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  1. Ced-Appendix-3 (xls file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-appendix-3.xlsx
    June 24, 2022 - Frame the question, which may involve use of a PICOTS framework Pearson Data Curate real world data … and/or develop the plan for data acquisition sufficient answer the question to meet the evidentiary … The specific clinical question of interest drives the consideration regarding whether an RWE approach … is sufficient and robust enough for the regulatory question at hand. … That is, are the data relevant and fit for purpose for the research question at hand?
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_executive.pdf
    February 01, 2013 - Summary of Evidence There is insufficient evidence to answer this Key Question. … Summary of Evidence There is insufficient evidence to answer this Key Question. … All studies addressing this Key Question evaluated IVUS only. … The summary of evidence for each Key Question is provided in Table C. … addressed Key Question 3.
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
    March 01, 2012 - Key Question 2. … Key Question 3. … Key Question 4. … Key Question 5a. … Key Question 5b.
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_executive.pdf
    September 01, 2014 - Key Question 1. … Key Question 1a. … Key Question 1b. … Key Question 1e. … Key Question 2.
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
    July 19, 2023 - 1), prophylactic treatment (Key Question 2), symptomatic treatment (Key Question 3), and repeat surgery … Following the described input, the final key questions are as follows: Key Question 1: What is the … Key Question 4: Among individuals who experience retethering after spinal detethering surgery, what … as defined by the reference standard does not fully match the review question. … We will stratify key question 3 (treatment) by symptom type, intensity, and patient age.
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pharma-nonpharma-ptsd-2022-update-app-g1.xlsx
    January 01, 2022 - 2.4) (If Y, PY to previous question) were these deviations likely to have affected the outcome? … 2.7) (If N, PN, NI to previous question) Was there potential for a substantial impact (on the result) … 3.3) (If N/PN to previous question) Could missingness in the outcome depend on its true value? … 3.4) (If Y, PY, NI to previous question) Is it likely that missingness in the outcome depended on its … 4.5) (If Y/PY/NI to previous question) Is it likely that assessment of the outcome was influenced by
  7. effectivehealthcare.ahrq.gov/sites/default/files/c-diff-infections-nomination-140925.pdf
    February 19, 2014 - Topic Description Key Questions: Key Question 1: How do different methods for detection of toxigenic … B § Gene detection tests versus immunoassays for toxins A and B § Patient characteristics Key Question … alcohol gel § Disinfection § Sustainability § Risk factors § Multiple component strategies Key Question … treatment § Strain of organism § Patient characteristics § Resistance of other pathogens Key Question
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0765-150129.pdf
    November 03, 2014 - Key Question #1: What is the comparative effectiveness of tympanostomy tubes in children with chronic … hearing levels (HLs); speech and language improvement; health-related quality of life (HRQoL) Key Question … Key Questions from Nominator: Key Question … indications for tympanostomy; patient satisfaction with the change in hearing following surgery Key Question … of TTO duration or recurrence; prevention of other complications; school absenteeism; HRQoL Key Question
  9. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_executive.pdf
    March 01, 2011 - Below we provide additional summary information for selected comparisons of interest by key question, … Key Question 1: Intermediate Outcomes Intermediate clinical outcomes were the most frequently evaluated … Therefore, most comparisons for this key question had a low strength of evidence. … Key Question 3: Adverse Events and Side Effects This Key Question was addressed by 107 studies. … Key Question 4: Differences in Subgroups Twenty-eight studies applied to Key Question 4.
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol-amendment.pdf
    March 22, 2023 - Key Question 1. … Key Question 2. … Key Question 3. … Key Question 4. … Key Question 6: Key Question 6a.
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
    October 01, 2014 - Key Question 1. … Key Question 2. … Key Question 3. … Key Question 1. … Key Question 2.
  12. effectivehealthcare.ahrq.gov/sites/default/files/module-iv-skills-for-successful-engagement.pdf
    May 29, 2025 - Focused on process § (Picture of books on a pedestal) Knowledgeable about the topic § (Picture of a question … However, the facilitator should be knowledgeable or skilled enough to question, probe, and approach … Slide 25 Module IV Quiz: Question 1 One of the challenges to stakeholder engagement is engaging … • Only allow discussion and input to occur during scheduled meetings Slide 29 Module IV Quiz: Question … process focused on group dynamics and processes • A superfluous skill Slide 30 Module IV Quiz: Question
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation-surveillance-160902.pdf
    May 29, 2025 - " Key$Question$3." … " Key$Question$4." … " Key$Question$5." … $Key$Question$2a. … $Key$Question$2c.
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/type-2-diabetes-medications-update_research-protocol.pdf
    April 06, 2010 - The Key Questions Key Question 1: In adults age 18 or older with type 2 diabetes mellitus, what is the … Outcomes for each question The outcomes for Key Question 1 are: • HgbA1c • Weight • Low density … □ For Key Question 1, we included the following outcomes: HgbA1c, weight, and serum lipid levels ( … □ For Key Question 3, we included the following outcomes: hypoglycemia, liver injury, congestive … □ For Key Question 1, we included only RCTs.
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_research-protocol.pdf
    October 01, 2013 - dose/volume and number of doses) Comparators Key Question 1 and Key Question 2 (see Table 2) ● … Key Question 3 and Key Question 4 (see Table 3) ● IOCM versus LOCM ● LOCM versus LOCM ● IOCM (by … Setting ● Key Question 1 through Key Question 4 ● Inpatient and outpatient populations Source: www.effectivehealthcare.ahrq.gov … Major prevention interventions and comparisons for Key Question 1 and Key Question 2 (These are the … Major contrast media and comparisons for Key Question 3 and Key Question 4 (These are the important
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/radiation-therapy-brain-metases-protocol.pdf
    October 10, 2019 - In addition, all subquestions for Key Question 1 were also added to Key Question 2, and vice versa. … Analysis plan for Key question 4: For Key Question 4, the synthesis will focus on key adverse events … For key question 2, the analysis will be centered around SRS as initial treatment. … For key question 3, the analysis will focus on postoperative treatment. … Box 1: Key Outcomes Outcomes for Key Question 4 (adverse events) 1.
  17. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-2007_executive.pdf
    January 01, 2007 - 3 Key Question 2. … Key Question 3. … Key Question 1. … Key Question 2. … Key Question 3.
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mass-casualty-events-scarce-resources_executive.pdf
    June 01, 2012 - This report addresses the following Key Questions: Key Question 1. … Key Question 2. … Key Question 3. … Key Question 4. … Our data extraction approach was tailored to each Key Question.
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-future_research.pdf
    October 26, 2012 - The PICOTS on this question will depend on study question and design 2.3 To what extent … The PICOTS on this question will depend on study question and design 2.3 To what extent … The study design evaluations for this question was combined with research question number 4.1 as … question number 4.1 below. … The study design evaluations for this question was combined with research question number 2.1 as they
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0768-141211.pdf
    October 23, 2014 - Key Question #1: What is the comparative effectiveness of tonsillectomy in children with recurrent throat … Outcome(s): Number of throat infections, complications of infection, or complications of surgery Key Question … Key Question … In consultation with our clinical reviewer, the scope of this topic from the original nominator question

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