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21. Screening for Prostate Cancer: Clinical Summary of USPSTF Recommendation (2012) (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/JosR5xCYBoK6K9BTbsaQD3
    May 15, 2012 - RECOMMENDATION Population Adult males Recommendation Do not use prostate-specific antigen (PSA … Contemporary recommendations for prostate cancer screening all incorporate the measurement of serum PSA … There is convincing evidence that PSA-based screening programs result in the detection of many cases … prostate cancer, and that a substantial percentage of men who have asymptomatic cancer detected by PSA … The benefits of PSA-based screening for prostate cancer do not outweigh the harms.

22. STATISTICAL BRIEF #42: Screening for Prostate Cancer with the Prostate-Specific Antigen Test, United States, 2002
    meps.ahrq.gov/data_files/publications/st42/draft/stat42.shtml
    September 01, 2004 - 50 to 64) without health insurance coverage were less likely than those with coverage to receive the PSA … Regardless of health insurance status, men ages 65 and older had a higher rate of PSA testing than did … Among men ages 50 to 64, Hispanic men were less likely to be screened for prostate cancer with a PSA … Preventive Services Task Force has declined to recommend routine screening with the PSA test. … Findings Less than half (45.5 percent) of men in the United States ages 50 to 64 received a PSA test

23. STATISTICAL BRIEF #42: Screening for Prostate Cancer with the Prostate-Specific Antigen Test, United States, 2002
    meps.ahrq.gov/data_files/publications/st42/stat42.shtml
    September 01, 2004 - 50 to 64) without health insurance coverage were less likely than those with coverage to receive the PSA … Regardless of health insurance status, men ages 65 and older had a higher rate of PSA testing than did … Among men ages 50 to 64, Hispanic men were less likely to be screened for prostate cancer with a PSA … Preventive Services Task Force has declined to recommend routine screening with the PSA test. … Findings Less than half (45.5 percent) of men in the United States ages 50 to 64 received a PSA test

24. Archived: Prostate Cancer: Screening, 2002 | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening-2002
    December 01, 2002 - detected 26 percent more cancers than PSA alone. 7 However, combining DRE and PSA also increases the … Sensitivity and specificity of PSA screening depend on the value used to define an abnormal PSA result … These include PSA density (the ratio of the PSA level to the volume of the prostate as measured by trans‐rectal … ultrasound (TRUS), PSA velocity (the rate at which the PSA increases over time), age‐ and race‐adjusted … reference ranges, and percentage of free PSA (the proportion of total PSA that is not bound to serum

25. Archived: Prostate Cancer: Screening, 2008 | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening-2008
    August 05, 2008 - The conventional PSA test cut-point of 4.0 μg/L misses some early cancer. … Variations of PSA screening have not yet been demonstrated to improve health outcomes. … age-adjusted PSA cut-points, free PSA, PSA density, PSA velocity, PSA slope, and PSA doubling time, have … over time (for example, measurements of PSA velocity, PSA slope, or PSA doubling time). … Prostate-specific antigen (PSA) best practice policy.

26. Recommendation: Prostate Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening
    May 08, 2018 - 69 years For men aged 55 to 69 years, the decision to undergo periodic prostate-specific antigen (PSA … C Men 70 years and older The USPSTF recommends against PSA-based screening for prostate cancer … Overall, 34% of invited men received a valid PSA screening test. … The false-positive rate for the PSA test depends on the PSA threshold used. … trial and men in the usual care group received 3 PSA tests. 26 This high PSA testing rate in the control

27. Screening for Prostate Cancer: U.S. Preventive Services Task Force Recommendation Statement (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/zYdjLaTCTBVUwgJTnzpVXr
    May 08, 2018 - EVIDENCE REVIEW The USPSTF reviewed the evidence on the benefits and harms of PSA-based screening for … The reviews also examined the benefits and harms of PSA-based screening in patient subpopulations at … Overall, 34% of invited men received a valid PSA screening test. … The false-positive rate for the PSA test depends on the PSA threshold used. … trial and men in the usual care group received 3 PSA tests.26 This high PSA testing rate in the control

28. Overview of Prostate Cancer Screening Decision Models: A Contextual Review for the U.S. Preventive Services Task Force (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/vTHBrY6VuqjoouJvUmtkr4
    May 01, 2018 - Lowering the age to stop screening, lengthening the intervals between PSA testing, and raising the PSA … Unlike the MISCAN-PRO or SCANS models, the PSAPC model models PSA growth (i.e., generates a PSA level … Updated screening patterns indicate that fewer AA men received PSA testing (at least one PSA test) in … > 4.0 µg/L or PSA velocity >0.35 µg/L per year †Annual (quinquennial if age <50 and PSA <1 µg/L) ‡ … PSA >2.5 µg/L or PSA velocity >0.35 µg/L per year §Annual (biennial if PSA <2.5 µg/L) ║Bienniel (quinquennial

29. Overview of Prostate Cancer Screening Decision Models: A Contextual Review for the U.S. Preventive Services Task Force (pdf file)
    www.uspreventiveservicestaskforce.org/Home/GetFile/1/16813/prostate-cancer-models-overview/pdf
    May 01, 2018 - Lowering the age to stop screening, lengthening the intervals between PSA testing, and raising the PSA … Unlike the MISCAN-PRO or SCANS models, the PSAPC model models PSA growth (i.e., generates a PSA level … Updated screening patterns indicate that fewer AA men received PSA testing (at least one PSA test) in … > 4.0 µg/L or PSA velocity >0.35 µg/L per year †Annual (quinquennial if age <50 and PSA <1 µg/L) ‡ … PSA >2.5 µg/L or PSA velocity >0.35 µg/L per year §Annual (biennial if PSA <2.5 µg/L) ║Bienniel (quinquennial

30. Statistical Brief #233: Screening for Prostate Cancer with the Prostate-Specific Antigen Test--United States, 2006 (pdf file)
    meps.ahrq.gov/data_files/publications/st233/stat233.pdf
    January 01, 2009 - Food and Drug Administration (FDA) has approved the prostate-specific antigen (PSA) test along with … Currently there is no consensus on the appropriate use of the PSA test for early detection of prostate … Furthermore the USPSTF suggests that men younger than 75 discuss the benefits and harms of the PSA test … However, less than half (44.2 percent) of men in the United States ages 50 to 64 received a PSA test … Men aged 65 to 74 were more likely to have received a PSA test for prostate screening than men ages

31. STATISTICAL BRIEF #233: Screening for Prostate Cancer with the Prostate-Specific Antigen Test -- United States, 2006
    meps.ahrq.gov/data_files/publications/st233/draft/stat233.shtml
    January 01, 2009 - 76.9 percent) of men ages 65 to 74 were reported to have been screened for prostate cancer with the PSA … Food and Drug Administration (FDA) has approved the prostate-specific antigen (PSA) test along with a … Currently there is no consensus on the appropriate use of the PSA test for early detection of prostate … However, less than half (44.2 percent) of men in the United States ages 50 to 64 received a PSA test … More than three-fourths (76.9 percent) of men ages 65 to 74 received a PSA test in the past two years

32. STATISTICAL BRIEF #233: Screening for Prostate Cancer with the Prostate-Specific Antigen Test -- United States, 2006
    meps.ahrq.gov/data_files/publications/st233/stat233.shtml
    January 01, 2009 - 76.9 percent) of men ages 65 to 74 were reported to have been screened for prostate cancer with the PSA … Food and Drug Administration (FDA) has approved the prostate-specific antigen (PSA) test along with a … Currently there is no consensus on the appropriate use of the PSA test for early detection of prostate … However, less than half (44.2 percent) of men in the United States ages 50 to 64 received a PSA test … More than three-fourths (76.9 percent) of men ages 65 to 74 received a PSA test in the past two years

33. Arthritis-Psoriatric Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_executive.pdf
    April 01, 2012 - Psoriatic Arthritis in Adults: Update of a 2007 Report Executive Summary Background Psoriatic arthritis (PsA … PsA has a highly variable presentation, which generally involves pain and inflammation in joints and … In the general population, the prevalence of PsA is estimated to be 0.3 percent to 1 percent. … Census, 520,000 people ages 18 or older in the United States have PsA. … However the current available evidence for PsA was limited.

34. PCA3 Testing for the Diagnosis and Management of Prostate Cancer | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/prostate-cancer-test/research-protocol
    October 14, 2011 - values, decreased percent-free PSA levels, elevated PSA velocities, complexed PSA, or externally validated … values, decreased percent-free PSA levels, elevated PSA velocities, complexed PSA, or externally validated … PCA3 comparators Total PSA Percent free PSA PSA velocity Complexed PSA Externally validated … , percent free PSA, PSA velocity, complexed PSA, externally validated nomograms) KQ3: No PCA3 testing … , % free PSA, PSA velocity, complexed PSA, or externally validated nomograms) in predicting initial or

35. Therapies for Clinically Localized Prostate Cancer | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/prostate-cancer-therapies/report
    September 17, 2020 - clinically localized prostate cancer (CLPC) detected clinically rather than by prostate-specific antigen (PSA … to no mortality difference versus RP or external beam radiation (EBR)+androgen deprivation (AD) in PSA … Among clinically rather than prostate-specific antigen (PSA) detected CLPC, Watchful Waiting (WW) may … Active Monitoring (AM) probably results in little to no difference in mortality in PSA-detected CLPC … RCTs in PSA-detected and MRI staged CLPC are needed.

36. Overdiagnosis in Prostate Cancer Screening Decision Models: A Contextual Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/KT7vaWK_JSDNNvEmUAjN8d
    May 01, 2018 - Modeling studies suggest that raising the PSA threshold, lengthening the interval of screening, and … PSA screening is superimposed to estimate lead time. … at diagnosis) Generates PSA level per individual at each screen, PSA >4 μg/L at screen referred … (1) increases w ith age w ithin category of Gleason score and PSA. … <1 µg/L) ‡PSA >2.5 µg/L or PSA velocity >0.35 µg/L per year Abbreviations: PSAPC = Prostate-Specific

37. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0332_07-29-2010.pdf
    January 01, 2010 - in comparing results of screening with PCA3 with results of traditional prostate specific antigen (PSA … Transcription-mediated amplification of PCA3 and PSA mRNA in urine sample b. … How does sensitivity and specificity vary by score (ratio of PCA3/PSA mRMA) cut-off? b. … How do these issues vary as a function of PSA result and biopsy status? 4. … Reduction in unnecessary initial biopsies resulting from false positive PSA results ii.

38. Screening for Prostate Cancer: Recommendation Statement (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/zxXWqacXvfKPyQB9LCrZjX
    August 01, 2008 - Variations of PSA screening, including the use of age- adjusted PSA cut-points, free PSA, PSA density … , PSA ve- locity, PSA slope, and PSA doubling time, have been pro- posed to improve detection of “clinically … over time (for example, measurements of PSA velocity, PSA slope, or PSA doubling time). … The conventional PSA test cut-point of 4.0 g/L m isses som e early cancer. … Prostate-specific antigen (PSA) best prac- tice policy.

39. Prostate-Cancer-Test Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
    October 14, 2011 - values, decreased percent-free PSA levels, elevated PSA velocities, complexed PSA, or externally validated … values, decreased percent- free PSA levels, elevated PSA velocities, complexed PSA, or externally validated …  PCA3 comparators ○ Total PSA ○ Percent free PSA ○ PSA velocity ○ Complexed PSA ○ Externally … , percent free PSA, PSA velocity, complexed PSA, externally validated nomograms) KQ3: No PCA3 testing … , % free PSA, PSA velocity, complexed PSA, or externally validated nomograms) in predicting initial

40. Overdiagnosis in Prostate Cancer Screening Decision Models: A Contextual Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/Home/GetFile/1/16812/prostate-models-overdiagnosis/pdf
    May 01, 2018 - Modeling studies suggest that raising the PSA threshold, lengthening the interval of screening, and … PSA screening is superimposed to estimate lead time. … at diagnosis) Generates PSA level per individual at each screen, PSA >4 μg/L at screen referred … (1) increases w ith age w ithin category of Gleason score and PSA. … <1 µg/L) ‡PSA >2.5 µg/L or PSA velocity >0.35 µg/L per year Abbreviations: PSAPC = Prostate-Specific