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Total Results: 839 records

Showing results for "phase".

41. Treatment of Hepatitis C Virus Infection in Adults: Future Research Needs (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-future_research.pdf
    April 01, 2013 - Table 4 and Appendix D: Three pending phase 2 trials have been removed from the report. … The scope is limited to phase 3 and 4 trials. … NCT01497366: A phase 3, multicenter, randomized, active-controlled study to investigate the safety … NCT01497834: A phase 3 Japanese study of BMS-790052 plus BMS-650032 combination therapy in chronic … II/III Simeprevir Study, or Who Received DAA Treatment in a Tibotec- Sponsored Phase I Study.

42. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amended.pdf
    February 07, 2025 - .: 75Q80124F32007 High Gastric or Esophagogastric Junction Adenocarcinoma: The GERCOR NEONIPIGA Phase … Updated analysis of SWOG-directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy … 3':ti,ab OR 'phase iii':ti,ab OR random*:ti,ab OR RCT:ti,ab) 13 'controlled clinical trial'/de OR … stud* OR trial*)) 14 'comparative effectiveness'/de OR 'comparative study'/de OR compar*:ti 15 'phase … 2' OR 'phase two' OR 'phase ii') NEXT/1 (stud* OR trial*)) 16 #3 AND (#4 OR #5 OR #6 OR #7) AND [

43. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/dementia_horizon-scan-high_impact-1306-revised.pdf
    July 09, 2013 - Results The table below lists the three topics for which (1) preliminary phase III data for drugs were … The Horizon Scanning System is tracking several drugs in late-phase development. … Flutemetamol has completed a U.S.- based phase III trial, while another phase III trial is ongoing. … -based phase III trial is ongoing for flutemetamol while another phase III trial has been completed … Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and

44. PULMONARY with "Discussions" in Exec Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
    October 01, 2015 - Results The table below lists the four topics for which (1) preliminary phase III data on drugs, phase … Three phase III trials on lumacaftor have been completed, and one phase III extension trial is ongoing … In the phase III ASCEND trial, patients (n=555) with IPF treated with pirfenidone had a significant … In two replicate phase III trials (INPULSIS-1 and INPULSIS-2), patients (n=1,066) with IPF who were … A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.

45. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1506.pdf
    December 01, 2015 - Results The table below lists the five topics for which (1) preliminary phase III data for drugs were … Clinicians based their off-label decisions on results from a phase II trial demonstrating high SVR12 … A number of other manufacturers also have all-oral HCV DAA regimens in phase II or phase III development … In the phase III, randomized controlled VALENCE trial, patients (n=419) with chronic HCV genotype 2 … In the phase III, open-label, randomized controlled ION-3 trial, patients (n=647) with chronic HCV

46. The Evidence-Based Care Challenge: A Case Study (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ebc-challenge-case-130621.pdf
    June 01, 2013 - Summary of Challenge Activities and Key Considerations Phase of Challenge Activity Examples of Relevant … Although it is not necessary to finalize the judging panel in the pre-challenge phase, hosts should … The first is the during launch phase, which is an occasion to introduce external stakeholders to the … The second opportunity is during the operations phase, or while the challenge is under way. … To maintain interest and generate buzz during the operations phase, AcademyHealth produced hard-copy

47. Topic 0562 Treatments for Biploar Disorder NSD FINAL SJ (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0663-131114.pdf
    April 10, 2013 - populations, interventions, comparators, and outcomes, will be further developed in the refinement phase

48. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol.pdf
    January 01, 2024 - Updated analysis of SWOG-directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy … 3':ti,ab OR 'phase iii':ti,ab OR random*:ti,ab OR RCT:ti,ab) 13 'controlled clinical trial'/de OR … stud* OR trial*)) 14 'comparative effectiveness'/de OR 'comparative study'/de OR compar*:ti 15 'phase … arm*' OR 'single arm' OR (('un controlled' OR 'non controlled' OR uncontrolled OR noncontrolled OR 'phase … 2' OR 'phase two' OR 'phase ii') NEXT/1 (stud* OR trial*)) 16 #3 AND (#4 OR #5 OR #6 OR #7) AND [

49. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1512.pdf
    December 01, 2015 - inclusion are those interventions expected to be within 0–3 years of potential diffusion (e.g., in phase … Biogen (Cambridge, MA) has advanced this candidate drug to phase III testing, despite initial analysis … of intermediate doses used in phase I testing showing no clinical efficacy. … early probable AD and may also delay disease progression; the developers have initiated a pivotal phase … The developer is conducting phase III trials with AVP-786 and AVP-923 for this indication, and we continue

50. #06 Developmental Delays ADHD, and Autism (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/06_devdelays_potential_high_impact_2012-12-10.pdf
    January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in phase … priority area (among the 13 topics being tracked as of October 26, 2012), for which (1) preliminary phase … III data for drugs, phase II or III data for devices and procedures, or some human data for off-label … Several drugs in phase I and II development are aimed at targeting social symptoms of ASD and are being … ineligible for consideration in the High Impact report at this time because they have not yet produced phase

51. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/dementia_hi_impact.pdf
    January 01, 2012 - III trials for pharmaceuticals or biotechnologies or in phase II or a trial with some preliminary … -based phase III trial is ongoing for flutemetamol. … Two agents in late-phase development for this purpose are discussed here. … -based phase III trial is ongoing for flutemetamol. … Results from a phase II trial were released in 2009 and were updated in 2010.

52. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/04_dementia_potential_high_impact_2012-12-10.pdf
    January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in phase … Results The table below lists the three topics for which (1) preliminary phase III data for drugs were … -based phase III trials are ongoing for flutemetamol, and the manufacturer anticipates a premarket … binding to beta-amyloid aggregates and did not bind to tau, synuclein, or other targets. 12,13 Phase … Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and

53. PKU Surveillance Assessment_CER 56_Low (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/phenylketonuria_surveillance.pdf
    January 15, 2013 - A small Phase 2 trial of PEGylated phenylalanine ammonium lyase (PAL), an enzyme that breaks down Phe … , was completed in September 2012; the Phase 3 trial is expected to begin in the 2nd quarter of 2013 … BioMarin Announces Decision to Start Phase 3 Program for PEG-PAL in 2Q 2013. … Preliminary Phase 2 Results Indicate Convenient and Accelerated Dosing Regimen Identified. … 1: baseline Phase 2: (2 weeks) doubling of natural protein intake Phase 3: (4 weeks) daily BH4

54. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0024_06-09-2008.pdf
    January 01, 2008 - populations, interventions, comparators, and outcomes, will be further developed in the refinement phase

55. Horizon Scanning Protocol and Operations Manual January 2013 Revision (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ahrq-healthcare-horizon-scan-protocol-operations-manual_130826.pdf
    August 01, 2013 - Is this being called an innovation AND is it in late phase development? … Is this being called an innovation AND is it in late phase clinical development? If so, select. 8. … Is the intervention in late-phase development for the U.S. health care system? … The “track-only” designation means that the intervention is in late-phase trials, but late-phase data … 1 and phase 2 clinical cancer trials X X X X X X A-9 Table 1.

56. #06 Developmental Delays ADHD, and Autism (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/developmental-delays-horizon-scan-high-impact-1506.pdf
    December 01, 2015 - inclusion are those interventions expected to be within 0–3 years of potential diffusion (e.g., in phase … In late 2014, investigators reported top-line results from a phase III study examining metadoxine for … second tracked topic covers dasotraline, an investigational triple-reuptake inhibitor currently in a phase … II/III trial for treating pediatric ADHD and a phase III trial for treating adult ADHD; each of these

57. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amendment.pdf
    May 02, 2025 - Updated analysis of SWOG-directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy … advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase … 3':ti,ab OR 'phase iii':ti,ab OR random*:ti,ab OR RCT:ti,ab) 13 'controlled clinical trial'/de OR … stud* OR trial*)) 14 'comparative effectiveness'/de OR 'comparative study'/de OR compar*:ti 15 'phase … 2' OR 'phase two' OR 'phase ii') NEXT/1 (stud* OR trial*)) 16 #3 AND (#4 OR #5 OR #6 OR #7) AND [

58. Diabetes Mellitus (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_2012-12-10.pdf
    January 01, 2012 - phase II data for devices and procedures, or some human data for off-label uses or programs were … Investigators in two phase III trials (RISE and RIDE trials) tested ranibizumab in patients with DME … This drug will compete with other drugs in phase III trials, such as Iluvien and aflibercept (Eylea … (Durham, NC) in September 2011 to begin a phase III program of six trials. 62,63 In the completed … Intarcia presents positive ITCA 650 phase 2 study results for type 2 diabetes at EASD.

59. Disposition of Comments_CER 231 Care Interventions for People Living With Dementia and Their Caregivers (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-231-dementia-care-interventions-disposition-comments.pdf
    July 31, 2020 - the science on dementia and the movement of pharmacological interventions to the MCI or preclinical phase … The systematic review underwent a comprehensive topic refinement phase. … person- centered care was foundational to determining the included outcomes during the topic refinement phase … intervention, comparator, outcomes, timing, setting) were derived from a comprehensive topic refinement phase … intervention, comparator, outcomes, timing, setting) were derived from a comprehensive topic refinement phase

60. bipolar-disorder-treatment-protocol-140623 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/bipolar-disorder-treatment_research-protocol.pdf
    June 23, 2014 - responses to treatment by bipolar type (type I or type II), polar episode (depression or mania), and phase … for people with bipolar disorder, including disease-specific characteristics such as bipolar type, phase … rates will be excluded at the abstraction phase … Results will be organized by bipolar type, phase, and patient characteristics. … i.pt. 40 clinical trial, phase ii.pt. 41 clinical trial,  phase iii.pt. 42 clinical trial, phase