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effectivehealthcare-admin.ahrq.gov/products/lysosomal-storage-diseases-therapies/research-protocol
December 01, 2020 - every other week, for the life of the patient. … What are the potential safety issues and harms with ERT? … What published and unpublished studies have reported on the use and safety of this intervention? … studies
Concurrent/prior treatments
Length of follow up
Outcomes measured
Adverse events/harms/safety … patient and one parent of a child patient will be consulted.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/uterine-fibroids_research-protocol.pdf
March 01, 2016 - including MRgFUS systems and power morcellators (see Table
A-2 in Appendix), though it has issued safety … and tumor characteristics that may
predict success or adverse events in patients considered for morcellation … Examples
include: baseline characteristics of the patients (e.g., age, menopausal status; symptom
status … Laparoscopic Uterine Power Morcellation in
Hysterectomy and Myomectomy: FDA Safety Communication, Updated … Available at
http://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/ucm424443.htm.
19.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/copd-anticholinergic-medicines_research.pdf
December 01, 2009 - Therefore, each patient was given a 30 day immortal period following the switch. … homogeneous patient population. … Thus, there is still
need to evaluate tiotropium safety in patient populations who are treatment naïve … Methodologic challenges to
studying patient safety and comparative
effectiveness. … Methodologic challenges to
studying patient safety and comparative
effectiveness.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_2012-12-11.pdf
January 01, 2012 - data and postmarket safety evaluation—set
forth by the U.S. … Kushner and colleagues announced results from a phase III clinical trial (SEQUEL)
evaluating the safety … However, a
potential increase in per-patient cost might serve as a barrier to acceptance by some patients … While
preliminary results are promising, further studies evaluating efficacy and safety are needed, … Safety and efficacy study of
EndoBarrier in subjects with type II diabetes and
obesity.
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effectivehealthcare-admin.ahrq.gov/products/telehealth-women/research
January 01, 2023 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … , depression, fear of partner, coercive control, self-efficacy, post-traumatic stress disorder, and safety … s preventive services for reproductive healthcare and interpersonal violence (IPV), and to evaluate patient … , depression, post-traumatic stress disorder, fear of partner, coercive control, self-efficacy, and safety … Telehealth use was facilitated by strategies to ensure safety of individuals who receive IPV services
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
August 22, 2008 - the most recent data in 2006 (37 year survival).2
The estimated annual direct medical costs per CF patient … KQ 6: In patients with CF, how is efficacy, effectiveness, safety or adverse events impacted
by rhGH … KQ 7: In patients with CF, how do the efficacy, effectiveness, safety or adverse events of
treatment … followup, and disease state (CF, idiopathic short
stature, or growth hormone deficiency)], patient … Patient Registry Annual Report 2006. Bethesda, MD: Cystic
Fibrosis Foundation; 2008.
3.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/crohns-disease-future_research.pdf
July 01, 2016 - Patient Stakeholder
Thomas Ullman, M.D.
Mt. … KQ 3 What is the comparative safety of therapies alone or in combination used in adults and children … Given that patient-
reported outcomes may be even more relevant to patients who are not currently experiencing … Study Design
Observational studies may be too short in duration to observe some safety outcomes. … outcomes
• Studies in non-white
populations
Children
• Trials and safety
studies in
children
Patient
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effectivehealthcare-admin.ahrq.gov/health-topics/diabetes-type-2?page=2
July 28, 2009 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … Report
Systematic Review Archived September 15, 2008
Comparative Effectiveness, Safety … Hypertension
Systematic Review Archived July 16, 2007
Comparative Effectiveness and Safety … 2005
Addressing Knowledge Gaps in Type 2 Diabetes Therapeutics: Comparative Effectiveness and Safety … Study to Assess Association of Variations in OCT Genes with Effectiveness of Metformin in Diabetic Patients
-
effectivehealthcare-admin.ahrq.gov/system/files/docs/topic-brief-hospital-length-of-stay.pdf
November 01, 2019 - at a safety net hospital. … in the Safety Net: Results of a Randomized
Controlled Trial. … Shift-to-Shift Handoff Effects on Patient Safety and
Outcomes. … Effect of Telehealth Interventions on
Hospitalization Indicators: A Systematic Review. … Hospitals and health systems, including CEOs, will use this information to
improve patient safety and
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effectivehealthcare-admin.ahrq.gov/products/hypertension-pulmonary-arterial/research-protocol
December 01, 2019 - Question 2
For patients with PAH, what is the comparative effectiveness and safety of a) echocardiography … outcomes (patient outcome efficacy)? … Question 3
For patients with PAH, what is the comparative effectiveness and safety of monotherapy or … PICOTS Criteria
Population(s):
KQ 1: Patients with suspected PAH and asymptomatic patients at high … disorder such as scleroderma)
KQs 2 and 3: Patients with PAH
KQ 1: Patients have neither 1
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2010_research-protocol.pdf
January 01, 2010 - KQ 2
What is the evidence for safety of SIT in patients with allergic rhinoconjunctivitis and/or … products, based
on AgE content, but this was never implemented.
4.CBER provides two US standard reagents … only "change in skin test reactivity" (in-vivo) and "change in antibody" (in-vitro) are accepted
indicators … Not all patients with asthma are allergic. … The activity domain contains 5 ‘patient-specific’ questions.
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effectivehealthcare-admin.ahrq.gov/products/uterine-fibroids/research-protocol
May 01, 2019 - uterine fibroids including MRgFUS systems and power morcellators (see Table A-2 ), though it has issued safety … and tumor characteristics that may predict success or adverse events in patients considered for morcellation … Examples include: baseline characteristics of the patients (e.g., age, menopausal status; symptom status … Laparoscopic Uterine Power Morcellation in Hysterectomy and Myomectomy: FDA Safety Communication, Updated … Available at http://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/ucm424443.htm .
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effectivehealthcare-admin.ahrq.gov/products/ems-blood-transfusion/protocol
February 01, 2025 - Which component combinations result in the best patient outcomes for which types of patients? … Hospital free days ICU free days Intermediate Outcomes in the prehospital or ED setting Physiological indicators … hemorrhagic shock characteristics (e.g., mechanism of injury/condition, severity, blood pressure, other indicators … MMAT = Mixed Methods Appraisal Tool; NA = not applicable; NHTSA = National Highway and Transportation Safety … the Funder
This project was funded by the National Highway and Transportation Safety
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/allergy-seasonal_executive.pdf
July 01, 2013 - effective during pregnancy, but their use may be restricted
because of concerns about maternal and fetal safety … treatment for mild SAR
• The comparative effectiveness and safety of SAR
treatments used in combination … all outcomes of interest were patient
reported. … SAR/PAR results (N = 4)
● Unable to obtain article (N = 2)
● Incomplete data (N = 1)
● Efficacy/safety … magnitude
and direction of change in drug disposition may facilitate
application of effectiveness and safety
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
March 01, 2012 - Despite recent advances in
patient care, fatal pulmonary embolism occurs in 0.1 -
0.5% of these patients … A separate question is
whether there are patient risk factors associated with
VTE events in patients … We
propose the following rubric: 1, Efficacy; 2, Safety; 3,
Cost. … 2) Improved
Efficacy; No improvement in Safety 3) No improvement
in Efficacy; Improved Safety 4) No … Furthermore, in
the clinical trials, highly selected patient groups were
used (excluding patients felt
-
effectivehealthcare-admin.ahrq.gov/health-topics/neurologic-diseases?page=4
January 24, 2011 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … Crohn’s Disease
Research Protocol Archived August 5, 2010
Technical Brief: Use and Safety … Archived August 5, 2010
Comparative Effectiveness and Safety of Analgesics for Osteoarthritis … Delivery
Research Protocol Archived July 1, 2010
Evaluation of Effectiveness and Safety … of Antiepileptic Medications in Patients with Epilepsy
Research Report Archived May
-
effectivehealthcare-admin.ahrq.gov/products/coronary-stents-outcomes/research
January 01, 2020 - Thus we are unable to directly address some important questions which have been raised regarding the safety … Effectiveness and Safety of Drug-Eluting Stents in Ontario. N Engl J Med 2007;357:1393-1402. … Balancing Efficacy and Safety of Drug-Eluting Stents in Patients Undergoing Percutaneous Coronary Intervention … Safety and Efficacy of Sirolimus- and Paclitaxel-Eluting Coronary Stents. … Unadjusted baseline characteristics of patients in study population
Patient Characteristics
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1512.pdf
December 01, 2015 - balloon removal from
other teams’ patients (3 patients, 0.11%), and at 1 patient (0.03%) each, Wernick … Patients were
reported to have generally tolerated the balloon well, with one early removal for patient … greatly and limit patient
acceptance, although patient interest in the procedure would likely remain … Perioperative safety in the longitudinal
assessment of bariatric surgery. … Safety of antiobesity drugs. Ther Adv Drug Saf.
2013;4(4):171-81.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/preterm-birth-terbutaline-pump_research-protocol.pdf
October 18, 2010 - Terbutaline sulfate is commonly used in selected patients as a maintenance
therapy to inhibit uterine … Further, as the level of
care offered to patients and the level of activity of patients on continuous … subcutaneous
terbutaline might differ from that of patients on comparative treatments, we will explore … Therefore, in addition to conducting heterogeneity analyses by other indicators of true
preterm labour … to ensure only one event is recorded per patient, in the case the
same patient experiences multiple
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/epc-making-sure-evidence-understood.pdf
July 01, 2020 - Department of Health and Human
Services that is charged with improving the quality, safety, efficiency … What information is needed to make better
recommendations to patients? … Consumers, patients,
caregivers, and patient
advocacy organizations
It is vital that research answer … with accurate, independent, scientifically rigorous information for
comparing the effectiveness and safety … Patient, Population or Problem:
◆ The “P” in PICO(TS) is a description of the patient(s) of interest