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21. Archived: Prostate Cancer: Screening, 2002 | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening-2002
    December 01, 2002 - detected 26 percent more cancers than PSA alone. 7 However, combining DRE and PSA also increases the … Sensitivity and specificity of PSA screening depend on the value used to define an abnormal PSA result … These include PSA density (the ratio of the PSA level to the volume of the prostate as measured by trans‐rectal … ultrasound (TRUS), PSA velocity (the rate at which the PSA increases over time), age‐ and race‐adjusted … reference ranges, and percentage of free PSA (the proportion of total PSA that is not bound to serum

22. Archived: Prostate Cancer: Screening, 2008 | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening-2008
    August 05, 2008 - The conventional PSA test cut-point of 4.0 μg/L misses some early cancer. … Variations of PSA screening have not yet been demonstrated to improve health outcomes. … age-adjusted PSA cut-points, free PSA, PSA density, PSA velocity, PSA slope, and PSA doubling time, have … over time (for example, measurements of PSA velocity, PSA slope, or PSA doubling time). … Prostate-specific antigen (PSA) best practice policy.

23. Is Prostate Cancer Screening Right for You? (pdf file)
    www.uspreventiveservicestaskforce.org/Home/GetFileByID/3795
    May 01, 2018 - Risks for Men 55–69 The prostate-specific antigen (PSA) screening test is the most common method clinicians … The PSA test measures the amount of PSA, a type of protein, in the blood. … When a man has an elevated PSA level, it may be caused by prostate cancer, but it could also be caused … (C grade) Men Offered PSA-Based Screening 1,000 Of Get a Positive Result 240 which may indicate … the trial. ***1.3 deaths are avoided per 1,000 men offered PSA-based screening.

24. Is Prostate Cancer Screening Right for You? (pdf file)
    www.uspreventiveservicestaskforce.org/Home/GetFileByToken/HV9RGq3wLyh6PyK4oxVtde
    May 01, 2018 - Risks for Men 55–69 The prostate-specific antigen (PSA) screening test is the most common method clinicians … The PSA test measures the amount of PSA, a type of protein, in the blood. … When a man has an elevated PSA level, it may be caused by prostate cancer, but it could also be caused … (C grade) Men Offered PSA-Based Screening 1,000 Of Get a Positive Result 240 which may indicate … the trial. ***1.3 deaths are avoided per 1,000 men offered PSA-based screening.

25. Recommendation: Prostate Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening
    May 08, 2018 - 69 years For men aged 55 to 69 years, the decision to undergo periodic prostate-specific antigen (PSA … C Men 70 years and older The USPSTF recommends against PSA-based screening for prostate cancer … Overall, 34% of invited men received a valid PSA screening test. … The false-positive rate for the PSA test depends on the PSA threshold used. … trial and men in the usual care group received 3 PSA tests. 26 This high PSA testing rate in the control

26. Screening for Prostate Cancer: U.S. Preventive Services Task Force Recommendation Statement (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/zYdjLaTCTBVUwgJTnzpVXr
    May 08, 2018 - EVIDENCE REVIEW The USPSTF reviewed the evidence on the benefits and harms of PSA-based screening for … The reviews also examined the benefits and harms of PSA-based screening in patient subpopulations at … Overall, 34% of invited men received a valid PSA screening test. … The false-positive rate for the PSA test depends on the PSA threshold used. … trial and men in the usual care group received 3 PSA tests.26 This high PSA testing rate in the control

27. Final Recommendation Statement: Prostate Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/RecommendationStatementFinal/prostate-cancer-screening
    May 08, 2018 - Estimated Effects After 13 Years of Inviting Men Aged 55 to 69 Years in the United States to PSA-Based … USPSTF Assessment PSA-based screening for prostate cancer has both potential benefits and harms. … Overall, 34% of invited men received a valid PSA screening test. … The false-positive rate for the PSA test depends on the PSA threshold used. … trial and men in the usual care group received 3 PSA tests. 26 This high PSA testing rate in the control

28. Statistical Brief #233: Screening for Prostate Cancer with the Prostate-Specific Antigen Test--United States, 2006 (pdf file)
    meps.ahrq.gov/data_files/publications/st233/stat233.pdf
    January 01, 2009 - Food and Drug Administration (FDA) has approved the prostate-specific antigen (PSA) test along with … Currently there is no consensus on the appropriate use of the PSA test for early detection of prostate … Furthermore the USPSTF suggests that men younger than 75 discuss the benefits and harms of the PSA test … However, less than half (44.2 percent) of men in the United States ages 50 to 64 received a PSA test … Men aged 65 to 74 were more likely to have received a PSA test for prostate screening than men ages

29. STATISTICAL BRIEF #233: Screening for Prostate Cancer with the Prostate-Specific Antigen Test -- United States, 2006
    meps.ahrq.gov/data_files/publications/st233/stat233.shtml
    January 01, 2009 - 76.9 percent) of men ages 65 to 74 were reported to have been screened for prostate cancer with the PSA … Food and Drug Administration (FDA) has approved the prostate-specific antigen (PSA) test along with a … Currently there is no consensus on the appropriate use of the PSA test for early detection of prostate … However, less than half (44.2 percent) of men in the United States ages 50 to 64 received a PSA test … More than three-fourths (76.9 percent) of men ages 65 to 74 received a PSA test in the past two years

30. STATISTICAL BRIEF #233: Screening for Prostate Cancer with the Prostate-Specific Antigen Test -- United States, 2006
    meps.ahrq.gov/data_files/publications/st233/draft/stat233.shtml
    January 01, 2009 - 76.9 percent) of men ages 65 to 74 were reported to have been screened for prostate cancer with the PSA … Food and Drug Administration (FDA) has approved the prostate-specific antigen (PSA) test along with a … Currently there is no consensus on the appropriate use of the PSA test for early detection of prostate … However, less than half (44.2 percent) of men in the United States ages 50 to 64 received a PSA test … More than three-fourths (76.9 percent) of men ages 65 to 74 received a PSA test in the past two years

31. PCA3 Testing for the Diagnosis and Management of Prostate Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-test/research-protocol
    December 01, 2019 - values, decreased percent-free PSA levels, elevated PSA velocities, complexed PSA, or externally validated … values, decreased percent-free PSA levels, elevated PSA velocities, complexed PSA, or externally validated … PCA3 comparators Total PSA Percent free PSA PSA velocity Complexed PSA Externally validated … , percent free PSA, PSA velocity, complexed PSA, externally validated nomograms) KQ3: No PCA3 testing … , % free PSA, PSA velocity, complexed PSA, or externally validated nomograms) in predicting initial or

32. Overview of Prostate Cancer Screening Decision Models: A Contextual Review for the U.S. Preventive Services Task Force (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/vTHBrY6VuqjoouJvUmtkr4
    May 01, 2018 - Lowering the age to stop screening, lengthening the intervals between PSA testing, and raising the PSA … Unlike the MISCAN-PRO or SCANS models, the PSAPC model models PSA growth (i.e., generates a PSA level … Updated screening patterns indicate that fewer AA men received PSA testing (at least one PSA test) in … > 4.0 µg/L or PSA velocity >0.35 µg/L per year †Annual (quinquennial if age <50 and PSA <1 µg/L) ‡ … PSA >2.5 µg/L or PSA velocity >0.35 µg/L per year §Annual (biennial if PSA <2.5 µg/L) ║Bienniel (quinquennial

33. Arthritis-Psoriatric Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_executive.pdf
    April 01, 2012 - Psoriatic Arthritis in Adults: Update of a 2007 Report Executive Summary Background Psoriatic arthritis (PsA … PsA has a highly variable presentation, which generally involves pain and inflammation in joints and … In the general population, the prevalence of PsA is estimated to be 0.3 percent to 1 percent. … Census, 520,000 people ages 18 or older in the United States have PsA. … However the current available evidence for PsA was limited.

34. Arthritis-Psoriatric Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_executive.pdf
    April 01, 2012 - Psoriatic Arthritis in Adults: Update of a 2007 Report Executive Summary Background Psoriatic arthritis (PsA … PsA has a highly variable presentation, which generally involves pain and inflammation in joints and … In the general population, the prevalence of PsA is estimated to be 0.3 percent to 1 percent. … Census, 520,000 people ages 18 or older in the United States have PsA. … However the current available evidence for PsA was limited.

35. PCA3 Testing for the Diagnosis and Management of Prostate Cancer | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/prostate-cancer-test/research-protocol
    October 14, 2011 - values, decreased percent-free PSA levels, elevated PSA velocities, complexed PSA, or externally validated … values, decreased percent-free PSA levels, elevated PSA velocities, complexed PSA, or externally validated … PCA3 comparators Total PSA Percent free PSA PSA velocity Complexed PSA Externally validated … , percent free PSA, PSA velocity, complexed PSA, externally validated nomograms) KQ3: No PCA3 testing … , % free PSA, PSA velocity, complexed PSA, or externally validated nomograms) in predicting initial or

36. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0332_07-29-2010.pdf
    January 01, 2010 - in comparing results of screening with PCA3 with results of traditional prostate specific antigen (PSA … Transcription-mediated amplification of PCA3 and PSA mRNA in urine sample b. … How does sensitivity and specificity vary by score (ratio of PCA3/PSA mRMA) cut-off? b. … How do these issues vary as a function of PSA result and biopsy status? 4. … Reduction in unnecessary initial biopsies resulting from false positive PSA results ii.

37. Effective Health Care (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0332_07-29-2010.pdf
    January 01, 2010 - in comparing results of screening with PCA3 with results of traditional prostate specific antigen (PSA … Transcription-mediated amplification of PCA3 and PSA mRNA in urine sample b. … How does sensitivity and specificity vary by score (ratio of PCA3/PSA mRMA) cut-off? b. … How do these issues vary as a function of PSA result and biopsy status? 4. … Reduction in unnecessary initial biopsies resulting from false positive PSA results ii.

38. Overview of Prostate Cancer Screening Decision Models: A Contextual Review for the U.S. Preventive Services Task Force (pdf file)
    www.uspreventiveservicestaskforce.org/Home/GetFile/1/16813/prostate-cancer-models-overview/pdf
    May 01, 2018 - Lowering the age to stop screening, lengthening the intervals between PSA testing, and raising the PSA … Unlike the MISCAN-PRO or SCANS models, the PSAPC model models PSA growth (i.e., generates a PSA level … Updated screening patterns indicate that fewer AA men received PSA testing (at least one PSA test) in … > 4.0 µg/L or PSA velocity >0.35 µg/L per year †Annual (quinquennial if age <50 and PSA <1 µg/L) ‡ … PSA >2.5 µg/L or PSA velocity >0.35 µg/L per year §Annual (biennial if PSA <2.5 µg/L) ║Bienniel (quinquennial

39. Screening for Prostate Cancer: Recommendation Statement (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/zxXWqacXvfKPyQB9LCrZjX
    August 01, 2008 - Variations of PSA screening, including the use of age- adjusted PSA cut-points, free PSA, PSA density … , PSA ve- locity, PSA slope, and PSA doubling time, have been pro- posed to improve detection of “clinically … over time (for example, measurements of PSA velocity, PSA slope, or PSA doubling time). … The conventional PSA test cut-point of 4.0 g/L m isses som e early cancer. … Prostate-specific antigen (PSA) best prac- tice policy.

40. Prostate-Cancer-Test Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
    October 14, 2011 - values, decreased percent-free PSA levels, elevated PSA velocities, complexed PSA, or externally validated … values, decreased percent- free PSA levels, elevated PSA velocities, complexed PSA, or externally validated …  PCA3 comparators ○ Total PSA ○ Percent free PSA ○ PSA velocity ○ Complexed PSA ○ Externally … , percent free PSA, PSA velocity, complexed PSA, externally validated nomograms) KQ3: No PCA3 testing … , % free PSA, PSA velocity, complexed PSA, or externally validated nomograms) in predicting initial