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effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-executive.pdf
December 01, 2009 - Conclusions
Key Question 1. … Our conclusions for Key Question 1 are
summarized in Table A and Figures A through D. … Key Question 3. … Due to the nature of Key Question 3, we did not use
formal inclusion criteria, nor did we come to many … The crux of
the decision then becomes the question, “Is core-needle
biopsy accurate enough?”
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse_disposition-comments.pdf
July 10, 2012 - For example, Key
Question 1 addresses the question of whether the provision of
screening and brief … Key Question 4a addresses the question of whether behavioural
interventions improve outcomes for people … Peer Reviewer #8 Results Key Question 1. … Peer Reviewer #8 Results Key Question 5. … Peer Reviewer #8 Results Key Question 6.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/allergy-seasonal_research-protocol.pdf
March 08, 2012 - Question 2
What are the comparative adverse effects of pharmacologic treatments for SAR for adults … Key Question 1: Comparative effectiveness of treatments—study inclusion criteria
Category Inclusion … Monotherapy and combination treatment comparisons
reviewed for pregnant women: Key Question 3*
AH1 … in Adults 12 Years of Age or Older
Key Question 3—Comparative Effectiveness and Adverse Effects of … Grading the Evidence for Each Key Question
G. Assessing Applicability
V. References
VI.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/predictors-trauma-care_research-protocol.pdf
May 31, 2017 - Key Question 1: For patients with known or suspected trauma who are treated out-of-
hospital by EMS … Examples are provided for each Key
Question; however, additional measures may be identified by the search … o Include:
§ Key Question 1: Physiologic measures of circulatory compromise,
including but not limited … ., end-tidal CO2, lactate,
base deficit), or advanced out-of-hospital airway intervention
§ Key Question … Date Section Original Protocol Revised Protocol Rationale
5/31/17 Key Question 3 Key Question 3: For
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
March 23, 2019 - Contextual Question:
What is the available evidence concerning levels in maternal serum/blood, fetal … Abbreviations: KQ = Key Question, TACs = trigeminal autonomic cephalgias
13
Figure 2. … Analytic Framework for Key Question 2: Interventions to treat Acute attacks of
primary headache during … Abbreviations: KQ = Key Question, NSAID = nonsteroidal antiinflammatory drug, TACs = trigeminal
autonomic … Addressing the Contextual Question
For drug levels, we will summarize data found in major databases
-
effectivehealthcare.ahrq.gov/sites/default/files/comparator-selection-in-observational-chapter-5.pptx
January 01, 2013 - Comparator choice should be primarily driven by a comparative effectiveness question prioritized primarily … When formulating a research question, therefore, careful attention to proper comparator selection, which … No Treatment
When a comparison to no treatment is a clinically appropriate question, researchers may … While this question is legitimate and important, operationalizing the question into an answerable research … Selection of the comparator group should be primarily driven by a comparative effectiveness question
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/decision-models-guidance_methods.pdf
October 01, 2016 - Specifying the research question and setting the modeling goals: Specifying an
answerable research question … Describe and justify the decision to
use modeling to address the research question. … Choose a perspective depending on the research question and the relevant stakeholders. … Describe and
justify the decision to use modeling to address the research question. … The preferred model structure depends on the research question and the model’s scope.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
August 22, 2008 - Studies will be included in the key question 3 evaluation if they are 1)
conducted in patients with … Studies will be
included in the key question 5 evaluation if they are 1) studies of rhGH therapy, 2) … KEY QUESTION 3 SEARCH
MEDLINE (OVID)
1. Epidemiologic studies/
2. … KEY QUESTION 5 SEARCH
MEDLINE (OVID)
1. Epidemiologic studies/
2. … SEARCH TERMS AND CITATIONS
KEY QUESTIONS 1, 2, 4, 6, AND 7 SEARCH
KEY QUESTION 3 SEARCH
KEY QUESTION
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_research-protocol-2014.pdf
January 01, 2014 - A question of interest is
whether any combination of clinical signs and symptoms and laboratory tests … The revisions to this question based on
the public comments and our rationale for the changes are presented … The Key Questions
The original key question on diagnosis of gout was divided into two questions. … Question segments:
a. … 2, in anticipation that few studies will address the question of adverse
outcomes or patient satisfaction
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effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-disposition-comments.pdf
June 09, 2021 - neurosurgeons
actively involved in it operate on a higher level of
knowledge than implied by the question … 1- The authors need to clarify better what is the
“Effect Estimate” they calculated that for each
question … The broader question was the
effect of chemotherapy as
compared to no chemotherapy
and that is displayed … How does effectiveness vary by
dose fractionation schedule and technique: This
goes to my earlier question … 2
4) We question the QOL analysis (figure 9)
stating that the Brown et al study had no
difference
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_executive.pdf
October 01, 2010 - The key questions examined are:
Key Question 1: In patients with CF, does treatment
with rhGH as an … Key Question 5:What is the risk of malignancy
associated with rhGH use as determined by (a) markers
of … Key Question 7: In patients with CF, how do the
efficacy, effectiveness, safety, or adverse events of … Studies were included in the Key
Question 3 evaluation if they were (1) conducted in
patients with CF … Final health outcomes in Key Question 2 and harms in
Key Question 4 associated with rhGH were meta-
analyzed
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rotator-cuff-tear_executive.pdf
July 01, 2010 - Key Question 1: Early versus late surgical repair. … Key Question 3: Comparative effectiveness of
nonoperative interventions. … Key Question 4: Comparative effectiveness of
nonoperative versus operative interventions. … Key Question 5: Complications. … Key Question 6: Prognostic factors.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_research-protocol.pdf
June 10, 2013 - The Key Questions
Question 1
Among adults who have been admitted for HF, do transitional care … Hospital days (of subsequent readmissions)
Question 2
Among adults who have been admitted for HF … Self-care burden
Question 3
This question has three parts:
a. … Question 4
This question has three parts:
a. … We will not grade the evidence for KQ 3; this question is a descriptive
question.
G.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/healthcare-infections_disposition-comments.pdf
August 10, 2015 - Peer Reviewer 2 Background Re Question 1, any role for microbiome-type studies? … Guiding Question 3 is presented in two
sections. … Peer Reviewer 6 Findings Guiding Question 2. … We have recently added Key Points to
Guiding Question 2 and Guiding Question 3
to orient the reader … Peer Reviewer 1 Summary
and
Implications
Question 4 is excellent.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-2.pdf
June 01, 2022 - Key Question 3. … A-1
Key Question 1. … A-1
Key Question 2. … A-2
Key Question 3. … Key Questions
Key Question 1. Opioid Therapy
Key Question 2.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/obesity-child_research-protocol.pdf
March 31, 2010 - Key Question 2: home-based interventions, including
o nutrition, diet, and healthy eating … o parenting styles/education
o policy
Key Question 3: primary care-based interventions, including … □ Outcome assessment must be at least 6 months after the baseline assessment
for key question 1 … or for key question 7 that includes a school-based
intervention. … Grading the Evidence for Each Key Question
At the completion of the review, we will grade the quantity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/obesity-child_executive.pdf
March 31, 2010 - Key Question 2. … Key Question 3. … Key Question 4. … Key Question 5. … Key Question 6.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
November 22, 2011 - System-level factors (e.g., settings where testing is performed)
Key Question 2
In patient … System-level factors (e.g., settings where testing is performed)
Key Question 3
Source … Key Question 4
What are the potential adverse effects or harms from genetic or phenotypic testing … ○ For Key Question 3 (comparative effectiveness of test-and-treat strategies):
A no-testing … Tests and test-directed treatments may
be associated with harms (Key Question 4).
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
December 14, 2012 - Given the small number of
patients where the question of
radiation therapy may be
considered, this … Agree, sentence edited and
“possibility” removed
#1 PR Findings On page 16 under guiding question … 2 line 37[sic] (p 21, guiding question
4?) … This issue should be
included and considered in the first paragraph under this question as well as … While this can be
considered with clinical validity,
the key question is how use of
the GEP assay
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/mgmt-hnhc-patients-protocol.pdf
November 07, 2019 - Original question: What are
the characteristics of patients
who are “high utilizers”? … Protocol revised question:
(see below)
The EPC modified KQ 1 for
clarity. … Original question: What are
the effective interventions for
adults identified as high
utilizers of … Original question: Overall,
what is the evidence about
which interventions targeting
which patient … Protocol revised question:
(see below)
The original question was a
comparative effectiveness
question