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Showing results for "phase".

  1. effectivehealthcare-admin.ahrq.gov/products/depression-harms/research
    May 01, 2020 - Studies mostly evaluated treatment of the acute phase (<12 weeks) of MDD that was of moderate severity … greater number of adverse events (high SOE, NNH 10) compared with placebo during treatment of the acute phase … harms of different antidepressants was limited to single RCTs, mostly studying treatment of the acute phase … In patients 65 years of age or older, treatment of the acute phase of MDD with SNRIs (duloxetine and
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1512.pdf
    December 01, 2015 - Four phase III trials are ongoing. … Four phase III trials are ongoing. … Two phase III trials are ongoing. … GSK presents mepolizumab phase III results in ERS. [internet]. … A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.
  3. effectivehealthcare-admin.ahrq.gov/products/cesarean-birth-future/research
    December 01, 2019 - Data Sources In phase 1, stakeholders participated in semistructured interviews to identify and describe … In phase 2, stakeholders participated in a modified Delphi process to rank the top 10 research priorities … We invited 11 stakeholders to participate in the phase 2 Delphi process.
  4. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0277_03-10-2008.pdf
    January 01, 2008 - populations, interventions, comparators, and outcomes, will be further developed in the refinement phase … The diseases covered in the AHRQ review will be defined during the refinement phase.
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ahrq-healthcare-horizon-scan-protocol-operations-manual-151001.pdf
    September 01, 2015 - The “track-only” designation means that the intervention is in late-phase trials, but late-phase data … All topics proceed through Phase 1. … Phase 2. … Phase 1 – Internal Expert Comment and Triage (all topics) In Phase 1. … Phase 2 – External Expert Comment Select topics enter Phase 2.
  6. effectivehealthcare-admin.ahrq.gov/sites/default/files/ahrq-healthcare-horizon-scan-protocol-operations-manual-151001.pdf
    September 01, 2015 - The “track-only” designation means that the intervention is in late-phase trials, but late-phase data … All topics proceed through Phase 1. … Phase 2. … Phase 1 – Internal Expert Comment and Triage (all topics) In Phase 1. … Phase 2 – External Expert Comment Select topics enter Phase 2.
  7. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/survival-quality_research.pdf
    April 01, 2013 - capecitabine alone HRQL analysis of Cameron 2008, phase III, randomized, open-label, multicenter … Is this study A) a phase III (RCT) trial B) does it address one of the combinations below: AND … Schetelig Level: 2, State: Excluded Refid: 1588, Independent radiologic review of OCEANS, a phase … Vahdat Level: 2, State: Excluded Refid: 1600, Phase II escalation study of sorafenib in patients … Mahner Level: 2, State: Excluded Refid: 1630, A Randomized, Phase II Trial of Standard Triweekly
  8. effectivehealthcare-admin.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1412.pdf
    December 22, 2014 - Results The table below lists the eight topics for which (1) preliminary phase III data on drugs, phase … A number of other manufacturers also have all-oral HCV regimens in phase II or phase III development … Sofosbuvir and RBV regimens: In phase III trials, patients infected with HCV genotypes 2 and 3 who … Daclatasvir/sofosbuvir: In a phase II, open-label randomized controlled trial, patients with chronic … In the phase III, randomized controlled VALENCE trial, patients (n=419) with chronic HCV genotype 2
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/13_pulmonary_potential_high_impact_june_2012.pdf
    January 01, 2012 - Results The table below lists the three topics for which (1) preliminary phase III or later data were … available for drugs or phase II, III, or later data were available for devices and procedures; (2) … Another drug, roflumilast, failed to meet its primary endpoints in a just-completed phase III trial … The drug is in several phase III clinical trials cosponsored by the Cystic Fibrosis Foundation. … Vertex corrects and provides additional data from recent interim analysis of phase 2 combination
  10. effectivehealthcare-admin.ahrq.gov/sites/default/files/13_pulmonary_potential_high_impact_2012-12-11.pdf
    January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in phase … Results The table below lists the one topic in the system for which (1) preliminary phase III or later … In a randomized, double-blind, placebo-controlled, phase III clinical trial, cosponsored by the Cystic … Vertex Pharmaceuticals initiates phase 3 registration program for VX-770, an oral CFTR potentiator … Final data from phase 2 combination study of VX- 809 and Kalydeco (ivacaftor) showed statistically
  11. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/substanceabuse_hi_impact.pdf
    January 01, 2012 - III trials for pharmaceuticals or biotechnologies or in phase II or a trial with some preliminary … The table below lists the eight topics for which (1) preliminary phase III data were available for … The buprenorphine implant is currently in two phase III trials, one of which is funded by the National … Titan Pharmaceuticals presents phase 3 probuphine data at society for Neuroscience annual meeting … Titan Pharmaceuticals announces positive top line results in confirmatory phase 3 trial of probuphine
  12. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0210_12-07-2009.pdf
    January 01, 2009 - populations, interventions, comparators, and outcomes, will be further developed in the refinement phase … cognitive rehabilitation therapies, neurorehabilitation, and/or medication used during the non- acute phase
  13. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-report-translation-c-diff-treatment-clinical-pathway.pdf
    November 01, 2019 - Details for each phase and associated tasks are presented in Table 2. … design phase). … Minimal changes were required during the review phase of the order set prototype. … Group Recommendation Statements by Clinical Phase and Target CDS Channel Task 4. … Categorize Recommendation Statements by Clinical Phase Task 4.
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/single-group-studies_white-paper.pdf
    January 01, 2013 - active treatments so that they could proceed to phase 3 investigations. … Comparison of error rates in single-arm versus randomized phase II cancer clinical trials. … Incorporating historical control data in planning phase II clinical trials. … for definitive phase III testing. … Quantitative evaluation of single-arm versus randomized phase II cancer clinical trials.
  15. #05 DEPRESSION (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1306.pdf
    October 01, 2014 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in phase … Results The table below lists the five topics for which (1) preliminary phase III data on drugs or phase … Paul, MN) are in phase III development for DBS for treating MDD. … III clinical trial.7 Three completed phase III trials did not demonstrate superiority of mifepristone … .16 In phase 1, using local anesthesia, a neurosurgeon drills into the patient’s skull and places the
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/04_dementia_potential_high_impact_june_2012.pdf
    January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in phase … Results The table below lists the three topics for which (1) preliminary phase III data for drugs, phase … -based phase III trials are ongoing for flutemetamol, and the manufacturer anticipates a premarket … exhibiting raised and normal beta-amyloid levels. 10 Flutemetamol is being investigated in two phasePhase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and
  17. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-0663-131114.pdf
    April 10, 2013 - populations, interventions, comparators, and outcomes, will be further developed in the refinement phase
  18. effectivehealthcare-admin.ahrq.gov/sites/default/files/arthritis_hi_impact.pdf
    January 01, 2014 - Results The table below lists the six topics for which (1) preliminary phase III or later phase data … Phase III trial results are expected in late 2011 and 2012. … The company started phase III trials of a subcutaneous formulation in December 2011. … Pfizer's tofacitinib meets endpoints in final phase III trials. … Trial watch: BLYS-targeted antibody shows promise in Phase III SLE trial.
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0024_06-09-2008.pdf
    January 01, 2008 - populations, interventions, comparators, and outcomes, will be further developed in the refinement phase
  20. effectivehealthcare-admin.ahrq.gov/products/medicare-medication-use/research
    December 01, 2019 - In addition, the existence of a Part D coverage gap before reaching the catastrophic coverage phase can

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