-
effectivehealthcare-admin.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1412.pdf
December 01, 2014 - Adoption could be limited by ketamine’s
cost, inconsistent clinical trial data, and safety risks, multiple … But one expert with a research
5
background, citing ketamine’s safety risk and lack of long-term … be limited; these experts cited ketamine’s safety risks and lack of robust clinical
trial data as … In
contrast, scopolamine’s known safety profile and possible oral and patch delivery options, bolstered … A
study to evaluate the safety and efficacy of
intranasal esketamine in treatment-resistant
depression
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effectivehealthcare-admin.ahrq.gov/products/lysosomal-storage-diseases-therapies/research-protocol
December 01, 2020 - every other week, for the life of the patient. … What are the potential safety issues and harms with ERT? … What published and unpublished studies have reported on the use and safety of this intervention? … studies
Concurrent/prior treatments
Length of follow up
Outcomes measured
Adverse events/harms/safety … patient and one parent of a child patient will be consulted.
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effectivehealthcare-admin.ahrq.gov/health-topics/neurologic-diseases?page=4
January 24, 2011 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … Crohn’s Disease
Research Protocol Archived August 5, 2010
Technical Brief: Use and Safety … Archived August 5, 2010
Comparative Effectiveness and Safety of Analgesics for Osteoarthritis … Delivery
Research Protocol Archived July 1, 2010
Evaluation of Effectiveness and Safety … of Antiepileptic Medications in Patients with Epilepsy
Research Report Archived May
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effectivehealthcare-admin.ahrq.gov/products/hypertension-pulmonary-arterial/research-protocol
December 01, 2019 - Question 2
For patients with PAH, what is the comparative effectiveness and safety of a) echocardiography … outcomes (patient outcome efficacy)? … Question 3
For patients with PAH, what is the comparative effectiveness and safety of monotherapy or … PICOTS Criteria
Population(s):
KQ 1: Patients with suspected PAH and asymptomatic patients at high … disorder such as scleroderma)
KQs 2 and 3: Patients with PAH
KQ 1: Patients have neither 1
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_technical-brief.pdf
December 01, 2012 - Patient-oriented and patient-advocacy Web sites for colon cancer were searched. … These GEP assays are all prognostic indicators.
Table 1. … The FDA addresses the safety and effectiveness of diagnostic tests and the quality
of the design and … Historically, the FDA has subjected test kits to premarket review of safety and effectiveness, but
not … result from both preanalytic factors (e.g.,
sample preparation) as well as analytic factors (such as reagents
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2010_research-protocol.pdf
January 01, 2010 - KQ 2
What is the evidence for safety of SIT in patients with allergic rhinoconjunctivitis and/or … products, based
on AgE content, but this was never implemented.
4.CBER provides two US standard reagents … only "change in skin test reactivity" (in-vivo) and "change in antibody" (in-vitro) are accepted
indicators … Not all patients with asthma are allergic. … The activity domain contains 5 ‘patient-specific’ questions.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
August 22, 2008 - the most recent data in 2006 (37 year survival).2
The estimated annual direct medical costs per CF patient … KQ 6: In patients with CF, how is efficacy, effectiveness, safety or adverse events impacted
by rhGH … KQ 7: In patients with CF, how do the efficacy, effectiveness, safety or adverse events of
treatment … followup, and disease state (CF, idiopathic short
stature, or growth hormone deficiency)], patient … Patient Registry Annual Report 2006. Bethesda, MD: Cystic
Fibrosis Foundation; 2008.
3.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
March 01, 2012 - Despite recent advances in
patient care, fatal pulmonary embolism occurs in 0.1 -
0.5% of these patients … A separate question is
whether there are patient risk factors associated with
VTE events in patients … We
propose the following rubric: 1, Efficacy; 2, Safety; 3,
Cost. … 2) Improved
Efficacy; No improvement in Safety 3) No improvement
in Efficacy; Improved Safety 4) No … Furthermore, in
the clinical trials, highly selected patient groups were
used (excluding patients felt
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/uterine-fibroids_research-protocol.pdf
March 01, 2016 - including MRgFUS systems and power morcellators (see Table
A-2 in Appendix), though it has issued safety … and tumor characteristics that may
predict success or adverse events in patients considered for morcellation … Examples
include: baseline characteristics of the patients (e.g., age, menopausal status; symptom
status … Laparoscopic Uterine Power Morcellation in
Hysterectomy and Myomectomy: FDA Safety Communication, Updated … Available at
http://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/ucm424443.htm.
19.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
November 01, 2012 - In patients with chronic plaque psoriasis,
what is the comparative safety of systemic biologic
agents … To be included, the patient population evaluated in the
study must have been adult patients (≥18 years … In an RCT that compared the efficacy and
safety of adalimumab with placebo in patients with
moderate … Study Evaluating the Efficacy and Safety of Etanercept and
Acitretin in Korean Patient With Moderate … Safety and
efficacy study on etanercept in patients with plaque psoriasis.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1512.pdf
December 01, 2015 - balloon removal from
other teams’ patients (3 patients, 0.11%), and at 1 patient (0.03%) each, Wernick … Patients were
reported to have generally tolerated the balloon well, with one early removal for patient … greatly and limit patient
acceptance, although patient interest in the procedure would likely remain … Perioperative safety in the longitudinal
assessment of bariatric surgery. … Safety of antiobesity drugs. Ther Adv Drug Saf.
2013;4(4):171-81.
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effectivehealthcare-admin.ahrq.gov/health-topics/dietary-proteins?page=4
March 09, 2010 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … Agents
Systematic Review Archived September 15, 2008
Comparative Effectiveness, Safety … in Adults
Systematic Review Archived July 16, 2007
Comparative Effectiveness and Safety … Archived May 23, 2006
Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients … Study to Assess Association of Variations in OCT Genes with Effectiveness of Metformin in Diabetic Patients
-
effectivehealthcare-admin.ahrq.gov/products/pediatric-ehr/technical-brief
December 01, 2019 - support the work of child health care providers and assure the delivery of quality care to pediatric patients … medication dosing, pediatric disease management, pediatric norms, and the relationship between pediatric patients … that if these functionalities are implemented well, the EHR will also better support the care of all patients … medical home; (2) a desire to support and maintain patient safety; and (3) the increasing presence of … Safety Practices and Ratings by a Technical Expert Panel, 2023-2024
Technical Brief
May
-
effectivehealthcare-admin.ahrq.gov/system/files/docs/topic-brief-hospital-length-of-stay.pdf
November 01, 2019 - at a safety net hospital. … in the Safety Net: Results of a Randomized
Controlled Trial. … Shift-to-Shift Handoff Effects on Patient Safety and
Outcomes. … Effect of Telehealth Interventions on
Hospitalization Indicators: A Systematic Review. … Hospitals and health systems, including CEOs, will use this information to
improve patient safety and
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/vte-prophyalaxis_executive.pdf
May 01, 2013 - The burden of VTE is higher among some patient
populations, including patients who have experienced … and safety of pharmacologic
strategies for VTE prevention in patients with liver disease. … effectiveness and safety of pharmacologic strategies among
patients with liver disease. … in the patient populations. … RCTs should evaluate the comparative effectiveness
and safety of LMWHs in obese patients.
-
effectivehealthcare-admin.ahrq.gov/products/coronary-stents-outcomes/research
January 01, 2020 - Thus we are unable to directly address some important questions which have been raised regarding the safety … Effectiveness and Safety of Drug-Eluting Stents in Ontario. N Engl J Med 2007;357:1393-1402. … Balancing Efficacy and Safety of Drug-Eluting Stents in Patients Undergoing Percutaneous Coronary Intervention … Safety and Efficacy of Sirolimus- and Paclitaxel-Eluting Coronary Stents. … Unadjusted baseline characteristics of patients in study population
Patient Characteristics
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/epc-making-sure-evidence-understood.pdf
July 01, 2020 - Department of Health and Human
Services that is charged with improving the quality, safety, efficiency … What information is needed to make better
recommendations to patients? … Consumers, patients,
caregivers, and patient
advocacy organizations
It is vital that research answer … with accurate, independent, scientifically rigorous information for
comparing the effectiveness and safety … Patient, Population or Problem:
◆ The “P” in PICO(TS) is a description of the patient(s) of interest
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prioritization-selection-of-harms.pdf
February 01, 2018 - The workgroup suggests that EPC reviews focus on indicators of more
severe harms (e.g., “serious” adverse … 9) How should input from technical and clinical experts and patients or patient advocacy groups be
used … How should input from technical and clinical experts and patients or patient advocacy groups be
used … Had to report data from
groups of in which at least
85% of the patients were
from one of the patient … What are the
harms of therapeutic interventions
for patients with ME/CFS and how
do they vary by patient
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/field-triage-glascow_research-protocol.pdf
February 25, 2016 - severity score ≥16, head AIS score >2 or >3,
presence of intracranial hemorrhage, and utilization indicators … • KQ1: Predictive utility for mortality, morbidity, injury severity score ≥16,25 or
utilization indicators … score of Glasgow
Coma Scale
Intermediate
outcomes
Over- or under-
triage
Utilization indicators … National Highway Traffic Safety Administration. Washington, DC. … patients.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/allergy-seasonal_executive.pdf
July 01, 2013 - effective during pregnancy, but their use may be restricted
because of concerns about maternal and fetal safety … treatment for mild SAR
• The comparative effectiveness and safety of SAR
treatments used in combination … all outcomes of interest were patient
reported. … SAR/PAR results (N = 4)
● Unable to obtain article (N = 2)
● Incomplete data (N = 1)
● Efficacy/safety … magnitude
and direction of change in drug disposition may facilitate
application of effectiveness and safety