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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
    September 22, 2014 - However, because these outcomes can be difficult to measure directly, other outcomes that occur intermediately … Therefore it will be important to capture how each study defines and measures appropriateness and consider … While this is not a direct measure of the primary outcomes, we will report these as indirect measures … of the strategy, such as increased time burden on clinicians, sustainability of intervention (e.g. measures … rated good in quality; the remainder will be rated fair in quality.
  2. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
    December 04, 2015 - For continuous outcomes measures, we will extract (by arm) the mean baseline and endpoint or change … scores, standard deviations (SD) or other measure of variability, and number analyzed. … quality, and 3 or fewer stars to indicate poor quality. … For quality of life and other continuous patient/parent/clinician-reported measures, we will use an … (e.g., aggression scales or subscales) if the scales are considered to measure the same construct;
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
    November 01, 2012 - psoriasis vulgaris, often appears as well-demarcated, erythematous plaques covered with silvery white scales … Therefore, we qualitatively evaluated the data and reported native measures of effect 5 that were … all were based on low strength of evidence.13,23 HRQoL was measured using both the DLQI and EQ-5D scales … Three scales were used to measure HRQoL in this trial—DLQI, EQ-5D, and SF-36 MCS (mental) and PCS ( … The validity and responsiveness of three quality of life measures in the assessment of psoriasis patients
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/glaucoma-treatment_research-protocol.pdf
    November 16, 2010 - Background and Objectives for the Systematic Review The Agency for Healthcare Research and Quality … www.effectivehealthcare.ahrq.gov/� Source: www.effectivehealthcare.ahrq.gov Published Online: November 16, 2010 Measures … Standardized mean differences will be calculated if continuous outcomes are measured by using different scales … Grading quality of evidence and strength of recommendations. BMJ 2004;328:1490. 14. … Agency for Healthcare Research and Quality.
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-update_research-protocol.pdf
    August 18, 2016 - , the Conner scales, and the SNAP-IV rating scales.21-23 Monitoring also includes assessment of any … Final Outcomes: Outcomes associated with having ADHD in childhood primarily are based on measures of … the diagnosis in the primary care setting and the diagnosis by the specialist will be converted into measures … Labeling will be any measure of stigma following diagnosis comparing those with and without ADHD. … o Risk of missed condition that can appear as ADHD (i.e., misdiagnosis) • Labeling will be any measure
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-diff-infections_research-protocol.pdf
    May 24, 2010 - Do performance measures vary with sample characteristics? … environmental cleaning, handcleansing, patient isolation, prebiotics or probiotics used as preventive measure … Prevention: placebo or active controls for probiotics used as preventive measure. … CDAD mortality rates Prevention Intermediate Process Measures/Outcomes 1. … Measures to control and prevent Clostridium difficile infection.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research.pdf
    March 01, 2018 - What were the differences, if any, in pre-specified outcome measures, statistical plan and size of the … completed studies which were in both: What were the differences, if any, in pre-specified outcome measures … , 9, 14 For two studies,9, 14 the ClinicalTrials.gov record and the publication reported different measures … All five of the studies listed quality of life as an outcome measure. … Topiramate and physiologic measures of nerve function in polyneuropathy.
  8. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd_executive.pdf
    September 01, 2011 - Similar considerations apply to the assessment of outcomes, which included measures of formal or informal … antireflux surgery also demonstrated improvement (in some cases statistically significant) on reflux symptom scales … No significant differences in heartburn score, SF-36 and Global REFLUX-QUAL scores, 24-hour pH study measures … is likely due to the considerable heterogeneity in the study populations, interventions, and outcome measures … in patients with exercise-induced asthma compared to a placebo, but not QoL or pulmonary function measures
  9. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/pelvic-pain_executive.pdf
    January 01, 2012 - Quality assessment. … We saw this variation in (1) definition of pelvic pain, (2) patient populations, (3) outcome measures … , (4) interventions, (5) timing of outcome measures and participant followup, and (6) comparators. … Studies differed considerably in terms of study populations, interventions, and outcome measures. … approaches to promote clear delineation of patient populations in CPP research • Standardizing outcome measures
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-adolescents_research-protocol.pdf
    March 29, 2011 - Outcomes • Respondents noted that outcome measures are variable across ASD research studies and … Residential supports • Comparators: o Placebo, usual care, or active control • Outcome measures … We will identify specific outcome measures to extract in consultation with the TEP and based on our … Pre-specifying each measure to extract is not feasible given the large number of assessment tools/measures … Assessment of Methodological Quality of Individual Studies We will assess study quality by using
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy-disposition-170415.pdf
    January 17, 2017 - Rockville, MD: Agency for Healthcare Research and Quality. January 2017. … its contents, and do not necessarily represent the views of the Agency for Healthcare Research and Quality … The multitude of outcome measures are defined. … Our key outcomes of interest included AHI, desaturation nadir, and measures of sleep quality including … under KQ1 I would like to read something about whether the AHI versus symptom relief is a better measure
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias_methods.pdf
    February 01, 2013 - The outcome measures included, and inclusion of non-English language papers account for at least some … that are notoriously characterized by variability in outcome measurement methods and a multitude of scales … choose to restrict to specific measurement methods (i.e., only including studies that used measurement scales … Because the study is registered at the beginning of the study, the intended primary outcome measures … Disagreements in meta-analyses using outcomes measured on continuous or rating scales: observer agreement
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/lung-cancer-nonsurgical-therapies_research-protocol.pdf
    February 22, 2012 - data analysis, including: ○ Statistical analyses (statistical test/estimation results) ○ Summary measures … ○ Sample variability measures ○ Precision of estimate ○ p values • Regression modeling techniques … ○ Were outcome measures clearly valid, reliable, and equally applied to treatment groups? … and elsewhere.27, 34, 35 When appropriate (e.g., similar instruments used or standardized effect measures … relevant and interpretable), outcome measures will be pooled according to AHRQ guidance, and synthesized
  14. effectivehealthcare.ahrq.gov/sites/default/files/grading.ppt
    January 01, 2013 - used by the Evidence-based Practice Centers (EPCs) to grade strength of evidence is based in large measure … reviewers can assess consistency on the basis of similarity of populations, interventions, and outcome measures … meta-analysis is appropriate, EPC reviewers can evaluate consistency by using statistical tests and measures … of life, or effects on laboratory measures or other surrogate variables) Each major harm (ranging … of life, or effects on laboratory measures or other surrogate variables) and each major harm (ranging
  15. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_executive.pdf
    September 01, 2009 - two options in terms of clinical events (e.g., myocardial infarction, stroke, or death), surrogate measures … Methodological Quality Assessment Study quality of RCTs was assessed with the Jadad scale, and of nonrandomized … Most of the evidence originates from short-term studies aimed at biochemical measures and therefore is … Measures of atherosclerosis Carotid intimal media thickness (IMT) can be measured by ultrasound and … • Measures of adherence and persistence are affected by the duration of the study period, and thus
  16. effectivehealthcare.ahrq.gov/sites/default/files/hip-fracture-pain.ppt
    May 01, 2011 - References: Agency for Healthcare Research and Quality. … Numerical scales show a linear correlation with VAS results. … Two methods are commonly used in clinical studies to measure the intensity of pain. … In using numerical scales, the patient is instructed to indicate a number, for example between 0 and … Numerical scales and the VAS show a linear correlation.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hip-fracture-pain.ppt
    May 01, 2011 - References: Agency for Healthcare Research and Quality. … Numerical scales show a linear correlation with VAS results. … Two methods are commonly used in clinical studies to measure the intensity of pain. … In using numerical scales, the patient is instructed to indicate a number, for example between 0 and … Numerical scales and the VAS show a linear correlation.
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/schizophrenia-adult_research-protocol.pdf
    September 23, 2016 - of life (using validated scales and including mental and physical health) § Ability to maintain … Re-hospitalization was not included because it is considered a flawed outcome measure for two reasons … the intervention, e.g.: • New or worsening symptoms (e.g., anxiety or depression) using validated scales … of life (using validated scales and including mental and physical health) • Ability to maintain … a priori, but poor-quality studies will be considered to be less reliable than higher quality studies
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/abnormal-uterine-bleeding_executive.pdf
    March 01, 2013 - However it is crucial to note that direct measures of ovulation are not employed in most available … function as reported by sexual function measures, general measures of sexual activity, frequency and … Quality (Risk of Bias) Assessment We assessed quality of RCTs using the Cochrane Collaboration Risk … For regularity of bleeding no two measures of outcome were the same. … Two studies were classified as good 6 quality,51,60 two studies as fair quality,55,63 and six
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_clinician.pdf
    August 01, 2016 - The other review assessed the evidence regarding the comparative efficacy of measures to prevent CIN … In 2013, the National Kidney Foundation– Kidney Disease Outcomes Quality Initiative recommended the … strength of a body of evidence when comparing medical interventions—Agency for Healthcare Research and Quality … Evidence-based Practice Center under Contract 290-2012-00007-I for the Agency for Healthcare Research and Quality … published in December 2015) and Contrast-Induced Nephropathy: Comparative Effectiveness of Preventive Measures

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