-
effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1506.pdf
June 01, 2015 - Novartis Pharmaceuticals. 16 week efficacy
and 2 year long term safety and efficacy of
secukinumab … Novartis Pharmaceuticals. 16 week efficacy
and 5 year long term efficacy, safety and
tolerability … anti-interleukin-17a
monoclonal antibody, improves active
psoriatic arthritis: 24-week efficacy and safety … antibody, improves active
psoriatic arthritis and inhibits radiographic
progression: efficacy and safety … 17a-monoclonal-antibody-improves-active-psoriatic-arthritis-and-inhibits-radiographic-progression-efficacy-and-safety-data-from-a-phase
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-diagnosis_research-protocol.pdf
June 06, 2011 - From the MCG machine, five ECG wires with electrodes
are attached to the patient at the four standard … KQ 4: Are there significant safety concerns/risks (i.e., radiation exposure, access
site complications … relief, and quality of life in the population of interest) (KQ
3); and whether there are significant safety … collect
demographics and data needed to determine outcomes (intermediate outcomes, health
outcomes, and safety … The safety outcomes will be framed to help identify
radiation exposure, contrast agent-induced nephropathy
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-diagnosis-future_research_1.pdf
February 01, 2013 - Recommended study design: an observational study of patients with varying patient
risk profiles. … Safety concerns Insufficient
13 studies (9 good quality, 4 fair) reported data pertinent to safety … Patient Advocate
We identified a patient advocate to represent the research priorities and issues
from … Recommended study design: an observational study of patients with varying
patient risk profiles.
7 … Artery Disease, NCT01368770, RCT of 500 patients.
-
effectivehealthcare.ahrq.gov/products/incident-user-design/research
May 15, 2012 - That means both patient cohorts were seen by physicians who evaluated their condition and decided that … Pharmacoepidemiol Drug Safety 2007;16:329-36.
4. Ray WA. … Pharmacoepidemiol Drug Safety 2006;15:81-92.
15. UKPDS Group. … Pharmacoepidemiol Drug Safety 2004;13:695-702.
19. Hippisley-Cox J, Coupland C. … Registries for Evaluating Patient Outcomes: A User’s Guide. AHRQ Publication No. 07-EHC001-1.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-artery-stenosis_research-2007.pdf
January 01, 2007 - attention on the strength and limits of evidence from research studies about the effectiveness and
safety … Analytic framework for evaluating the effectiveness and safety of treatments for renal
artery stenosis … A variety of indicators of the
severity of ARAS and of health problems, such as poorer kidney function … The
reviewed studies did not report any indicators that may predict improved outcomes. … The reviewed studies
did not report any indicators that may predict improved outcomes.
-
effectivehealthcare.ahrq.gov/products/antiplatelet-treatment/research-protocol
November 22, 2011 - whether a patient will have a bad outcome on standard clopidogrel therapy? … Which test (or combination of tests or no test) provides the best guide for whether a patient should … and over multiple measurements on the same patient), with some patients showing no platelet response … Efficacy and safety of clopidogrel pretreatment before percutaneous coronary intervention with and without … Meta-analysis of the efficacy and safety of clopidogrel plus aspirin as compared to antiplatelet monotherapy
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-executive-summary-2023-update.pdf
January 01, 2023 - In patients with chronic (mainly neuropathic) pain
with short-term treatment (4 weeks to <6 months): … prescribed
cannabis (1)
Whole-plant
cannabis,
“certified
12.5%
THC” (CBD
NR) route
determined
by patient … final
mean dose 16.6/15.4
mg THC/CBD/day vs.
17.2 mg THC/day
None specified;
based on
individual patient … a Patients could choose any medicinal product they preferred in these studies. … Effectiveness, Safety, and Tolerability of
Nabiximols Oromucosal Spray vs Typical
Oral Long-Acting
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_overview.pdf
March 27, 2014 - How do the efficacy, effectiveness, safety, and adverse effects of
treatment with DMARDs differ among … Antirheumatic Drugs (DMARDs) in Children with Juvenile Idiopathic Arthritis (JIA) indicated there were
new safety … activity:
Active joint count (AJC)
Physician global assessment of disease activity (PGA)
Parent/patient
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-231-dementia-interventions-evidence-summary_0.pdf
August 01, 2020 - adaptations of the ACCESS model) may
improve system-level markers, including guideline-based quality indicators … Consolidated Standards of Reporting Trials
4
statement), pre-registration of trials, data safety … [Summary for
patients in Ann Intern Med. 2006 Nov
21;145(10):I39; PMID: 17116914]. … [Summary for
patients in Ann Intern Med. 2006 Nov
21;145(10):I31; PMID: 17116913]. … Effectiveness and Safety of Dementia Care
Management in Primary Care: A
Randomized Clinical Trial.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-future_research.pdf
April 01, 2013 - Do these harms differ according to patient subgroup characteristics, including but not
limited to HCV … Do these harms differ according to patient subgroup characteristics, including but not
limited to HCV … Do these harms
differ according
to patient
subgroup
characteristics? … treated with pegylated
interferons in Georgia
Long-term SVR according to patient
characteristics … , Efficacy and
Pharmacokinetics of BI
201335 NA in Patient With
Genotype 1 Chronic
Hepatitis C
-
effectivehealthcare.ahrq.gov/products/deliberative-methods/research
February 01, 2013 - health issues continues to grow, particularly in response to new mandates in the United States for patient … and consumer engagement in health care research prioritization, care service delivery, and safety and
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/for-women-in-the-postpartum-period-what-is-the-effectiveness-and-safety-of-screening-and-treatment-for-depression-please-use-the-uspstf-framework-which-considers-not-only-screening-but-followup-treatment-and-management-the-tr
October 01, 2011 - For women in the postpartum period, what is the effectiveness and safety of screening and treatment for … What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … (For example, improvements in patient symptoms or problems from treatment or diagnosis.) … Improvements in patient depressive symptoms
Improvements in parenting skills
Improvements in quality
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/phenylketonuria_research-protocol.pdf
March 29, 2011 - dopamine in
the brain.16,17 Despite potential benefits, there is uncertainty about the efficacy and safety … of the long-term use of LNAAs and the target patient population, including the
appropriateness of … with PKU that merit
further study.5 Like pregnant women, safety and efficacy of the use of sapropterin … Primary outcomes in patient
1. … Primary outcomes in patient
1. Decreasing Phe levels in the blood
2.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-radiation_technical-brief.pdf
November 01, 2009 - Type of cancer and patient eligibility criteria
3.b. … For many patients in whom a whole region has to be irradiated (e.g., the
whole pelvis in some patients … For example, in patients with glial tumors it
ranged from 5 to 39 months, whereas in patients with … Types of cancer and patient eligibility criteria
3.b. … Adverse events, harms, and safety issues reported
-
effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1506.pdf
June 01, 2015 - Experts cited the cost, need for daily injections, and unknown long-term safety
profile as potential … Patients were reported to have generally tolerated the balloon
well, with one early removal for patient … .”38 However, two experts anticipated lower patient acceptance.37,42 One
clinical expert stated, “Patients … Perioperative safety in the longitudinal
assessment of bariatric surgery. … Safety of antiobesity drugs. Ther Adv Drug Saf.
2013;4(4):171-81.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-217-infertility-evidence-summary.pdf
May 01, 2019 - Management of Infertility Evidence Summary
Purpose of Review
Evaluate the comparative effectiveness and safety … Different treatments also carry different safety
risks. … What are the comparative safety and
effectiveness of available treatment strategies for
women with … o Donor
• ART
o Patient
o Donor
Intermediate
Outcomes
• Time to
pregnancy
Adverse Effects-Patient … Clomiphene
Live birth (any/
patient)
2 RCTs44,85 (909)
1 SR (9 studies,
1783 patients)103
Improvement
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-217-infertility-evidence-summary.pdf
May 01, 2019 - Management of Infertility Evidence Summary
Purpose of Review
Evaluate the comparative effectiveness and safety … Different treatments also carry different safety
risks. … What are the comparative safety and
effectiveness of available treatment strategies for
women with … o Donor
• ART
o Patient
o Donor
Intermediate
Outcomes
• Time to
pregnancy
Adverse Effects-Patient … Clomiphene
Live birth (any/
patient)
2 RCTs44,85 (909)
1 SR (9 studies,
1783 patients)103
Improvement
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/impact-healthcare-algorithms-racial-ethnic-disparities-March-3.pdf
July 01, 2023 - function
Novel risk prediction algorithm for postpartum depression
Replaced race with biological indicators … Example: an algorithm to distinguish between malignant and benign
moles trained on light-skinned patients … around 6 core goals: accountability,
standard, v2: general transparency, fairness, reliability and safety … standardized health data and
AHRQ’s efforts to effectively use those data to improve the quality and
safety … of patient care
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/phenylketonuria_surveillance.pdf
January 15, 2013 - 2013
Key Findings:
• All conclusions for KQ1-7 are still considered
valid
• No new significant safety … Is the portion of the CER that is
probably or certainly out of date an issue of safety (a drug withdrawn … What is the Effectiveness of BH4 in Patients with PKU? … Efficacy and safety of BH4 before the age of
4 years in patients with mild
phenylketonuria. … What is the Effectiveness of BH4 in Patients with PKU?
-
effectivehealthcare.ahrq.gov/products/diagnostic-errors-emergency/protocol
December 21, 2020 - Approximately how many patients does this equate to nationally in the US? … Do different causes have differential impact on patient outcomes (i.e., harms)? … were seen in the year 2000 or later
More than 50% of the patients were seen prior to the year … Diagnostic error in the emergency department: learning from national patient safety incident report analysis … Diagnostic errors—the next frontier for patient safety.