-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/abnormal-uterine-bleeding_disposition-comments.pdf
March 21, 2013 - AUB-E wasn’t acknowledged and patients were
not systematically evaluated for AUB-C. … For KQ1B, risk of
bias associated with blinding of patients,
personnel and outcome assessment was … For KQ1A, risk
of bias associated with blinding of patients
and personnel and incomplete outcome data … section identifies 4 studies that may
provide additional information on relative effectiveness and
safety … commended for a careful and detailed
analysis of a large number of studies assessing effectiveness
and safety
-
effectivehealthcare.ahrq.gov/sites/default/files/08_functional_limitations_potential_high_impact_2012-12-10.pdf
January 01, 2012 - Use of the system would
represent a way to purportedly enhance patient mobility and allow patients … of dimethyl fumarate because of the efficacy and safety profile reported in patients with
RRMS. … Experts remained divided on per-patient costs with OBI-1 therapy, but thought clinicians and
patients … Regarding potential
acceptance by patients and clinicians, one clinical expert commented, “The safety … One research expert opined that elderly
patients may have more reservations than a younger patient
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/bariatric-surgery_research.pdf
June 01, 2010 - about the outcomes, clinical effectiveness, safety, and appropriateness of health care items and … We tabulated the number of unique therapeutic classes of drug that the patient had ―on
hand‖ at the … If this supply would result in the patient having sufficient drug
―on hand‖ to overlap with a seven … day window surrounding the time point of interest, the patient
was considered to have been on this … utilization variables (hospitalizations, outpatient visits,
medical and pharmacy payments) and other indicators
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rtc-design-principles_research.pdf
January 01, 2009 - the new test produces
other benefits, such as improved safety or reduced costs. … more efficient RCT designs may be possible.1,2 In other situations, comparative
evidence about the safety … itself, such as safety and acceptability, without changing patient
management. … As shown in Figure 1, differences in test safety and test
accuracy always deserve consideration. … Alternatively, if the new test is intended to provide other attributes such as
improved safety, the
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
June 01, 2012 - In secondary analyses, we explored a broader patient
population by including those studies that had … Insufficient 13 studies (9 good quality, 4 fair) reported data pertinent to safety concerns or risks … Study results on these
issues were reported for the total patient population and
did not separate the … Third, most studies lacked long-term followup
of the patient population, which affected our ability … Reporting of risk, harms, and/or safety outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/ahrq-healthcare-horizon-scan-protocol-operations-manual-151001.pdf
September 01, 2015 - Anticipated Cost Per Patient (if known)
11. … Potential Patient and Clinical Staff Safety Issues
14. … Patient Safety Issues (if applicable)
11. Required Resources
12. … as
• Additional, stronger, confirmatory data that could change perspectives on potential impact
• Safety … safety alert been issued that could signal a safety/efficacy change in perspectives
2.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ahrq-healthcare-horizon-scan-protocol-operations-manual-151001.pdf
September 01, 2015 - Anticipated Cost Per Patient (if known)
11. … Potential Patient and Clinical Staff Safety Issues
14. … Patient Safety Issues (if applicable)
11. Required Resources
12. … as
• Additional, stronger, confirmatory data that could change perspectives on potential impact
• Safety … safety alert been issued that could signal a safety/efficacy change in perspectives
2.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/health-systems-research.pdf
October 01, 2017 - The
experience and reputation are the most important indicators a KI uses for whether a source will … They were interested in the most reasonable actions, not
necessarily a list of options, to use in patient … How to use evidence that is frequently not applicable to the typical patient or patient subset
seen … KIs were concerned about the extent to which the evidence in the
literature is applicable to the patient … to get these patients and so how can we sort of assess these patients in a
way that really helps us
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_disposition-comments.pdf
February 26, 2013 - ) with Figures 3
and 4 which for patient level data are shown for 6 RCT’s and 6
non-randomized studies … This is consistent with
patients included in the various FFR trials – all patients were
assessed by … Improved
patient-centered outcomes from FFR have been demonstrated
in a wide variety of patient subsets … of all cause death, documented MI, unplanned
hospitalization leading to urgent revascularization), safety … Enrollment in FAME II
was recently halted early by the DSMB (data safety and
monitoring board) due
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research.pdf
June 01, 2017 - The information in this report is intended to help health care decisionmakers—patients and
clinicians … information, i.e., in the context of available
resources and circumstances presented by individual patients … NCT01404611 gives results for 330 patients for time to cessation of otorrhea and adverse
events up to … NCT01908803 gives results for 68 patients for proportion of subjects with sustained clinical
cure at … Safety and
Efficacy of Intratympanic Ciprofloxacin
Otic Suspension in Children With Middle
Ear Effusion
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_surveillance.pdf
March 01, 2013 - patients with PsA, do drug therapies differ in their ability to improve patient-reported symptoms, functional … The most
commonly reported SIE in PsA
patients was urinary tract infection
(0.4 per 100 patient years … Adalimumab: long-term safety in
23 458 patients from global clinical trials in
rheumatoid arthritis … No safety issues
noted. … The
most commonly
reported SIE in PsA
patients was urinary
tract infection (0.4
per 100 patient
-
effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1512.pdf
December 01, 2015 - According to the Cystic Fibrosis Foundation’s 2014 patient registry, almost 47%
of CF patients in the … One phase III trial is
ongoing, evaluating pirfenidone’s long-term safety and efficacy in patients … However, experts thought
that patients are likely to accept lumacaftor/ivacaftor if long-term safety … Safety
and efficacy of treatment with lumacaftor in
combination with ivacaftor in patients with CF … Safety and
tolerability of nintedanib in patients with Ipf:
interim analysis from an open-label extension
-
effectivehealthcare.ahrq.gov/sites/default/files/functional-limitations-horizon-scan-high-impact-1306.pdf
June 01, 2013 - Using the
system would represent a way to purportedly enhance patient mobility and allow patients to … fumarate because of the efficacy and safety profile reported in patients with RRMS, the
experts thought … Regarding acceptance by both patients and clinicians, one clinical expert commented, “The safety
profile … Experts generally agreed that potential patient adoption would be high because of patients’ desire to … One research expert opined that elderly patients may have more reservations than a younger patient
-
effectivehealthcare.ahrq.gov/products/hypothyroidism-hyperthyroidism-screening-treatment/research-protocol
March 10, 2010 - over 35 years of age every 5 years (more frequently if the patient is at increased risk), but has not … sh]
toxicity [sh]
contraindications [sh]
complications [sh]
1 OR 2 OR 3 OR 4 OR 5
(safe OR safety … adverse [tiab]
(effect$ OR reaction$ OR event$ OR outcome$) [tiab]
8 AND 9
10 OR 7 OR 6
P
Patient … issues of testing
Patient Satisfaction[Mesh]
Perception"[Mesh]
Family[Mesh]
Stress, Physiological … Committee on Patient S, Quality I, Committee on Professional L.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/horizon-scan_research-protocol.pdf
December 01, 2011 - Potential Patient and Clinical Staff Safety Issues
17. … Patient Safety Issues (if applicable)
15. Required Resources
16. … data from conferences or published articles reporting different results or
confirming efficacy and safety … Safety data that could change perspectives
c. … Has a patient safety alert been issued that could signal a safety/efficacy
change in perspectives?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-future_research.pdf
May 01, 2012 - attention on the strength and limits of evidence from research studies about the effectiveness and
safety … For KQ 2, long-term effectiveness and safety studies of several psychostimulants in children
over the … Web-based prioritization exercises allowed each stakeholder to
distribute a limited number of star-shaped indicators … or patient derived information … Many patients and providers are
likely to switch treatments if patients experience harmful side effects
-
effectivehealthcare.ahrq.gov/sites/default/files/01_-arthritis_potential_high_impact_june_2012.pdf
January 01, 2012 - These safety concerns may present barriers to
approval or barriers to diffusion if approved. … determinations stated MSC therapy is investigational because of insufficient evidence or long-term
safety … Both groups had similar safety
profiles.
29
In a study of patients with knee OA (Outerbridge grades … as a hospital
blood bank or blood processing laboratory) according to standard blood processing safety … These safety concerns may
present significant barriers to approval and diffusion if approved.
-
effectivehealthcare.ahrq.gov/products/osteoarthritis-knee-update/research-protocol
June 16, 2016 - update if needed--a systematic review that was conducted in 2007 1 that assessed the efficacy and safety … As a result of the divergent findings of several recent systematic reviews on the efficacy and safety … Because our EPC recently completed a SR on the effectiveness and safety of hyaluronic acid to treat OA … for scientific information packets that contain any unpublished information on the efficacy and/or safety … For assessments of safety, we will consider the consistency between the findings of trials to those of
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_executive.pdf
October 01, 2006 - This report summarizes the evidence evaluating the
effect and safety of angioplasty with stent placements … What are the patient characteristics, including
etiology, predominant clinical presentation,
and severity … A
variety of indicators of the severity of ARAS and of
health problems, such as poorer kidney function … The
reviewed studies did not report any indicators that may
predict improved outcomes. … The other trial included patients with lower
grade stenosis (>50 percent) but did not exclude
patients
-
effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update-disposition-170621.pdf
March 16, 2017 - develop,
for example if tardive dyskinesia takes years to
develop then one is less certain about the safety … Was this a covariates model
with subgroup indicators as covariates? … , and Thioridazine,
15 patients. … Ref 123
had one patient discontinue however it does not
appear that this was considered a major AE … The objectives of this
study were to collect safety data in long term
treatment of pediatric subjects