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Total Results: 839 records

Showing results for "phase".

61. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/14_substance_abuse_potential_high_impact_2012-12-11.pdf
    January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in phase … Results The table below lists two topics for which (1) preliminary phase III data were available for … The buprenorphine implant is in two phase III trials, one of which is funded by the National Institute … Titan Pharmaceuticals presents phase 3 probuphine data at Society for Neuroscience annual meeting … Titan Pharmaceuticals announces positive top line results in confirmatory phase 3 trial of probuphine

62. Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-nomination-apbi-breast-cancer.pdf
    April 01, 2017 - European Society for Radiotherapy and Oncology (GEC-ESTRO) trial, 1184 patients were enrolled in a phase … Data from other large randomized phase 3 trials evaluating APBI, including the National Surgical Adjuvant … The Austrian Multi Institutional study has reported its findings specifically for age.7 In this phase … Clinical trials Two large phase 3 trials, the Intraoperative radiother- apy with electrons (ELIOT) trial … Late toxicity and patient self-assessment of breast appearance/satisfaction onRTOG0319: a phase 2 trial

63. Diabetes Mellitus (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/diabetes_hi_impact.pdf
    March 01, 2012 - III trials for pharmaceuticals or biotechnologies or in phase II or a trial with some preliminary … Results The table below lists the 15 topics for which (1) preliminary phase III data for drugs, or phase … -week results from its phase II trial. … At least six SGLT2 inhibitors are in phase II and III trials. … Intarcia presents positive ITCA 650 phase 2 study results for type 2 diabetes at EASD.

64. Management of Primary Headache During Pregnancy: Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
    March 23, 2019 - of primary headache and are pregnant (or attempting to become pregnant, i.e., in the preconception phase … Do the (comparative) benefits and harms vary by phase (i.e., preconception, first trimester of pregnancy … Do the (comparative) benefits and harms vary by phase (i.e., preconception, first trimester of pregnancy … Population(s): • Women who are pregnant (or attempting to become pregnant/in the preconception phase … In particular, we will extract, as available, data on phase (i.e., preconception, first trimester of

65. Disposition of Comments for CER 195 Management of Uterine Fibroids (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-195-disposition-comments-uterine-fibroids.pdf
    December 14, 2017 - Allergan is conducting a Phase III development program specifically in the United States with two Phase … The first positive Phase III trial results have been already released and the second Phase III trial … See below for correction of identified errors with regard to European Phase III trials. … This now includes the two Donnez Phase III trials discussed above. … Two of the four Ulipristal trials consisted of small Phase II studies.

66. Topic Brief: Accelerated Partial Breast Irradiation for Breast Cancer (pdf file)
    effectivehealthcare.ahrq.gov/system/files/docs/topic-brief-apbi-breast-cancer.pdf
    August 01, 2022 - early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase … QOL After APBI (Multicatheter Brachytherapy) Versus WBI: 5- Year Results, Phase 3 GEC-ESTRO Trial. … in early breast cancer after breast-conserving surgery (GEC-ESTRO): 5-year results of a randomised, phase … Randomized phase II study of hypofractionated WBI versus APBI using VMAT: early toxicity results. … A phase II trial to determine the cosmetic outcomes and toxicity of 27 Gy in five-fraction accelerated

67. Topic Brief: Radiation Therapy for Bone Metastases (pdf file)
    effectivehealthcare.ahrq.gov/system/files/docs/topic-brief-radiation-therapy-bone-metastases.pdf
    August 01, 2022 - Short-course regimen of palliative radiotherapy in complicated bone metastases: a phase i-ii study ( … A phase I dose-escalation trial of stereotactic ablative body radiotherapy for non-spine bone and lymph … A Prospective Randomized Phase II Study of 1 vs 2 Fractions of Palliative Radiation Therapy for Patients … A phase III randomized-controlled, single-blind trial to improve quality of life with stereotactic body … Radiotherapy for Pain Relief in Patients With Predominantly Nonspine Bone Metastases: a Randomized Phase

68. 08 Functional Limitations Potential High Impact 2012-12-10 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/08_functional_limitations_potential_high_impact_2012-12-10.pdf
    January 01, 2012 - A phase II/III trial began in 2010 for acquired hemophilia and is ongoing. … A phase III trial started in late 2011 to treat hemophilia A (congenital hemophilia) is ongoing. … Placebo- controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. … Placebo- controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. … ThromboGenics' microplasmin phase III program progressing according to schedule. [internet].

69. Diabetes Mellitus (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1306.pdf
    January 01, 2016 - phase II or equivalent data for devices and procedures, or some human data for off-label uses or … In March 2013, Intarcia began phase III trials of ITCA 650/pump system. … This drug will compete with other drugs in phase III trials, such as Iluvien and aflibercept (Eylea … In March 2013, ITCA 650’s developer announced enrolling the first patients in its phase III FREEDOM … Intarcia presents positive ITCA 650 phase 2 study results for type 2 diabetes at EASD.

70. Liver-Cancer Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
    October 01, 2014 - without HCC to identify lesions in the liver that are clinically suspicious for HCC.4 The evaluation phase … imaging, timing of delayed phase imaging (≥120 seconds after administration of contrast or <120 s) … Studies with delayed phase imaging reported somewhat higher sensitivity (0.89; 95% CI, 0.81 to 0.94; … 7 studies) than studies without delayed phase imaging (0.74; 95% CI, 0.66 to 0.87; 7 studies). … imaging, timing of delayed phase imaging, and section thickness.

71. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/14_substanceabuse_potential_high_impact_june_2012.pdf
    January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in phase … Results The table below lists nine topics for which (1) preliminary phase III data were available for … The buprenorphine implant is in two phase III trials, one of which is funded by the National Institute … Titan Pharmaceuticals presents phase 3 probuphine data at Society for Neuroscience annual meeting. … Titan Pharmaceuticals announces positive top line results in confirmatory phase 3 trial of probuphine

72. Obesity (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/obesity_hi_impact.pdf
    April 17, 2012 - III trials for pharmaceuticals or biotechnologies or in phase II or a trial with some preliminary … Results The table below lists the nine topics for which (1) preliminary phase III data on drug topics … Antiobesity Drugs for Treatment of Obesity  Key Facts: Three drugs are in phase III development for … In 2010, Greenway and colleagues announced results from a 56-week phase III trial (COR-I) evaluating … Orexigen Therapeutics announces publication of COR-I phase 3 study of Contrave in lancet.

73. PULMONARY with "Discussions" in Exec Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1312.pdf
    December 01, 2013 - Results The table below lists the five topics for which (1) preliminary phase III data on drugs, phase … One of these, thalidomide, has been investigated in a phase III trial for off-label use to treat cough … Several phase III trials have been cosponsored by the Cystic Fibrosis Foundation, of Bethesda, MD. … Food and Drug Administration (FDA) in 2012, continues to be under study in a phase II trial and a phase … Diffusion: The system is in the innovative phase in the United States.

74. Ch 1-User-Guide-To-Ocer 130129 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ch_1-user-guide-to-ocer_130129.pdf
    August 13, 2012 - The first phase of human testing is usually conducted in a limited number of healthy volunteers (phase … then the drug is further studied in a small number of volunteers who have the targeted condition (phase … If phase 2 studies show that the drug has a therapeutic effect and lacks significant adverse effects … , trials with large numbers of people are conducted to determine the drug’s safety and efficacy (phase … assess the safety of the drug in routine clinical care after the drug is approved for marketing (phase

75. SAMHSA (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/goldstrom.pdf
    May 29, 2025 - process and inclusive of many stakeholders, there needs to be sufficient time for feedback at each phase

76. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/vaccine-safety_research-protocol.pdf
    September 18, 2012 - The clinical evaluation of a vaccine typically consists of three phases.8 Phase I studies—which typically … Phase II studies evaluate the immunogenicity of the vaccine and provide preliminary estimates on the … Phase III trials provide the information on a vaccine’s safety and effectiveness that is required to

77. Systematic Review on Nonopioid Pharmacologic Treatments for Chronic Pain: Surveillance Report 3 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-3-nonopioid-pharm-chronic-pain.pdf
    July 01, 2022 - A randomized, double-blind, placebo- controlled phase III trial of duloxetine in Japanese patients … Randomized, double-blind, placebo- controlled phase III trial of duloxetine monotherapy in Japanese … A randomized, double-blind, placebo- controlled phase III trial of duloxetine in Japanese fibromyalgia … Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised … Open- label phase 3 study of diclofenac conjugated to hyaluronate (diclofenac etalhyaluronate: ONO-

78. PULMONARY with "Discussions" in Exec Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1506.pdf
    October 01, 2015 - Results The table below lists the five topics for which (1) preliminary phase III data for drugs or … In the phase III TRAFFIC and TRANSPORT trials, patients treated with lumacaftor/ivacaftor (Orkambi™ … Two phase III studies are ongoing in patients who are 6–11 years old and homozygous for F508del and … Lumacaftor/ivacaftor is also being ES-4 investigated as a fixed-dose combination in a phase III … A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.

79. Obesity (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_2012-12-11.pdf
    January 01, 2012 - Results The table below lists the four topics for which (1) preliminary phase III data for drugs, phase … FDA approved the drug on June 27, 2012, on the basis of three completed phase III trials. … According to the company’s drug pipeline, liraglutide 3 mg (NN8022) is 4 in phase III trials … FDA approved the drug on July 17, 2012, on the basis of two completed, phase III trials. … This study is an extension of a phase III, clinical trial (CONQUER).

80. Systematic Review on Nonopioid Pharmacologic Treatments for Chronic Pain: Surveillance Report 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-1-nonopioid-pharm-chronic-pain.pdf
    April 01, 2022 - Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised … in patients with knee pain due to osteoarthritis: an exploratory post hoc analysis of a Japanese phase … or chronic low back pain with early pain reduction: an exploratory post- hoc analysis of Japanese phase … Open- label phase 3 study of diclofenac conjugated to hyaluronate (diclofenac etalhyaluronate: ONO- … ][TM]s effect in Chinese patients with chronic pain due to osteoarthritis: post hoc analyses of a phase