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effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1512.pdf
December 01, 2015 - The drug potentially holds additional promise as an AUD therapy because its safety
profile is better … Commercial clients pay prorated
annual licensing fees for CaringTXT; end-user patients incur no costs … and
per-patient prevalence. … CaringTXT annual licenses cost about
$12,000 to $18,000 for an average-sized university or college client … Impact of a
text messaging pilot program on patient
medication adherence.
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effectivehealthcare.ahrq.gov/sites/default/files/05_depression_potential_high_impact_2012-12-10.pdf
January 01, 2012 - In patients with PMD, cortisol is secreted at higher rates (hypersecreted) than it is
secreted in patients … models, other than potentially increasing patient volume in treatment centers … It expects to complete patient enrollment at 20 clinical sites in 2013. … For
example, TMS is contraindicated in patients with implanted DBS devices, and the safety of ECT in … models, other than potentially increasing patient volume in treatment centers.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_executive.pdf
September 01, 2011 - How do the efficacy, effectiveness,
safety, and adverse effects of treatment with DMARDs
differ among … How do the efficacy, effectiveness, Insufficient Only one study—an RCT of methotrexate versus
safety, … In addition, patient-level
meta-analysis may help address this challenge. … • The need for study populations who are
representative of typical patients with JIA. … Randomized discontinuation trials
have helped to define the risk of flare in patients who
respond to
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research.pdf
June 01, 2017 - The information in this report is intended to help health care decisionmakers—patients and
clinicians … information, i.e., in the context of available
resources and circumstances presented by individual patients … NCT01404611 gives results for 330 patients for time to cessation of otorrhea and adverse
events up to … NCT01908803 gives results for 68 patients for proportion of subjects with sustained clinical
cure at … Safety and
Efficacy of Intratympanic Ciprofloxacin
Otic Suspension in Children With Middle
Ear Effusion
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
November 22, 2011 - whether a
patient will have a bad outcome on standard clopidogrel therapy? … Which test (or combination of tests
or no test) provides the best guide for whether a patient should … and over multiple measurements on the same patient), with some patients showing
no platelet response … Efficacy and safety of clopidogrel
pretreatment before percutaneous coronary intervention with and … Meta-analysis of the efficacy and safety of
clopidogrel plus aspirin as compared to antiplatelet monotherapy
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/incident-user-design_research.pdf
May 01, 2012 - about the outcomes, clinical effectiveness, safety, and appropriateness of health care items and
services … When investigators know that a patient has used the intervention before the window chosen
to define … Pharmacoepidemiol Drug Safety
2007;16:329-36.
4. Ray WA. … Pharmacoepidemiol Drug
Safety 2006;15:81-92.
15. UKPDS Group. … Pharmacoepidemiol
Drug Safety 2004;13:695-702.
19. Hippisley-Cox J, Coupland C.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/patient-monitoring-systems-appendix-c.xlsx
January 01, 2024 - Safety Practices
RCT randomized controlled trial
RR risk ratio
RRS rapid response system
RRT rapid … Tele-Rapid Response Team (Tele-RRT): The effect of implementing patient safety network system on outcomes … and Medical Research Council, Alfred Health, Eastern Health, Monash Health, Australian Commission on Safety … Control, No Alert One RRT alerts per patient NR 1252 Patients with events: NA (NA) NR NR None
Levin … , 2024 Arm 2 Intervention, Alert One RRT alerts per patient NR 1488 Patients with events: 373 (25.1)
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-blood-transfusion-protocol-amendment.pdf
February 04, 2025 - Which component combinations result in the best patient outcomes
for which types of patients? … free days
o ICU free days
Intermediate Outcomes in the prehospital or ED setting
• Physiological indicators … hemorrhagic shock characteristics (e.g., mechanism of injury/condition, severity,
blood pressure, other indicators … = Mixed Methods Appraisal Tool;
NA = not applicable; NHTSA = National Highway and Transportation Safety … Role of the Funder
This project was funded by the National Highway and Transportation Safety Administration
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1306.pdf
October 01, 2014 - In
patients with PMD, cortisol is secreted at higher rates than in patients with nonpsychotic
MDD … They commented that if proved effective for this condition, the drug
might improve patient outcomes … It expects to complete patient enrollment at 20 clinical sites in 2013. … For example, TMS is contraindicated in patients with implanted DBS
devices, and the safety of ECT in … Health care delivery infrastructure and patient management: Ketamine would affect the
way patients
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-future_research.pdf
April 01, 2013 - KQ 3: Which patient characteristics predict the effectiveness and safety of pharmacologic treatments … by
selected patient characteristics:
• Onabotulinumtoxin A was more effective in patients with a … 2
Key Question 3
Which patient characteristics predict the effectiveness and safety of pharmacologic … KQ 3: Which patient characteristics predict the effectiveness and safety of pharmacologic treatments … Designed to Test the Effectiveness and Safety of Treating Patients With Lacosamide for
Migraine Prophylaxis
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
December 01, 2010 - • Patient insight into illness.
• Health-related quality of life. … • Patient satisfaction.
• Patient-reported outcomes. … psychosis
Loxapine Approved 1975 Schizophrenia
Adults
Safety and effectiveness in pediatric … Perphenazine Approved 1965 Schizophrenia
Adults
Safety and effectiveness in pediatric
patients … Adults
Pediatric use: safety & effectiveness not
established in patients <18 yrs
1. agranulocytosis
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_overview.pdf
March 27, 2014 - How do the efficacy, effectiveness, safety, and adverse effects of
treatment with DMARDs differ among … Antirheumatic Drugs (DMARDs) in Children with Juvenile Idiopathic Arthritis (JIA) indicated there were
new safety … activity:
Active joint count (AJC)
Physician global assessment of disease activity (PGA)
Parent/patient
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adult-treatment_disposition-comments.pdf
April 03, 2013 - Or do some patients have
major benefit on outcome X, and other patients on outcome Y? … …"
a) Seeking Safety (SS) was designed for both genders. … The
relevant paragraph was (and
still is) in the Seeking Safety
results section titled
Prevention … We agree that this study has
some limitations that limit what
we can conclude about
seeking safety … We also changed it to “seeking
safety” rather than “safety
seeking” to be consistent with
wording
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_surveillance.pdf
August 01, 2012 - for Updating Systematic Reviews for the EHC Program
CER # 20:
Comparative effectiveness and safety … Comparative effectiveness and safety of
radiotherapy treatments for head and neck
cancer. … A
dosimetric correlation of radiation dose and
early grade 3 dysphagia in oropharyngeal
cancer patients … A
matched cohort comparison of head and
neck squamous cell carcinoma patients
treated with intensity … Multivariate analysis of quality of life
outcome for nasopharyngeal carcinoma
patients after treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1306.pdf
June 11, 2013 - interventions that have the
highest potential for impact on clinical care, the health care system, patient … Despite the safety and efficacy of emergency contraception (EC), its use remains low. … Despite the safety and efficacy of EC, its use remains low.4 Barriers to EC use include lack of
knowledge … Overall, experts
concluded that despite these obstacles, the potential for adoption by both patients … for this intervention to disrupt care processes and patient management.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_executive.pdf
March 01, 2011 - In addition to having an increased number of
medication choices, patients with type 2 diabetes often … organized these deficiencies and
recommendations using the PICOTS format for
specifying research questions: patient … Populations
Studies often employed narrow inclusion criteria,
enrolling patients at lowest risk for … complications, and
they commonly used run-in periods to avoid enrolling
patients with adverse effects … We identified the following research gaps
related to target patient populations:
1.
-
effectivehealthcare.ahrq.gov/sites/default/files/ch-7-user-guide-to-ocer_130129.pdf
March 29, 2012 - sources of confounding in observational
comparative effectiveness studies include
provider actions, patient … than for uncomplicated
hypertension.1 Any attempt to compare the safety
or effectiveness between CCBs … status in their
causal models.11, 13
96
Developing an Observational CER Protocol: A User’s Guide
Patient … We now live in an era where every interaction
between the patient and the health care system
produces … the strengths and weaknesses of the
data source (e.g., administrative claims, EMRs, chart review,
patient
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-kidney-disease-anemia-2011_executive.pdf
January 01, 2011 - Objectives
The purpose of this review is to evaluate the impact on
patient-centered outcomes of the … Key Questions and Analytic Framework
(Figure A)
As test results have little direct impact on patient … Key Question 1
What is the impact on patient-centered outcomes of using
newer laboratory biomarkersa … through decisions and treatments, and then
report on patient outcomes. … Safety issues with intravenous iron products in the
management of anemia in chronic kidney disease.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-updates_methods.pdf
July 01, 2011 - They provide syntheses of
relevant evidence to inform real-world health care decisions for patients, … /evidence-based-policy-
center/derp/index.cfm), has conducted SRs of comparative effectiveness and safety … questions for potential modifications are assessed to accommodate
new evidence (e.g., new drugs, safety … more effective intervention(s)
is introduced, or existing (or new) interventions are extended to new patient … Cumulative meta-analysis: a
consideration of indicators of
sufficiency and stability.
-
effectivehealthcare.ahrq.gov/sites/default/files/s158.pdf
October 01, 2007 - In addition, frail elderly
patients, who use the most drugs and have the highest adverse
event rates, … Presented at the Agency for Healthcare Research and Quality meeting on
Comparative Effectiveness and Safety … , even after a wide variety of health
indicators available in claims data were controlled for. … Controlling for a wide variety of health
indicators available in claims data (for a list, see Table 3 … The treatment of unrelated disor-
ders in patients with chronic medical diseases.