-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/lysosomal-storage-diseases-therapies_disposition-comments.pdf
January 01, 2014 - The 2006 publication addresses safety and efficacy
outcomes that support the main label claims. … What about patient selection for
treatment (e.g. whether to treat patients with Hunter,
Hurler with … Other elements of ACA insulate patients
from catastrophic costs and may offset lower income patient … Public
Bozarth
Methods Page
8
Only 2 patients (one patient/one caregiver) interviewed for a
technical … The purpose of the report was to commment on
the efficacy and safety of ERT.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/patient-centered-medical-home_research-protocol.pdf
February 23, 2012 - as a way of improving patient experiences,
outcomes, safety, and system efficiency.10-12 It is based … Intermediate patient outcomes (e.g., change in HbA1c for diabetic patients).
b. … A systems-based approach to quality, safety, and delivery of evidence-based care. … Intermediate patient outcomes (e.g., change in HbA1c for diabetic
patients).
ii. … care, superb access to care, and a systems-
based approach to quality and safety.
-
effectivehealthcare.ahrq.gov/products/ptsd-repository-update/protocol
September 21, 2021 - reporting; (4) serve as a source for clinicians seeking information on effectiveness of interventions for patients … up-to-date accounting of evidence to respond to inquiries; and (7) augment and inform the use of existing patient … meditation or "mind body" or mindfulness or music or "prolonged exposure" or relaxation or "seeking safety … meditation or "mind body" or mindfulness or music or "prolonged exposure" or relaxation or "seeking safety … depression
% with substance use disorder
% with history of traumatic brain injury
Indicate if patients
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_disposition-comments.pdf
January 01, 2015 - We removed the word safety from
the title for Table D. … We
have discussed patient preference as well as
cost briefly as potential drivers. … Efficacy and
safety of the once-weekly GLP-1 receptor agonist
albiglutide versus sitagliptin in patients … varies with patient
characteristics. … 16 patients 0.2 in the placebo group P 0.42
definite acute pancreatitis in 17 patients 0.2 and 9
patients
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_disposition-comments.pdf
September 01, 2011 - “In addition, the patient herself could
administer 0.25 mL twice daily if increased
uterine activity … Peer Reviewer 4 KQ4
(Neonatal
Harms)
Significant information about the safety of SCT infusion was … 4 KQ6
(incidence
of pump
Failure)
Lastly, many of the articles with good data on efficacy (and safety … As
previously noted, the safety data should be bolstered by including the
references previously mentioned … Source: www.effectivehealthcare.ahrq.gov
12
helpful in the appropriate patient as well as to
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/deficit-hyperactivity.pdf
January 01, 2019 - Deficit Hyperactivity Disorder: Diagnosis and Treatment in
Children and Adolescents
Background
The Patient-Centered … What are the comparative safety and effectiveness of pharmacologic and/or
nonpharmacologic treatments … What are the comparative safety and effectiveness of different monitoring
strategies to evaluate the … pharmacologic
agents approved by the FDA for the
treatment of ADHD that have enrollment
of fewer than 100 patients … with comparator; for diagnostic
accuracy, cross-sectional studies are acceptable if they
include patients
-
effectivehealthcare.ahrq.gov/products/atrial-fibrillation/research-protocol
January 27, 2012 - Do the comparative safety and effectiveness of these therapies differ among specific patient subgroups … Do the comparative safety and effectiveness of these therapies differ among specific patient subgroups … Do the comparative safety and effectiveness of these therapies differ among specific patient subgroups … Do the comparative safety and effectiveness of these therapies differ among specific patient subgroups … Do the comparative safety and effectiveness of these therapies differ among specific patient subgroups
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_executive.pdf
August 01, 2013 - The number of patients included in studies ranged
from fewer than 100 to 170,291, with overlap in patient … The number of patients included in studies ranged
from fewer than 600 to 170,291, with overlap in patient … Warfarin
Ischemic stroke 1 (707) SOE = Low
9 LAA patients (1.3 events per 100 patient-years) and 6 … warfarin patients (1.6 events per 100 patient-years) had
ischemic stroke, demonstrating no difference … Given
variability in patient populations, concomitant therapies,
and underlying patient care, cross-trial
-
effectivehealthcare.ahrq.gov/products/migraine-prevention/research-protocol
November 03, 2011 - Patients with chronic migraine represent the majority of patients seen in headache specialty clinics … Question 3
Which patient characteristics predict the effectiveness and safety of pharmacological treatments … Patient satisfaction. … ; or patients in emergency rooms. … NCT00210821
Comparing the Safety and Effectiveness of Topiramate With the Safety and Effectiveness
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/insulin-blood-sugar-2010_disposition-comments.pdf
January 01, 2010 - Safety evaluation
showed that fewer patients with T2 diabetes
were affected by adverse events. … better safety profile.” … Efforts
to understand the role of family factors in the
maintenance of CSII therapy with clinical
indicators … correct title
should include "methods" and not "devices" and
read "Comparative Effectiveness and Safety … of whether or not a
patient was randomized to a treatment arm.
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
January 01, 2015 - therefore, have a strong impact on the choice of the
drug for second-line combination therapy in a patient … factors, as suggested in recent
guidelines.4 These include clinical factors such as patient
age and … Finally, we did not evaluate patient-reported
outcomes, such as quality of life; future research is … needed
to identify ideal measures to assess treatment-sensitive
patient-reported outcomes in diabetes … Patient preferences for noninsulin
diabetes medications: a systematic review.
-
effectivehealthcare.ahrq.gov/sites/default/files/05_depression_potential_high_impact_2012-12-10.pdf
January 01, 2012 - In patients with PMD, cortisol is secreted at higher rates (hypersecreted) than it is
secreted in patients … models, other than potentially increasing patient volume in treatment centers … It expects to complete patient enrollment at 20 clinical sites in 2013. … For
example, TMS is contraindicated in patients with implanted DBS devices, and the safety of ECT in … models, other than potentially increasing patient volume in treatment centers.
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1306.pdf
October 01, 2014 - In
patients with PMD, cortisol is secreted at higher rates than in patients with nonpsychotic
MDD … They commented that if proved effective for this condition, the drug
might improve patient outcomes … It expects to complete patient enrollment at 20 clinical sites in 2013. … For example, TMS is contraindicated in patients with implanted DBS
devices, and the safety of ECT in … Health care delivery infrastructure and patient management: Ketamine would affect the
way patients
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-treatment_surveillance.pdf
January 01, 2013 - KQ 2: Does treatment of open-angle glaucoma improve patient-reported outcomes? … It will still be
possible to compare the
effectiveness of different treatments
on patient-reported … Safety:
Both demonstrated comparable safety
and tolerability
Digiuni 201214
Double-blind RCT
184 … Safety: no major complications were
observed. … to 12 months postop
Efficacy:
SLT and ALT were equally effective
Safety:
15 patients excluded for
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-treatment_research-protocol.pdf
September 29, 2011 - What are the significant safety concerns associated with each treatment strategy (i.e., adverse
drug … What are the significant safety concerns associated with each treatment strategy (i.e., adverse
drug … What are the significant safety concerns associated with each treatment strategy (i.e., adverse
drug … volume, setting, guideline-based
treatment protocols)
Safety and adverse effects, including adverse … The safety outcomes will be framed to help
identify adverse events, including adverse drug reactions
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/binge-eating-disposition-160504.pdf
December 09, 2015 - Efficacy and Safety of Lisdexamfetamine for Treatment
of Adults With Moderate to Severe Binge-Eating … the published
data on which the drug was approved is inadequate to reach
conclusions on long-term safety … However, these data
should be presented, even if only to say that more data on longer
terms safety … Efficacy and Safety of Lisdexamfetamine for Treatment
of Adults With Moderate to Severe Binge-Eating … American College of Neuropsychopharmacology
(ACNP 2012)
• Lisdexamfetamine Dimesylate Safety and
-
effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1306.pdf
June 11, 2013 - interventions that have the
highest potential for impact on clinical care, the health care system, patient … Despite the safety and efficacy of emergency contraception (EC), its use remains low. … Despite the safety and efficacy of EC, its use remains low.4 Barriers to EC use include lack of
knowledge … Overall, experts
concluded that despite these obstacles, the potential for adoption by both patients … for this intervention to disrupt care processes and patient management.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/deficit-hyperactivity.pdf
January 01, 2019 - Deficit Hyperactivity Disorder: Diagnosis and Treatment in
Children and Adolescents
Background
The Patient-Centered … What are the comparative safety and effectiveness of pharmacologic and/or
nonpharmacologic treatments … What are the comparative safety and effectiveness of different monitoring
strategies to evaluate the … pharmacologic
agents approved by the FDA for the
treatment of ADHD that have enrollment
of fewer than 100 patients … with comparator; for diagnostic
accuracy, cross-sectional studies are acceptable if they
include patients
-
effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1406.pdf
June 01, 2014 - Although propofol may be preferred for these
reasons, its use is complicated by safety concerns. … of the controversy among
clinical specialties (gastroenterology versus anesthesiology) about its safety … Patient
acceptance of the technology might be low, although one expert thought that elderly patients … Clinicians can access objective, accurate,
and timely data about patient adherence, to monitor patients … It may be
solely age-based (i.e., patients 65 years and older) or also based on patient complaint and
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_executive.pdf
April 01, 2012 - Finally,
very little is known about the benefits or risks of these
drugs in different patient subgroups … KQ 2: For patients with PsA, do drug therapies differ
in their ability to improve patient-reported symptoms … KQ 3: For patients with PsA, do drug therapies differ in
harms, tolerability, patient adherence, or … eligibility (inclusion and exclusion) criteria were
designed with respect to study design or duration, patient … Safety and efficacy
of adalimumab in treatment of patients with psoriatic arthritis who
had failed