-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update-surveillance-160328.pdf
March 28, 2016 - $Comparative$efficacy$and$safety$of$aliskiren$and$
irbesartan$in$patients$with$hypertension$and$metabolic … $Antihypertensive$efficacy$and$
safety$of$olmesartan$medoxomil$and$ramipril$in$elderly$patients$with … $
rather$than$hypertensive$
patients),$it$highlights$the$safety$
concerns$associated$with$
combining … $Antihypertensive$efficacy$and$safety$of$olmesartan$medoxomil$and$
ramipril$in$elderly$patients$with … $Comparative$efficacy$and$safety$of$aliskiren$and$irbesartan$in$patients$with$
hypertension$and$metabolic
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effectivehealthcare-admin.ahrq.gov/products/antipsychotics-children/research-protocol
December 01, 2019 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … , patient insight into illness. … followup), patient baseline characteristics (diagnosis and age at diagnosis, age, sex, race, weight, … in each group, and the number of patients affected. … Adults
Pediatric use: safety & effectiveness not established in patients <18 yr
1. agranulocytosis
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/coronary-stents-outcomes_research.pdf
January 01, 2010 - about the outcomes, clinical effectiveness, safety, and
appropriateness of health care items and services … Effectiveness and Safety of Drug-
Eluting Stents in Ontario. … Balancing
Efficacy and Safety of Drug-Eluting
Stents in Patients Undergoing
Percutaneous Coronary … Safety and Efficacy of Sirolimus- and
Paclitaxel-Eluting Coronary Stents. … Unadjusted baseline characteristics of patients in study population
Patient Characteristics Study
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effectivehealthcare-admin.ahrq.gov/health-topics/digestive-diseases?page=1
March 14, 2012 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … Research Protocol Archived March 13, 2012
Gene Expression Profiling for Predicting Outcomes in Patients … October 4, 2010
Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients … Disease
Research Protocol Archived August 5, 2010
Comparative Effectiveness and Safety … Agents for Metastatic Colorectal Cancer
Research Report December 2, 2009
Comparative Safety
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
September 01, 2011 - As a clinician, I want to know how best to treat an
individual patient with a defined subtype of JIA … One patient experiences a hematoma occurring on
day 108 which was deemed unrelated to the study drug … Acute infusional adverse events were reported
in one (2%) patient in the abatacept group and two (3% … All studies of safety were
addressed in KQ3. … Of the 14 patients enrolled
in the infliximab arm, 5 patients failed to complete 12 months – 4
because
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/type-2-diabetes-insulin_executive.pdf
September 01, 2008 - However,
the addition of insulin to treatment
Comparative Effectiveness, Safety, and
Indications of … A number of patient-related factors have been
identified that may help physicians to select patients … Insulin lispro 75/25 was associated with a higher rate of
overall hypoglycemia measured as episode/patient … Key Question 4: Effect of premixed insulin
analogues based on patient characteristics
Comparison of … injection patterns and glucose testing
depending on the type of medication regimen
prescribed, evaluating patient
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/skin-lesions-evaluation_research-protocol.pdf
August 23, 2010 - What are the potential safety issues and harms associated with the use of non-invasive
diagnostic techniques … Guiding question 3:
What published and unpublished studies have reported on the use and safety of these … Provide a synthesis of the following information:
i Indication/patient inclusion criteria
ii Type … of techniques/modalities
iii Study design and size
iv Role of the test in patient management
v … Strategies for early melanoma detection: Approaches to the
patient with nevi.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_june_2012.pdf
January 01, 2012 - significantly increased the regulatory bar for gaining approval—specifically
regarding preapproval safety … data and postmarket safety evaluation—set forth by the U.S. … Kushner and colleagues announced results from a phase III clinical trial (SEQUEL)
evaluating the safety … However, potential increase in per-
patient costs might serve as barriers to acceptance by some patients … Safety and efficacy study of
EndoBarrier in subjects with type II diabetes and
obesity.
-
effectivehealthcare-admin.ahrq.gov/products/health-careassociated-infections/research-protocol
December 01, 2019 - Improving patient safety through infection control: a new healthcare imperative. … Michigan Health and Hospital Association Keystone Center for Patient Safety and Quality. … Shekelle PG, Pronovost PJ, Wachter RM, et al, and the Patient Safety Practices Technical Expert Panel … Assessing the Evidence for Context-Sensitive Effectiveness and Safety of Patient Safety Practices: Developing … Recommended Elements for Reporting on Patient Safety Practices
(Source: Shekelle et al. 2010)
The
-
effectivehealthcare-admin.ahrq.gov/health-topics/diabetes-medicines
November 29, 2016 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … Mellitus
Research Protocol Archived June 2, 2011
Comparative Effectiveness and Safety … Therapy
Research Protocol Archived April 5, 2010
Comparative Effectiveness and Safety … Report
Systematic Review Archived September 15, 2008
Comparative Effectiveness, Safety … Study to Assess Association of Variations in OCT Genes with Effectiveness of Metformin in Diabetic Patients
-
effectivehealthcare-admin.ahrq.gov/products/atypical-antipsychotics-off-label-update/research-protocol
March 01, 2020 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … Comparative Effectiveness of Off-label Use of Atypical Antipsychotics reviewed the scientific evidence on the safety … Studies that did not report any outcomes of efficacy, effectiveness, safety/adverse events, or utilization … We will define loss to follow-up as the number of patients excluded from efficacy analyses, expressed … as a proportion of the number of patients randomized.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/musculoskeletal-disorders-imaging_disposition-comments.pdf
November 01, 2011 - Safety: The ramfiicaitons regarding potential need for alternative
imaging methods (pg 16, lines 10- … 13) to rule out specific pathologies
is to some extent a safety issue (e.g. ? … safety/outcomes. … vs. an adverse event related to the
safety of the device or procedure? … frequency of
positive MRI exams on clinically asymptomatic
patients.
-
effectivehealthcare-admin.ahrq.gov/products/skin-lesions-evaluation/research-protocol
December 01, 2019 - whether or not patients have a history of other malignancies. … What are the potential safety issues and harms associated with the use of non-invasive diagnostic techniques … Guiding question 3:
What published and unpublished studies have reported on the use and safety of these … the technique/modality was used
Outcomes assessed
Adverse events, harms and safety issues reported … Strategies for early melanoma detection: Approaches to the patient with nevi.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_surveillance.pdf
October 29, 2012 - • There are no safety concerns
Summary Decision:
This CER’s priority for updating is Low … UUI in 40% patients on 150 U; p=0.022
• >75% improvement versus baseline in UUI in 40% patients on 100 … UUI in 40%
patients on 150 U; p=0.022
>75% improvement versus
baseline in UUI in 40%
patients on … The
efficacy
and
safety
of
solifenacin
in
patients
with
overactive
bladder … in 40% patients
on 150 U; p=0.022
>75% improvement versus baseline in UUI in 40% patients
on 100
-
effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-women-in-the-postpartum-period-what-is-the-effectiveness-and-safety-of-screening-and-treatment-for-depression-please-use-the-uspstf-framework-which-considers-not-only-screening-but-followup-treatment-and-management-the-t
November 01, 2017 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … What patients or group(s) of patients does your question apply to? … Are there subgroups of patients that your question might apply to? … (For example, improvements in patient symptoms or problems from treatment or diagnosis.) … Improvements in patient depressive symptoms
Improvements in parenting skills
Improvements in quality
-
effectivehealthcare-admin.ahrq.gov/products/phenylketonuria/research-protocol
December 01, 2019 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … of the long-term use of LNAAs and about the target patient population, including the appropriateness … , the safety and efficacy of using sapropterin dihydrochloride in children under the age of 8, including … long-term effects of pharmacological treatment or the desired Phe concentration ranges for various patient … Primary outcomes in a patient:
Decreasing Phe levels in the blood
Improved nutritional status
-
effectivehealthcare-admin.ahrq.gov/health-topics/hyperglycemia
June 05, 2013 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … Mellitus
Research Protocol Archived June 2, 2011
Comparative Effectiveness and Safety … Mellitus
Systematic Review Archived September 15, 2008
Comparative Effectiveness, Safety
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_surveillance.pdf
June 01, 2012 - the
majority of conclusions for KQ1-KQ2 were not still valid
• No FDA, Health Canada, and MHRA safety … magnitude/direction of
changes in estimates, potential changes in practice or therapy preference, safety … evidence does
not support statements on whether
other clinical features (such as
demographics or indicators … NR;
(n=76)
Two years Primary:
20% or
greater
decrease in
creatinine
clearance;
Secondary:
safety … evidence does not support statements on
whether other clinical features (such as demographics or
indicators
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/patient-monitoring-systems-rapid-review.pdf
December 01, 2024 - patient safety studies. … Director, General Patient Safety Program
Center for Quality Improvement and Patient Safety
Agency for … Standard Patient safety/harm
search string for all PSPs topics
“patient safety”[mh] OR “patient … Standard Patient safety/harm
search string for all PSPs topics
[mh “patient safety”] OR “patient … patient
safety?
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-outcomes_methods.pdf
July 01, 2012 - consequences if the tested
individual is in a profession that requires disclosure of health threats for the safety … of their key questions:
whether prediction of prognosis with spirometry, with or without clinical indicators … , is more
accurate than prediction based on clinical indicators alone. … The sponsoring organizations were
interested in predicting patients’ survival free of premature death … Spirometry is a noninvasive test that most
patients tolerate well.