-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_executive.pdf
September 01, 2009 - Key Question 2. … Key Question 3. … Key Question 1. … Key Question 2. … Key Question 3.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_executive.pdf
September 01, 2011 - Key Question 2: improve other surrogate outcomes,
including gestational age at delivery, incidence of … Key Question 3: increase the maternal harms of
arrhythmia, heart failure, hyperglycemia,
hypokalemia, … Key Question 4: increase the neonatal terbutaline-
related harms of hypoglycemia, hypocalcemia, and
ileus … Key Question 5: Can the differences in the outcomes
above be partially explained by the differences in … Key Question 1 6 10,11,13,17-19
Key Question 2 12 10-21
Key Question 3 6 10,12,13,18,19,21
Key Question
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-treatment-ssri_surveillance.pdf
January 01, 2013 - Key Question 1a. … Key Question 2. … Key Question 3. … Key Question 4. … Key Question 2.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-adults-prisons_disposition-comments.pdf
August 21, 2013 - Results: yes to all of the above except the last question. Thank you. … 1 can not be answered and Key question 2 can
only be minimally answered. … Who will fund
such research is an even greater question!
Thank you. … I believe key question 1 is too broad to be meaningful or
useful. … Isn’t
determining this the focus of key question 2?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/skin-substitute_0.pdf
October 03, 2019 - Studies will be included if they address a guiding question; present data on
patients with chronic wounds … text Conference abstracts
Outcomes Reports at least 1 outcome of interest listed
under Guiding Question … 4
Does not report any outcome of interest
listed under Guiding Question 4
Timing Any NA
Setting … FDA requested that the
question be changed to
remove any reference to
FDA regulatory
procedures. … FDA requested that the
question be changed to
remove any reference to
FDA regulatory
procedures.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/selecting-evidence.ppt
January 01, 2010 - Assess whether OSs address the review question
Are there gaps in trial evidence? … Systematic review question
(including PICOTS)
Yes
Refocus the review
question on gaps
Assess the suitability … Assess whether OSs address the review question
Are there gaps in trial evidence? … Yes
Refocus the review
question on gaps
Assess the suitability of OSs:
Natural history of the disease … Refocus the study question on gaps in trial evidence.
-
effectivehealthcare.ahrq.gov/sites/default/files/selecting-evidence.ppt
January 01, 2010 - Assess whether OSs address the review question
Are there gaps in trial evidence? … Systematic review question
(including PICOTS)
Yes
Refocus the review
question on gaps
Assess the suitability … Assess whether OSs address the review question
Are there gaps in trial evidence? … Yes
Refocus the review
question on gaps
Assess the suitability of OSs:
Natural history of the disease … Refocus the study question on gaps in trial evidence.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
March 01, 2011 - The Key Questions
Question 1
a. … Question 2
Source: www.effectivehealthcare.ahrq.gov
Published Online: January 12, 2012 … Question 3
What is the comparative effectiveness and safety of pharmacologic and mechanical strategies … Question 4
What is the comparative effectiveness and safety of pharmacologic and mechanical strategies … Abbreviations: INR = international normalized ratio; IVC = inferior vena cava; KQ = key question; PTT
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-epilepsy-amended-protocol.pdf
March 07, 2021 - Key Question 1. … Key Question 2. … Key Question 3. What are the harms or comparative harms of treatments for infantile epilepsy? … For Key Question 3 (harms), we will include single-arm studies as well as controlled
studies.
6. … On Key Question 2, they noted the importance of including
cost-effectiveness into the analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_surveillance.pdf
October 29, 2012 - The key questions of the original CER are as follows:
Key Question 1. … Key Question 2. How effective is the pharmacological treatment of UI in women?
1. … Key Question 3. How effective is the nonpharmacological treatment of UI in women?
1. … #1
No new evidence was identified to answer Key Question # 1. … No new evidence
was identified for
this key question.
NA NA NA NA NA
Key Question 2.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_surveillance.pdf
September 01, 2012 - Two articles were included for Key Question 1
and are shown in the evidence table in Appendix B.4, 5 … Key Question 2. … Key Question 3. … Do Not Know
Key Question 1. … Key Question 3.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-pain_research-protocol.pdf
August 05, 2010 - The following key questions will be the focus of our report:
Question 1
a. … Question 2
Do the comparative benefits and harms of oral treatments for osteoarthritis vary for
certain … To identify articles relevant to each key question, we will search the Cochrane Database
of Systematic … of literature about a particular
key question in accordance with the Grading the Strength of a Body … We will rate the strength of evidence for each key question using the four categories
recommended by
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/genitourinary-symptoms-protocol_0.pdf
July 10, 2023 - • Key Question 2: What is the effectiveness and comparative effectiveness of
hormonal, non-hormonal, … • Key Question 3: What are the harms (and comparative harms) of hormonal, non-
hormonal, and energy-based … 3
• Key Question 4: What is the appropriate follow-up interval to assess improvement,
sustained … Systematic reviews that directly address a question in our review and assess ROB
for included individual … Data Synthesis
Results will be organized first by key question.
-
effectivehealthcare.ahrq.gov/sites/default/files/s16.pdf
October 01, 2007 - The end result is
that the question answered by a trial may differ in important
ways from the most important … question for patients, clinicians
or policymakers—differences arising from the population
and the intervention … Therapy: Should a 60-Year-Old Woman Take
Aspirin for Primary Prevention of Cardiovascular Disease
Question … patients and hospitals within the system
in question (eg, a network of hospitals and group practices … Question Evidence Findings
Can it work?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting_research-protocol.pdf
August 19, 2011 - pageAction=displayTopic&topicID=299
3
address this clinical question specifically. … Key Questions (KQ)
Our review will focus on the following five KQs:
• Key Question 1: For patients … • Key Question 2: For patients undergoing PCI, what is the impact of using an IVDx
technique to guide … • Key Question 3: For patients having just undergone a PCI, what is the impact of using an
IVDx technique … Date Section Original Protocol Revised Protocol Rationale
3/1/2012 Key Question
1
For patients
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-pancreas_research-protocol.pdf
August 09, 2013 - Key Questions
Question 1
What is the comparative effectiveness of imaging techniques (e.g., MDCT … Question 2
What is the comparative effectiveness of imaging techniques (e.g., MDCT angiography
± … Key Question 3 on the rates of procedural harms. … Key Question 3b on patient perspectives of imaging tests. Any study design will be
accepted. … Was this strategy appropriate to address the relevant Key Question of the CER?
3.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
April 01, 2013 - Key Question 4
How do tumor characteristics (e.g., Gleason score, tumor volume, screen-detected vs. … Inclusion criteria: Key Question 1
Question Components Inclusion Criteria
Major treatment options of … Inclusion criteria: Key Question 2
Question Components Inclusion Criteria
Effectiveness outcomes according … Inclusion criteria: Key Question 3
Question Components Inclusion Criteria
• Association between provider … Inclusion criteria: Key Question 4
Question Components Inclusion Criteria
Effectiveness outcomes according
-
effectivehealthcare.ahrq.gov/sites/default/files/tx-for-localized-prostate-cancer_surveillanceassesment_20120614.pdf
May 01, 2012 - Key Question 2. How do patient characteristics affect outcomes? … Key Question 4. How do tumor characteristics affect outcomes? … Key Question 2. How do patient characteristics affect outcomes? … Key Question 4. How do tumor characteristics affect outcomes? … Do Not Know
Key Question 1.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tx-for-localized-prostate-cancer_surveillanceassesment_20120614.pdf
May 01, 2012 - Key Question 2. How do patient characteristics affect outcomes? … Key Question 4. How do tumor characteristics affect outcomes? … Key Question 2. How do patient characteristics affect outcomes? … Key Question 4. How do tumor characteristics affect outcomes? … Do Not Know
Key Question 1.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections-surveillance-140925.pdf
January 01, 2014 - 1, two of eight conclusions for Key Question
2, one of three conclusions for Key Question 3, and one … of five conclusions for Key
Question 4 are possibly out of date … • For Key Question 3, conclusions regarding treatment are possibly out of date. … Key Question 2. What are effective prevention strategies? … Key Question 2. What are effective prevention strategies?