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41. For women, when comparing noninvasive testing,which testing method (echocardiography, MIBI-SPECT, pharmacological testing, etc.) is more accurate in diagnosing coronary artery disease. There has been inadequate studies done on women for… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-women-when-comparing-noninvasive-testingwhich-testing-method-echocardiography-mibi-spect-pharmacological-testing-etc-is-more-accurate-in-diagnosing-coronary-artery-disease-there-has-been-inadequate-studies-done-on-women-
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.

42. Diagnosis and treatment of low back pain:Key questions:In patients with low back pain, what are the benefits and harms of identifying risk factors for chronicity and targeting treatment based on assessed… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/diagnosis-and-treatment-of-low-back-painbr-key-questionsbr-olliin-patients-with-low-back-pain-what-are-the-benefits-and-harms-of-identifying-risk-factors-for-chronicity-and-targeting-treatment-based-on-assessed-riskliliin-pa
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.

43. Peripheral Artery Disease (PAD) - defined as peripheral artery disease of the lower extremities 1) Does aspirin reduce the risk of adverse cardiovascular events (MI, stroke, cardiovascular death) in patients with PAD? Is there a… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/peripheral-artery-disease-pad-defined-as-peripheral-artery-disease-of-the-lower-extremities-1-does-aspirin-reduce-the-risk-of-adverse-cardiovascular-events-mi-stroke-cardiovascular-death-in-patients-with-pad-is-there-a-diffe
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … disparities, inequities, or impact on vulnerable populations your question applies to.

44. Description of a question or questions about a health care test or treatment: o In women with leiomyomas who are candidates for surgery, does the use of adjunctive medical treatment result in better outcomes? (Preoperative adjuvants &… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/description-of-a-question-or-questions-about-a-health-care-test-or-treatment-o-in-women-with-leiomyomas-who-are-candidates-for-surgery-does-the-use-of-adjunctive-medical-treatment-result-in-better-outcomes-preoperative-adjuv
    November 01, 2017 - SHARE: Description of a question … Topic Suggestion Disposition (PDF, 1.2 MB) Briefly describe a specific question … Description of a question or questions about a health care test or treatment: In women with leiomyomas … How will an answer to your research question be used or help inform decisions for you or your group? … Page originally created June 2014 Internet Citation: Description of a question

45. For patients with PKU, there is now a pharmaceutical drug to treat this condition. In the past is was treated by medical foods that eliminated the harmful substance phenylalanine. The cost of the new drug is $70K year. The cost to treat… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-patients-with-pku-there-is-now-a-pharmaceutical-drug-to-treat-this-condition-in-the-past-is-was-treated-by-medical-foods-that-eliminated-the-harmful-substance-phenylalanine-the-cost-of-the-new-drug-is-70k-year-the-cost-t
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Describe the timeframe in which an answer to your question is needed.

46. 1. What are the benefits and harms of rhythm control compared to rate control (including newer agents) ? What are the benefits and harms of strict vs more lenient rate control? 2. What are the benefits and harms of different… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/1-what-are-the-benefits-and-harms-of-rhythm-control-compared-to-rate-control-including-newer-agents-what-are-the-benefits-and-harms-of-strict-vs-more-lenient-rate-control-2-what-are-the-benefits-and-harms-of-different-antico
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.  

47. What are the best practice Behavioral Health programs for type 1 diabetes, type 2 diabetes and gestational diabetes. Does educational counseling help paitients improve control and adherence to treatment? | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-are-the-best-practice-behavioral-health-programs-for-type-1-diabetes-type-2-diabetes-and-gestational-diabetes-does-educational-counseling-help-paitients-improve-control-and-adherence-to-treatment
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed. One to three years.

48. For patients with Crohn's disease, what treatments or therapies, alone or in conjunction with one another, provide the highest rate of disease management with the lowest risk of long term complications, particularly in young women? | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-patients-with-crohns-disease-what-treatments-or-therapies-alone-or-in-conjunction-with-one-another-provide-the-highest-rate-of-disease-management-with-the-lowest-risk-of-long-term-complications-particularly-in-young-wome
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Women, 20-35 Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.

49. Mindfulness meditation encompasses a range of meditation techniques that have been increasingly used to treat behavioral disorders, especially those associated with stress. Some of these were previously described in AHRQ Publication No.… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/mindfulness-meditation-encompasses-a-range-of-meditation-techniques-that-have-been-increasingly-used-to-treat-behavioral-disorders-especially-those-associated-with-stress-some-of-these-were-previously-described-in-ahrq-publi
    November 01, 2017 - Topic Suggestion Disposition (PDF, 146.4 KB) Briefly describe a specific question … , substance abuse, stress associated with care-giving or other stressful occupations) Does your question … any phenotype-dependent effects would be of interest Are there subgroups of patients that your question … to promote to the attention of insurance providers What specifically motivated you to ask this question … Describe the timeframe in which an answer to your question is needed.

50. How can patients who have chronic diseases better prepare for critical illness and the end of life? Will a decision aid, using individualized estimates of outcomes, help shared decision making about advance care planning? | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/how-can-patients-who-have-chronic-diseases-better-prepare-for-critical-illness-and-the-end-of-life-will-a-decision-aid-using-individualized-estimates-of-outcomes-help-shared-decision-making-about-advance-care-planning
    November 01, 2017 - Does your question include a comparison of different health care approaches? … patients with chronic disease Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed. As soon as possible.

51. Does the use of Cytochrome P450 2C19 (CYP2C19) testing to predict response to clopidogrel in people: (1) with acute coronary syndrome, (2) who have suffered other cardiovascular disease-related events (e.g., ischemic stroke, symptomatic… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/does-the-use-of-cytochrome-p450-2c19-cyp2c19-testing-to-predict-response-to-clopidogrel-in-people-1-with-acute-coronary-syndrome-2-who-have-suffered-other-cardiovascular-disease-related-events-eg-ischemic-stroke-symptomatic-
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers?

52. 1. Does mass spectrometric analysis and therapeutic monitoring of tacrolimus as compared with immunoassay analysis and therapeutic monitoring produce a) better organ survival rate, b) fewer rejections, c) less nephrotoxicity and/or d) cost… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/1-does-mass-spectrometric-analysis-and-therapeutic-monitoring-of-tacrolimus-as-compared-with-immunoassay-analysis-and-therapeutic-monitoring-produce-a-better-organ-survival-rate-b-fewer-rejections-c-less-nephrotoxicity-andor
    November 01, 2017 - Does your question include a comparison of different health care approaches? … adult renal patients Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … any health disparities, inequities, or impact on vulnerable populations your question applies to.

53. What evidence exists for programs to increase patient adherence to prescription medications? Which programs/approaches are most effective at increasing adherence for which populations and conditions? If little or no evidence exists, can… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-evidence-exists-for-programs-to-increase-patient-adherence-to-prescription-medications-which-programsapproaches-are-most-effective-at-increasing-adherence-for-which-populations-and-conditions-if-little-or-no-evidence-ex
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed. When possible.

54. For patients with chronic diseases where large numbers of physicians do not follow guideline based care, such as with asthma-the most common chronic disease, what are the most and least effective interventions to modify physician and other… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-patients-with-chronic-diseases-where-large-numbers-of-physicians-do-not-follow-guideline-based-care-such-as-with-asthma-the-most-common-chronic-disease-what-are-the-most-and-least-effective-interventions-to-modify-physic
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Describe the timeframe in which an answer to your question is needed.

55. Pharma-Nonpharma-Ptsd-2023-Update-App-G-1 (xls file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/pharma-nonpharma-ptsd-2023-update-app-g-1.xlsx
    January 01, 2023 - : Question 1.2 Bias Due to Randomization: Question 1.3 Bias Due to Randomization: Section 1 RoB Judgment … Interventions: Question 2.2 Bias Due to Deviations From Intended Interventions: Question 2.3 Bias Due … : Question 2.5 Bias Due to Deviations From Intended Interventions: Question 2.6 Bias Due to Deviations … 3.1 Detail Bias Due to Missing Outcome Data: Question 3.2 Bias Due to Missing Outcome Data: Question … RoB 2 questions Question Number Question Text 1.1 Was the allocation sequence random?

56. What is the comparative effectiveness and harms of treatments for traumatic brain injury? Preliminary Key Questions 1. What is the comparative effectiveness of the treatments for TBI for grades I-IV? 2. For patients, what are the potential… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-is-the-comparative-effectiveness-and-harms-of-treatments-for-traumatic-brain-injury-preliminary-key-questions-1-what-is-the-comparative-effectiveness-of-the-treatments-for-tbi-for-grades-i-iv-2-for-patients-what-are-the
    November 01, 2017 - Does your question include a comparison of different health care approaches? … What patients or group(s) of patients does your question apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … disparities, inequities, or impact on vulnerable populations your question applies to.

57. Our topic of nomination is Postpartum Hemorrhage. The following is a list of clinical questions practitioners consider when managing such cases: • What should be considered in the initial evaluation of a patient with excessive bleeding in… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/our-topic-of-nomination-is-postpartum-hemorrhage-the-following-is-a-list-of-clinical-questions-practitioners-consider-when-managing-such-cases-what-should-be-considered-in-the-initial-evaluation-of-a-patient-with-excessive-b
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Postpartum women Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.

58. Diagnosis and management of goutKey questions: What is the accuracy of clinical criteria only in the diagnosis of acute gouty arthropathy instead of synovial fluid analysis? In adults with a history of gout, do… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/diagnosis-and-management-of-goutbr-key-questionsbr-ol-liwhat-is-the-accuracy-of-clinical-criteria-only-in-the-diagnosis-of-acute-gouty-arthropathy-instead-of-synovial-fluid-analysisli-liin-adults-with-a-history-of-gout-do-re
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.

59. With the rates of birth by cesarean section on the rise, what factors influence (and which have the greatest impact on) the probability of delivery by cesarean in low-risk women? Which interventions are most effective at reducing the risk… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/with-the-rates-of-birth-by-cesarean-section-on-the-rise-what-factors-influence-and-which-have-the-greatest-impact-on-the-probability-of-delivery-by-cesarean-in-low-risk-women-which-interventions-are-most-effective-at-reducin
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Are there subgroups of patients that your question might apply to? … What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.

60. For persons who present with acute cough illness (ACI), what is the comparative effectiveness of various interventions for reducing inappropriate antimicrobial use? | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-persons-who-present-with-acute-cough-illness-aci-what-is-the-comparative-effectiveness-of-various-interventions-for-reducing-inappropriate-antimicrobial-use
    November 01, 2017 - Does your question include a comparison of different health care approaches? … Are there subgroups of patients that your question might apply to? … New evidence has emerged since 2 What specifically motivated you to ask this question? … Does your question represent uncertainty for clinicians and/or policy-makers? … Describe the timeframe in which an answer to your question is needed.