-
effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1512.pdf
November 01, 2016 - acceptance is likely to be high because of the ease of administration and good
safety profile, most … Study to evaluate the long-term safety
and efficacy of elagolix in subjects with moderate
to severe … A global phase 3 study to evaluate the
safety and efficacy of elagolix in subjects with
moderate … Global study to evaluate the long-term
safety and efficacy of elagolix in subjects with
moderate … A clinical study to evaluate the safety and
efficacy of elagolix in subjects with moderate to
severe
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fetal-surgery_disposition-comments.pdf
July 05, 2011 - , too many words:
„and of‟
Corrected
Peer Reviewer
#7
Methods “Adverse events of harms of safety … also,that the biggest problem with this (and many
other fetalsurgery indications) is poor prognostic
indicators … We have added an emphasis on the
limited utility of prognostic indicators
and emphasized that only … it, as it is non-essential
Peer Reviewer
#11
Results line 4 from bottom, after “a data and safety … Especially when you're number of shunt
patients a group 1 was 13.
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes_hi_impact.pdf
March 01, 2012 - the surgery in this
patient population. … Along with
updates to safety information about ongoing or completed studies, included in the response … Experts expressed a desire for further
data evaluating safety and efficacy of these modifications to … combination therapy (with oral hypoglycemic agents and insulin)
and to assess its cardiovascular safety … That FDA committee
voted to not recommend approval because of safety concerns and the company submitted
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cesarean-birth-future_research.pdf
August 09, 2012 - facilitate the collection of the
most appropriate clinical
outcomes as well as process
and systems indicators … to conduct large-scale studies in this area hinges on the development
of standard terminology and indicators … Historically, the quest to develop standardized
obstetric indicators has not been an easy task. … Patient? Clinician?
2. … Respect for patient autonomy supports that patients should be allowed to accept
increased levels of
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-blood-transfusion-protocol.pdf
September 24, 2024 - Which component combinations result in the best patient outcomes
for which types of patients? … free days
o ICU free days
Intermediate Outcomes in the prehospital or ED setting
• Physiological indicators … hemorrhagic shock characteristics (e.g., mechanism of
injury/condition, severity, blood pressure, other indicators … = Mixed Methods Appraisal Tool;
NA = not applicable; NHTSA = National Highway and Transportation Safety … Role of the Funder
This project was funded by the National Highway and Transportation Safety Administration
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/delirium-disposition-comments.pdf
September 03, 2019 - We agree that
this term is unhelpful and we have changed it to
“personal safety attendant” throughout … interested to note how few side effects
were reported, we remain circumspect when
emphasizing their safety … Moreover, greater “bottom line” emphasis should be
placed on the safety of antipsychotics and the fact … The strength of evidence tables (6-24) include a column
titled "Study Limitations" with low & medium indicators … Critical outcomes by patient group and are listed in Figure
B.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-protocol-2021_0.pdf
January 01, 2021 - serve as a source for clinicians seeking information on effectiveness of
interventions for patients … criteria are:
• Population(s):
o Adults (≥18 years old) diagnosed with PTSD by a clinician or through patient … meditation
or "mind body" or mindfulness or music or "prolonged exposure" or relaxation or
"seeking safety … meditation
or "mind body" or mindfulness or music or "prolonged exposure" or relaxation or
"seeking safety … Indicate if patients with suicidality were excluded (Y/N)
r. Participants’ trauma type(s)
s.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd4-final-protocol.pdf
October 01, 2022 - reporting; (4) serve as a source for clinicians seeking information on effectiveness of interventions
for patients … criteria are:
• Population(s):
o Adults (≥18 years old) diagnosed with PTSD by a clinician or through patient … meditation or "mind body" or mindfulness or music
or "prolonged exposure" or relaxation or "seeking safety … meditation or
"mind body" or mindfulness or music or "prolonged exposure" or relaxation or "seeking
safety … Indicate if patients with suicidality were excluded (Y/N)
r. Participants’ trauma type(s)
s.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive-2016.pdf
January 01, 2016 - How do benefits or harms of contrast media differ by
patient characteristics (known risk factors such … definitive evidence
of a difference in CIN incidence between IOCM and
LOCM that varied according to patient … A prospective, double-blind,
randomized, controlled trial on the efficacy and cardiorenal safety
of … The relative renal safety of
iodixanol compared with low-osmolar contrast media: a meta-
analysis of … Effect of administration route on
the renal safety of contrast agents: a meta-analysis of randomized
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-outcomes_methods.pdf
July 01, 2012 - consequences if the tested
individual is in a profession that requires disclosure of health threats for the safety … of their key questions:
whether prediction of prognosis with spirometry, with or without clinical indicators … , is more
accurate than prediction based on clinical indicators alone. … The sponsoring organizations were
interested in predicting patients’ survival free of premature death … Spirometry is a noninvasive test that most
patients tolerate well.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-insulin_executive.pdf
September 01, 2008 - However,
the addition of insulin to treatment
Comparative Effectiveness, Safety, and
Indications of … A number of patient-related factors have been
identified that may help physicians to select patients … Insulin lispro 75/25 was associated with a higher rate of
overall hypoglycemia measured as episode/patient … Key Question 4: Effect of premixed insulin
analogues based on patient characteristics
Comparison of … injection patterns and glucose testing
depending on the type of medication regimen
prescribed, evaluating patient
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/peripheral-artery-disease-treatment_research-protocol.pdf
January 31, 2013 - with
aortoiliac disease, supervised exercise therapy improved peak walking time and patient-reported … Patient characteristics such as advanced age, concomitant coronary artery disease or heart
failure, … including patient characteristics, severity of symptoms, anatomic considerations, and
patient and physician … with CLI.38
Amputation-free survival is generally considered the best limb and patient outcome for … for determining outcomes
(intermediate outcomes, health outcomes, and safety outcomes).
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/radiation-therapy-brain-metases-protocol.pdf
October 10, 2019 - Do adverse effects vary by important patient characteristics (i.e., age,
performance status, patient … The draft protocol is informed by key
informants representing patients, care givers, patient advocates … Safety of cranial radiotherapy
concurrent with tyrosine kinase inhibitors in non-small cell lung cancer … Effectiveness and safety of "real"
concurrent stereotactic radiotherapy and immunotherapy in metastatic … https://www.fda.gov/safety/reporting-serious-problems-fda/what-serious-adverse-event.
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/impact-healthcare-algorithms-racial-ethnic-disparities-March-3.pdf
July 01, 2023 - function
Novel risk prediction algorithm for postpartum depression
Replaced race with biological indicators … Example: an algorithm to distinguish between malignant and benign
moles trained on light-skinned patients … around 6 core goals: accountability,
standard, v2: general transparency, fairness, reliability and safety … standardized health data and
AHRQ’s efforts to effectively use those data to improve the quality and
safety … of patient care
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/patient-generated-health-data-protocol-chronic-conditions.pdf
March 17, 2020 - From the patient perspective,
some patients may lack access to PGHD technologies or have a low comfort … Which patients in which settings are most at
risk of harms?
5. … The technology must collect patient data without manual input that can potentially
be used by the patient … EXCLUDE:
Comparators that
include the same
PGHD intervention do
not address the
efficacy/safety … EXCLUDE: studies
with <10 patients/arm
at follow-up.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-future_research.pdf
October 26, 2012 - KQ3
KQ4
Testing for recurrence
Nursing
home/extended
care resident
(clinical indicators … Recurrence
Clearance
Complications
Symptom
resolution
Prevention
Adult with
clinical
indicators … KQ3
KQ4
Testing for recurrence
Nursing
home/extended
care resident
(clinical indicators … Recurrence
Clearance
Complications
Symptom
resolution
Prevention
Adult with
clinical
indicators … Safety and Efficacy of Multiple Daily Dosing of Oral LFF571 in Patients With
Moderate Clostridium Difficile
-
effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_2012-12-10.pdf
January 01, 2012 - calibrating the CGM (where applicable) and
checking sensor performance as needed plus associated reagents … with T1DM, longer safety and efficacy studies are needed before they
can properly determine whether … moderately high potential for impact on the health care system, provided
additional efficacy and safety … In terms of
patient acceptance, this same expert conceded patients could be willing to accept the risk … Efficacy and
safety of exenatide once weekly versus liraglutide
in subjects with type 2 diabetes
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rural-telehealth-amended-protocol.pdf
February 25, 2021 - • Population(s):
o Rural individual patients, patient families/care partners, and patient populations … behavior, and decisions such as choice of treatment
or antibiotic stewardship; Access measure and indicators … including but not limited to
time to diagnosis or time to treatment
o KQ2: Indicators and measures … KQ2:
a) Indicators and measures of uptake of telehealth
(e.g., rates of use, timing to implementation … The Rural Health Safety Net Under Pressure: Rural Hospital
Vulnerability. 2020.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/progestogens-preterm-birth_research-protocol.pdf
June 01, 2010 - associated with preterm birth represent untold distress for
families, as well as significant costs to patients … 17-OHP
treatment regimen is relatively modest; one study estimates it to be about $400 per treated
patient … Adherence is influenced by the timing, dose, route, and interval of the progestogen
given, patient factors … Adverse events may occur at any point after the treatment is received, and are
affected by patient factors … factors such as specialty, and health care system factors such as cost and availability, as
well as patient
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/phenylketonuria_surveillance.pdf
January 15, 2013 - 2013
Key Findings:
• All conclusions for KQ1-7 are still considered
valid
• No new significant safety … Is the portion of the CER that is
probably or certainly out of date an issue of safety (a drug withdrawn … What is the Effectiveness of BH4 in Patients with PKU? … Efficacy and safety of BH4 before the age of
4 years in patients with mild
phenylketonuria. … What is the Effectiveness of BH4 in Patients with PKU?