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effectivehealthcare.ahrq.gov/decision-aids/prostate-cancer/05.html
June 08, 2018 - For those men that choose screening, two tests that may be used to detect prostate cancer are:
PSA … blood test: A blood test that detects a protein, called prostate-specific antigen (PSA), made by the … This test shows how much PSA is in your blood. … If your PSA levels are higher than normal or have increased over time, your doctor might test you for
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www.ahrq.gov/research/findings/nhqrdr/chartbooks/careaffordability/measures3.html
June 01, 2018 - Services Task Force recommended against screening men age 75 and over with prostate-specific antigen (PSA … Overall Rate: In 2014, 21.1% of men age 40 and over reported a PSA test in the past year (data not shown … Groups With Disparities:
In 2014, men ages 40-54 were less likely to receive a PSA test in the past … Among men ages 40-54, Asians were less likely than Whites to receive PSA testing and Blacks were more … Among men age 75 and over, AI/ANs were less likely than Whites to receive PSA testing.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/prostate-cancer-screening
May 08, 2018 - Objective: To systematically review evidence on prostate-specific antigen (PSA)–based prostate cancer … Effectiveness of PSA-Based Screening
Key Question 1. … What are the harms of PSA-based screening for prostate cancer and diagnostic follow-up? … Contamination in PLCO control group, and low adherence with single PSA screening in CAP. … ERSPC sites with variable PSA thresholds for positive test results.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-summary.pdf
September 01, 2020 - clinically localized prostate cancer (CLPC) detected clinically rather than
by prostate-specific antigen (PSA … to no mortality difference versus RP
or external beam radiation (EBR)+androgen deprivation (AD) in PSA … ProtecT PSA-based active monitoring group is labeled active surveillance in figure. … Absolute effects are
likely smaller among PSA-detected CLPC due to its more indolent course. … AM was compared with RP or EBR plus AD in PSA screen–detected CLPC.
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effectivehealthcare.ahrq.gov/sites/default/files/prostate-cancer-therapies-summary.pdf
September 01, 2020 - clinically localized prostate cancer (CLPC) detected clinically rather than
by prostate-specific antigen (PSA … to no mortality difference versus RP
or external beam radiation (EBR)+androgen deprivation (AD) in PSA … ProtecT PSA-based active monitoring group is labeled active surveillance in figure. … Absolute effects are
likely smaller among PSA-detected CLPC due to its more indolent course. … AM was compared with RP or EBR plus AD in PSA screen–detected CLPC.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer_executive.pdf
February 01, 2008 - We focused on baseline PSA levels and
Gleason histologic score. … Prostate cancers not
detected by PSA testing. … with PSA levels and rate of PSA
rise … levels
in men with PSA-detected disease. … PSA
testing.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening-1996
January 01, 1996 - , 17 and its role in screening has largely been replaced by PSA. … PSA elevations are not specific for prostate cancer. … suggested that PSA density (the PSA concentration divided by the gland volume as measured by TRUS) may … Other studies suggest that the rate of change (PSA velocity), rather than the actual PSA level, is a … PSA screening for asymptomatic prostate cancer: truth in advertising.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_executive.pdf
December 01, 2011 - Two cohorts
used PSA density (PSA per volume of prostate tissue)
thresholds. … All seven cohorts in the PSA screening era
included regular PSA testing. … screening era reported
that PSA testing became part of followup protocol after PSA
became available. … All six cohorts in the PSA screening era
included regular PSA testing as part of followup protocol. … at diagnosis,
decreased free-to-total PSA ratio, or more rapid PSA
increase, but not comorbidities or
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary43/prostate-cancer-screening-2012
October 07, 2011 - group (50% received ≥1 PSA test). … Annual PSA for 6 y
Annual DRE for 4 y
PSA cut point >4.0 µg/L
Positive … PSA previously >3.0 µg/L, a PSA increase of 20% over previous year's value or over predicted PSA … < 10 µg/L: 22% PSA 11–29 µg/L: 28% PSA > 30 µg/L: 23% PSA unknown: 27%
Age, period of diagnosis, method … < 10 µg/L: 57% PSA 10–20 µg/L: 26% PSA > 20 µg/L: 11% PSA unknown: 13%
Age at diagnosis, race/ethnicity
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_disposition-comments.pdf
April 01, 2013 - Current AUA guidelines for PSA screening recommend another
serum PSA when presented with an abnormal … values (PSA velocity) if available, free
PSA if available, family history, race, etc. are considered … It is likely that tPSA
and PSA density are correlated because tPSA is used in the calculation of
PSA … serum PSA, this approach introduces the following issues:
1) PSA is used differently for repeat … PSA data.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/HUjbcP7uLa2SrGpVW4Fbhd
August 07, 2008 - Insufficient Evidence)
Men Age 75 Years or Older
Do not screen
Grade: D
The prostate-specific antigen (PSA … The conventional PSA test cut-point of 4.0 g/L misses some early cancer. … Variations of PSA screening have not yet been demonstrated to improve health outcomes. … If PSA screening reduces mortality, screening every 4 years may be as beneficial as annual screening. … Interventions
Clinicians should discuss the potential benefits and known harms of PSA screening with
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effectivehealthcare.ahrq.gov/products/prostate-cancer-test/research
April 01, 2013 - Comparators included total prostate specific antigen (PSA) elevations, free PSA, PSA density, PSA velocity … , externally validated nomograms, complexed PSA, and multivariate models. … Comparison of PCA3 to total PSA (tPSA) had the most available studies (22) but was subject to spectrum
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_surveillance.pdf
March 01, 2013 - Thus, 14 articles were reviewed for PsA. … A new meta-analysis9 found PsA
Response Criteria (PsARC)
response at 12-14 weeks was
significantly … This drug is
not approved for
PsA. … This drug is
not approved for
PsA.
EPC Investigator felt the
conclusions were up to date. … This drug is
not approved for
PsA.
EPC Investigator felt the
conclusions were up to date.
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effectivehealthcare.ahrq.gov/decision-aids/prostate-cancer/07.html
June 08, 2018 - Your doctor will use your PSA level, Gleason Score, and tumor "T stage" to determine whether your cancer … Prostate Cancer Risk Groups
Low Risk
Low-risk cancer has PSA levels less than 10 ng/ml, Gleason … Intermediate/Medium Risk
Medium-risk cancer has PSA levels of 10–20 ng/ml, Gleason Scores of 7, or … High Risk
High-risk cancer has PSA levels of more than 20 ng/ml, Gleason Scores of 8 or higher, or
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_executive.pdf
December 01, 2014 - Comparative Effectiveness Review
Number 146
a physical examination, prostate-specific
antigen (PSA … Effective Health Care Program
2
The PSA test is used to measure blood levels of PSA, a
protein produced … separating a “normal” PSA
level from an abnormal level also remains a subject of
debate. … PSA, PSA kinetics (rate of rise in
PSA over time and doubling time for PSA), and digital
rectal examination … cancer (especially low PSA/low-risk disease, but possibly
intermediate PSA/intermediate-risk disease
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www.uspreventiveservicestaskforce.org/Home/GetFileByID/3786
October 09, 2018 - How to interpret the recommendation
What is the PSA test? … The PSA test measures the amount of prostate-specific antigen,
a type of protein, in a man’s blood. … When a man has an
elevated PSA level, it may be caused by prostate cancer, but it
could also be caused … What’s the harm in getting a PSA test? … It includes
regular, repeated PSA testing and often repeated digital rectal
examination and prostate
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www.uspreventiveservicestaskforce.org/Home/GetFileByToken/-BbKrbuLt9RAPvf3BQrUMW
October 09, 2018 - How to interpret the recommendation
What is the PSA test? … The PSA test measures the amount of prostate-specific antigen,
a type of protein, in a man’s blood. … When a man has an
elevated PSA level, it may be caused by prostate cancer, but it
could also be caused … What’s the harm in getting a PSA test? … It includes
regular, repeated PSA testing and often repeated digital rectal
examination and prostate
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effectivehealthcare.ahrq.gov/products/arthritis-psoriatric/research-protocol
December 06, 2010 - PDF 729.3 KB
Background and Objectives for the Systematic Review
Psoriatic arthritis (PsA … PsA has a highly variable presentation, which generally involves pain and inflammation in joints and … Additionally, PsA may predate the development of skin disease leading to some diagnostic uncertainty. … In the general population the prevalence of PsA is estimated to be 0.3% to 1%. … Treatment of psoriatic arthritis (PsA) aims to control pain and inflammation and, ultimately, to slow
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www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/file/supporting_documents/prostate-cancer-draft-bulletin.pdf
April 03, 2017 - For men ages 70 years and older, the
potential benefits of PSA-based screening do not outweigh
the … (D recommendation)
Visit
www.screeningforprostatecancer.org
for more information
The PSA test … When a man has an elevated PSA, it may be caused by prostate cancer, but it could also be caused by … PSA-based
screening and follow-up prostate biopsies cannot tell for sure which cancers are likely to … based in part on new evidence on the use of active surveillance,
which includes regular, repeated PSA
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effectivehealthcare.ahrq.gov/products/prostate-cancer-therapies-update/consumer
January 21, 2016 - PSA blood test: This blood test tells how much PSA (a protein made by the prostate gland) is in your … Many men with prostate cancer have PSA levels that are higher than normal or that have gotten higher … A high PSA level does not always mean a man has prostate cancer. … This growth, and other health conditions, can cause a high PSA level in men who do not have prostate … Determining risk level
Risk Level*
PSA Level
Gleason Score
T-Score
* From the 2015 clinical