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  1. effectivehealthcare.ahrq.gov/products/transparency-neuropathy/research-protocol
    September 06, 2016 - For this project we will focus on the following sub-question: Key Question 2a: What is the safety and … Data synthesis Description of the identified studies (question 1) For the first question we will … Description of incomplete or discontinued trials (question 3) We will create separate tables for those … studies that are incomplete or discontinued to address Question 3: "For studies in ClinicalTrials.gov … These data will be extracted as above to address this question.
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
    March 01, 2012 - Key Question 2. … Key Question 3. … Key Question 4. … Key Question 5a. … Key Question 5b.
  3. effectivehealthcare.ahrq.gov/system/files/docs/topic-brief-hospital-length-of-stay.pdf
    November 01, 2019 - Collectively they cover many interventions relevant to question 1. … Literature identified for each Question Question Systematic reviews (7/2016-8/2019) Primary studies … We found 111 reviews that addressed Question 1, and 3 that addressed Question 2. … Question 1. … Collectively they cover many interventions relevant to question 1.
  4. effectivehealthcare.ahrq.gov/sites/default/files/cer-226-labor-dystocia-comments.pdf
    May 14, 2020 - We have however revised the key question to be consistent with the order in which these specific … Results Peer Reviewer #1 On page 75, for KQ4, it appears the question is only about EA, yet look at … The key question provides an overview of the question to be addressed in that section. … of this question to: “Evaluating differences in outcomes with abnormal labor” or something to that … with abnormal labor we have not modified the specific key question wording.
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0768-141211.pdf
    October 23, 2014 - Key Question #1: What is the comparative effectiveness of tonsillectomy in children with recurrent throat … Outcome(s): Number of throat infections, complications of infection, or complications of surgery Key Question … Key Question … In consultation with our clinical reviewer, the scope of this topic from the original nominator question
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
    July 19, 2023 - 1), prophylactic treatment (Key Question 2), symptomatic treatment (Key Question 3), and repeat surgery … Following the described input, the final key questions are as follows: Key Question 1: What is the … Key Question 4: Among individuals who experience retethering after spinal detethering surgery, what … as defined by the reference standard does not fully match the review question. … We will stratify key question 3 (treatment) by symptom type, intensity, and patient age.
  7. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_executive.pdf
    March 01, 2011 - Below we provide additional summary information for selected comparisons of interest by key question, … Key Question 1: Intermediate Outcomes Intermediate clinical outcomes were the most frequently evaluated … Therefore, most comparisons for this key question had a low strength of evidence. … Key Question 3: Adverse Events and Side Effects This Key Question was addressed by 107 studies. … Key Question 4: Differences in Subgroups Twenty-eight studies applied to Key Question 4.
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
    October 01, 2014 - Key Question 1. … Key Question 2. … Key Question 3. … Key Question 1. … Key Question 2.
  9. effectivehealthcare.ahrq.gov/products/type-2-diabetes-medications-update/research-protocol
    April 05, 2010 - The Key Questions Key Question 1: In adults age 18 or older with type 2 diabetes mellitus, what is … Outcomes for each question The outcomes for Key Question 1 are: HgbA1c Weight Low density lipoprotein … High density lipoprotein Triglycerides The outcomes for Key Question 2 are: All-cause mortality … Analytic Framework HgbA1c = hemoglobin A1c; KQ = Key Question; NPH = neutral protamine Hagedorn … For Key Question 1, we included only RCTs.
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/type-2-diabetes-medications-update_research-protocol.pdf
    April 06, 2010 - The Key Questions Key Question 1: In adults age 18 or older with type 2 diabetes mellitus, what is the … Outcomes for each question The outcomes for Key Question 1 are: • HgbA1c • Weight • Low density … □ For Key Question 1, we included the following outcomes: HgbA1c, weight, and serum lipid levels ( … □ For Key Question 3, we included the following outcomes: hypoglycemia, liver injury, congestive … □ For Key Question 1, we included only RCTs.
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-implicit-bias-protocol.pdf
    August 04, 2023 - For Review Question 2, 5 we will focus on identifying relevant measures that are included in … PSPs used and explanations of the rationale presented in the studies we find for Review Question 5 … For Review Question 8, we will identify publicly available patient safety toolkits developed by AHRQ … Risk of Bias (Quality) Assessment For studies that address Review Question 5 about the effectiveness … For Review Question 5 about the effectiveness of HCW implicit bias training and education PSPs, we
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_research-protocol.pdf
    October 01, 2013 - dose/volume and number of doses) Comparators Key Question 1 and Key Question 2 (see Table 2) ● … Key Question 3 and Key Question 4 (see Table 3) ● IOCM versus LOCM ● LOCM versus LOCM ● IOCM (by … Setting ● Key Question 1 through Key Question 4 ● Inpatient and outpatient populations Source: www.effectivehealthcare.ahrq.gov … Major prevention interventions and comparisons for Key Question 1 and Key Question 2 (These are the … Major contrast media and comparisons for Key Question 3 and Key Question 4 (These are the important
  13. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-2007_executive.pdf
    January 01, 2007 - 3 Key Question 2. … Key Question 3. … Key Question 1. … Key Question 2. … Key Question 3.
  14. effectivehealthcare.ahrq.gov/sites/default/files/prehospital-airway-management-draft-report.pdf
    November 01, 2020 - Key Question 1 a. … Key Question 2 a. … Key Question 3 a. … Studies Total Key Question 1 2 18 20 Key Question 2 2 17 19 Key Question 3 4 34 38 Key Question … , or ETI (Key Question 4).
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prehospital-airway-management-draft-report.pdf
    November 01, 2020 - Key Question 1 a. … Key Question 2 a. … Key Question 3 a. … Studies Total Key Question 1 2 18 20 Key Question 2 2 17 19 Key Question 3 4 34 38 Key Question … , or ETI (Key Question 4).
  16. Ced-Appendix-3 (xls file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-appendix-3.xlsx
    June 24, 2022 - Frame the question, which may involve use of a PICOTS framework Pearson Data Curate real world data … and/or develop the plan for data acquisition sufficient answer the question to meet the evidentiary … The specific clinical question of interest drives the consideration regarding whether an RWE approach … is sufficient and robust enough for the regulatory question at hand. … That is, are the data relevant and fit for purpose for the research question at hand?
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pharma-nonpharma-ptsd-2022-update-app-g1.xlsx
    January 01, 2022 - 2.4) (If Y, PY to previous question) were these deviations likely to have affected the outcome? … 2.7) (If N, PN, NI to previous question) Was there potential for a substantial impact (on the result) … 3.3) (If N/PN to previous question) Could missingness in the outcome depend on its true value? … 3.4) (If Y, PY, NI to previous question) Is it likely that missingness in the outcome depended on its … 4.5) (If Y/PY/NI to previous question) Is it likely that assessment of the outcome was influenced by
  18. effectivehealthcare.ahrq.gov/products/progestogens-preterm-birth/research-protocol
    April 15, 2010 - Key Questions: Question 1 In pregnant women who are at risk for preterm birth (< 37 weeks estimated … Question 6 What is the effect of health systems and provider factors on the use of progestogens for … Outcomes for each Key Question Fetal/neonatal outcomes: Gestational age at birth, including preterm … The dimensions columns in each evidence table will vary according to Key Question, but the Tables will … Grading the Evidence for Each Key Question Quality Grading.
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-failure-rescue-protocol_0.pdf
    July 01, 2023 - For Review Question 2, we will focus on identifying relevant measures that are included in the Centers … including PSPs used and explanations of the rationale presented in the studies we find for Review Question … For Review Question 8, we will identify publicly available patient safety toolkits developed by AHRQ … Risk of Bias (Quality) Assessment For studies that address Question 5 about the effectiveness of PSPs … For Question 5 about the effectiveness of PSPs, we will record information about the context of each
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mass-casualty-events-scarce-resources_executive.pdf
    June 01, 2012 - This report addresses the following Key Questions: Key Question 1. … Key Question 2. … Key Question 3. … Key Question 4. … Our data extraction approach was tailored to each Key Question.

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