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effectivehealthcare.ahrq.gov/sites/default/files/related_files/care-adults-down-syndrome-protocol-amendment.pdf
February 05, 2025 - Population, intervention, comparator, outcome, timing, setting (PICOTS)
PICOTS KQ1 KQ2
Population Adults … In cases where studies include mixed populations—such as individuals with Down
syndrome alongside those … In
cases of evidence synthesis that relies on papers with mixed populations, we may attempt a
sensitivity … National population‐based estimates for major birth
defects, 2010–2014. … multi-disciplinary group of clinical, content, and methodological
experts who provide input in defining populations
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar_research.pdf
August 01, 2015 - In this population, potential priorities for research on
blood glucose monitoring methods identified … Outcomes rated as
priorities for future research in this population were HbA1c, adherence, nonsevere … Full
accounting of diabetes and pre-diabetes in
the U.S. population in 1988-1994 and 2005-
2006. … research, while the method of insulin delivery and outcomes of interest varied by population. … Full
accounting of diabetes and pre-diabetes in
the U.S. population in 1988-1994 and 2005-
2006.
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effectivehealthcare.ahrq.gov/sites/default/files/ch_6-user-guide-to-ocer_130129.pdf
October 30, 2012 - data on effectiveness
as treatments are used in different medical care
settings and broader patient populations … since the
onset of the disease.12-14 This measure of disease
activity has been tested in different populations … across different
subgroups of individuals, and contain common
domains that are relevant to almost all populations … If a PRO questionnaire is to be used in non–
English-speaking populations or in multiple
languages, … For example, there
may be a greater tendency of some populations to
succumb to acquiescence bias (agreeing
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-260-improved-cancer-outcomes-disposition-comments.pdf
May 22, 2023 - This will help to provide
context to the populations frequently addressed in
the included studies. … ”
that “The focus of nutrition interventions within
head and neck and gastrointestinal populations … is not unexpected due to the higher risk of
malnutrition in these populations due to a
combination … with the Draft Report’s statement
“Because cancer risk increases with age, the
rapidly growing older population … that readers may
have additional interests of the role of nutrition
intervention by other study and population
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0520-131115.pdf
May 29, 2025 - The scope of this topic, including populations, interventions, comparators, and outcomes, will
be further … PICO from Nomination
Population(s): Patients with symptomatic and asymptomatic CAD
Intervention(s): … There are new primary studies that compared two or more
NITs, evaluated NITs in the asymptomatic populations
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effectivehealthcare.ahrq.gov/sites/default/files/s131.pdf
October 01, 2007 - Glynn, PhD, ScD*
Background: The goal of restricting study populations is to make
patients more homogeneous … findings.5
The objective of this article is to develop a structured
approach to restricting patient populations … to achieve a more homogeneous
study population. … arises of whether the RCT results based on more selected
populations can be generalized and continue … Association Between Statin Use and 1-Year Mortality in Increasingly Restricted Patient Populations
Cohort
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
September 01, 2021 - These interventions were evaluated in
younger (non-Medicare-eligible) populations, but findings can … probably be
applied to older populations … Ideally, future trials of interventional
procedures should enroll older, Medicare-eligible populations … effectiveness and harms of
selected interventional procedures for acute and chronic pain in the Medicare population … & Medicaid Services (CMS) but are relevant for and have potential utility for
use in the Medicare population
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/wheelchair-users-amended-protocol.pdf
June 21, 2019 - The populations of interest are those with MS, CP, and SCI. … • Exclude: Other populations. … population of wheelchair users and potential wheelchair users. … • Other populations
• Studies of mixed
populations with <80%
MS, CP, SCI
Intervention Any gross … Spinal cord injury and type 2 diabetes:
results from a population health survey.
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effectivehealthcare.ahrq.gov/sites/default/files/suppl-2-user-guide-to-ocer_130129.pdf
January 01, 2011 - Using a
dichotomous treatment (A) and outcome (Y) as
the example, the causal effect in a population … the probability of the outcome occurring
when the entire population is untreated
Pr[Ya=0=1]. … Populations, like individuals,
cannot simultaneously receive different levels
of treatment. … being
evaluated, when the goal is to make an inference
to the full population. … of the target
population.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND__0399_01-07-2011.pdf
January 01, 2011 - The scope of this topic, including
populations, interventions, comparators, and outcomes, will be further … Staff-Generated PICO: Comparative effectiveness of the various liver-directed
therapies for unresectable HCC
Population … Number(s): 0335a-b
Document Completion Date: 02-25-11
2
therapies in the setting of HCC
Population … Population(s): Patients with unresectable hepatic metastases.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0367_11-08-2010.pdf
January 01, 2010 - The scope of this topic, including populations, interventions, comparators, and
outcomes, will be further … Staff-Generated PICO:
Population(s): All postpartum women up to 1 year postpartum (including intrauterine … preterm, and term deliveries), with consideration of efficacy and safety of
approaches in different populations … (Medicaid or CHIP enrollees; racially, ethnically, and
socioeconomically diverse populations; women
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-3.pdf
June 01, 2022 - The full protocol for the original report, including detailed inclusion criteria using the
PICOTS (populations … new evidence appear inconsistent and new studies were
appropriate for pooling based on similarity in populations … Inclusion and exclusion criteria
PICOTS Include Exclude
Populations
and Conditions
All KQs: Adults … Exclusion reason: Ineligible population
123. … Exclusion reason: Ineligible population
198.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/topic-brief2-opioid-withdrawal.pdf
April 01, 2021 - Tapering
may be more challenging in Medicare populations due to higher medical complexity, presence … However, the quality of evidence is low or very low, and few studies
specifically evaluated populations … Furthermore, current guidance does not specifically address tapering in Medicare
populations. … Questions and PICOTS (population, intervention, comparator, outcome, timing and
setting)
Questions … Tapering From Long-term Opioid Therapy
in Chronic Pain Population.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-brief2-opioid-withdrawal.pdf
April 01, 2021 - Tapering
may be more challenging in Medicare populations due to higher medical complexity, presence … However, the quality of evidence is low or very low, and few studies
specifically evaluated populations … Furthermore, current guidance does not specifically address tapering in Medicare
populations. … Questions and PICOTS (population, intervention, comparator, outcome, timing and
setting)
Questions … Tapering From Long-term Opioid Therapy
in Chronic Pain Population.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/care-adults-down-syndrome-protocol.pdf
July 09, 2024 - Population, intervention, comparator, outcome, timing, setting (PICOTS)
PICOTS KQ1 KQ2
Population Adults … In cases where studies include mixed populations—such as individuals with Down
syndrome alongside those … In
cases of evidence synthesis that relies on papers with mixed populations, we may attempt a
sensitivity … National population‐based estimates for major birth
defects, 2010–2014. … multi-disciplinary group of clinical, content, and methodological
experts who provide input in defining populations
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin-future_research.pdf
August 01, 2014 - For example, the proposed topics could be categorized either by
different segments of the population …
This is a major priority
population. …
o
o
o
This is a major priority
population. …
#1 priority population. … trials,
which have shown PCT useful for reducing antibiotic use in this
population without reducing
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
March 01, 2011 - incidence of DVT in the United States ranges from 48 to
122 per 100,000.
1,2
With the ageing U.S. population … Special Populations at Risk for Venous Thromboembolism
The burden of VTE is higher among special populations … The concern about
anticoagulant thromboprophylaxis in this population is progression of intracranial … There is clinical uncertainty about the
optimal choice of VTE prophylaxis in this patient population … Current practice of thromboprophylaxis in the burn population:
a survey study of 84 US burn centers
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-map-technical-brief-49-disposition-comments.pdf
September 05, 2024 - lack rigorous metrics to assess
effectiveness for whom and under what
condition (e.g., what target population … The grouping included population evaluated by
primary studies and systematic reviews. … Questions for this Technical
Brief was present when HCBS were initially
developed for the target population … delay transition to institutional
setting is a bit presumptuous, given other
options for the aging population … maps (Figures 2 and 3) is
an effective way to visualize the distribution of
HCBS interventions by population
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effectivehealthcare.ahrq.gov/sites/default/files/topic-refinement.ppt
March 01, 2010 - Clinicians:
clarify (sub)populations to focus on,
identify areas in which studies differ that can affect … Clinicians can clarify (sub)populations to focus on, identify areas in which studies differ that can … In the growth hormone project, we wanted to determine what populations were being assessed: were they … framework in general and our placement of height in the framework: Because human growth hormone is used in populations … and looks for a link between growth hormone use in other populations where the body of literature is
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced%20-appendix-2.xlsx
May 29, 2025 - CED tempts CMS to second-guess the work of FDA; "unless otherwise contraindicated for populations represented … KIs should have also represented life sciences industries, patients, and underrepresented populations … Benefits and risks across diverse clinical populations in diverse clinical settings, without imposing … to retire CED CED tempts CMS to second-guess the work of FDA; "unless otherwise contraindicated for populations … Benefits and risks across diverse clinical populations in diverse clinical settings, without imposing