-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label_executive.pdf
January 01, 2007 - The purpose of this report is to
review the scientific evidence on the safety
and effectiveness of such … Table B
summarizes findings on adverse events and safety. … than risperidone patients. … This risk was
equivalent to 1 additional stroke for every 31
patients treated in this patient population … patients.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_surveillance.pdf
April 01, 2016 - 5 subject matter experts,
and concluded that all conclusions related to comparative efficacy and safety … Key Question 4:
For adults with TRD, do nonpharmacologic interventions differ in their safety, adverse … headache, scalp pain, dizziness, a combination of a foul taste
and smell sensation, seizures in a patient … (SOE: Low)
of seizures in a patient with seizure history,
and six cases of suicidal ideation (in … patients
with history of suicidal ideation).
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1506.pdf
June 01, 2015 - A significant unmet need exists for fast-acting
treatments for this patient population. … questioned whether adoption would be dampened by potential out-of-pocket patient costs
and shifts … Accordingly, IV scopolamine’s anticipated
per-patient and per-treatment costs are unknown. … Multiple experts also
opined that direct cost to patients, unresolved dosing protocols, and safety … , although unsettled safety and long-term efficacy
data led three experts to state that ketamine and
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-executive-summary-2023-update.pdf
January 01, 2023 - In patients with chronic (mainly neuropathic) pain
with short-term treatment (4 weeks to <6 months): … prescribed
cannabis (1)
Whole-plant
cannabis,
“certified
12.5%
THC” (CBD
NR) route
determined
by patient … final
mean dose 16.6/15.4
mg THC/CBD/day vs.
17.2 mg THC/day
None specified;
based on
individual patient … a Patients could choose any medicinal product they preferred in these studies. … Effectiveness, Safety, and Tolerability of
Nabiximols Oromucosal Spray vs Typical
Oral Long-Acting
-
effectivehealthcare.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_june_2012.pdf
January 01, 2012 - significantly increased the regulatory bar for gaining approval—specifically
regarding preapproval safety … data and postmarket safety evaluation—set forth by the U.S. … Kushner and colleagues announced results from a phase III clinical trial (SEQUEL)
evaluating the safety … However, potential increase in per-
patient costs might serve as barriers to acceptance by some patients … Safety and efficacy study of
EndoBarrier in subjects with type II diabetes and
obesity.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
January 01, 2007 - All the
same issues noted for RA of short- and long-term risks
and safety, as well as performance in … to reduce patient-reported
symptoms, to slow or limit progression of
radiographic joint damage, or … and
observational studies is insufficient to draw conclusions
about the comparative tolerability and safety … Safety and efficacy of
adalimumab in treatment of patients with psoriatic
arthritis who had failed disease … : patient-reported outcomes of the
Adalimumab Effectiveness in Psoriatic Arthritis Trial.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_surveillance.pdf
June 01, 2012 - the
majority of conclusions for KQ1-KQ2 were not still valid
• No FDA, Health Canada, and MHRA safety … magnitude/direction of
changes in estimates, potential changes in practice or therapy preference, safety … evidence does
not support statements on whether
other clinical features (such as
demographics or indicators … NR;
(n=76)
Two years Primary:
20% or
greater
decrease in
creatinine
clearance;
Secondary:
safety … evidence does not support statements on
whether other clinical features (such as demographics or
indicators
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/skin-lesions-evaluation_research-protocol.pdf
August 23, 2010 - What are the potential safety issues and harms associated with the use of non-invasive
diagnostic techniques … Guiding question 3:
What published and unpublished studies have reported on the use and safety of these … Provide a synthesis of the following information:
i Indication/patient inclusion criteria
ii Type … of techniques/modalities
iii Study design and size
iv Role of the test in patient management
v … Strategies for early melanoma detection: Approaches to the
patient with nevi.
-
effectivehealthcare.ahrq.gov/sites/default/files/developmental-delays-horizon-scan-high-impact-1406.pdf
June 01, 2014 - medications for this indication, the ease of oxytocin administration, and its
favorable cost and safety … with ASDs.10-13 Research in both healthy patients and patients
diagnosed with ASDs has determined … including at least one with headquarters in the United States (ABC
Nutriceuticals, Boise, ID), but safety … Experts also remarked that additional data supporting
oxytocin’s efficacy would also increase patient … A
review of safety, side-effects and subjective
reactions to intranasal oxytocin in human research
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_8-user-guide-to-ocer_130129.pdf
October 01, 2013 - ablation for
hepatocellular carcinoma compared to resection
or no treatment5 and a comparison of the safety … Diagnoses or procedures coded for payment No Yes
Behavioral risk factors Yes* No
Diet Sometimes* No
Indicators … missing biochemistry lab data
compared to early-stage patients (6-9% incomplete in early-stage patients … Assessing
accuracy of diagnosis-type indicators for flagging
complications in administrative data. … Study
design for a comprehensive assessment of
biologic safety using multiple healthcare data
systems
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease-future_research.pdf
July 01, 2016 - Patient Stakeholder
Thomas Ullman, M.D.
Mt. … KQ 3 What is the comparative safety of therapies alone or in combination used in adults and children … Given that patient-
reported outcomes may be even more relevant to patients who are not currently experiencing … Study Design
Observational studies may be too short in duration to observe some safety outcomes. … outcomes
• Studies in non-white
populations
Children
• Trials and safety
studies in
children
Patient
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/machine-learning-quality_research.pdf
September 01, 2012 - Using information mining of
the medical literature to improve drug safety. … MEASUREMENTS: The percentage of indicators at or above
predefined targets and the percentage of patients … safety in a General Surgery Department. … safety. … It is dedicated to quality improvement, patient safety,
and peer review, which is conducted by a national
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_disposition-comments.pdf
June 05, 2013 - Conclusion The Conclusion Should More Robustly Acknowledge the Safety
and Effectiveness of Non-Surgical … the conducting of a clinical trial that can produce
strong evidence to support the effectiveness and safety … papers that have similar profiles, for example
Vertruyen et al (page 143, line 3) and Carelli et al (Safety … level of evidence indicating effectiveness and safety
and that long-term studies of bariatric surgery … in this patient
population are needed to assess the overall safety and
effectiveness compared to non-surgical
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-911-workforce-disposition-comments.pdf
November 01, 2022 - Background
and Purpose, I disagree saying the 911 workers have contact
with the public and multiple patients … of the background section to
indicate that public-facing EMS clinicians
have contact with multiple patients … o acknowledge that exposures may result from activities
not involving direct contact with patients … ) evaluation of strategies implemented by 911 call
centers that aid in the detection of infectious patients … The
Needlestick Safety & Prevention Act of 2000 was passed by the
U.S.
-
effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1312.pdf
December 01, 2013 - They
were especially concerned about patient motivation to use this system and thought the patients … Despite the safety and efficacy of emergency contraception (EC), its use
remains low. … Despite its safety and efficacy, EC use remains low.4 Barriers to use include lack of
knowledge or … Overall, experts concluded that
despite these obstacles, the potential for adoption by both patients … for this intervention to disrupt care processes and patient management.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy_executive.pdf
January 01, 2017 - current state of evidence, and assesses the quality of
studies that aim to determine the outcomes and safety … for Future
Research
Tonsillectomy is heavily researched, with far more data
available to assess safety … high quality research will be needed to evaluate these
technologies, in terms of both efficacy and safety … A better understanding of these
factors would allow for more specific patient selection. … Morbidity in patients waiting for
tonsillectomy in Cardiff: a cross-sectional study.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_research-protocol.pdf
December 09, 2009 - It may be patient defined or proxy reported. … For the questions on safety and adverse effects, in addition to the above databases, we
will search … Does functional recovery in elderly hip
fracture patients differ between patients admitted from long-term … Pain management after total joint replacement and its impact on
patient outcomes. … Evidence for
safety of
pharmacologic and
nonpharmacologic
pain management
interventions
K3:
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_executive.pdf
May 01, 2013 - The treatment
options offered to PAD patients depend
on whether the patient is asymptomatic or
symptomatic … Safety concerns
SOE=Insufficient
2 RCTs, 3,986 patients
Inconclusive evidence due to
heterogeneous … 1 patient
who underwent amputation in the 2 RCTs.
20
Table B. … 1 patient
who underwent amputation. … Safety concerns
SOE=Insufficient
5 RCTs, 282 patients
Inconclusive evidence due to heterogeneity of
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-267-adhd-executive-summary.pdf
March 01, 2024 - Commissioned by the Patient-Centered Outcomes Research Institute (PCORI), this
review assesses evidence … concerns about treatment strategies, including over- and under-treatment; and
how to best monitor ADHD patients … • Despite the large body of research, comparative effectiveness and safety
information is limited … Despite the large body of research, comparative effectiveness and safety information
is limited. … Studies did not provide information on key comparative effectiveness
and safety outcomes, and SoE is
-
effectivehealthcare.ahrq.gov/system/files/docs/topic-brief-hospital-length-of-stay.pdf
November 01, 2019 - at a safety net hospital. … in the Safety Net: Results of a Randomized
Controlled Trial. … Shift-to-Shift Handoff Effects on Patient Safety and
Outcomes. … Effect of Telehealth Interventions on
Hospitalization Indicators: A Systematic Review. … Hospitals and health systems, including CEOs, will use this information to
improve patient safety and