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effectivehealthcare.ahrq.gov/sites/default/files/pdf/vaccine-safety_research-protocol.pdf
September 18, 2012 - The clinical evaluation of a vaccine typically consists of three phases.8 Phase I studies—which
typically … Phase II studies evaluate the immunogenicity of the
vaccine and provide preliminary estimates on the … Phase III trials provide the information on a vaccine’s safety
and effectiveness that is required to
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effectivehealthcare.ahrq.gov/sites/default/files/ch_1-user-guide-to-ocer_130129.pdf
August 13, 2012 - The first phase of human testing is
usually conducted in a limited number of healthy
volunteers (phase … then the drug is further studied in a small number
of volunteers who have the targeted condition
(phase … If phase 2 studies show that the drug
has a therapeutic effect and lacks significant
adverse effects … , trials with large numbers of
people are conducted to determine the drug’s
safety and efficacy (phase … assess the
safety of the drug in routine clinical care after the
drug is approved for marketing (phase
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effectivehealthcare.ahrq.gov/products/prostate-cancer-therapies/protocol
September 12, 2019 - therapy versus active surveillance in men with low-risk prostate cancer (CLIN1001 PCM301): an open-label, phase … Patients With Low-Risk Prostate Cancer Treated With Hypofractionated vs Conventional Radiotherapy: A Phase … 26 (763246)
29 27 and 28 (43063)
30 limit 29 to (clinical trial, all or clinical trial, phase … i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or clinical trial
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effectivehealthcare.ahrq.gov/sites/default/files/14_substanceabuse_potential_high_impact_june_2012.pdf
January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in
phase … Results
The table below lists nine topics for which (1) preliminary phase III data were available for … The buprenorphine implant is in two phase III trials,
one of which is funded by the National Institute … Titan Pharmaceuticals presents phase 3 probuphine
data at Society for Neuroscience annual meeting. … Titan Pharmaceuticals announces positive top line
results in confirmatory phase 3 trial of probuphine
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effectivehealthcare.ahrq.gov/news/improved-format-ehc-reports
Home »
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EHC Reports Have a New Look
EHC Reports Have a New Look
In an effort to make reports shorter and easier to read, we are phasing in new designs for evidence reports and summaries. Evidence Summaries have been redesigned to be no longer than four pages and pres…
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effectivehealthcare.ahrq.gov/sites/default/files/obesity_hi_impact.pdf
April 17, 2012 - III trials
for pharmaceuticals or biotechnologies or in phase II or a trial with some preliminary … Results
The table below lists the nine topics for which (1) preliminary phase III data on drug topics … Antiobesity Drugs for Treatment of Obesity
Key Facts: Three drugs are in phase III development for … In 2010, Greenway and colleagues announced results from a 56-week phase III trial (COR-I)
evaluating … Orexigen Therapeutics announces publication of
COR-I phase 3 study of Contrave in lancet.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0007_03-17-2008.pdf
January 01, 2008 - populations, interventions, comparators, and
outcomes, will be further developed in the refinement phase
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0260_07-16-2010.pdf
January 01, 2010 - populations, interventions, comparators, and outcomes, will be further developed in the
refinement phase
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effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1312.pdf
December 01, 2013 - Results
The table below lists the five topics for which (1) preliminary phase III data on drugs, phase … One of these, thalidomide, has been investigated in a
phase III trial for off-label use to treat cough … Several phase III trials have been cosponsored by the Cystic Fibrosis Foundation,
of Bethesda, MD. … Food and Drug Administration (FDA) in 2012,
continues to be under study in a phase II trial and a phase … Diffusion: The system is in the innovative phase in the United States.
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effectivehealthcare.ahrq.gov/products/psoriasis-chronic/research-protocol
September 27, 2011 - . † Plaque psoriasis development stage is described by: Phase (number of studies): status (if applicable … juvenile idiopathic arthritis in pediatric patients 6 years of age and older
Currently available; Phase … I (2): complete; Phase II: complete
Certolizumab pegol (CDP870)
Cimzia® (injectable)
UCB Inc. … Prophylaxis of acute organ rejection in patients receiving renal transplants
Currently available; Phase … to the low and very prolonged serum levels common to a particular dosage form
Currently available; Phase
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effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1506.pdf
October 01, 2015 - Results
The table below lists the five topics for which (1) preliminary phase III data for drugs or … In the phase III TRAFFIC and TRANSPORT trials, patients treated with
lumacaftor/ivacaftor (Orkambi™ … Two phase III studies are ongoing in patients who are 6–11 years
old and homozygous for F508del and … Lumacaftor/ivacaftor is also being
ES-4
investigated as a fixed-dose combination in a phase III … A phase 3 trial of pirfenidone in patients with
idiopathic pulmonary fibrosis.
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effectivehealthcare.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_2012-12-11.pdf
January 01, 2012 - Results
The table below lists the four topics for which (1) preliminary phase III data for drugs, phase … FDA approved the drug on June 27, 2012, on the basis of three completed phase
III trials. … According to the company’s drug pipeline, liraglutide 3 mg (NN8022) is
4
in phase III trials … FDA approved the drug on July 17, 2012, on the basis of two
completed, phase III trials. … This
study is an extension of a phase III, clinical trial (CONQUER).
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-topic-refinement_methods.pdf
January 01, 2013 - We use the term “provisional” to refer to the elements of the initial topic refinement phase. … previous phase (e.g., Key Questions developed in the initial topic refinement). … to the systematic review phase. … Initial Topic Refinement Phase
During the initial topic refinement phase, the topic refinement team … • Input about issues not adequately addressed in the initial topic refinement phase.
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effectivehealthcare.ahrq.gov/news/health-systems-journal-article
July 03, 2020 - Home »
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AHRQ Researchers Show How Learning Health Systems Can Help Organizations Improve Practice
AHRQ Researchers Show How Learning Health Systems Can Help Organizations Improve Practice
A recent Journal of Hospital Medicine article by AHRQ researchers explored ho…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-3-nonopioid-pharm-chronic-pain.pdf
July 01, 2022 - A
randomized, double-blind, placebo-
controlled phase III trial of duloxetine in
Japanese patients … Randomized, double-blind, placebo-
controlled phase III trial of duloxetine
monotherapy in Japanese … A
randomized, double-blind, placebo-
controlled phase III trial of duloxetine in
Japanese fibromyalgia … Efficacy and safety of fasinumab in patients
with chronic low back pain: a phase II/III
randomised … Open-
label phase 3 study of diclofenac conjugated
to hyaluronate (diclofenac etalhyaluronate:
ONO-
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effectivehealthcare.ahrq.gov/products/suicide-prevention/research-protocol
December 28, 2015 - The results of this phase will inform KQs 1, 2 and 3. … This phase will further inform KQ 1. … The primary data abstraction processes are described in detail for each phase of the review. … The final coding schema will be similar to the schema used for the systematic review phase. … in the data synthesis phase of KQ 1.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/suicide-prevention_research-protocol.pdf
December 23, 2015 - The results of this phase will inform KQs 1, 2 and 3. … This phase will further inform KQ 1. … The primary data abstraction processes are described in detail for each phase of
the review. … The final coding schema will be similar to the schema
used for the systematic review phase. … in the data synthesis phase
of KQ 1.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-1-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - Efficacy and safety of fasinumab in patients
with chronic low back pain: a phase II/III
randomised … in patients with
knee pain due to osteoarthritis: an
exploratory post hoc analysis of a Japanese
phase … or chronic low back pain with
early pain reduction: an exploratory post-
hoc analysis of Japanese phase … Open-
label phase 3 study of diclofenac conjugated
to hyaluronate (diclofenac etalhyaluronate:
ONO- … ][TM]s effect in Chinese patients with
chronic pain due to osteoarthritis: post hoc
analyses of a phase
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-3-noninvasive-nonpharma.pdf
August 01, 2022 - Phase 3 randomized, placebo-controlled,
double-blind study of lasmiditan for acute
treatment of migraine … Lasmiditan is an effective acute treatment
for migraine: a phase 3 randomized study. … Rimegepant for the acute treatment
of migraine: subgroup analyses from 3
phase 3 clinical trials by … STOP 301: A Phase 3, open-label study
of safety, tolerability, and exploratory
efficacy of INP104, … Evaluation of injection-site-related
adverse events with galcanezumab: a post
hoc analysis of phase
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-3.pdf
August 01, 2022 - Lasmiditan is an effective acute treatment
for migraine: a phase 3 randomized study. … Ubrogepant for the acute
treatment of migraine: pooled efficacy
from ACHIEVE I and ACHIEVE II
phase … Rimegepant for the acute treatment
of migraine: subgroup analyses from 3
phase 3 clinical trials by … STOP 301: A Phase 3, open-label study
of safety, tolerability, and exploratory
efficacy of INP104, … Evaluation of injection-site-related
adverse events with galcanezumab: a post
hoc analysis of phase