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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/autism-adolescents_research-protocol.pdf
March 29, 2011 - Question 5
Among adolescents and young adults with ASDs, what harms are associated with available … Question 6
What are the effects of interventions on family outcomes? … Grading the Evidence for Each Key Question
Assessing the strength of evidence. … Question 4
Among adolescents and young adults with ASDs, what harms are associated with available … Question 6
What are the effects on family adaptation and family outcomes of interventions directed
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antipsychotics-children_executive.pdf
February 01, 2012 - Key Question 1: Disorder-specific and nonspecific
symptoms. … Summary of the strength of evidence for symptoms (Key Question 1)
Outcome Comparison (# studies) SOE … Summary of the strength of evidence for symptoms
(Key Question 1) (continued)
Outcome Comparison (# … Key Question 3: Short- and long-term outcomes. … Key Question 4: Subpopulations.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/hepatitis-c-screening_research-protocol.pdf
October 20, 2011 - Question 2
This Key Question has two parts:
a. … Question 3
What are the harms associated with screening for HCV infection, including adverse effects … Question 4
Source: www.effectivehealthcare.ahrq.gov
Published Online: October 20, 2011 … Question 5
What are the harms associated with the workup for guiding treatment decisions? … Question 6
This KQ has three parts:
a.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-238-cervical-ripening-appendix-e-1.xlsx
January 01, 2009 - Study characteristics of RCTs addressing Key Questions 1 and 2
Key Question Author, Year
Country
Quality … Outpatient Intervention Inpatient Intervention Fetal Monitoring Protocol Funding Source Comments
Key Question … Key Question 2 Henry, 2013
Australia
Fair Age, mean (yr): 32.82
≤19: NR
≥35: NR
BMI, mean (kg/m2): … Key Question 2 Sciscione, 2001
USA
Fair Age, mean (yr): 29.17
≤19: NR
≥35: NR
BMI, mean (kg/m2): NR … Study characteristics of cohort studies addressing Key Question 3
Key Question Author, Year
Country
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effectivehealthcare-admin.ahrq.gov/products/opioids-chronic-pain/protocol
May 01, 2020 - The Key Questions
Key Question 1. Effectiveness and Comparative Effectiveness
a. … Key Question 2. Harms and Adverse Events
a. … Key Question 3. Dosing Strategies
a. … Key Question 4. Risk Assessment and Risk Mitigation Strategies
a. … For Key Question 4a, we will exclude studies that do not evaluate the performance of a risk prediction
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effectivehealthcare-admin.ahrq.gov/products/decision-models-guidance/methods
April 01, 2021 - Describe and justify the decision to use modeling to address the research question. … Make data choices based on the research question and the model's scope and structure. … Describe and justify the decision to use modeling to address the research question. … The preferred model structure depends on the research question and the model's scope. … Make data choices based on the research question and the model's scope and structure.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_executive.pdf
October 01, 2007 - Key Question 2. … Key Question 1b. … Key Question 2a. … Key Question 2c. … Key Question 2d.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/traumatic-brain-injury-rehabilitation-future_research.pdf
January 01, 2013 - Analytic framework
Abbreviations: KQ = Key Question; TBI = traumatic brain injury
The literature … This question was addressed by
the CER KQs. … If a
stakeholder assigned a question the number one priority, that question received three points; … This question was
addressed by the CER KQs. … Research Design Considerations
This question was explored in the CER.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mrsa-screening-2010_disposition-comments.pdf
January 01, 2010 - In the Results
chapter, each Key Question has a strength of
evidence section that has been revised … In the Results chapter, each
Key Question has a strength of evidence section
that has been revised … ES-10 (pdf p. 20), line 43: “y Question 1:” should be “Key
Question 1:”
We have corrected this typo … How is this question different from what was described for Questions 3a/b/c? … 3B but not Key
Question 3A?
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/rotator-cuff-tears-future_research.pdf
February 01, 2013 - 1
Exercise
Complications / harms
Complications / harms
Key Question 2
Key Question 3
Key … Question 4
Key Question 5
Key Question 5
Patient /
clinical factors
POPULATION INTERVENTION … The most important question in rotator cuff treatment is “what to do and for whom?” … as the important overarching question. … Weighted scores totaled the
number of stars stakeholders assigned to an individual issue or question
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effectivehealthcare-admin.ahrq.gov/products/pelvic-pain/research-protocol
December 01, 2020 - Key Questions
Question 1. … Question 2. … Question 3. … Question 4. … Question 5.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-236-mental-health-pregnancy-evidence-summary.pdf
April 01, 2021 - For women who are currently or planning to become pregnant, a
critical question is whether the benefits … Key Question (KQ) 1: Benefits of Pharmacologic Treatments Versus No
Treatment or Placebo for Pregnant … For the benefits question
4
(KQ 1), eligible studies had comparator arms of women with … For the harms question (KQ 3), however, we were more inclusive and
included studies with comparator
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research.pdf
March 01, 2018 - Question 2. … Question 3. … Question 2. … Question 4. … Question 2.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule-future_research.pdf
May 01, 2013 - Insufficient
KQ = Key Question; ROM = radiopaque markers; WMC = wireless motility capsule
Overall … The highest ranked question
reflected the uncertainty in the role of the WMC in outcomes for patients … The other top ranked question asked whether these same patients with suspected
gastroparesis would have … Summary of research needs (top tier)
Gap Question Population Intervention Comparator Outcomes Timinga … We also offered them space to comment on any specific study designs relevant to a
particular question
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/tonsillectomy_research-protocol.pdf
February 10, 2016 - Analytic framework for Key Question 1
*Includes breathing difficulties during sleep … Analytic framework for Key Question 1b
*Includes breathing difficulties during sleep … Analytic framework for Key Question 1c
*Includes breathing difficulties during sleep … Analytic framework for Key Question 1d
*Includes breathing difficulties during … Abbreviations: KQ = Key Question;; OSDB = Obstructive Sleep-Disordered Breathing
Harms
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effectivehealthcare-admin.ahrq.gov/products/urinary-incontinence-update/research-protocol
December 01, 2020 - Based on stakeholder input, the 2012 AHRQ review Key Question 1 on the diagnostic evaluation of UI was … We will add patient-centered outcomes identified from the contextual question on how patients define … § Other patient-centered outcomes based on the findings of the Contextual Question.
IV. … Addressing the Contextual Question
To address the contextual question, we will follow the guidance … Based on data and input garnered from these sources, we will answer the contextual question in a narrative
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effectivehealthcare-admin.ahrq.gov/products/bladder-cancer-non-muscle-invasive/research-protocol
December 01, 2020 - Key Question 1
What is the diagnostic accuracy of various urinary biomarkers compared with other urinary … Key Question 4
For patients with high risk non-muscle-invasive bladder cancer treated with TURBT, what … Key Question 5
In surveillance of patients treated for non-muscle-invasive bladder cancer, what is … Key Question 8
What are the comparative adverse effects of various treatments for non-muscle-invasive … Systematic reviews will be used as primary sources of evidence if they address a key question and are
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/surveillance-report-1-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - Key Question 1b. … Key Question 2a. … Key Question 2b. … B-1
Key Question 1. … B-1
Key Question 2.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting-future_research.pdf
January 01, 2014 - Key Question 2. … 2
Key Question 3. … Key Question 4. … Key Question 5. … Each final FRN topic was assessed as
to the context of the research question.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/children-special-needs-transition_disposition-comments.pdf
June 17, 2014 - We
have added a comment in Guiding
Question 1 to address this point. … We have
expanded the text on registries in Guiding
Question 1. … PMID: 15164956) in the
report in Guiding Question 1a. … research and not
answering a guiding question”. … We have added text under Guiding
Question 1b.