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61. Population: Children < 18 years of age: 1. What are the incidences and prevalences of non-inflammatory pain syndromes (e.g., benign hypermobility syndrome, patellofemoral stress syndrome, fibromyalgia, and growing pain) in children and… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/population-children-18-years-of-age-1-what-are-the-incidences-and-prevalences-of-non-inflammatory-pain-syndromes-eg-benign-hypermobility-syndrome-patellofemoral-stress-syndrome-fibromyalgia-and-growing-pain-in-children-and-a
    November 01, 2017 - What patients or group(s) of patients does your question apply to? … Children < 18 yo Are there subgroups of patients that your question might apply to? … Appropriateness for EHC Program Does your question include a health care drug, intervention, device … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.

62. What is the comparative effectiveness of various local treatments for (1) unresectable liver metastases and (2) unresectable, localized hepatocellular carcinoma (HCC)? Does the comparative effectiveness vary when lesions are unresectable… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-is-the-comparative-effectiveness-of-various-local-treatments-for-1-unresectable-liver-metastases-and-2-unresectable-localized-hepatocellular-carcinoma-hcc-does-the-comparative-effectiveness-vary-when-lesions-are-unresec
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … In addition, t What specifically motivated you to ask this question? … Describe the timeframe in which an answer to your question is needed.

63. What is the effectiveness of interventions designed to support children in transition from pediatric care to adult care with special health care needs? Ineffective transition planning can have significant negative consequences on children… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-is-the-effectiveness-of-interventions-designed-to-support-children-in-transition-from-pediatric-care-to-adult-care-with-special-health-care-needs-ineffective-transition-planning-can-have-significant-negative-consequence
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed. As soon as possible.

64. What is the comparative effectiveness of genetic and other diagnostic tests to identify and treat intellectual and developmental disabilities caused by genetic mutations in post-natal to early childhood populations? | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-is-the-comparative-effectiveness-of-genetic-and-other-diagnostic-tests-to-identify-and-treat-intellectual-and-developmental-disabilities-caused-by-genetic-mutations-in-post-natal-to-early-childhood-populations
    November 01, 2017 - Does your question include a comparison of different health care approaches? … This question was prioritized by stakeholders engaged in the Topic Identification project conducted by … Does your question represent uncertainty for clinicians and/or policy-makers? … Potential Impact How will an answer to your research question be used or help inform decisions for … Describe the timeframe in which an answer to your question is needed.

65. The American College of Chest Physicians (ACCP) proposes to update the medical therapies section of 2007 updated publication on Medical Therapies for Pulmonary Arterial Hypertension: ACCP Evidence-Based Clinical Practice Guidelines.1 1.… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/the-american-college-of-chest-physicians-accp-proposes-to-update-the-medical-therapies-section-of-2007-updated-publication-on-medical-therapies-for-pulmonary-arterial-hypertension-accp-evidence-based-clinical-practice-guidel
    November 01, 2017 - What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.

66. For adults and children with asthma what is the effectiveness of the Buteyko Breathing method on reducing bronchodilator and inhaled steroid use and improving health status? | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-adults-and-children-with-asthma-what-is-the-effectiveness-of-the-buteyko-breathing-method-on-reducing-bronchodilator-and-inhaled-steroid-use-and-improving-health-status
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.

67. In patients with cerebral palsy (CP) and difficulties with feeding, what is the effectiveness of of anti-reflux procedure (since often done in conjunction with gastrostomy placement) or type of tube (J-tube or G-J tube versus typical PEG… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/in-patients-with-cerebral-palsy-cp-and-difficulties-with-feeding-what-is-the-effectiveness-of-of-anti-reflux-procedure-since-often-done-in-conjunction-with-gastrostomy-placement-or-type-of-tube-j-tube-or-g-j-tube-versus-typi
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers?

68. For the disabled and elderly with multiple comorbidities, what is the comparative effectiveness of physician housecalls on outcomes and total cost? | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-the-disabled-and-elderly-with-multiple-comorbidities-what-is-the-comparative-effectiveness-of-physician-housecalls-on-outcomes-and-total-cost
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers?

69. What is the effectiveness of interventions intended to treat anxiety disorders in children (
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-is-the-effectiveness-of-interventions-intended-to-treat-anxiety-disorders-in-children-18-years-of-age-over-the-long-term-6-12-months-what-is-the-effectiveness-of-interventions-intended-to-prevent-the-development-of-anxi
    November 01, 2017 - Topic Suggestion Disposition (PDF, 1.2 MB) Briefly describe a specific question … Does your question include a comparison of different health care approaches? … What specifically motivated you to ask this question? … Potential Impact How will an answer to your research question be used or help inform decisions for … Describe the timeframe in which an answer to your question is needed.

70. PICO Population(s): Breastfeeding infants 6 months or less with ankyloglossia Intervention(s): Frenotomy, Frenectomy, or Frenulotomy Comparator(s): Breastfeeding management without surgical intervention Outcomes(s): Successful exclusive… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/pico-populations-breastfeeding-infants-6-months-or-less-with-ankyloglossia-interventions-frenotomy-frenectomy-or-frenulotomy-comparators-breastfeeding-management-without-surgical-intervention-outcomess-successful-exclusive-b
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Describe the timeframe in which an answer to your question is needed.

71. • The roles of the psychiatric hospital, lengths of stay, and transition support services after discharge | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/the-roles-of-the-psychiatric-hospital-lengths-of-stay-and-transition-support-services-after-discharge
    November 01, 2017 - Patients with Serious Mental Illness (SMI) Are there subgroups of patients that your question might … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … The question is whether such approaches promote community recovery or lead to rapid re-hospitalization … Describe the timeframe in which an answer to your question is needed. As soon as possible.

72. Key Questions 1. Does routine preoperative testing compared to no testing or alternative testing strategies improve outcomes (such as surgical complications, other morbidity, and mortality) among patients undergoing elective surgery? 2.… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/key-questions-1-does-routine-preoperative-testing-compared-to-no-testing-or-alternative-testing-strategies-improve-outcomes-such-as-surgical-complications-other-morbidity-and-mortality-among-patients-undergoing-elective-surg
    November 01, 2017 - Topic Suggestion Disposition (PDF, 128.7 KB) Briefly describe a specific question … What patients or group(s) of patients does your question apply to? … are identified which might require further evaluation Are there subgroups of patients that your question … Describe the timeframe in which an answer to your question is needed. … Describe any health disparities, inequities, or impact on vulnerable populations your question applies

73. ? For women in the postpartum period, what is the effectiveness and safety of screening and treatment for depression? Please use the USPSTF framework, which considers not only screening but followup treatment and management. The treatment… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-women-in-the-postpartum-period-what-is-the-effectiveness-and-safety-of-screening-and-treatment-for-depression-please-use-the-uspstf-framework-which-considers-not-only-screening-but-followup-treatment-and-management-the-t
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Describe the timeframe in which an answer to your question is needed.

74. Migraine patients in the ER receive various IV medications from different ER doctors within the physician group. As I have watched particular drug combinations given to my patients and to my daughter in the ER, I have witnessed total… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/migraine-patients-in-the-er-receive-various-iv-medications-from-different-er-doctors-within-the-physician-group-as-i-have-watched-particular-drug-combinations-given-to-my-patients-and-to-my-daughter-in-the-er-i-have-witnesse
    November 01, 2017 - What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.

75. In patients with dementia, what is the effectiveness of psychological treatment (i.e., non-pharmacological; e.g., cognitive or behavioral therapy for individuals with dementia; environmental and behavioral interventions to address… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/in-patients-with-dementia-what-is-the-effectiveness-of-psychological-treatment-ie-non-pharmacological-eg-cognitive-or-behavioral-therapy-for-individuals-with-dementia-environmental-and-behavioral-interventions-to-address-beh
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Appropriateness for EHC Program Does your question include a health care drug, intervention, device … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.

76. What is the comparative effectiveness of different models of survivorship care and sets of services on late and long-term net health outcomes (e.g., for breast cancer)? | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-is-the-comparative-effectiveness-of-different-models-of-survivorship-care-and-sets-of-services-on-late-and-long-term-net-health-outcomes-eg-for-breast-cancer
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Describe the timeframe in which an answer to your question is needed.

77. Local Nonsurgical Therapies for Stage I and Symptomatic Obstructive Non–Small-Cell Lung Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/lung-cancer-nonsurgical-therapies/research
    December 01, 2019 - 1), (2) patients with stage I NSCLC who are deemed operable but decline surgery (Key Question 2), and … (3) patients with endoluminal NSCLC causing obstruction (Key Question 3). … Data were abstracted for each Key Question by a team of reviewers, with independent data verification … I NSCLC; 6 were relevant to Key Question 2, considering medically operable patients with stage I NSCLC … Among 17 papers included for Key Question 3, 5 were RCTs, 1 was a nonrandomized comparative study, and

78. Calcineurin Inhibitors for Kidney Transplant | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/calcineurin-inhibitor/research
    December 01, 2019 - Key Question 1 compares immunoassay analysis with liquid chromatographic or mass spectrometric analytical … Key Question 2 examines CsA monitoring timepoints. … Key Question 3 evaluates alternatives to full-dose CNI regimens. … Results We included 105 studies; 11 addressed Key Question 1, six addressed Key Question 2, and 88 … addressed Key Question 3.

79. Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics – Update | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/atypical-antipsychotics-off-label-update/research-protocol
    March 01, 2020 - Population: Same as in Question 1 Intervention: Same as in Question 1 Comparator: Same as in Question … Timing: Same as in Question 1 Settings: Same as in Question 1 Question 3: What subset of … Timing: Same as in Question 1 Settings: Same as in Question 1 Question 4: What are the potential … Population: Same as in Question 1 Intervention: Same as in Question 1 Comparator: Same as in Question … Population: Same as in Question 1 Intervention: Same as in Question 1 Comparator: Same as in Question

80. For persons with PTSD (and those exposed to traumatic event/s as defined by DSM-IV-TR or ICD-10), what is the comparative effectiveness of different psychotherapy modalities/psychological treatments? o Is EMDR an effective treatment for… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-persons-with-ptsd-and-those-exposed-to-traumatic-events-as-defined-by-dsm-iv-tr-or-icd-10-what-is-the-comparative-effectiveness-of-different-psychotherapy-modalitiespsychological-treatments-o-is-emdr-an-effective-treatme
    November 01, 2017 - . evidence-based guidelines by NICE and others) As a potentially important precursor to the above question … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed. … Describe any health disparities, inequities, or impact on vulnerable populations your question applies