal … Abbreviations: KQ = Key Question, TACs = trigeminal autonomic cephalgias 13 Figure 2. … Analytic Framework for Key Question 2: Interventions to treat Acute attacks of primary headache during … Abbreviations: KQ = Key Question, NSAID = nonsteroidal antiinflammatory drug, TACs = trigeminal autonomic … Addressing the Contextual Question For drug levels, we will summarize data found in major databases
  6. effectivehealthcare.ahrq.gov/sites/default/files/comparator-selection-in-observational-chapter-5.pptx
    January 01, 2013 - Comparator choice should be primarily driven by a comparative effectiveness question prioritized primarily … When formulating a research question, therefore, careful attention to proper comparator selection, which … No Treatment When a comparison to no treatment is a clinically appropriate question, researchers may … While this question is legitimate and important, operationalizing the question into an answerable research … Selection of the comparator group should be primarily driven by a comparative effectiveness question
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/decision-models-guidance_methods.pdf
    October 01, 2016 - Specifying the research question and setting the modeling goals: Specifying an answerable research question … Describe and justify the decision to use modeling to address the research question. … Choose a perspective depending on the research question and the relevant stakeholders. … Describe and justify the decision to use modeling to address the research question. … The preferred model structure depends on the research question and the model’s scope.
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
    August 22, 2008 - Studies will be included in the key question 3 evaluation if they are 1) conducted in patients with … Studies will be included in the key question 5 evaluation if they are 1) studies of rhGH therapy, 2) … KEY QUESTION 3 SEARCH MEDLINE (OVID) 1. Epidemiologic studies/ 2. … KEY QUESTION 5 SEARCH MEDLINE (OVID) 1. Epidemiologic studies/ 2. … SEARCH TERMS AND CITATIONS KEY QUESTIONS 1, 2, 4, 6, AND 7 SEARCH KEY QUESTION 3 SEARCH KEY QUESTION
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_research-protocol-2014.pdf
    January 01, 2014 - A question of interest is whether any combination of clinical signs and symptoms and laboratory tests … The revisions to this question based on the public comments and our rationale for the changes are presented … The Key Questions The original key question on diagnosis of gout was divided into two questions. … Question segments: a. … 2, in anticipation that few studies will address the question of adverse outcomes or patient satisfaction
  10. effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-disposition-comments.pdf
    June 09, 2021 - neurosurgeons actively involved in it operate on a higher level of knowledge than implied by the question … 1- The authors need to clarify better what is the “Effect Estimate” they calculated that for each question … The broader question was the effect of chemotherapy as compared to no chemotherapy and that is displayed … How does effectiveness vary by dose fractionation schedule and technique: This goes to my earlier question … 2 4) We question the QOL analysis (figure 9) stating that the Brown et al study had no difference
  11. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_executive.pdf
    October 01, 2010 - The key questions examined are: Key Question 1: In patients with CF, does treatment with rhGH as an … Key Question 5:What is the risk of malignancy associated with rhGH use as determined by (a) markers of … Key Question 7: In patients with CF, how do the efficacy, effectiveness, safety, or adverse events of … Studies were included in the Key Question 3 evaluation if they were (1) conducted in patients with CF … Final health outcomes in Key Question 2 and harms in Key Question 4 associated with rhGH were meta- analyzed
  12. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/rotator-cuff-tear_executive.pdf
    July 01, 2010 - Key Question 1: Early versus late surgical repair. … Key Question 3: Comparative effectiveness of nonoperative interventions. … Key Question 4: Comparative effectiveness of nonoperative versus operative interventions. … Key Question 5: Complications. … Key Question 6: Prognostic factors.
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_research-protocol.pdf
    June 10, 2013 - The Key Questions Question 1 Among adults who have been admitted for HF, do transitional care … Hospital days (of subsequent readmissions) Question 2 Among adults who have been admitted for HF … Self-care burden Question 3 This question has three parts: a. … Question 4 This question has three parts: a. … We will not grade the evidence for KQ 3; this question is a descriptive question. G.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/healthcare-infections_disposition-comments.pdf
    August 10, 2015 - Peer Reviewer 2 Background Re Question 1, any role for microbiome-type studies? … Guiding Question 3 is presented in two sections. … Peer Reviewer 6 Findings Guiding Question 2. … We have recently added Key Points to Guiding Question 2 and Guiding Question 3 to orient the reader … Peer Reviewer 1 Summary and Implications Question 4 is excellent.
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-2.pdf
    June 01, 2022 - Key Question 3. … A-1 Key Question 1. … A-1 Key Question 2. … A-2 Key Question 3. … Key Questions Key Question 1. Opioid Therapy Key Question 2.
  16. Title (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/obesity-child_research-protocol.pdf
    March 31, 2010 -  Key Question 2: home-based interventions, including o nutrition, diet, and healthy eating … o parenting styles/education o policy  Key Question 3: primary care-based interventions, including … □ Outcome assessment must be at least 6 months after the baseline assessment for key question 1 … or for key question 7 that includes a school-based intervention. … Grading the Evidence for Each Key Question At the completion of the review, we will grade the quantity
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/obesity-child_executive.pdf
    March 31, 2010 - Key Question 2. … Key Question 3. … Key Question 4. … Key Question 5. … Key Question 6.
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
    November 22, 2011 - System-level factors (e.g., settings where testing is performed) Key Question 2 In patient … System-level factors (e.g., settings where testing is performed) Key Question 3 Source … Key Question 4 What are the potential adverse effects or harms from genetic or phenotypic testing … ○ For Key Question 3 (comparative effectiveness of test-and-treat strategies):  A no-testing … Tests and test-directed treatments may be associated with harms (Key Question 4).
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
    December 14, 2012 - Given the small number of patients where the question of radiation therapy may be considered, this … Agree, sentence edited and “possibility” removed #1 PR Findings On page 16 under guiding question … 2 line 37[sic] (p 21, guiding question 4?) … This issue should be included and considered in the first paragraph under this question as well as … While this can be considered with clinical validity, the key question is how use of the GEP assay
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/mgmt-hnhc-patients-protocol.pdf
    November 07, 2019 - Original question: What are the characteristics of patients who are “high utilizers”? … Protocol revised question: (see below) The EPC modified KQ 1 for clarity. … Original question: What are the effective interventions for adults identified as high utilizers of … Original question: Overall, what is the evidence about which interventions targeting which patient … Protocol revised question: (see below) The original question was a comparative effectiveness question

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