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  1. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-adherence_research-protocol.pdf
    September 13, 2011 - Key Questions (KQs) Change KQ 2 to a new contextual question (contextual question 3; Appendix … The revised KQs and contextual question are attached (Appendix B). … The original KQ 2 has been changed to a contextual question. 04/16/2012 II. … The original KQ 2 has been changed to a contextual question. 4/16/2012 IV. … The original KQ 2 has been changed to a contextual question.
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-0855-170515.pdf
    April 28, 2017 - The questions for this nomination are: Key Question 1a. … Key Question 1b. … Key Question 2a. … 2 Key Question 2b. … Key Questions and PICOs Key Question 1a.
  3. effectivehealthcare-admin.ahrq.gov/sites/default/files/tnd-0855-170515.pdf
    April 28, 2017 - The questions for this nomination are: Key Question 1a. … Key Question 1b. … Key Question 2a. … 2 Key Question 2b. … Key Questions and PICOs Key Question 1a.
  4. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/medical-test-reviews-risk-bias.ppt
    June 01, 2012 - Practice Question 1 (1 of 2) Practice Question 1 (1 of 2) Explanation for Question 1: The correct … True False Practice Question 2 (1 of 2) Practice Question 2 (1 of 2) Explanation for Question 2: … Practice Question 2 (2 of 2) Practice Question 2 (2 of 2) What is the QUADAS-2? … 3 (1 of 2) Practice Question 3 (1 of 2) Explanation for Question 3: The correct answer is d. … True False Practice Question 4 (1 of 2) Practice Question 4 (1 of 2) Explanation for Question 4:
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/medical-test-reviews-risk-bias.ppt
    June 01, 2012 - Practice Question 1 (1 of 2) Practice Question 1 (1 of 2) Explanation for Question 1: The correct … True False Practice Question 2 (1 of 2) Practice Question 2 (1 of 2) Explanation for Question 2: … Practice Question 2 (2 of 2) Practice Question 2 (2 of 2) What is the QUADAS-2? … 3 (1 of 2) Practice Question 3 (1 of 2) Explanation for Question 3: The correct answer is d. … True False Practice Question 4 (1 of 2) Practice Question 4 (1 of 2) Explanation for Question 4:
  6. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/labor-nitrous-oxide_disposition-comments.pdf
    August 23, 2012 - as a bulleted point into Key Question 4. … Reviewer #11 Methods Key Question 4, pp. 17-18: I question the term “harms” to describe nausea and drowsiness … Reviewer #11 Methods Key Question 4. … Reviewer #11 Methods Key Question 4. … Findings are presented by key question.
  7. effectivehealthcare-admin.ahrq.gov/sites/default/files/product/pdf/respectful-maternity-care-protocol.pdf
    September 16, 2022 - Contextual Question CQ1. … Key Question 1: Our working definition for “validated” tools and measures will consider studies that … Contextual Question: This question aims to identify definitions and components of RMC described in the … These sources may be more apt to inform the contextual question. Search Strategy. … Contextual Question: We will organize the contextual question according to the sub- questions, and qualitatively
  8. Gout Executive-2016 (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/gout_executive-2016.pdf
    January 01, 2016 - Key Question 1. a. … Key Question 2. … Key Question 1. a. … Key Question 1d. … Key Question 2.
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/protocol-social-isolation.pdf
    January 01, 2013 - framework for Addressing Social Isolation to Improve Health of Older Adults: A Rapid Evidence Review Question … isolation and loneliness Adults 60+ years old Health outcomes Health care utilization Harms Question … An arrow labeled "Question 1" connects "Interventions that target social isolation and loneliness" to … An arrow labeled "Question 2" connects "Interventions that target social isolation and loneliness" to
  10. effectivehealthcare-admin.ahrq.gov/products/mhs4-opioid-stewardship/protocol
    September 05, 2023 - For Review Question 2, we will focus on identifying relevant measures that are included in the Centers … , including PSPs used and explanations of the rationale presented in the studies we find for Review Question … For Review Question 8, we will identify publicly available patient safety toolkits developed by AHRQ … Risk of Bias (Quality) Assessment For studies that address Review Question 5 about … For Review Question 5 about the effectiveness of PSPs, we will record information about the context of
  11. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/treatment-resistant-depression_research-protocol.pdf
    December 09, 2009 - ]) • Comparators: ECT, rTMS, VNS, psychotherapy, pharmacologic treatments • Outcomes for each question … We will systematically search, review, and analyze the scientific evidence for each key question and … To identify articles relevant to each key question, we began with a focused MEDLINE search on depression … Grading the Evidence for Each Key Question We will rate the strength of evidence based on the standard … See notes under the key question for the rationale.
  12. effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-screening/research-protocol
    December 01, 2019 - Question 3: Interval of Screening What is the test performance of fecal DNA testing across different … Question 4: Analytic Validity What is the analytic validity (analytic sensitivity, specificity, and … Question 5: Acceptability of Testing What is the acceptability and adherence of fecal DNA screening … Question 6: Harms What are the potential harms of fecal DNA testing? … Question 1 How have fecal DNA assays evolved over time?
  13. effectivehealthcare-admin.ahrq.gov/products/bereaved-persons/protocol
    December 01, 2023 - 1), screening tools (Key Question 2), bereavement interventions (Key Question 3), and maladaptive grief-related … Key Question 4: What are the effectiveness, comparative effectiveness and harms of interventions for … We will tailor the risk of bias assessment to the question the study is used to answers. … target condition as defined by the reference standard does not fully match the review question. … Data Synthesis We will answer each key question with the available evidence.
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_surveillance.pdf
    June 01, 2012 - The conclusion(s) for each key question are found in the executive summary of the CER report.1 2 … No new evidence was identified for this question. … Conclusion: 1 of 3 conclusions is possibly out of date Key Question # 3 Signals from studies … identified through update search: No new evidence was identified for this question. … (Yes/No/Don’t know) If yes, please provide references Comments Key Question 1.
  15. effectivehealthcare-admin.ahrq.gov/sites/default/files/carman-presentation.pdf
    November 11, 2015 - We come in as researchers and we say, “This is really the important question.” … And our patient says, “That’s not my question at all. My question is, when do I go back to work? … That’s my question.” … And everyone here knows there is not a RCT that will answer that question for anyone. … And what happens when we say I can’t answer that question. I don’t have the technology.
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/diagnostic-error-executive-summary.pdf
    August 01, 2023 - We synthesized results for each question and extrapolated U.S. estimates. … 2), and the chief causes of and risk factors for these errors (Key Question 3). … Results for Key Question 1 relied heavily on two large studies (one of medical malpractice claims, the … Overall (i.e., not disease-specific) error and harm rates for Key Question 2 relied heavily on three … Specific gaps identified for each question, with potential remedies, are described in the full report
  17. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
    September 01, 2016 - For this project we will focus on the fol- lowing sub-question: Key Question 2a: What is the safety … Published online: September 1, 2016 6 For the first question we will describe all studies … Description of incomplete or discontinued trials (question 3) We will create separate tables for those … studies that are incomplete or discontinued to address Question 3: “For studies in ClinicalTrials.gov … These data will be extracted as above to address this question.
  18. effectivehealthcare-admin.ahrq.gov/products/mhs4-active-infection/protocol
    September 01, 2023 - We will ask our content experts to answer Review Question 3 and 4 by citing selected references, including … surveillance PSPs used and explanations of the rationale presented in the studies we find for Review Question … For Review Question 8, we will identify publicly available patient safety toolkits developed by AHRQ … Since Review Question 5 calls for identification of studies on the effectiveness of infection surveillance … Risk of Bias (Quality) Assessment For studies that address Review Question 5 about
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/lung-cancer-staging_research-protocol.pdf
    December 08, 2014 - Quality of life Question 3. … Question 2) • Comparative tumor response (Key Question 2) • Comparative survival (Key QuestionQuestion 2) • Comparative harms due to undertreatment (Key Question 2) • Association between age … (Key Question 3) • Association between tumor characteristics and comparative accuracy (Key Question … This grade is provided separately for each outcome of each comparison of each Key Question.
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/patient-monitoring-systems-protocol.pdf
    July 01, 2023 - Safer (MHS) IV: Patient Monitoring Systems to Prevent Failure to Rescue Review Questions Review Question … For Contextual Question 4, we will identify publicly available patient safety toolkits developed by … Eligibility Criteria We will search for original studies and systematic reviews on the Review Question … Information will be organized to answer the Review Question and Contextual Questions, and will include … For the Review Question about the effectiveness of PSPs, we will record information about the context

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