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  1. Obesity (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/obesity_hi_impact.pdf
    April 17, 2012 - III trials for pharmaceuticals or biotechnologies or in phase II or a trial with some preliminary … Results The table below lists the nine topics for which (1) preliminary phase III data on drug topics … Antiobesity Drugs for Treatment of Obesity  Key Facts: Three drugs are in phase III development for … In 2010, Greenway and colleagues announced results from a 56-week phase III trial (COR-I) evaluating … Orexigen Therapeutics announces publication of COR-I phase 3 study of Contrave in lancet.
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0260_07-16-2010.pdf
    January 01, 2010 - populations, interventions, comparators, and outcomes, will be further developed in the refinement phase
  3. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0007_03-17-2008.pdf
    January 01, 2008 - populations, interventions, comparators, and outcomes, will be further developed in the refinement phase
  4. effectivehealthcare-admin.ahrq.gov/products/psoriasis-chronic/research-protocol
    December 01, 2019 - . † Plaque psoriasis development stage is described by: Phase (number of studies): status (if applicable … juvenile idiopathic arthritis in pediatric patients 6 years of age and older Currently available; Phase … I (2): complete; Phase II: complete Certolizumab pegol (CDP870) Cimzia® (injectable) UCB Inc … Prophylaxis of acute organ rejection in patients receiving renal transplants Currently available; Phase … † Plaque psoriasis development stage is described by: Phase (number of studies): status (if
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1312.pdf
    December 01, 2013 - Results The table below lists the five topics for which (1) preliminary phase III data on drugs, phase … One of these, thalidomide, has been investigated in a phase III trial for off-label use to treat cough … Several phase III trials have been cosponsored by the Cystic Fibrosis Foundation, of Bethesda, MD. … Food and Drug Administration (FDA) in 2012, continues to be under study in a phase II trial and a phase … Diffusion: The system is in the innovative phase in the United States.
  6. effectivehealthcare-admin.ahrq.gov/products/copd/research
    January 01, 2021 - ), early pulmonary rehabilitation commenced before hospital discharge during the initial most acute phase … ), early pulmonary rehabilitation commenced before hospital discharge during the initial most acute phase
  7. effectivehealthcare-admin.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1506.pdf
    October 01, 2015 - Results The table below lists the five topics for which (1) preliminary phase III data for drugs or … In the phase III TRAFFIC and TRANSPORT trials, patients treated with lumacaftor/ivacaftor (Orkambi™ … Two phase III studies are ongoing in patients who are 6–11 years old and homozygous for F508del and … Lumacaftor/ivacaftor is also being ES-4 investigated as a fixed-dose combination in a phase III … A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.
  8. Obesity (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_2012-12-11.pdf
    January 01, 2012 - Results The table below lists the four topics for which (1) preliminary phase III data for drugs, phase … FDA approved the drug on June 27, 2012, on the basis of three completed phase III trials. … According to the company’s drug pipeline, liraglutide 3 mg (NN8022) is 4 in phase III trials … FDA approved the drug on July 17, 2012, on the basis of two completed, phase III trials. … This study is an extension of a phase III, clinical trial (CONQUER).
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-topic-refinement_methods.pdf
    January 01, 2013 - We use the term “provisional” to refer to the elements of the initial topic refinement phase. … previous phase (e.g., Key Questions developed in the initial topic refinement). … to the systematic review phase. … Initial Topic Refinement Phase During the initial topic refinement phase, the topic refinement team … • Input about issues not adequately addressed in the initial topic refinement phase.
  10. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/surveillance-report-3-nonopioid-pharm-chronic-pain.pdf
    July 01, 2022 - A randomized, double-blind, placebo- controlled phase III trial of duloxetine in Japanese patients … Randomized, double-blind, placebo- controlled phase III trial of duloxetine monotherapy in Japanese … A randomized, double-blind, placebo- controlled phase III trial of duloxetine in Japanese fibromyalgia … Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised … Open- label phase 3 study of diclofenac conjugated to hyaluronate (diclofenac etalhyaluronate: ONO-
  11. Untitled (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/suicide-prevention_research-protocol.pdf
    December 23, 2015 - The results of this phase will inform KQs 1, 2 and 3. … This phase will further inform KQ 1. … The primary data abstraction processes are described in detail for each phase of the review. … The final coding schema will be similar to the schema used for the systematic review phase. … in the data synthesis phase of KQ 1.
  12. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/surveillance-report-1-nonopioid-pharm-chronic-pain.pdf
    April 01, 2022 - Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised … in patients with knee pain due to osteoarthritis: an exploratory post hoc analysis of a Japanese phase … or chronic low back pain with early pain reduction: an exploratory post- hoc analysis of Japanese phase … Open- label phase 3 study of diclofenac conjugated to hyaluronate (diclofenac etalhyaluronate: ONO- … ][TM]s effect in Chinese patients with chronic pain due to osteoarthritis: post hoc analyses of a phase
  13. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-3.pdf
    August 01, 2022 - Lasmiditan is an effective acute treatment for migraine: a phase 3 randomized study. … Ubrogepant for the acute treatment of migraine: pooled efficacy from ACHIEVE I and ACHIEVE II phase … Rimegepant for the acute treatment of migraine: subgroup analyses from 3 phase 3 clinical trials by … STOP 301: A Phase 3, open-label study of safety, tolerability, and exploratory efficacy of INP104, … Evaluation of injection-site-related adverse events with galcanezumab: a post hoc analysis of phase
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/surveillance-report-2-nonopioid-pharm-chronic-pain.pdf
    April 01, 2022 - Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised … in patients with knee pain due to osteoarthritis: an exploratory post hoc analysis of a Japanese phase … or chronic low back pain with early pain reduction: an exploratory post- hoc analysis of Japanese phase … Open- label phase 3 study of diclofenac conjugated to hyaluronate (diclofenac etalhyaluronate: ONO- … ][TM]s effect in Chinese patients with chronic pain due to osteoarthritis: post hoc analyses of a phase
  15. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cultural-competence_research-protocol.pdf
    July 09, 2014 - The literature set identified at this phase will be examined from a content analysis perspective for …  ii.pt.   41   clinical  trial,  phase  iii.pt.   42   clinical  trial,  phase …  i.pt.   40   clinical  trial,  phase  ii.pt.   41   clinical  trial,  phase   … iii.pt.   42   clinical  trial,  phase  iv.pt.   43   controlled  clinical  trial.pt …  i.pt.   40   clinical  trial,  phase  ii.pt.   41   clinical  trial,  phase  
  16. effectivehealthcare-admin.ahrq.gov/products/distributed-network-expansion/research
    January 01, 2019 - The enhancements described below will be incorporated into Phase 2 of our Distributed Research Network … We designated this activity as Phase 1.5, to distinguish it from the task order that ended in August … Our approach was based on lessons learned from Phase 1 of DRN and specifically on our findings that a … Data Mart Client Functions Workflow Manager— In this phase, the Data Mart Client was extended so … Document Scope This document describes the functional requirements and design for DRN phase 1.5.
  17. #05 DEPRESSION (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/05_depression_potential_high_impact_2012-12-10.pdf
    January 01, 2012 - inclusion are those interventions expected to be within 0–4 years of potential diffusion (e.g., in phase … Results The table below lists the seven topics for which (1) preliminary phase III data on drugs or … Mifepristone for treating PMD is being investigated in one phase III clinical trial. … Three phase III trials did not individually demonstrate statistical superiority of mifepristone over … Paul, MN) are both in phase III development for DBS for MDD.
  18. effectivehealthcare-admin.ahrq.gov/sites/default/files/functional-limitations-horizon-scan-high-impact-1306.pdf
    June 01, 2013 - Results The table below lists the 17 topics for which (1) preliminary phase III data were available … In phase III trials, icatibant provided significant symptom relief within about 2 hours and initial … Placebo- controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. … Placebo- controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. … ThromboGenics' microplasmin phase III program progressing according to schedule. [internet].
  19. #05 DEPRESSION (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1312.pdf
    October 01, 2014 - Results The table below lists the five topics for which (1) preliminary phase III data for drugs were … Completed phase III trials did not demonstrate statistical superiority of mifepristone over placebo … Paul, MN) are in phase III development for DBS for treating BPD and MDD. … Reclaim/Activa trials for MDD have an anticipated completion date of October 2014; phase III trials … III clinical trial.9 Three completed phase III trials did not demonstrate superiority of mifepristone
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ptsd-comments.pdf
    November 04, 2020 - Since the Phase 1 work and report, we have worked closely with the National Center for PTSD to obtain … Since the Phase 1 work and report, we have worked closely with the National Center for PTSD to obtain … For this phase of development, as recommended by the TEP and NCPTSD, treatments were categorized according … of the PTSD-Repository and updated in this next phase of work. … in a subsequent article highlighting the updates to the PTSD- Repository completed in this second phase

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