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  1. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_executive.pdf
    February 01, 2013 - Summary of Evidence There is insufficient evidence to answer this Key Question. … Summary of Evidence There is insufficient evidence to answer this Key Question. … All studies addressing this Key Question evaluated IVUS only. … The summary of evidence for each Key Question is provided in Table C. … addressed Key Question 3.
  2. effectivehealthcare-admin.ahrq.gov/system/files/docs/topic-brief-hospital-length-of-stay.pdf
    November 01, 2019 - Collectively they cover many interventions relevant to question 1. … Literature identified for each Question Question Systematic reviews (7/2016-8/2019) Primary studies … We found 111 reviews that addressed Question 1, and 3 that addressed Question 2. … Question 1. … Collectively they cover many interventions relevant to question 1.
  3. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
    March 01, 2012 - Key Question 2. … Key Question 3. … Key Question 4. … Key Question 5a. … Key Question 5b.
  4. effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-226-labor-dystocia-comments.pdf
    May 14, 2020 - We have however revised the key question to be consistent with the order in which these specific … Results Peer Reviewer #1 On page 75, for KQ4, it appears the question is only about EA, yet look at … The key question provides an overview of the question to be addressed in that section. … of this question to: “Evaluating differences in outcomes with abnormal labor” or something to that … with abnormal labor we have not modified the specific key question wording.
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-0768-141211.pdf
    October 23, 2014 - Key Question #1: What is the comparative effectiveness of tonsillectomy in children with recurrent throat … Outcome(s): Number of throat infections, complications of infection, or complications of surgery Key Question … Key Question … In consultation with our clinical reviewer, the scope of this topic from the original nominator question
  6. effectivehealthcare-admin.ahrq.gov/products/emt-naloxon/research-protocol
    August 01, 2019 - Key Question 2 For patients with confirmed or suspected opioid overdose in out-of-hospital settings … Key Question 3 For patients with confirmed or suspected opioid overdose in out-of-hospital settings … Key Question 4 For patients with confirmed or suspected opioid overdose in out-of-hospital settings … , subcutaneous or intravenous) versus intranasal route of administration Key Question 1a : Comparisons … of different doses of intranasal, intramuscular, and intravenous naloxone Key Question 2 : Titration
  7. effectivehealthcare-admin.ahrq.gov/products/tethered-spinal-cord/protocol
    August 01, 2023 - 1), prophylactic treatment (Key Question 2), symptomatic treatment (Key Question 3), and repeat surgery … Following the described input, the final key questions are as follows: Key Question 1: What is the … Key Question 4: Among individuals who experience retethering after spinal detethering surgery, what … as defined by the reference standard does not fully match the review question. … We will stratify key question 3 (treatment) by symptom type, intensity, and patient age.
  8. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
    July 19, 2023 - 1), prophylactic treatment (Key Question 2), symptomatic treatment (Key Question 3), and repeat surgery … Following the described input, the final key questions are as follows: Key Question 1: What is the … Key Question 4: Among individuals who experience retethering after spinal detethering surgery, what … as defined by the reference standard does not fully match the review question. … We will stratify key question 3 (treatment) by symptom type, intensity, and patient age.
  9. Layout 1 (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_executive.pdf
    March 01, 2011 - Below we provide additional summary information for selected comparisons of interest by key question, … Key Question 1: Intermediate Outcomes Intermediate clinical outcomes were the most frequently evaluated … Therefore, most comparisons for this key question had a low strength of evidence. … Key Question 3: Adverse Events and Side Effects This Key Question was addressed by 107 studies. … Key Question 4: Differences in Subgroups Twenty-eight studies applied to Key Question 4.
  10. effectivehealthcare-admin.ahrq.gov/products/mhs4-surgical-report-cards/protocol
    September 01, 2023 - For Review Question 2, we will focus on identifying relevant measures that are included in the Centers … For Review Question 8, we will identify publicly available patient safety toolkits developed by AHRQ … Since Review Question 5 calls for identification of studies on the effectiveness of PSPs, we will describe … For Review Question 8, we will list the name and source of each relevant toolkit along with a 1-2 sentence … Risk of Bias (Quality) Assessment For studies that address Review Question 5 about
  11. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
    October 01, 2014 - Key Question 1. … Key Question 2. … Key Question 3. … Key Question 1. … Key Question 2.
  12. effectivehealthcare-admin.ahrq.gov/products/skin-lesions-evaluation/research-protocol
    December 01, 2019 - Guiding question 2: What is the current clinical context in which these new non-invasive modalities … Guiding question 3: What published and unpublished studies have reported on the use and safety of these … to comparative studies) Length of follow-up (applicable only to longitudinal studies) Guiding question … Data to be abstracted for answering Guiding Question 3 are described in section III.2. … Data Presentation We will generate tables (evidence map) summarizing items relevant to Guiding Question
  13. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/type-2-diabetes-medications-update_research-protocol.pdf
    April 06, 2010 - The Key Questions Key Question 1: In adults age 18 or older with type 2 diabetes mellitus, what is the … Outcomes for each question The outcomes for Key Question 1 are: • HgbA1c • Weight • Low density … □ For Key Question 1, we included the following outcomes: HgbA1c, weight, and serum lipid levels ( … □ For Key Question 3, we included the following outcomes: hypoglycemia, liver injury, congestive … □ For Key Question 1, we included only RCTs.
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mhs4-implicit-bias-protocol.pdf
    August 04, 2023 - For Review Question 2, 5 we will focus on identifying relevant measures that are included in … PSPs used and explanations of the rationale presented in the studies we find for Review Question 5 … For Review Question 8, we will identify publicly available patient safety toolkits developed by AHRQ … Risk of Bias (Quality) Assessment For studies that address Review Question 5 about the effectiveness … For Review Question 5 about the effectiveness of HCW implicit bias training and education PSPs, we
  15. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_research-protocol.pdf
    October 01, 2013 - dose/volume and number of doses) Comparators Key Question 1 and Key Question 2 (see Table 2) ● … Key Question 3 and Key Question 4 (see Table 3) ● IOCM versus LOCM ● LOCM versus LOCM ● IOCM (by … Setting ● Key Question 1 through Key Question 4 ● Inpatient and outpatient populations Source: www.effectivehealthcare.ahrq.gov … Major prevention interventions and comparisons for Key Question 1 and Key Question 2 (These are the … Major contrast media and comparisons for Key Question 3 and Key Question 4 (These are the important
  16. Layout 1 (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-2007_executive.pdf
    January 01, 2007 - 3 Key Question 2. … Key Question 3. … Key Question 1. … Key Question 2. … Key Question 3.
  17. Ced-Appendix-3 (xls file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ced-appendix-3.xlsx
    June 24, 2022 - Frame the question, which may involve use of a PICOTS framework Pearson Data Curate real world data … and/or develop the plan for data acquisition sufficient answer the question to meet the evidentiary … The specific clinical question of interest drives the consideration regarding whether an RWE approach … is sufficient and robust enough for the regulatory question at hand. … That is, are the data relevant and fit for purpose for the research question at hand?
  18. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/pharma-nonpharma-ptsd-2022-update-app-g1.xlsx
    January 01, 2022 - 2.4) (If Y, PY to previous question) were these deviations likely to have affected the outcome? … 2.7) (If N, PN, NI to previous question) Was there potential for a substantial impact (on the result) … 3.3) (If N/PN to previous question) Could missingness in the outcome depend on its true value? … 3.4) (If Y, PY, NI to previous question) Is it likely that missingness in the outcome depended on its … 4.5) (If Y/PY/NI to previous question) Is it likely that assessment of the outcome was influenced by
  19. effectivehealthcare-admin.ahrq.gov/products/ems-blood-transfusion/protocol
    February 01, 2025 - There was also one Contextual Question (CQ): CQ 1 . … Key Question 6. … Contextual Question 1. … Abbreviations : CQ = Contextual Question; EMS = emergency medical services; KQ = Key Question; PRBC = … Contextual Question 1.
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ems-blood-transfusion-protocol-amendment.pdf
    February 04, 2025 - Key Question 2 a. … Key Question 3 a. … Key Question 4 a. … Key Question 5 a. … Key Question 6.

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