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Total Results: 839 records

Showing results for "phase".

21. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1512.pdf
    November 01, 2016 - Results The table below lists the single topic for which (1) preliminary phase III data for drugs were … Three phase III trials are ongoing. … from a completed phase III trial, M12-665.10 That trial (n=872) is evaluating the change in pain, … A global phase 3 study to evaluate the safety and efficacy of elagolix in subjects with moderate … Elagolix treatment for endometriosis-associated pain: Results from a phase 2, randomized, double-

22. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1506.pdf
    November 01, 2016 - Results The table below lists the single topic for which (1) preliminary phase III data for drugs were … Four phase III trials are ongoing. … According to a manufacturer press release, positive preliminary results reported from one phase III … A global phase 3 study to evaluate the safety and efficacy of elagolix in subjects with moderate … Elagolix treatment for endometriosis-associated pain: Results from a phase 2, randomized, double-

23. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1506.pdf
    June 01, 2015 - Results The table below lists the single topic for which (1) preliminary phase III data for drugs (or … II/III or phase III clinical trials. … The manufacturer considers the phase I data encouraging enough that it plans to advance directly to … a phase III trial later this year. … U.S. and European investigators are leading phase II and II/III clinical trials studying intranasal

24. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1512.pdf
    January 28, 2016 - A number of other manufacturers also have all-oral HCV DAA regimens in phase II or phase III development … Grazoprevir/elbasvir is being evaluated in several phase II and III trials for treating chronic HCV … Four additional phase III trials on grazoprevir/elbasvir are ongoing. … In a phase III study, patients with HCV genotype 1 infection achieved an average SVR12 rate of 92%. … In the phase III ION studies, patients achieved SVR12 rates of 94% to 99%.

25. Underperformance of Contemporary Phase III Oncology Trials and Strategies for Improvement | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/grant-manuscripts/underperformance-abstract

26. PULMONARY with "Discussions" in Exec Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1512.pdf
    December 01, 2015 - Four phase III trials are ongoing. … Four phase III trials are ongoing. … Two phase III trials are ongoing. … GSK presents mepolizumab phase III results in ERS. [internet]. … A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.

27. Horizon Scanning Protocol and Operations Manual September 2015 Revision (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ahrq-healthcare-horizon-scan-protocol-operations-manual-151001.pdf
    September 01, 2015 - The “track-only” designation means that the intervention is in late-phase trials, but late-phase data … All topics proceed through Phase 1. … Phase 2. … Phase 1 – Internal Expert Comment and Triage (all topics) In Phase 1. … Phase 2 – External Expert Comment Select topics enter Phase 2.

28. Horizon Scanning Protocol and Operations Manual September 2015 Revision (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ahrq-healthcare-horizon-scan-protocol-operations-manual-151001.pdf
    September 01, 2015 - The “track-only” designation means that the intervention is in late-phase trials, but late-phase data … All topics proceed through Phase 1. … Phase 2. … Phase 1 – Internal Expert Comment and Triage (all topics) In Phase 1. … Phase 2 – External Expert Comment Select topics enter Phase 2.

29. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0277_03-10-2008.pdf
    January 01, 2008 - populations, interventions, comparators, and outcomes, will be further developed in the refinement phase … The diseases covered in the AHRQ review will be defined during the refinement phase.

30. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1412.pdf
    December 22, 2014 - Results The table below lists the eight topics for which (1) preliminary phase III data on drugs, phase … A number of other manufacturers also have all-oral HCV regimens in phase II or phase III development … Sofosbuvir and RBV regimens: In phase III trials, patients infected with HCV genotypes 2 and 3 who … Daclatasvir/sofosbuvir: In a phase II, open-label randomized controlled trial, patients with chronic … In the phase III, randomized controlled VALENCE trial, patients (n=419) with chronic HCV genotype 2

31. PULMONARY with "Discussions" in Exec Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/13_pulmonary_potential_high_impact_june_2012.pdf
    January 01, 2012 - Results The table below lists the three topics for which (1) preliminary phase III or later data were … available for drugs or phase II, III, or later data were available for devices and procedures; (2) … Another drug, roflumilast, failed to meet its primary endpoints in a just-completed phase III trial … The drug is in several phase III clinical trials cosponsored by the Cystic Fibrosis Foundation. … Vertex corrects and provides additional data from recent interim analysis of phase 2 combination

32. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/substanceabuse_hi_impact.pdf
    January 01, 2012 - III trials for pharmaceuticals or biotechnologies or in phase II or a trial with some preliminary … The table below lists the eight topics for which (1) preliminary phase III data were available for … The buprenorphine implant is currently in two phase III trials, one of which is funded by the National … Titan Pharmaceuticals presents phase 3 probuphine data at society for Neuroscience annual meeting … Titan Pharmaceuticals announces positive top line results in confirmatory phase 3 trial of probuphine

33. PULMONARY with "Discussions" in Exec Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/13_pulmonary_potential_high_impact_2012-12-11.pdf
    January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in phase … Results The table below lists the one topic in the system for which (1) preliminary phase III or later … In a randomized, double-blind, placebo-controlled, phase III clinical trial, cosponsored by the Cystic … Vertex Pharmaceuticals initiates phase 3 registration program for VX-770, an oral CFTR potentiator … Final data from phase 2 combination study of VX- 809 and Kalydeco (ivacaftor) showed statistically

34. Translation of a C. difficile Treatment Clinical Pathway Into Machine-Readable Clinical Decision Support Artifacts Prototyped for Electronic Health Record Implementation (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-report-translation-c-diff-treatment-clinical-pathway.pdf
    November 01, 2019 - Details for each phase and associated tasks are presented in Table 2. … design phase). … Minimal changes were required during the review phase of the order set prototype. … Group Recommendation Statements by Clinical Phase and Target CDS Channel Task 4. … Categorize Recommendation Statements by Clinical Phase Task 4.

35. Single-arm studies in comparative effectiveness reviews (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/single-group-studies_white-paper.pdf
    January 01, 2013 - active treatments so that they could proceed to phase 3 investigations. … Comparison of error rates in single-arm versus randomized phase II cancer clinical trials. … Incorporating historical control data in planning phase II clinical trials. … for definitive phase III testing. … Quantitative evaluation of single-arm versus randomized phase II cancer clinical trials.

36. #05 DEPRESSION (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1306.pdf
    October 01, 2014 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in phase … Results The table below lists the five topics for which (1) preliminary phase III data on drugs or phase … Paul, MN) are in phase III development for DBS for treating MDD. … III clinical trial.7 Three completed phase III trials did not demonstrate superiority of mifepristone … .16 In phase 1, using local anesthesia, a neurosurgeon drills into the patient’s skull and places the

37. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/04_dementia_potential_high_impact_june_2012.pdf
    January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in phase … Results The table below lists the three topics for which (1) preliminary phase III data for drugs, phase … -based phase III trials are ongoing for flutemetamol, and the manufacturer anticipates a premarket … exhibiting raised and normal beta-amyloid levels. 10 Flutemetamol is being investigated in two phase … Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and

38. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0210_12-07-2009.pdf
    January 01, 2009 - populations, interventions, comparators, and outcomes, will be further developed in the refinement phase … cognitive rehabilitation therapies, neurorehabilitation, and/or medication used during the non- acute phase

39. Arthritis and Nontraumatic Joint Disease (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/arthritis_hi_impact.pdf
    January 01, 2014 - Results The table below lists the six topics for which (1) preliminary phase III or later phase data … Phase III trial results are expected in late 2011 and 2012. … The company started phase III trials of a subcutaneous formulation in December 2011. … Pfizer's tofacitinib meets endpoints in final phase III trials. … Trial watch: BLYS-targeted antibody shows promise in Phase III SLE trial.

40. Research White Paper: A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research Studies (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/primary-research-design_research.pdf
    January 01, 2012 - Phase 1 involved a focused literature search to identify existing frameworks and processes that have … In phase 2, we convened a multidisciplinary group with varied expertise to develop a stepwise framework … In phase 3, we identified two systematic reviews and applied this framework to their results. … Phase 4 invited external opinions from additional experts to further refine the framework. … Phase 4 In a final phase, we invited external opinions from four additional experts with experience