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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_disposition-comments.pdf
October 07, 2011 - daily, which is achieved by doubling the dose at
approximately 2-week intervals, as tolerated by the patient … For Results Key Question 2, safety information, please note that ACE
inhibitors pose unique, albeit … congestive heart failure, or nephropathy);
however all have examined an overlapping
set of efficacy and safety … of “class
effects”, specifically related to ACEIs and ARBs, discussing that
mechanism of action, safety … We underscore the importance of
updating any corollary materials (e.g., patient guides) in order to
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-radiation_executive.pdf
November 01, 2009 - Each of four reviewers
extracted study, patient, and treatment
characteristics; clinical outcomes;
and … CS=cancer-specific survival; GI=gastrointestinal; OvS=overall survival.
3
Most studies reported patient … This Technical Brief did not intend to assess outcomes
or evaluate the validity of claims on the safety … focused systematic reviews will not be
able to provide a definitive answer on the effectiveness
and safety … studies (preferably randomized) are likely
necessary to provide meaningful answers on the relative
safety
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/crohns-disease_disposition-comments.pdf
February 25, 2014 - centered outcomes, and observational studies along with RCT
for safety. … All patients in global safety summary
were Crohn’s Disease patients. … Please consider inclusion of this safety data. … According to our analytic
framework, patient-reported
outcomes are relevant. … questions
in terms of final patient important outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-disorders-imaging_disposition-comments.pdf
November 01, 2011 - Safety: The ramfiicaitons regarding potential need for alternative
imaging methods (pg 16, lines 10- … 13) to rule out specific pathologies
is to some extent a safety issue (e.g. ? … safety/outcomes. … vs. an adverse event related to the
safety of the device or procedure? … frequency of
positive MRI exams on clinically asymptomatic
patients.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment-future_research.pdf
January 01, 2014 - with patient dropouts. … retention
Patients Standardized characterization and reporting of patient
and wound characteristics … It is also extremely painful to the patient. … Population
Standards for Describing Participating Patients and Their Ulcers
Reporting of patient characteristics … ,
patient-reported and other secondary outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/s143.pdf
October 01, 2007 - Chief among them is the indication for the
drug—a patient must have the condition for which the drug … In addition, a collection of less explicit character-
istics of both the patient and prescriber influence … the choice of
a particular drug for a particular patient at a particular time. … complete (it in-
cludes all variables that actually went into the prescribing
From the *Ingenix i3 Drug Safety … Seeger, PharmD, DrPH, Ingenix i3 Drug Safety, 950
Winter Street, Suite 3800, Waltham, MA 02451.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cesarean-birth_research.pdf
January 01, 2020 - To what extent do patient educational and support tools affect patient decisions to undergo elective … Development (NICHD); Neoventa Medical
Study Design: Allocation: Randomized; Endpoint Classification: Safety … Justine Hospital Research Institute
Study Design: Allocation: Randomized; Endpoint Classification: Safety … Secondary outcomes will include multiple safety measures of the mothers and their
babies. … In addition to measures of safety, our secondary analyses will address the feasibility and
acceptability
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-5-protocol-update-2023.pdf
January 01, 2023 - reporting; (4) serve as a source for clinicians seeking information on
effectiveness of interventions for patients … meditation or "mind body" or mindfulness or music or "prolonged exposure" or
relaxation or "seeking safety … meditation or "mind body" or mindfulness or music or "prolonged exposure" or
relaxation or "seeking safety … Allowed PTSD psychotherapy, other psychotherapy, and psychotropic medication indicators
12. … Patients with suicidality excluded indicator
13.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/epc-making-sure-evidence-understood.pdf
July 01, 2020 - Department of Health and Human
Services that is charged with improving the quality, safety, efficiency … What information is needed to make better
recommendations to patients? … Consumers, patients,
caregivers, and patient
advocacy organizations
It is vital that research answer … with accurate, independent, scientifically rigorous information for
comparing the effectiveness and safety … Patient, Population or Problem:
◆ The “P” in PICO(TS) is a description of the patient(s) of interest
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/venous-ulcers-treatment_disposition-comments.pdf
January 27, 2014 - The patient perspective is important to the EPC program,
and we tried very hard to recruit patients … A wound care organization recommended this
particular patient to us because the patient has had chronic … of 188 patients. … The
data demonstrated safety and
efficacy in healing patients
with VLUs in ulcers greater
than 1 … As
stated previously, the Apligraf
pivotal study was only
designed to test safety and
efficacy in
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_appendixes.pdf
January 01, 2006 - Peds: safety and efficacy
not established in pediatric
patients
sulindac Elimination half-life: … Patient
masked? … Patient
masked? … Trials of etoricoxib and lumiracoxib (Safety only)
Author
Year
Patient
masked? … Patient global
response pooled data indicated that patients taking 25mg rofecoxib v celecoxib had good-excellent
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ambulatory-safety_disposition-comments.pdf
October 19, 2016 - Patient Safety in Ambulatory Settings. Technical
Brief No. 27. … And
appropriate anti-‐ coagulation was
not considered a safety issue, though patients are
hurt badly … Is this a big
problem affecting patients? Which issues cause the
most patient harm? … Guiding Question #1 concerned patient safety
practices. … This patient safety practice has already been adopted
by NQF’s Patient Safety Measures in 2007, approved
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-1-year-final-report-updated-title_0.pdf
May 01, 2024 - Director, General Patient Safety Program
Center for Quality Improvement and Patient
Safety
Agency … effectiveness of patient safety practices (PSPs). … safety progress,”7 a claim supported by a recent meta-
analysis indicating that as many as 1 in 20 patients … the purpose of improving patient safety. … safety practices
Patient Safety Practice Summary of Final Advice Categorization of
Final Advice
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_disposition-comments.pdf
May 29, 2013 - Will follow these as one of
sets of guidelines to follow while patient is in IPR. … research is extraordinarily difficult when
trying to compare surgery to usual medical care since
patient … The EXACT trial (n=23) limited patient
selection to TASC category A and B, with only a few
patients … Thus, patient with
TASC D lesions were not included in the trial. … viability, consider splitting into efficacy outcomes (eg
maximal walking distance, quality of life) and safety
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
March 01, 2012 - Despite recent advances in
patient care, fatal pulmonary embolism occurs in 0.1 -
0.5% of these patients … A separate question is
whether there are patient risk factors associated with
VTE events in patients … We
propose the following rubric: 1, Efficacy; 2, Safety; 3,
Cost. … 2) Improved
Efficacy; No improvement in Safety 3) No improvement
in Efficacy; Improved Safety 4) No … Furthermore, in
the clinical trials, highly selected patient groups were
used (excluding patients felt
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1512.pdf
December 01, 2015 - Many of newly added topics
use this integrated approach, and we look forward to the generation of safety … options, experts expressed concerns about the drug’s safety profile and
best administration method … Although intravenous ketamine has
known safety risks and might require increased infrastructure or … Optimism for this
intervention’s potential was tempered by available efficacy and safety data; several … Several experts were concerned about ketamine’s adverse event profile and noted that
safety risks could
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update-surveillance-160328.pdf
May 29, 2025 - $Comparative$efficacy$and$safety$of$aliskiren$and$
irbesartan$in$patients$with$hypertension$and$metabolic … $Antihypertensive$efficacy$and$
safety$of$olmesartan$medoxomil$and$ramipril$in$elderly$patients$with … $
rather$than$hypertensive$
patients),$it$highlights$the$safety$
concerns$associated$with$
combining … $Antihypertensive$efficacy$and$safety$of$olmesartan$medoxomil$and$
ramipril$in$elderly$patients$with … $Comparative$efficacy$and$safety$of$aliskiren$and$irbesartan$in$patients$with$
hypertension$and$metabolic
-
effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1512.pdf
December 01, 2015 - balloon removal from
other teams’ patients (3 patients, 0.11%), and at 1 patient (0.03%) each, Wernick … Patients were
reported to have generally tolerated the balloon well, with one early removal for patient … greatly and limit patient
acceptance, although patient interest in the procedure would likely remain … Perioperative safety in the longitudinal
assessment of bariatric surgery. … Safety of antiobesity drugs. Ther Adv Drug Saf.
2013;4(4):171-81.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_surveillance.pdf
October 29, 2012 - , 4, 5 and 6 up to date
• Expert opinion: conclusions still valid
• There are no new significant safety … using searches through August, 2011 and
addressed six key questions to evaluate effectiveness and safety … Administration (FDA), Health Canada, and Medicines and Healthcare Products Regulatory
Agency (MHRA) safety … Taken
into consideration the totality of evidence (i.e., updating signals, expert opinion, and safety … Experts: Still valid
Safety surveillance alerts: No
Conclusion: Up to date
7
Table 1.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-anticholinergic-medicines_research.pdf
December 01, 2009 - Therefore, each patient was given a 30 day immortal period following the switch. … homogeneous patient population. … Thus, there is still
need to evaluate tiotropium safety in patient populations who are treatment naïve … Methodologic challenges to
studying patient safety and comparative
effectiveness. … Methodologic challenges to
studying patient safety and comparative
effectiveness.