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  1. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_executive.pdf
    September 01, 2009 - Key Question 2. … Key Question 3. … Key Question 1. … Key Question 2. … Key Question 3.
  2. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_executive.pdf
    September 01, 2011 - Key Question 2: improve other surrogate outcomes, including gestational age at delivery, incidence of … Key Question 3: increase the maternal harms of arrhythmia, heart failure, hyperglycemia, hypokalemia, … Key Question 4: increase the neonatal terbutaline- related harms of hypoglycemia, hypocalcemia, and ileus … Key Question 5: Can the differences in the outcomes above be partially explained by the differences in … Key Question 1 6 10,11,13,17-19 Key Question 2 12 10-21 Key Question 3 6 10,12,13,18,19,21 Key Question
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-treatment-ssri_surveillance.pdf
    January 01, 2013 - Key Question 1a. … Key Question 2. … Key Question 3. … Key Question 4. … Key Question 2.
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-adults-prisons_disposition-comments.pdf
    August 21, 2013 - Results: yes to all of the above except the last question. Thank you. … 1 can not be answered and Key question 2 can only be minimally answered. … Who will fund such research is an even greater question! Thank you. … I believe key question 1 is too broad to be meaningful or useful. … Isn’t determining this the focus of key question 2?
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/skin-substitute_0.pdf
    October 03, 2019 - Studies will be included if they address a guiding question; present data on patients with chronic wounds … text Conference abstracts Outcomes Reports at least 1 outcome of interest listed under Guiding Question … 4 Does not report any outcome of interest listed under Guiding Question 4 Timing Any NA Setting … FDA requested that the question be changed to remove any reference to FDA regulatory procedures. … FDA requested that the question be changed to remove any reference to FDA regulatory procedures.
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/selecting-evidence.ppt
    January 01, 2010 - Assess whether OSs address the review question Are there gaps in trial evidence? … Systematic review question (including PICOTS) Yes Refocus the review question on gaps Assess the suitability … Assess whether OSs address the review question Are there gaps in trial evidence? … Yes Refocus the review question on gaps Assess the suitability of OSs: Natural history of the disease … Refocus the study question on gaps in trial evidence.
  7. effectivehealthcare.ahrq.gov/sites/default/files/selecting-evidence.ppt
    January 01, 2010 - Assess whether OSs address the review question Are there gaps in trial evidence? … Systematic review question (including PICOTS) Yes Refocus the review question on gaps Assess the suitability … Assess whether OSs address the review question Are there gaps in trial evidence? … Yes Refocus the review question on gaps Assess the suitability of OSs: Natural history of the disease … Refocus the study question on gaps in trial evidence.
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
    March 01, 2011 - The Key Questions Question 1 a. … Question 2 Source: www.effectivehealthcare.ahrq.gov Published Online: January 12, 2012 … Question 3 What is the comparative effectiveness and safety of pharmacologic and mechanical strategies … Question 4 What is the comparative effectiveness and safety of pharmacologic and mechanical strategies … Abbreviations: INR = international normalized ratio; IVC = inferior vena cava; KQ = key question; PTT
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-epilepsy-amended-protocol.pdf
    March 07, 2021 - Key Question 1. … Key Question 2. … Key Question 3. What are the harms or comparative harms of treatments for infantile epilepsy? … For Key Question 3 (harms), we will include single-arm studies as well as controlled studies. 6. … On Key Question 2, they noted the importance of including cost-effectiveness into the analysis.
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_surveillance.pdf
    October 29, 2012 - The key questions of the original CER are as follows: Key Question 1. … Key Question 2. How effective is the pharmacological treatment of UI in women? 1. … Key Question 3. How effective is the nonpharmacological treatment of UI in women? 1. … #1 No new evidence was identified to answer Key Question # 1. … No new evidence was identified for this key question. NA NA NA NA NA Key Question 2.
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_surveillance.pdf
    September 01, 2012 - Two articles were included for Key Question 1 and are shown in the evidence table in Appendix B.4, 5 … Key Question 2. … Key Question 3. … Do Not Know Key Question 1. … Key Question 3.
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-pain_research-protocol.pdf
    August 05, 2010 - The following key questions will be the focus of our report: Question 1 a. … Question 2 Do the comparative benefits and harms of oral treatments for osteoarthritis vary for certain … To identify articles relevant to each key question, we will search the Cochrane Database of Systematic … of literature about a particular key question in accordance with the Grading the Strength of a Body … We will rate the strength of evidence for each key question using the four categories recommended by
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/genitourinary-symptoms-protocol_0.pdf
    July 10, 2023 - • Key Question 2: What is the effectiveness and comparative effectiveness of hormonal, non-hormonal, … • Key Question 3: What are the harms (and comparative harms) of hormonal, non- hormonal, and energy-based … 3 • Key Question 4: What is the appropriate follow-up interval to assess improvement, sustained … Systematic reviews that directly address a question in our review and assess ROB for included individual … Data Synthesis Results will be organized first by key question.
  14. S16 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s16.pdf
    October 01, 2007 - The end result is that the question answered by a trial may differ in important ways from the most important … question for patients, clinicians or policymakers—differences arising from the population and the intervention … Therapy: Should a 60-Year-Old Woman Take Aspirin for Primary Prevention of Cardiovascular Disease Question … patients and hospitals within the system in question (eg, a network of hospitals and group practices … Question Evidence Findings Can it work?
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting_research-protocol.pdf
    August 19, 2011 - pageAction=displayTopic&topicID=299 3 address this clinical question specifically. … Key Questions (KQ) Our review will focus on the following five KQs: • Key Question 1: For patients … • Key Question 2: For patients undergoing PCI, what is the impact of using an IVDx technique to guide … • Key Question 3: For patients having just undergone a PCI, what is the impact of using an IVDx technique … Date Section Original Protocol Revised Protocol Rationale 3/1/2012 Key Question 1 For patients
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-pancreas_research-protocol.pdf
    August 09, 2013 - Key Questions Question 1 What is the comparative effectiveness of imaging techniques (e.g., MDCT … Question 2 What is the comparative effectiveness of imaging techniques (e.g., MDCT angiography ± … Key Question 3 on the rates of procedural harms. … Key Question 3b on patient perspectives of imaging tests. Any study design will be accepted. … Was this strategy appropriate to address the relevant Key Question of the CER? 3.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
    April 01, 2013 - Key Question 4 How do tumor characteristics (e.g., Gleason score, tumor volume, screen-detected vs. … Inclusion criteria: Key Question 1 Question Components Inclusion Criteria Major treatment options of … Inclusion criteria: Key Question 2 Question Components Inclusion Criteria Effectiveness outcomes according … Inclusion criteria: Key Question 3 Question Components Inclusion Criteria • Association between provider … Inclusion criteria: Key Question 4 Question Components Inclusion Criteria Effectiveness outcomes according
  18. effectivehealthcare.ahrq.gov/sites/default/files/tx-for-localized-prostate-cancer_surveillanceassesment_20120614.pdf
    May 01, 2012 - Key Question 2. How do patient characteristics affect outcomes? … Key Question 4. How do tumor characteristics affect outcomes? … Key Question 2. How do patient characteristics affect outcomes? … Key Question 4. How do tumor characteristics affect outcomes? … Do Not Know Key Question 1.
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tx-for-localized-prostate-cancer_surveillanceassesment_20120614.pdf
    May 01, 2012 - Key Question 2. How do patient characteristics affect outcomes? … Key Question 4. How do tumor characteristics affect outcomes? … Key Question 2. How do patient characteristics affect outcomes? … Key Question 4. How do tumor characteristics affect outcomes? … Do Not Know Key Question 1.
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections-surveillance-140925.pdf
    January 01, 2014 - 1, two of eight conclusions for Key Question 2, one of three conclusions for Key Question 3, and one … of five conclusions for Key Question 4 are possibly out of date … • For Key Question 3, conclusions regarding treatment are possibly out of date. … Key Question 2. What are effective prevention strategies? … Key Question 2. What are effective prevention strategies?

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