-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0024_06-09-2008.pdf
January 01, 2008 - populations, interventions, comparators, and
outcomes, will be further developed in the refinement phase
-
effectivehealthcare.ahrq.gov/products/copd/research
October 11, 2019 - ), early pulmonary rehabilitation commenced before hospital discharge during the initial most acute phase … ), early pulmonary rehabilitation commenced before hospital discharge during the initial most acute phase
-
effectivehealthcare.ahrq.gov/sites/default/files/ebc-challenge-case-130621.pdf
June 01, 2013 - Summary of Challenge Activities and Key Considerations
Phase of Challenge Activity Examples of Relevant … Although it is
not necessary to finalize the judging panel in the pre-challenge phase, hosts should … The first is the during launch phase, which is an
occasion to introduce external stakeholders to the … The second opportunity is during the operations phase, or
while the challenge is under way. … To maintain interest and generate buzz during the operations phase, AcademyHealth produced
hard-copy
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/primary-research-design_research.pdf
January 01, 2012 - Phase 1
involved a focused literature search to identify existing frameworks and processes that have … In phase 2, we convened a
multidisciplinary group with varied expertise to develop a stepwise framework … In phase 3, we
identified two systematic reviews and applied this framework to their results. … Phase 4 invited
external opinions from additional experts to further refine the framework. … Phase 4
In a final phase, we invited external opinions from four additional experts with experience
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-future_research.pdf
April 01, 2013 - Table 4 and Appendix D: Three pending phase 2 trials have been removed from the
report. … The scope is limited to phase 3 and 4 trials. … NCT01497366: A phase 3, multicenter,
randomized, active-controlled study to
investigate the safety … NCT01497834: A phase 3 Japanese study of
BMS-790052 plus BMS-650032 combination
therapy in chronic … II/III Simeprevir
Study, or Who Received
DAA Treatment in a Tibotec-
Sponsored Phase I Study.
-
effectivehealthcare.ahrq.gov/sites/default/files/dementia_horizon-scan-high_impact-1306-revised.pdf
July 09, 2013 - Results
The table below lists the three topics for which (1) preliminary phase III data for drugs were … The Horizon Scanning System is tracking several
drugs in late-phase development. … Flutemetamol has completed a U.S.-
based phase III trial, while another phase III trial is ongoing. … -based phase III trial is ongoing for flutemetamol while another phase
III trial has been completed … Phase
1 study of the Pittsburgh compound B derivative
18F-flutemetamol in healthy volunteers and
-
effectivehealthcare.ahrq.gov/sites/default/files/06_devdelays_potential_high_impact_2012-12-10.pdf
January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in
phase … priority area (among the 13 topics
being tracked as of October 26, 2012), for which (1) preliminary phase … III data for drugs, phase II or
III data for devices and procedures, or some human data for off-label … Several drugs in phase I and II
development are aimed at targeting social symptoms of ASD and are being … ineligible for consideration in the High Impact report at this time
because they have not yet produced phase
-
effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1512.pdf
December 01, 2015 - inclusion are those interventions expected to be within 0–3 years of potential diffusion (e.g., in
phase … Biogen (Cambridge, MA) has advanced this candidate
drug to phase III testing, despite initial analysis … of intermediate doses used in phase I testing
showing no clinical efficacy. … early probable AD and may also
delay disease progression; the developers have initiated a pivotal phase … The developer is conducting phase III trials with
AVP-786 and AVP-923 for this indication, and we continue
-
effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
October 01, 2015 - Results
The table below lists the four topics for which (1) preliminary phase III data on drugs, phase … Three phase III trials on lumacaftor have been completed, and one phase III extension
trial is ongoing … In the phase III ASCEND trial, patients
(n=555) with IPF treated with pirfenidone had a significant … In two replicate phase III trials (INPULSIS-1 and INPULSIS-2), patients (n=1,066) with IPF
who were … A phase 3 trial of pirfenidone in patients with
idiopathic pulmonary fibrosis.
-
effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1506.pdf
December 01, 2015 - Results
The table below lists the five topics for which (1) preliminary phase III data for drugs were … Clinicians based their off-label decisions on results from a
phase II trial demonstrating high SVR12 … A
number of other manufacturers also have all-oral HCV DAA regimens in phase II or phase III
development … In the phase III, randomized controlled VALENCE trial, patients (n=419) with chronic HCV
genotype 2 … In the phase III, open-label, randomized controlled ION-3 trial, patients (n=647) with
chronic HCV
-
effectivehealthcare.ahrq.gov/sites/default/files/dementia_hi_impact.pdf
January 01, 2012 - III trials
for pharmaceuticals or biotechnologies or in phase II or a trial with some preliminary … -based phase III trial is
ongoing for flutemetamol. … Two agents in late-phase development for this
purpose are discussed here. … -based phase III trial is ongoing for flutemetamol. … Results from a phase II trial were
released in 2009 and were updated in 2010.
-
effectivehealthcare.ahrq.gov/products/bipolar-disorder-treatment/research-protocol
June 23, 2014 - responses to treatment by bipolar type (type I or type II), polar episode (depression or mania), and phase … for people with bipolar disorder, including disease-specific characteristics such as bipolar type, phase … Results will be organized by bipolar type, phase, and patient characteristics. … Some columns or cells may be exploded into their own matrix, for example phase severity, again depending … clinical trial, phase ii.pt.
clinical trial, phase iii.pt.
clinical trial, phase iv.pt.
-
effectivehealthcare.ahrq.gov/sites/default/files/04_dementia_potential_high_impact_2012-12-10.pdf
January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in
phase … Results
The table below lists the three topics for which (1) preliminary phase III data for drugs were … -based phase III trials are ongoing for flutemetamol, and the manufacturer anticipates a
premarket … binding to beta-amyloid aggregates and did not
bind to tau, synuclein, or other targets.
12,13
Phase … Phase
1 study of the Pittsburgh compound B derivative
18F-flutemetamol in healthy volunteers and
-
effectivehealthcare.ahrq.gov/sites/default/files/developmental-delays-horizon-scan-high-impact-1506.pdf
December 01, 2015 - inclusion are those interventions expected to be within 0–3 years of potential diffusion (e.g., in
phase … In late 2014, investigators reported
top-line results from a phase III study examining metadoxine for … second tracked topic covers
dasotraline, an investigational triple-reuptake inhibitor currently in a phase … II/III trial for treating
pediatric ADHD and a phase III trial for treating adult ADHD; each of these
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/phenylketonuria_surveillance.pdf
January 15, 2013 - A small Phase 2 trial of PEGylated phenylalanine ammonium lyase (PAL), an enzyme that breaks down Phe … , was completed in September 2012; the Phase 3 trial is
expected to begin in the 2nd quarter of 2013 … BioMarin
Announces Decision to Start Phase 3
Program for PEG-PAL in 2Q 2013. … Preliminary Phase 2 Results Indicate
Convenient and Accelerated Dosing
Regimen Identified. … 1: baseline
Phase 2: (2 weeks) doubling
of natural protein intake
Phase 3: (4 weeks) daily BH4
-
effectivehealthcare.ahrq.gov/sites/default/files/ahrq-healthcare-horizon-scan-protocol-operations-manual_130826.pdf
August 01, 2013 - Is this being called an innovation AND is it in late phase development? … Is this being called an innovation AND is it in late phase clinical development? If so, select.
8. … Is the intervention in late-phase development for the U.S. health care system? … The “track-only” designation means that the intervention is in late-phase
trials, but late-phase data … 1 and phase 2
clinical cancer trials
X X X X X X
A-9
Table 1.
-
effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_2012-12-10.pdf
January 01, 2012 - phase II data for devices and procedures, or some human data for off-label uses or programs were … Investigators in two phase III
trials (RISE and RIDE trials) tested ranibizumab in patients with DME … This drug will
compete with other drugs in phase III trials, such as Iluvien and aflibercept (Eylea … (Durham, NC) in September 2011 to begin a phase III program of six trials.
62,63
In the
completed … Intarcia presents positive ITCA 650 phase 2 study
results for type 2 diabetes at EASD.
-
effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_2012-12-10.pdf
January 01, 2012 - phase II data for devices and procedures, or some human data for off-label uses or programs were … Investigators in two phase III
trials (RISE and RIDE trials) tested ranibizumab in patients with DME … This drug will
compete with other drugs in phase III trials, such as Iluvien and aflibercept (Eylea … (Durham, NC) in September 2011 to begin a phase III program of six trials.
62,63
In the
completed … Intarcia presents positive ITCA 650 phase 2 study
results for type 2 diabetes at EASD.
-
effectivehealthcare.ahrq.gov/sites/default/files/14_substance_abuse_potential_high_impact_2012-12-11.pdf
January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in
phase … Results
The table below lists two topics for which (1) preliminary phase III data were available for … The buprenorphine implant is in
two phase III trials, one of which is funded by the National Institute … Titan Pharmaceuticals presents phase 3
probuphine data at Society for Neuroscience
annual meeting … Titan Pharmaceuticals announces positive top line
results in confirmatory phase 3 trial of probuphine
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/bipolar-disorder-treatment_research-protocol.pdf
June 23, 2014 - responses to treatment by bipolar type
(type I or type II), polar episode (depression or mania), and phase … for people with bipolar disorder,
including disease-specific characteristics such as bipolar type, phase … rates will be excluded at the abstraction phase … Results will be organized by bipolar type, phase, and patient characteristics. … i.pt.
40 clinical trial, phase ii.pt.
41 clinical trial,
phase iii.pt.
42 clinical trial, phase