-
effectivehealthcare.ahrq.gov/products/phenylketonuria/research-protocol
February 08, 2011 - dopamine, in the brain. 16,17 Despite potential benefits, there is uncertainty about the efficacy and safety … of the long-term use of LNAAs and about the target patient population, including the appropriateness … , the safety and efficacy of using sapropterin dihydrochloride in children under the age of 8, including … long-term effects of pharmacological treatment or the desired Phe concentration ranges for various patient … Primary outcomes in a patient:
Decreasing Phe levels in the blood
Improved nutritional status
Quality
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1312.pdf
October 01, 2014 - DBS to the
subcallosal cingulate white matter supported the long-term safety and antidepressant efficacy … The safety of
ECT in patients with an implanted DBS system has not been established. … ketamine would have a minimal
impact on health outcomes in the absence of data on long-term effects, safety … Efficacy and safety of mifepristone for the
treatment of psychotic depression. … Neuropsychological safety of nucleus accumbens
deep brain stimulation for major depression:
effects
-
effectivehealthcare.ahrq.gov/products/antipsychotics-children/research-protocol
June 04, 2010 - , patient insight into illness. … insight into illness
Patient or parent/care provider reported outcomes, including levels of physical … insight into illness
Patient or parent/care provider reported outcomes, including levels of physical … followup), patient baseline characteristics (diagnosis and age at diagnosis, age, sex, race, weight, … Adults
Pediatric use: safety & effectiveness not established in patients <18 yr
1. agranulocytosis
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
December 04, 2015 - Within each KQ, we will
assess outcomes for subgroups of patients or studies based on patient and clinical … (patientsafety,
effectiveness, and policy challenges. … Efficacy and safety of second-generation
antipsychotics in children and adolescents with psychotic and … Drug Safety. 2011 Aug 1;34(8):651-68. PMID: 21751826.
17.
-
effectivehealthcare.ahrq.gov/products/atypical-antipsychotics-off-label-update/research-protocol
May 19, 2010 - Comparative Effectiveness of Off-label Use of Atypical Antipsychotics reviewed the scientific evidence on the safety … risk of death and antipsychotics drugs, and comparison of the development of adverse effects between patients … Studies that did not report any outcomes of efficacy, effectiveness, safety/adverse events, or utilization … We will define loss to follow-up as the number of patients excluded from efficacy analyses, expressed … as a proportion of the number of patients randomized.
-
effectivehealthcare.ahrq.gov/health-topics/health-occupations
January 17, 2012 - Presentation)
Presentation
April 19, 2012
Using Deliberative Methods to Engage Patients … White Paper
September 30, 2009
Instrumental Variable Methods in Comparative Safety … Effectiveness Systematic Reviews
Methods Guide – Chapter
October 5, 2009
How Patients … Meta-Analysis for Binary Outcomes
Research Report
March 20, 2013
Eliciting Patients … February 23, 2012
Clinical Effectiveness of Coronary Stents in the Elderly: Results From 262,700 Patients
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-203-adhd-disposition-comments.pdf
January 01, 2018 - In my assessment, post-marketing
surveillance studies of effectiveness and safety are badly
missing … These outcomes were seen as
being both patient-centered and most
critical for decisionmaking across … Effectiveness,
safety, and tolerability of
lisdexamfetamine dimesylate in children with attention- … A long-term o pen-label
safety and effectiveness trial of lisdexamfetamine dimesylate in
adolescents … Atomoxetine
improves patient and family coping in attention
deficit/hyperactivity disorder: a randomized
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update-surveillance-160328.pdf
March 28, 2016 - $Comparative$efficacy$and$safety$of$aliskiren$and$
irbesartan$in$patients$with$hypertension$and$metabolic … $Antihypertensive$efficacy$and$
safety$of$olmesartan$medoxomil$and$ramipril$in$elderly$patients$with … $
rather$than$hypertensive$
patients),$it$highlights$the$safety$
concerns$associated$with$
combining … $Antihypertensive$efficacy$and$safety$of$olmesartan$medoxomil$and$
ramipril$in$elderly$patients$with … $Comparative$efficacy$and$safety$of$aliskiren$and$irbesartan$in$patients$with$
hypertension$and$metabolic
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_disposition-comments.pdf
October 07, 2011 - daily, which is achieved by doubling the dose at
approximately 2-week intervals, as tolerated by the patient … For Results Key Question 2, safety information, please note that ACE
inhibitors pose unique, albeit … congestive heart failure, or nephropathy);
however all have examined an overlapping
set of efficacy and safety … of “class
effects”, specifically related to ACEIs and ARBs, discussing that
mechanism of action, safety … We underscore the importance of
updating any corollary materials (e.g., patient guides) in order to
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-stents-outcomes_research.pdf
January 01, 2010 - about the outcomes, clinical effectiveness, safety, and
appropriateness of health care items and services … Effectiveness and Safety of Drug-
Eluting Stents in Ontario. … Balancing
Efficacy and Safety of Drug-Eluting
Stents in Patients Undergoing
Percutaneous Coronary … Safety and Efficacy of Sirolimus- and
Paclitaxel-Eluting Coronary Stents. … Unadjusted baseline characteristics of patients in study population
Patient Characteristics Study
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/healthcare-system-draft-technical-brief.pdf
February 01, 2023 - Patient-level
interventions refer to those targeted at patients, such as patient education. … an Urban Safety-Net Setting. … Community–Clinical Linkages: The Effects of the Healthy Here
Wellness Referral Center on Chronic Disease Indicators … Impact of a Primary Care CKD Registry in a US Public
Safety-Net Health Care Delivery System: A Pragmatic … Evaluating Patient Navigation to Improve First Appointment
No-show Rates in Uninsured Patients with
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
September 01, 2011 - As a clinician, I want to know how best to treat an
individual patient with a defined subtype of JIA … One patient experiences a hematoma occurring on
day 108 which was deemed unrelated to the study drug … Acute infusional adverse events were reported
in one (2%) patient in the abatacept group and two (3% … All studies of safety were
addressed in KQ3. … Of the 14 patients enrolled
in the infliximab arm, 5 patients failed to complete 12 months – 4
because
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-insulin_executive.pdf
September 01, 2008 - However,
the addition of insulin to treatment
Comparative Effectiveness, Safety, and
Indications of … A number of patient-related factors have been
identified that may help physicians to select patients … Insulin lispro 75/25 was associated with a higher rate of
overall hypoglycemia measured as episode/patient … Key Question 4: Effect of premixed insulin
analogues based on patient characteristics
Comparison of … injection patterns and glucose testing
depending on the type of medication regimen
prescribed, evaluating patient
-
effectivehealthcare.ahrq.gov/products/rural-telehealth/protocol
January 15, 2021 - or patient populations. … Population(s):
Rural individual patients, patient families/care partners, and patient populations … including but not limited to time to diagnosis or time to treatment
KQ2: Indicators and measures … KQ2:
Indicators and measures of uptake of telehealth (e.g., rates of use, timing to implementation) … The Rural Health Safety Net Under Pressure: Rural Hospital Vulnerability . 2020.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/skin-lesions-evaluation_research-protocol.pdf
August 23, 2010 - What are the potential safety issues and harms associated with the use of non-invasive
diagnostic techniques … Guiding question 3:
What published and unpublished studies have reported on the use and safety of these … Provide a synthesis of the following information:
i Indication/patient inclusion criteria
ii Type … of techniques/modalities
iii Study design and size
iv Role of the test in patient management
v … Strategies for early melanoma detection: Approaches to the
patient with nevi.
-
effectivehealthcare.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_june_2012.pdf
January 01, 2012 - significantly increased the regulatory bar for gaining approval—specifically
regarding preapproval safety … data and postmarket safety evaluation—set forth by the U.S. … Kushner and colleagues announced results from a phase III clinical trial (SEQUEL)
evaluating the safety … However, potential increase in per-
patient costs might serve as barriers to acceptance by some patients … Safety and efficacy study of
EndoBarrier in subjects with type II diabetes and
obesity.
-
effectivehealthcare.ahrq.gov/sites/default/files/study-design-considerations-chapter-2.pptx
January 01, 2013 - Cohort design has the potential to increase efficiency
Well suited for rare adverse events in vaccine safety … The design was originally proposed for rare adverse events in vaccine safety studies for which it seems … Regardless of the design chosen, selection of appropriate data source(s), the patient population, inclusion … Regardless of the design chosen, selection of appropriate data source(s), the patient population, inclusion … Regardless of the design chosen, selection of appropriate data source(s), the patient population, inclusion
-
effectivehealthcare.ahrq.gov/products/antipsychotics-children-update/research-protocol
December 07, 2015 - Within each KQ, we will assess outcomes for subgroups of patients or studies based on patient and clinical … Broadened use of atypical antipsychotics: safety, effectiveness, and policy challenges. … Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and … Drug Safety. 2011 Aug 1;34(8):651-68. PMID: 21751826.
Correll CU, Penzner JB, Parikh UH, et al. … Limited evidence in children <12 years
Use and safety have not been evaluated in other childhood
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-disorders-imaging_disposition-comments.pdf
November 01, 2011 - Safety: The ramfiicaitons regarding potential need for alternative
imaging methods (pg 16, lines 10- … 13) to rule out specific pathologies
is to some extent a safety issue (e.g. ? … safety/outcomes. … vs. an adverse event related to the
safety of the device or procedure? … frequency of
positive MRI exams on clinically asymptomatic
patients.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_surveillance.pdf
October 29, 2012 - • There are no safety concerns
Summary Decision:
This CER’s priority for updating is Low … UUI in 40% patients on 150 U; p=0.022
• >75% improvement versus baseline in UUI in 40% patients on 100 … UUI in 40%
patients on 150 U; p=0.022
>75% improvement versus
baseline in UUI in 40%
patients on … The
efficacy
and
safety
of
solifenacin
in
patients
with
overactive
bladder … in 40% patients
on 150 U; p=0.022
>75% improvement versus baseline in UUI in 40% patients
on 100