-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/health-careassociated-infections_executive.pdf
November 01, 2012 - safety practices:8
• Theory behind patient safety practice
• Existing patient safety infrastructure … patient safety culture and teamwork at the unit level. … Safety Practice 9 3 4 0 16
Existing Patient Safety Infrastructure 8 6 2 4 20
External Factors 9 7 … Assessing the Evidence
for Context-Sensitive Effectiveness and Safety of Patient
Safety Practices: … Advancing
the science of patient safety. Ann Intern Med. 2011 May
17;154(10):693-6.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/field-triage-glascow_research-protocol.pdf
February 25, 2016 - severity score ≥16, head AIS score >2 or >3,
presence of intracranial hemorrhage, and utilization indicators … • KQ1: Predictive utility for mortality, morbidity, injury severity score ≥16,25 or
utilization indicators … score of Glasgow
Coma Scale
Intermediate
outcomes
Over- or under-
triage
Utilization indicators … National Highway Traffic Safety Administration. Washington, DC. … patients.
-
effectivehealthcare.ahrq.gov/sites/default/files/s16.pdf
October 01, 2007 - evidence is centered on the protocol-driven ran-
domized trials, which the FDA requires to establish safety … information from
industry-funded trials may remain unpublished, limiting the
ability to examine potential safety … carefully studied in trials (especially rare or
slow emerging harms); explore sources of heterogeneity in
safety … may depend on severity of
strokes, patient preferences. … patients; audits could examine the rates at which
women and patients over age 80 are undergoing surgery
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/the-roles-of-the-psychiatric-hospital-lengths-of-stay-and-transition-support-services-after-discharge
November 23, 2010 - addressed, whether the individual and involved family felt that the stay was sufficient to address safety … Compare the effectiveness of diverse models of
What patients or group(s) of patients does your question … Patients with Serious Mental Illness (SMI)
Are there subgroups of patients that your question might … (For example, improvements in patient symptoms or problems from treatment or diagnosis.) … and future safety.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_technical-brief.pdf
December 01, 2012 - Patient-oriented and patient-advocacy Web sites for colon cancer were searched. … These GEP assays are all prognostic indicators.
Table 1. … The FDA addresses the safety and effectiveness of diagnostic tests and the quality
of the design and … Historically, the FDA has subjected test kits to premarket review of safety and effectiveness, but
not … result from both preanalytic factors (e.g.,
sample preparation) as well as analytic factors (such as reagents
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_1-user-guide-to-ocer_130129.pdf
August 13, 2012 - end-users and facilitates appropriate
translation of the results into health care practice
and use by patient … If the FDA
approves, human testing for safety and efficacy
can begin. … These endpoints may be
categorized as clinical endpoints, patient-reported
outcomes and quality of … On the other hand, a patient who has
a health condition where there are few treatments
may be willing … Likewise, some patient groups were
reported to be concerned by the decision since it
presumably would
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1412.pdf
December 01, 2014 - Adoption could be limited by ketamine’s
cost, inconsistent clinical trial data, and safety risks, multiple … But one expert with a research
5
background, citing ketamine’s safety risk and lack of long-term … be limited; these experts cited ketamine’s safety risks and lack of robust clinical
trial data as … In
contrast, scopolamine’s known safety profile and possible oral and patch delivery options, bolstered … A
study to evaluate the safety and efficacy of
intranasal esketamine in treatment-resistant
depression
-
effectivehealthcare.ahrq.gov/products/lysosomal-storage-diseases-therapies/research-protocol
October 05, 2011 - every other week, for the life of the patient. … What are the potential safety issues and harms with ERT? … What published and unpublished studies have reported on the use and safety of this intervention? … studies
Concurrent/prior treatments
Length of follow up
Outcomes measured
Adverse events/harms/safety … patient and one parent of a child patient will be consulted.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/uterine-fibroids_research-protocol.pdf
March 01, 2016 - including MRgFUS systems and power morcellators (see Table
A-2 in Appendix), though it has issued safety … and tumor characteristics that may
predict success or adverse events in patients considered for morcellation … Examples
include: baseline characteristics of the patients (e.g., age, menopausal status; symptom
status … Laparoscopic Uterine Power Morcellation in
Hysterectomy and Myomectomy: FDA Safety Communication, Updated … Available at
http://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/ucm424443.htm.
19.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-anticholinergic-medicines_research.pdf
December 01, 2009 - Therefore, each patient was given a 30 day immortal period following the switch. … homogeneous patient population. … Thus, there is still
need to evaluate tiotropium safety in patient populations who are treatment naïve … Methodologic challenges to
studying patient safety and comparative
effectiveness. … Methodologic challenges to
studying patient safety and comparative
effectiveness.
-
effectivehealthcare.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_2012-12-11.pdf
January 01, 2012 - data and postmarket safety evaluation—set
forth by the U.S. … Kushner and colleagues announced results from a phase III clinical trial (SEQUEL)
evaluating the safety … However, a
potential increase in per-patient cost might serve as a barrier to acceptance by some patients … While
preliminary results are promising, further studies evaluating efficacy and safety are needed, … Safety and efficacy study of
EndoBarrier in subjects with type II diabetes and
obesity.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
August 22, 2008 - the most recent data in 2006 (37 year survival).2
The estimated annual direct medical costs per CF patient … KQ 6: In patients with CF, how is efficacy, effectiveness, safety or adverse events impacted
by rhGH … KQ 7: In patients with CF, how do the efficacy, effectiveness, safety or adverse events of
treatment … followup, and disease state (CF, idiopathic short
stature, or growth hormone deficiency)], patient … Patient Registry Annual Report 2006. Bethesda, MD: Cystic
Fibrosis Foundation; 2008.
3.
-
effectivehealthcare.ahrq.gov/products/skin-lesions-evaluation/research-protocol
August 23, 2010 - whether or not patients have a history of other malignancies. … Guiding question 3:
What published and unpublished studies have reported on the use and safety of these … /modalities
Study design and size
Role of the test in patient management
Setting where the technique … /modality was used
Outcomes assessed
Adverse events, harms and safety issues reported
Comparators … Strategies for early melanoma detection: Approaches to the patient with nevi.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease-future_research.pdf
July 01, 2016 - Patient Stakeholder
Thomas Ullman, M.D.
Mt. … KQ 3 What is the comparative safety of therapies alone or in combination used in adults and children … Given that patient-
reported outcomes may be even more relevant to patients who are not currently experiencing … Study Design
Observational studies may be too short in duration to observe some safety outcomes. … outcomes
• Studies in non-white
populations
Children
• Trials and safety
studies in
children
Patient
-
effectivehealthcare.ahrq.gov/system/files/docs/topic-brief-hospital-length-of-stay.pdf
November 01, 2019 - at a safety net hospital. … in the Safety Net: Results of a Randomized
Controlled Trial. … Shift-to-Shift Handoff Effects on Patient Safety and
Outcomes. … Effect of Telehealth Interventions on
Hospitalization Indicators: A Systematic Review. … Hospitals and health systems, including CEOs, will use this information to
improve patient safety and
-
effectivehealthcare.ahrq.gov/products/uterine-fibroids/research-protocol
February 29, 2016 - uterine fibroids including MRgFUS systems and power morcellators (see Table A-2 ), though it has issued safety … and tumor characteristics that may predict success or adverse events in patients considered for morcellation … Examples include: baseline characteristics of the patients (e.g., age, menopausal status; symptom status … Laparoscopic Uterine Power Morcellation in Hysterectomy and Myomectomy: FDA Safety Communication, Updated … Available at http://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/ucm424443.htm .
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2010_research-protocol.pdf
January 01, 2010 - KQ 2
What is the evidence for safety of SIT in patients with allergic rhinoconjunctivitis and/or … products, based
on AgE content, but this was never implemented.
4.CBER provides two US standard reagents … only "change in skin test reactivity" (in-vivo) and "change in antibody" (in-vitro) are accepted
indicators … Not all patients with asthma are allergic. … The activity domain contains 5 ‘patient-specific’ questions.
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/for-adult-patients-with-bipolar-disorder-including-bipolar-i-and-bipolar-ii-disorder-what-is-the-comparative-effectiveness-of-available-treatments-including-psychotherapy-other-psychosocial-treatments-medications-and-other-so
April 22, 2013 - What are the safety risks and adverse effects of available treatments for bipolar disorder, compared … Yes:
Patients with inadequate response
Patients with co-occurring substance use disorders
Patients … (For example, improvements in patient symptoms or problems from treatment or diagnosis.) … Adverse effects and safety risks of treatments for bipolar disorder, including to the fetus of women … Effectiveness is influenced by patient factors including general medical and psychiatric comorbidities
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/for-low-risk-women-delivering-a-full-term-baby-vaginally-what-is-the-comparative-effectiveness-of-the-use-of-nitrous-oxide-for-pain-management-versus-an-epidural-or-other-pain-management-strategies-what-are-the-effects-on-the
June 29, 2009 - What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … (For example, improvements in patient symptoms or problems from treatment or diagnosis.) … There is currently controversy in the US over the effectiveness and safety of nitrous oxide in delivery
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/allergy-seasonal_executive.pdf
July 01, 2013 - effective during pregnancy, but their use may be restricted
because of concerns about maternal and fetal safety … treatment for mild SAR
• The comparative effectiveness and safety of SAR
treatments used in combination … all outcomes of interest were patient
reported. … SAR/PAR results (N = 4)
● Unable to obtain article (N = 2)
● Incomplete data (N = 1)
● Efficacy/safety … magnitude
and direction of change in drug disposition may facilitate
application of effectiveness and safety