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21. Overdiagnosis in Prostate Cancer Screening Decision Models: A Contextual Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/KT7vaWK_JSDNNvEmUAjN8d
    May 01, 2018 - Modeling studies suggest that raising the PSA threshold, lengthening the interval of screening, and … PSA screening is superimposed to estimate lead time. … at diagnosis) Generates PSA level per individual at each screen, PSA >4 μg/L at screen referred … (1) increases w ith age w ithin category of Gleason score and PSA. … <1 µg/L) ‡PSA >2.5 µg/L or PSA velocity >0.35 µg/L per year Abbreviations: PSAPC = Prostate-Specific

22. Archived: Prostate Cancer: Screening, 1996 | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening-1996
    January 01, 1996 - , 17 and its role in screening has largely been replaced by PSA. … PSA elevations are not specific for prostate cancer. … suggested that PSA density (the PSA concentration divided by the gland volume as measured by TRUS) may … Other studies suggest that the rate of change (PSA velocity), rather than the actual PSA level, is a … PSA screening for asymptomatic prostate cancer: truth in advertising.

23. Archived: Evidence Summary: Prostate Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary43/prostate-cancer-screening-2012
    October 07, 2011 - group (50% received ≥1 PSA test). … Annual PSA for 6 y Annual DRE for 4 y PSA cut point >4.0 µg/L Positive … PSA previously >3.0 µg/L, a PSA increase of 20% over previous year's value or over predicted PSA … < 10 µg/L: 22% PSA 11–29 µg/L: 28% PSA > 30 µg/L: 23% PSA unknown: 27% Age, period of diagnosis, method … < 10 µg/L: 57%  PSA 10–20 µg/L: 26%  PSA > 20 µg/L: 11% PSA unknown: 13% Age at diagnosis, race/ethnicity

24. Screening for Prostate Cancer: Clinical Summary (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/HUjbcP7uLa2SrGpVW4Fbhd
    August 07, 2008 - Insufficient Evidence) Men Age 75 Years or Older Do not screen Grade: D The prostate-specific antigen (PSA … The conventional PSA test cut-point of 4.0 g/L misses some early cancer. … Variations of PSA screening have not yet been demonstrated to improve health outcomes. … If PSA screening reduces mortality, screening every 4 years may be as beneficial as annual screening. … Interventions Clinicians should discuss the potential benefits and known harms of PSA screening with

25. Overdiagnosis in Prostate Cancer Screening Decision Models: A Contextual Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/Home/GetFile/1/16812/prostate-models-overdiagnosis/pdf
    May 01, 2018 - Modeling studies suggest that raising the PSA threshold, lengthening the interval of screening, and … PSA screening is superimposed to estimate lead time. … at diagnosis) Generates PSA level per individual at each screen, PSA >4 μg/L at screen referred … (1) increases w ith age w ithin category of Gleason score and PSA. … <1 µg/L) ‡PSA >2.5 µg/L or PSA velocity >0.35 µg/L per year Abbreviations: PSAPC = Prostate-Specific

26. Evidence Summary: Prostate Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/prostate-cancer-screening
    May 08, 2018 - Objective: To systematically review evidence on prostate-specific antigen (PSA)–based prostate cancer … Effectiveness of PSA-Based Screening Key Question 1. … What are the harms of PSA-based screening for prostate cancer and diagnostic follow-up? … Contamination in PLCO control group, and low adherence with single PSA screening in CAP. … ERSPC sites with variable PSA thresholds for positive test results.

27. Prostate Cancer Screening Recommendation Frequently Asked Questions (pdf file)
    www.uspreventiveservicestaskforce.org/Home/GetFileByID/3786
    October 09, 2018 - How to interpret the recommendation What is the PSA test? … The PSA test measures the amount of prostate-specific antigen, a type of protein, in a man’s blood. … When a man has an elevated PSA level, it may be caused by prostate cancer, but it could also be caused … What’s the harm in getting a PSA test? … It includes regular, repeated PSA testing and often repeated digital rectal examination and prostate

28. Prostate Cancer Screening Recommendation Frequently Asked Questions (pdf file)
    www.uspreventiveservicestaskforce.org/Home/GetFileByToken/-BbKrbuLt9RAPvf3BQrUMW
    October 09, 2018 - How to interpret the recommendation What is the PSA test? … The PSA test measures the amount of prostate-specific antigen, a type of protein, in a man’s blood. … When a man has an elevated PSA level, it may be caused by prostate cancer, but it could also be caused … What’s the harm in getting a PSA test? … It includes regular, repeated PSA testing and often repeated digital rectal examination and prostate

29. U.S. Preventive Services Task Force Seeks Comments on Draft Recommendation Statement on Screening for Prostate Cancer (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/file/supporting_documents/prostate-cancer-draft-bulletin.pdf
    April 03, 2017 - For men ages 70 years and older, the potential benefits of PSA-based screening do not outweigh the … (D recommendation) Visit www.screeningforprostatecancer.org for more information The PSA test … When a man has an elevated PSA, it may be caused by prostate cancer, but it could also be caused by … PSA-based screening and follow-up prostate biopsies cannot tell for sure which cancers are likely to … based in part on new evidence on the use of active surveillance, which includes regular, repeated PSA

30. U.S. Preventive Services Task Force Issues Final Recommendation on Screening for Prostate Cancer (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/file/supporting_documents/prostate-cancer-news-bulletin-updated-102018.pdf
    May 08, 2018 - patients with important new information about the benefits and harms of prostate-specific antigen (PSA … the Task Force recommends that men ages 55 to 69 make an individual decision about whether to get PSA-based … The PSA test measures the amount of prostate-specific antigen, a type of protein, in a man’s blood. … An elevated PSA level may be caused by prostate cancer, but it could also be caused by other conditions … PSA-based screening and the prostate biopsies used to follow-up on high PSA levels cannot tell for sure

31. Clinical Summary: Screening for Prostate Cancer (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/D2Y537H2WCXLrT82Z2M46u
    April 30, 2018 - Screening for prostate cancer begins with a test that measures the amount of prostate-specific antigen (PSA … An elevated PSA level may be caused by prostate cancer but can also be caused by other conditions, including … Men with a positive PSA test result may undergo a transrectal ultrasound-guided core-needle biopsy of

32. Prostate-Specific Antigen–Based Screening for Prostate Cancer: Evidence Report and Systematic Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/b-rsH7WPpNC3uL9NeoXBfF
    May 08, 2018 - OBJECTIVE To systematically review evidence on prostate-specific antigen (PSA)–based prostate cancer … Randomization to PSA screening was not associated with reduced risk of prostate cancer mortality in either … 2 What are the harms of PSA-based screening for prostate cancer and diagnostic follow-up? a. … Effectiveness of PSA-Based Screening Key Question 1. … What are the harms of PSA-based screening for pros- tate cancer and diagnostic follow-up?

33. Screening for Prostate Cancer: A Review of the Evidence for the U.S. Preventive Services Task Force (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/G9P7o8jDh4J3NnAk6y-SYL
    December 01, 2011 - What are the harms of PSA-based screening for prostate cancer? … of trial participants had under- gone PSA screening before entry. … One trial used a high PSA cut point (10 �g/L) (16). … group (50% received �1 PSA test). … What are the harms of PSA-based screening for prostate cancer?

34. Testimony for the House Energy and Commerce Health Subcommittee Hearing (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/tfcongresstestimony%20(3).pdf
    November 30, 2016 - the process of updating our 2012 recommendation statement on screening for prostate cancer with the PSA … We recommended against routinely screening all men with PSA tests, but importantly also included this … language in the recommendation statement: “The USPSTF recognizes the common use of PSA screening … Physicians should not offer or order PSA screening unless they are prepared to engage in shared decision … Similarly, patients requesting PSA screening should be provided with the opportunity to make informed

35. Public Comment on Draft Recommendation Statement: Screening for Prostate Cancer | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/announcements/public-comment-draft-recommendation-statement-screening-prostate-cancer
    May 08, 2017 - evidence, the Task Force determined that the potential benefits and harms of prostate-specific antigen (PSA

36. Task Force Resources | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/task-force-resources
    May 04, 2025 - USPSTF’s 2018 prostate cancer recommendation and explains the benefits and harms of screening using the PSA

37. Second Annual Report to Congress on High-Priority Evidence Gaps for Clinical Preventive Services (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/annlrpt2012%20(2).pdf
    November 01, 2012 - evidence and determined that the small potential benefit of screening for prostate-specific antigen (PSA … Serious harms are common with biopsies and treatment for prostate cancer detected by PSA. … The Task Force therefore recommended against PSA-based screening. … D Prostate cancer: Prostate-Specific antigen (PSa)-Based Screening in all men The USPSTF recommends … against prostate-specific antigen (PSA)-based screening for prostate cancer.

38. Eighth Annual Report to Congress on High-Priority Evidence Gaps for Clinical Preventive Services (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/usptf-annual-report-congress-2018%20(1).pdf
    January 01, 2018 - 69 Years For men ages 55 to 69 years, the decision to undergo periodic prostate-specific antigen (PSA … Screening in Men Age 70 Years and Older The USPSTF recommends against prostate-specific antigen (PSA … Screening For men ages 55 to 69 years, the decision to undergo periodic prostate- specific antigen (PSA … (Grade C) The USPSTF recommends against PSA-based screening for prostate cancer in men age 70 years

39. Cancer Older Adults (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/cancer_older_adults.pdf
    September 28, 2012 - An 80-year-old man with a high prostate-specific antigen (PSA) and biopsy-proven prostate cancer (true

40. High-Priority Evidence Gaps for Clinical Preventive Services (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/annlrpt2013%20(4).pdf
    November 01, 2013 - Preventive Services Task Force | 33 Grade Title D Prostate Cancer: Prostate-Specific Antigen (PSA … )-Based Screening in All Men The USPSTF recommends against PSA-based screening for prostate cancer.