-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/Evidence%20Summary_0_0.pdf
April 01, 2020 - with moderate or severe disorders and for
patients with mild disorders who do not improve. … accounts for underlying
patient characteristics. … A double-blind
efficacy and safety study of duloxetine fixed doses in
children and adolescents with … Suicidality in
pediatric patients treated with antidepressant drugs. … Treatment
for Adolescents with Depression Study (TADS):
safety results.
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effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
March 01, 2022 - https://effectivehealthcare.ahrq.gov/products/safety-vaccines/research
7
Automated-Entry Patient-Generated … for patients, implementation of an opioid
safety initiative, provision of patient information
and … adaptations
of the ACCESS model) may improve system-level
markers, including guideline-based quality
indicators … Direct patient care strategies are
those that directly inform the patients’ own treatment
decisions … Evidence Gaps
Study Populations
• With the exception of critically ill patients, studies
of patient
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/future05-breastcancer-10-5-2010final.pdf
September 01, 2010 - attention on the strength and limits of evidence from research studies about the effectiveness and
safety … Patient - understanding why more patients
do not use SERMs
b. … C2: What factors influence patient and clinician decision making? … A Phase I, open
label, oral, single-dose, escalating,
randomized, parallel study to evaluate
safety … Tamoxifen-associated
vasculitis in a breast cancer patient.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rotator-cuff-tear-surveillance-140925.pdf
February 01, 2014 - No Signal
3.3 Safety surveillance alerts [Cycle 3]
There were no safety surveillance alerts relevant … and University
of California, Los Angeles
(UCLA) scores
Clinical outcomes of pain
intensity and patient … Papadopoulos 2011 Functional outcome 57 patients (62 Arthroscopic Factors predictive of: Patient age, … Nho SJ, et 2009 Prospective analysis 193 patients who All-arthroscopic repair Patient demographic and … Overall, 72 of the 137 studies examined the impact of
prognostic factors on patient outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
June 01, 2012 - In secondary analyses, we explored a broader patient
population by including those studies that had … Insufficient 13 studies (9 good quality, 4 fair) reported data pertinent to safety concerns or risks … Study results on these
issues were reported for the total patient population and
did not separate the … Third, most studies lacked long-term followup
of the patient population, which affected our ability … Reporting of risk, harms, and/or safety outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy-disposition-170415.pdf
January 17, 2017 - objective of systematically reviewing the evidence
from research studies about the effectiveness and
safety … The key findings are important
for clinicians, patients and stakeholders. … Adequate allocation
concealment prevents foreknowledge of the
group to which a patient would be assigned … Peer reviewer #4 Results KQ4: Were there differences in the risk tonsillectomy
by age of the patient … Adequate allocation
concealment prevents foreknowledge of the
group to which a patient would be assigned
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_disposition-comments.pdf
December 01, 2011 - also allowed Gleason 7 patients. … Behavioral indicators. … disease-specific
outcomes of these studies,
acknowledging that it will give only a
general sense of the safety … We have clarified that no study used formal assessment of
any behavioral indicators. … researchers in the field of AS should be
lauded for their efforts to advance this field
and enhance the safety
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_4-user-guide-to-ocer_130129.pdf
January 01, 2010 - Each intervention (e.g., medication, surgery,
patient education program) requires a unique and
thoughtful … characteristics of exposure, observational
comparative effectiveness studies often have
to rely on proxy indicators … This example may be best illustrated
by a comparative safety evaluation of the impact
of oral corticosteroids … Is
it necessary to know whether a given medication
was taken by the patient on a particular day or … The characteristics of the exposure and the patient
population are likely to influence the validity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_disposition-comments.pdf
May 13, 2014 - For
example, for disulfiram, we know this is a magic bullet to stop drinking if the
patient takes the … For instance, if a patient is
taking disulfiram and drinks, the person will know if he/she is taking … Hepatic safety of injectable extended-
release naltrexone in patients with chronic hepatitis C and HIV … #1;
Alkermes,
Inc.,
Bernard
Silverman,
maker of
Vivitrol
Results Review Key Question 3 and Safety … Hepatic safety of injectable
extended-release naltrexone in patients with chronic hepatitis C and HIV
-
effectivehealthcare.ahrq.gov/sites/default/files/s166.pdf
October 01, 2007 - The efficacy and safety of benzodiazepines and nonbenzodiazepines,
relative to placebo, were compared … Office of Medical Applications of Research
(OMAR) to perform a systematic review of the efficacy
and safety … authors to make decisions about the main
comparisons to be meta-analyzed with respect to the efficacy
and safety … To examine the relative efficacy and safety of active
treatments, we performed indirect comparisons (
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-treatment_research-protocol.pdf
September 30, 2010 - UI because of sampling and self-
selection of the survey participants.1 Clinic-based studies include patients … methods help to prescribe appropriate treatments for different types of incontinence to
best benefit patients … We will monitor the FDA website for warnings and safety information for all
eligible drugs and devices … Patient outcomes (clinical events). … Attributable risk will be calculated as the outcome events rate in patients exposed to different
clinical
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/wireless-motility-capsule_executive.pdf
May 01, 2013 - Testing can
explain why a patient fails basic therapy and can help
identify or exclude patients as … scintigraphy†
Harms Low 2 Harms associated with WMC are minimal and no
major safety issues were reported … scintigraphy
Patient-centered
outcomes
Insufficient 0 No studies reported on patient-centered outcomes … such as patient satisfaction or change
in symptom scores. … Phase 2 Study to Evaluate Safety & Efficacy
of RM-131 Administered to Patients With Diabetic Gastroparesis
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-update_research-protocol.pdf
January 15, 2015 - In the United States, 12 to 14 percent
of new patients entering dialysis programs have been found to … cases.10 Especially given the inconclusive evidence to date, it is
important to best understand which patient … What are the patient characteristics, including etiology, predominant clinical
presentation, and severity … Analytic framework for evaluating the effectiveness and
safety of treatments for renal artery
stenosis … publications or interview
or lectures or legal cases or legislation or letter or news or newspaper article or patient
-
effectivehealthcare.ahrq.gov/sites/default/files/study-objectives-and-questions-chapter-1.pptx
January 01, 2013 - Synthesize the literature and characterize the known effects of the exposures and interventions on patient … synthesize the literature and characterize the known effects of the exposures and interventions on patient … investigators should summarize in the protocol what is known about the efficacy, effectiveness, and safety … Based on a conceptual model, define study questions using PICOTS:
Population: What is the patient population … How do patients and other stakeholders define a meaningful difference between interventions?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_clinician.pdf
May 01, 2016 - sympathomimetic drugs for weight loss has been associated with serious
cardiovascular adverse events, and the safety … These patients should be monitored for emergence and worsening of
suicidal thoughts and behaviors. … treatment outcomes
among important subgroups defined by age, sex, race,
ethnicity, or other relevant patient … the importance of talking with their health care
professionals if any adverse effects develop
�� Patient … To order free print copies of the patient resource, call the
AHRQ Publications Clearinghouse at 800-
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-protocol.pdf
July 10, 2018 - or their loved ones are
considering, and augment and inform the use of existing tools to assist in patient … • Settings—No restriction by location of either the provider or patient (e.g., military base,
Veterans … Attendance and substance use outcomes for the Seeking
Safety program: sometimes less is more. … Number of trauma types and traumatic events experienced per patient*
c. … Exclusion of patients with suicidality*
Outcomes
a.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-protocol.pdf
July 10, 2018 - or their loved ones are
considering, and augment and inform the use of existing tools to assist in patient … • Settings—No restriction by location of either the provider or patient (e.g., military base,
Veterans … Attendance and substance use outcomes for the Seeking
Safety program: sometimes less is more. … Number of trauma types and traumatic events experienced per patient*
c. … Exclusion of patients with suicidality*
Outcomes
a.
-
effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1512.pdf
December 01, 2015 - According to the Cystic Fibrosis Foundation’s 2014 patient registry, almost 47%
of CF patients in the … One phase III trial is
ongoing, evaluating pirfenidone’s long-term safety and efficacy in patients … However, experts thought
that patients are likely to accept lumacaftor/ivacaftor if long-term safety … Safety
and efficacy of treatment with lumacaftor in
combination with ivacaftor in patients with CF … Safety and
tolerability of nintedanib in patients with Ipf:
interim analysis from an open-label extension
-
effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1312.pdf
December 01, 2013 - designed to cater to
the special needs of the senior population (people aged 65 and older) to improve safety … safety.20,21 During the transition, medications may be altered and self-care
responsibilities increased … The authors also reported “strong indicators of clinical
effectiveness and a 98 percent ‘would recommend … effectiveness and safety. … In general, experts called for more substantial
data proving the safety and effectiveness of this care
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_executive.pdf
September 19, 2014 - *Including opioid management plans, patient education, urine drug screening, use of prescription drug … http://www.cdc.gov/homeandrecreational safety/overdose/
facts.html. Accessed July 17, 2014.
22. … Long-term safety
and tolerability of tapentadol extended release for the
management of chronic low … Methadone safety:
a clinical practice guideline from the American Pain
Society and College on Problems … The efficacy
and safety of fentanyl buccal tablet compared with
immediate-release oxycodone for the